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  3. Pentasa 1 gm Suppository 7's

Pentasa 1 gm Suppository 7's, Pack of 7 SUPPOSITORYS
Pentasa 1 gm Suppository 7's, Pack of 7 SUPPOSITORYS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Pentasa 1 gm Suppository is used to treat ulcerative colitis. It contains Mesalazine, which helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding. It may cause side effects such as diarrhoea, stomach pain, headache or nausea.

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Composition :

MESALAZINE-1000MG

Manufacturer/Marketer :

Ferring Pharmaceuticals Pvt Ltd

Consume Type :

RECTAL

Return Policy :

Not Returnable

Expires on or after :

About Pentasa 1 gm Suppository

Pentasa 1 gm Suppository is used to treat ulcerative colitis and ulcerative proctitis. Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rectum.

Pentasa 1 gm Suppository contains Mesalazine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling).

Sometimes, you may experience diarrhoea, stomach pain, headache or nausea. Most of these side effects of Pentasa 1 gm Suppository do not require medical attention and typically resolve on their own over time. However, if the side effects persist or worsen, please consult your doctor.

Follow your doctor's instructions on the dosage and timing of this medication. Pentasa 1 gm Suppository is for rectal use only. It is advised to wash your hands before and after applying the medicament. Ensure the rectal area is clean and dry before application.

Inform your doctor if you are allergic to any components present in Pentasa 1 gm Suppository. Pentasa 1 gm Suppository should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before taking Pentasa 1 gm Suppository. Avoid taking Pentasa 1 gm Suppository if you have severe kidney failure. If you have stomach pain, cramps, severe headache, fever or rash, after taking Pentasa 1 gm Suppository, stop taking it immediately and consult a doctor.

Uses of Pentasa 1 gm Suppository

Pentasa 1 gm Suppository is used in the treatment of Ulcerative colitis and Ulcerative proctitis. The detailed uses of Pentasa 1 gm Suppository are as follows:

  • Management of Irritable Bowel Syndrome (IBS): Pentasa 1 gm Suppository helps manage IBS symptoms like bloating, gas, and abdominal discomfort.
  • Support for Ulcerative Colitis: Pentasa 1 gm Suppository supports ulcerative colitis management by reducing flare-ups and promoting gut health.
  • Restoration of Gut Flora Post-Antibiotics: Pentasa 1 gm Suppository helps to restore beneficial gut bacteria after antibiotic use.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions and use it as advised by the doctor. 
  • Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum. Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture.
  • Wash your hands before and after applying the medicament. Ensure the rectal area is clean and dry before application.
  • For rectal use only.

Medicinal Benefits

  • Pentasa 1 gm Suppository contains Mesalamine, an anti-inflammatory drug used to treat ulcerative colitis and ulcerative proctitis.
  • This medicine helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.
  • Pentasa 1 gm Suppository may also prevent further episodes of ulcerative colitis.

How Pentasa 1 gm Suppository Works

Pentasa 1 gm Suppository contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Pentasa 1 gm Suppository
  • Eating and drinking slowly can help swallow less air, which reduces burps.
  • Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
  • Prevent smoking as it can impact your whole body.
  • Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
  • Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

What if I have taken an overdose of Pentasa 1 gm Suppository

Do not use Pentasa 1 gm Suppository in more doses or more often than prescribed. If you have any unusual signs or symptoms, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to this medication or any of its components.
  • The use of Pentasa 1 gm Suppository should be exercised with caution in the elderly.
  • Avoid taking Pentasa 1 gm Suppository if you have severe kidney failure.
  • Do not use Pentasa 1 gm Suppository if you are pregnant, planning to become pregnant, or breastfeeding without first consulting the doctor.
  • Pentasa 1 gm Suppository is recommended not to be used in populations with severe renal or hepatic impairment, so inform your doctor if you have severe renal or hepatic impairment.
  • Use Pentasa 1 gm Suppository as directed by a doctor, in the dose and duration advised.
  • Pentasa 1 gm Suppository is for rectal use. Do not swallow it. In case of accidental swallowing, drink plenty of water and consult a doctor immediately.
  • Pentasa 1 gm Suppository is not recommended for use in children.

Drug-Drug Interactions

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MesalazineCidofovir
Critical
MesalazineNizatidine
Severe

Drug-Drug Interactions

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MesalazineCidofovir
Critical
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Pentasa 1 gm Suppository with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Pentasa 1 gm Suppository with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Nizatidine with Pentasa 1 gm Suppository can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Pentasa 1 gm Suppository with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineTenofovir alafenamide
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Tenofovir alafenamide with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Pentasa 1 gm Suppository with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Metrizamide with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Pentasa 1 gm Suppository with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Iomeprol with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Pentasa 1 gm Suppository and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineDeferasirox
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Deferasirox with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Pentasa 1 gm Suppository and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.
MesalazineRanitidine
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Ranitidine with Pentasa 1 gm Suppository can decrease the levels of Pentasa 1 gm Suppository, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Pentasa 1 gm Suppository with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineOmeprazole
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of omeprazole with Pentasa 1 gm Suppository can decrease the effects of Pentasa 1 gm Suppository.

How to manage the interaction:
There could be a possible interaction between Pentasa 1 gm Suppository and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Iodamide with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley, and berries, which help promote faster healing.
  • Opt for food and drinks rich in Omega-3 fatty acids to alleviate pain, swelling, and inflammation. Omega 3 fatty acid-enriched foods include flaxseeds, walnuts, soybean oil, salmon, and tuna if you prefer non-veg.
  • Eat more fibre-rich foods such as fruits and vegetables.
  • Eat smaller meals all day.
  • Drink small amounts of water throughout the day.
  • If you are intolerant to lactose, lower your intake of milk.
  • Avoid consuming foods high in sugar and fat, as well as processed foods, as these may trigger inflammation.
  • Try to avoid alcohol as it can affect your stomach and intestines and also limit the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Pentasa 1 gm Suppository Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of alcohol with Pentasa 1 gm Suppository is unknown. Consult the physician.

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Pregnancy

Unsafe

Pentasa 1 gm Suppository should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Consult your doctor

Pentasa 1 gm Suppository should not be used while breastfeeding unless necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Pentasa 1 gm Suppository.

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Driving

Safe if prescribed

Pentasa 1 gm Suppository usually does not affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor before using Pentasa 1 gm Suppository if you have a history of liver disease. It should be used cautiously in patients with mild to moderately impaired liver function. It is not recommended for use in populations with severe liver impairment.

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Kidney

Caution

Inform your doctor before using Pentasa 1 gm Suppository if you have a history of kidney disease. It should be used cautiously in patients with mild to moderate kidney impairment. It is not recommended for use in populations with severe kidney impairment.

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Children

Not applicable

Pentasa 1 gm Suppository is intended for adults. Not recommended for children.

Have a query?

FAQs

Pentasa 1 gm Suppository is used to treat ulcerative colitis, a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon).

Pentasa 1 gm Suppository contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves symptoms such as stomach pain or bleeding.

Pentasa 1 gm Suppository may cause diarrhoea as a common side effect. However, if the condition persists or worsens, accompanied by fever, watery stools, or persistent stomach pain, please consult a doctor. Also, drink plenty of water while using Pentasa 1 gm Suppository to prevent dehydration.

You are not recommended to take Pentasa 1 gm Suppository with aspirin as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking Pentasa 1 gm Suppository with other medicines.

No, you are not recommended to stop using Pentasa 1 gm Suppository suddenly, as it may cause recurring symptoms. Therefore, use Pentasa 1 gm Suppository for as long as your doctor has prescribed it, and if you experience any difficulty while using Pentasa 1 gm Suppository, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

K-28/1, ADDITIONAL MIDC , ANAND NAGAR , AMBERNATH - 421506 , INDIA
Other Info - PEN0413

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 12:22 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.914.pdf
  2. https://www.ciplamed.com/product-index/mesalo-foam
  3. https://www.indiamart.com/proddetail/pentasa-enema-24013227162.html?srsltid=AfmBOooY4QaSyH4wMQ9BJsBNEScKMhwLcwvrHZTwszRKbelcD3INAI1Q

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