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compositionComposition:PEGINTERFERON ALFA 2B-100MCG
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Prescription Medicine
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Pegihep 100 Injection is used to treat Chronic (long-term) hepatitis C infection. It contains Peginterferon alpha-2b, which works by decreasing the amount of hepatitis C virus (HCV) in the body. In some cases, Pegihep 100 Injection may cause side effects such as injection site reactions, breathing problems (including shortness of breath), feeling depressed, trouble sleeping, thinking, or concentrating, dizziness, severe stomach pain or cramps, fever or chills, and painful or inflamed muscles (sometimes severe).

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PEGINTERFERON ALFA 2B-100MCG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pegihep 100 Injection

Pegihep 100 Injection is a prescription injection used to treat long-term viral infections of the liver, such as chronic hepatitis C and chronic hepatitis B. Its primary medical purpose is to help your body's immune system fight off the virus and reduce viral activity. By lowering the amount of the virus in your body, it helps protect your liver from long-term damage.

This medication is typically injected once a week and must be used consistently to get the best results. Since it is an injection, it does not depend on food intake, so you can inject it with or without eating. To support your treatment, it is highly recommended to eat a balanced diet, stay well-hydrated, and completely avoid alcohol, which can further strain your liver.

Many people experience temporary flu-like symptoms, such as fever, chills, and muscle aches, after their injection. While these are common, you must consult your doctor immediately if you experience severe mood changes, deep sadness, or signs of a serious infection.

Do not take this if you have autoimmune hepatitis, severe liver failure, or a history of severe mental health issues like deep depression. You must talk to your doctor before starting this medicine if you have a history of heart disease, thyroid problems, or autoimmune conditions.

This medicine can interact with other drugs, including certain asthma medications, by altering how your liver processes them. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist before using Pegihep 100 Injection to ensure it is safe for your specific situation.

Uses of Pegihep 100 Injection

Pegihep 100 Injection is used to treat long-term viral infections of the liver. The detailed uses of Pegihep 100 Injection are as follows:

  • Chronic Hepatitis C: Pegihep 100 Injection helps by slowing down the multiplication of the virus in the body, which protects liver cells from damage and scarring.
  • Chronic Hepatitis B: Pegihep 100 Injection works to strengthen your immune response, helping your body control the virus and reduce active liver inflammation.
     

Key Benefits

Pegihep 100 Injection helps treat chronic viral infections by reducing the amount of virus in the body and limiting further damage to affected organs. With regular use as prescribed, it helps control the infection, supports recovery, and lowers the risk of long-term complications.

  • Controls Viral Infection: By suppressing viral replication, this medicine helps reduce the amount of virus in the body, allowing the immune system to better control the infection.
  • Protects Liver Health: For viral liver infections such as chronic hepatitis, this medicine helps reduce ongoing liver inflammation, supports healing of liver tissue, and lowers the risk of complications such as liver scarring (cirrhosis) and liver failure.
  • Supports Long-Term Recovery: By keeping the virus under control, this medicine helps improve liver function, reduce fatigue and other symptoms associated with active infection, and promotes better overall health over time.
     
Side effects of Pegihep 100 Injection
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Mood swings can be managed but cannot be controlled. Therefore, spending time in nature can help you feel light and improve your mood.
  • Practice meditation, deep breathing and do regular exercise that can positively affect your mood. Also helps in processing the situation before responding to it.
  • Food has direct impact on mood. Therefore, eat foods that are less processed and reduce sugar intake.
  • Consult your doctor if the mood swings are uncontrollable or unmanageable.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Pegihep 100 Injection will be administered by a nurse or doctor.
  • Do not self-administer.

How Pegihep 100 Injection Works

Pegihep 100 Injection contains peginterferon alfa 2B, which works by mimicking the action of natural proteins that your immune system produces to fight off viral invaders. When injected, it attaches to specific targets on the surface of your cells, triggering a biological defence system. Once active, this medicine blocks the virus from entering healthy cells and stops it from multiplying. At the same time, it alerts and strengthens your body’s natural defence cells, making them more effective at finding and destroying cells that are already infected. The unique structure of this medication allows it to stay in your body for a longer period, providing a steady and continuous defence against the virus with fewer injections.
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Alcohol

Caution

Avoid consumption of alcohol while taking Pegihep 100 Injection.

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Pregnancy

Unsafe

If you are pregnant or plan to become pregnant, do not use Pegihep 100 Injection. You should not begin taking Pegihep 100 Injection until a pregnancy test has revealed that you are not pregnant. You or your partner may use effective birth control measures and be tested for pregnancy every month during your treatment and for six months afterwards. If you become pregnant at this period, contact your doctor right away. Pegihep 100 Injection may harm your fetus.

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Breast Feeding

Unsafe

You should not breastfeed your baby while on treatment with Pegihep 100 Injection as it may harm your infant.

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Driving

Unsafe

Do not drive or operate any machinery as Pegihep 100 Injection may make you drowsy, dizzy, or confused.

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Liver

Unsafe

Pegihep 100 Injection is not recommended for use in patients with decompensated liver disease as it may worsen the condition. Inform your doctor if you have liver cirrhosis before receiving Pegihep 100 Injection.

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Kidney

Caution

Use Pegihep 100 Injection with caution if you have kidney disease, as this medicine may worsen your condition. Inform your doctor if you have kidney problems.

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Children

Consult your doctor

Safety and effectiveness of Pegihep 100 Injection in pediatric patients below the age of 18 years have not been established. Please consult your doctor for more information.

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Heart

Consult your doctor

Please consult your doctor before receiving Pegihep 100 Injection if you have pre-existing heart problems. Your doctor will prescribe Pegihep 100 Injection if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Pegihep 100 Injection to geriatric patients. Your doctor will prescribe Pegihep 100 Injection if the benefits outweigh the risks.

What if I have taken an overdose of Pegihep 100 Injection

In case of an accidental overdose, seek immediate emergency medical help.

Diet & Lifestyle Advise

  • Avoid alcohol entirely: Alcohol puts extra strain on your liver and can worsen liver damage while using this medication.
  • Stay well-hydrated: Drink plenty of water and clear fluids, especially on injection days, to help reduce flu-like symptoms and protect your kidneys.
  • Eat smaller, frequent meals: If you experience mild nausea or loss of appetite, eating small, nutritious meals throughout the day can help maintain your energy.
  • Prioritise rest: Schedule your injections when you can rest afterwards, as fatigue is a common side effect of this treatment.
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Have a query?

How Soon It Starts Working

The time required for Pegihep 100 Injection to start to work: Pegihep 100 Injection ideally starts working within 3-12 hours of intramuscular or subcutaneous dose and 30 minutes followed by an intravenous administration of the dose. The time for which the effects of Pegihep 100 Injection last: The duration of action for Pegihep 100 Injection is clinically unknown.

What if you forget to take Pegihep 100 Injection

If you miss a dose, inject it as soon as you remember if it is within the timeframe recommended by your doctor. However, if it is almost time for your next scheduled injection, skip the missed dose and return to your regular schedule. Never inject a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store Pegihep 100 Injection in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Always check the liquid inside the syringe or vial before use; it should be clear and colourless. Do not inject it if you see cloudiness, discolouration, or particles.
  • Rotate your injection sites (such as different areas of your abdomen or thigh) with each dose to reduce the risk of skin irritation.
  • Never reuse a needle or syringe, and never share them with anyone else to prevent serious infections.
  • Keep all scheduled appointments for blood tests so your doctor can monitor your liver health, thyroid function, and blood cell counts.
  • Use highly effective birth control while using this medication, as it can cause harm to an unborn baby. Talk to your doctor immediately if you suspect you are pregnant.
     

Drug-Drug Interactions

verifiedApollotooltip
  • May increase the blood levels and side effects of certain medications, such as theophylline (used for breathing issues).
  • May interact with other antiviral medications, potentially increasing the risk of side effects like nerve pain or severe blood disorders.
Peginterferon alfa-2bCladribine
Severe
Peginterferon alfa-2bEltrombopag
Severe

Drug-Drug Interactions

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Peginterferon alfa-2bCladribine
Severe
How does the drug interact with Pegihep 100 Injection:
Taking Pegihep 100 Injection with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Pegihep 100 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Peginterferon alfa-2bEltrombopag
Severe
How does the drug interact with Pegihep 100 Injection:
When Eltrombopag is combined with Pegihep 100 Injection the serum concentration of Eltrombopag can be increased.

How to manage the interaction:
Although taking Eltrombopag and Pegihep 100 Injection together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to call your doctor right away. These symptoms include chronic hepatitis C, advanced liver disease, cirrhosis, liver failure, and other liver-related problems. You should also seek medical attention if you experience confusion, fever, joint pain, swelling, or any other unusual symptoms. Don't hesitate to reach out to a doctor if you have concerns about your health. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Pegihep 100 Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Pegihep 100 Injection is used to treat Chronic (long-term) hepatitis C infection.
Pegihep 100 Injection contains Peginterferon alpha-2b works by decreasing the amount of hepatitis C virus (HCV) in the body.
No, it may not be effective in preventing the spread of hepatitis C to others.
Peginterferon alfa-2b is used alone or in combination with other medication to treat chronic (long-term) hepatitis C infection. It may not cure hepatitis C or keep you from developing complications like cirrhosis (liver scarring), liver failure, or liver cancer.
A combination of Pegihep 100 Injection with telbivudine is not recommended.
Pegihep 100 Injection cause or worsen serious or life-threatening autoimmune, ischemic, neuropsychiatric and infectious diseases. Patients with these conditions should be continuously evaluated through clinical and laboratory examinations on a regular basis and stop using Pegihep 100 Injection. Many, but not all, of these problems are resolved after PEG-Intron medication is discontinued.
Yes, you can take over-the-counter medication to reduce fever. However, if fever persists, consult your doctor.
Yes, Pegihep 100 Injection may impair fertility. If you have concerns regarding this, please discuss with your doctor.
No, Pegihep 100 Injection does not cause weight gain. Instead, it may cause weight loss as side effect. If you experience sudden changes in weight, consult a doctor.
Yes, Pegihep 100 Injection may cause side effects such as injection site reactions, feeling depressed, breathing problems (including shortness of breath), trouble sleeping, dizziness, painful or inflamed muscles, severe stomach pain or cramps, and fever or chills. If any of these side effects persist or worsen, please consult your doctor.
No, you should completely avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage and can make your treatment less effective. Talk to your doctor if you need support in avoiding alcohol.
The recommended sites for injection are your abdomen (stomach area, avoiding the belly button) or the middle of your thigh. Make sure to rotate the site with every injection to prevent skin irritation. Talk to your doctor or nurse if you need guidance on injection techniques.
Flu-like symptoms like fever and chills are common, especially after the first few doses. Injecting the medicine at bedtime and staying well-hydrated can help. Ask your doctor if you can take an over-the-counter pain reliever before your injection to manage these symptoms.
No, you should not take this medicine if you are pregnant or planning to become pregnant, as it can be harmful to an unborn baby. Both men and women using this medicine must use effective birth control during treatment. Talk to your doctor immediately if you or your partner becomes pregnant.
Yes, some people experience temporary hair thinning or hair loss while using this medicine. Hair growth typically returns to normal after the treatment is completed. Talk to your doctor if this is causing you distress.
This medicine can cause fatigue, dizziness, or confusion in some people, especially right after an injection. Avoid driving or operating machinery if you feel dizzy or tired. Talk to your doctor if these symptoms persist.
Your doctor will schedule regular blood tests to monitor your liver function, thyroid function, and blood cell counts throughout your treatment. It is highly important to keep all of these appointments to ensure the medicine is working safely. Talk to your doctor for a specific schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, India.
Other Info - PEG0101
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