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Peg-Lasgen Injection 5 ml is used in the treatment of Acute Lymphoblastic Leukaemia (ALL) and hypersensitivity to asparaginase. Acute lymphoblastic leukaemia is a type of cancer where the body makes too many abnormal white blood cells. These cells proliferate quickly and interfere with normal blood cell production, causing symptoms such as fatigue and easy bruising. It is more common in children but can also affect adults.
Peg-Lasgen Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood. Since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die.
A healthcare professional will administer Peg-Lasgen Injection 5 ml. In some cases, this medicine may cause side effects like nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. The majority of these side effects may not require medical treatment and will subside with time. However, if the side effects persist or worsen, see a doctor.
Before starting treatment, be sure to inform your doctor about any other medications or herbal products you are currently taking. Peg-Lasgen Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment. Pregnant and breastfeeding women should consult their doctor before receiving Peg-Lasgen Injection 5 ml. This medicine is given to children in doses as advised by the doctor, depending on the age. Peg-Lasgen Injection 5 ml should be stored in cold places at 2°C to 8°C.
Peg-Lasgen Injection 5 ml is a pegylated form of L-asparaginase, an enzyme that breaks down L-asparagine. This enzyme specifically targets leukaemia cells in acute lymphoblastic leukaemia (ALL), which cannot produce enough L-asparagine on their own and depend on it from the blood for protein production. It works by breaking down the amino acid asparagine, which leukaemia cells need to proliferate. Its pegylated form reduces the risk of hypersensitivity reactions and provides a longer duration of action, allowing for less frequent dosing. This makes it more tolerable for patients, especially those who have experienced allergic reactions to other forms of asparaginase.
Caution
Avoid or limit alcohol consumption while on treatment with Peg-Lasgen Injection 5 ml as it may worsen your condition.
Caution
If you are pregnant or planning pregnancy, inform your doctor before receiving Peg-Lasgen Injection 5 ml. Your doctor will prescribe this medicine only if clearly needed.
Caution
It is not known if Peg-L-Asparaginase passes into breast milk. Please consult the doctor if you are breastfeeding. Your doctor will advise you to discontinue breastfeeding or the medicine based on your condition.
Caution
Peg-Lasgen Injection 5 ml may cause drowsiness or dizziness. If you experience any such side effects, avoid driving or operating machinery.
Caution
If you have pre-existing or a history of liver disease, inform your doctor before receiving Peg-Lasgen Injection 5 ml. Your doctor may recommend regular tests to monitor liver function while receiving Peg-Lasgen Injection 5 ml.
Caution
If you have pre-existing or a history of kidney disease, inform your doctor before receiving Peg-Lasgen Injection 5 ml. Your doctor may recommend regular tests to monitor kidney function while receiving Peg-Lasgen Injection 5 ml.
Safe if prescribed
The dosage for children is recommended based on their age, body weight, and the child's condition.
Caution
Please inform your doctor if you have heart problems before taking Peg-Lasgen Injection 5 ml, as it may cause blood clots, allergic reactions, and changes in blood pressure or glucose levels, which can be more serious in individuals with cardiovascular conditions.
Caution
Please inform your doctor if you are geriatric before taking Peg-Lasgen Injection 5 ml, as there is limited information available on its safety in this age group.
Have a query?
Inform your doctor if you have had severe allergic reactions to asparaginase, bleeding problems, or blood clots. Let your doctor know if you get a fever, have liver issues, or take medicines that could harm your liver. Peg-Lasgen Injection 5 ml can cause liver damage, brain problems, or pancreas issues. If you experience stomach pain, let your doctor know. Peg-Lasgen Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment. If you are pregnant, planning for pregnancy, or are breastfeeding, please inform your doctor before receiving Peg-Lasgen Injection 5 ml. Avoid driving after receiving Peg-Lasgen Injection 5 ml if you experience drowsiness or dizziness.
Drug-Drug Interaction: Inform the doctor if you are taking anticancer drugs (cytarabine, methotrexate, vincristine), anticoagulants (warfarin, heparin), corticosteroids (prednisone), anti-inflammatory medications (ibuprofen, naproxen), glucocorticoids (dexamethasone) and oral contraceptives.
Drug-Food Interaction: No interactions found.
Drug-Disease Interaction: Peg-Lasgen Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment.
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Peg-Lasgen Injection 5 ml is used in the treatment of Acute Lymphoblastic Leukaemia (ALL) and hypersensitivity to asparaginase.
Peg-Lasgen Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood, and since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die. Thereby, Peg-Lasgen Injection 5 ml helps treat Acute Lymphoblastic Leukaemia.
Peg-Lasgen Injection 5 ml may cause glucose intolerance in some people. Consult the doctor if you have high/low blood glucose levels.
Peg-Lasgen Injection 5 ml is given as an injection, usually through an intravenous (IV) or intramuscular (IM) route. The dosage and frequency depend on your condition and doctor’s recommendation.
Peg-Lasgen Injection 5 ml may cause stomach pain in some patients. You are advised to inform your doctor immediately if you experience stomach pain, as it may be a sign of pancreatitis, an inflammation of the pancreas.
Do not drive or operate machinery while using this medication, as it may cause drowsiness, fatigue, or confusion, which can reduce your ability to concentrate and respond quickly.
Peg-Lasgen Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment.
If you have a history of liver complications, inform your doctor before receiving Peg-Lasgen Injection 5 ml, as it can affect liver function. Individuals with a history of liver issues are at higher risk for liver damage. Your doctor will monitor liver function through regular tests and may adjust the dosage if necessary.
Yes, Peg-Lasgen Injection 5 ml can be administered to children, particularly to treat Acute Lymphoblastic Leukaemia (ALL). However, the dosage and administration are adjusted based on the child's age and weight. Always follow your doctor's recommendations for pediatric use.
During your treatment with Peg-Lasgen Injection 5 ml, avoid alcohol, infection risks, blood-thinning medications, and unapproved treatments. Check with your doctor before taking any new medications or supplements, and avoid high-fat foods if you experience digestive issues. Consult a doctor if you have any concerns or if any signs of infection occur.
Peg-Lasgen Injection 5 ml causes side effects such as nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. Seek medical care if the side effects persist or worsen.
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