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compositionComposition:PIMAVANSERIN-34MG
prescription
Prescription Medicine
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Parkrel Capsule 10's is used in the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. It contains Pimavanserin, which helps restore its level in the brain. Thereby, improves the symptoms of Parkinson's disease. Some people may experience headache, dizziness, nausea, vomiting, peripheral edema, gait disturbance (difficulty/abnormal walking), and constipation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PIMAVANSERIN-34MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Parkrel Capsule 10's

Parkrel Capsule 10's is a prescription medication used to treat hallucinations and delusions associated with Parkinson’s disease psychosis. It helps manage these challenging sensory changes by targeting specific chemical receptors in the brain. This medication is specifically designed to help quiet these symptoms without worsening the physical movement difficulties of Parkinson's disease.

To get the best results, you should take Parkrel Capsule 10's consistently once every day, ideally at the same time. You can take this medication with or without food, depending on your preference. Combining this treatment with a stable daily routine and keeping your living space well-lit can further help reduce confusion and visual triggers.

Some people taking this medication may experience mild side effects, such as swelling in the legs or ankles, nausea, or mild confusion. However, you must contact your doctor immediately if you experience serious side effects, such as a fast or irregular heartbeat, severe dizziness, or fainting.

Before starting this treatment, talk to your doctor if you have a history of heart rhythm problems, kidney disease, or liver damage. Do not take this if you have a history of certain heart conditions, and note that this medication should not be used to treat dementia-related psychosis that is not linked to Parkinson's disease.

This medicine can interact with other drugs that affect your heart rhythm, as well as certain antifungal or antibiotic medications, so it is important to share your full medication list with your pharmacist. Additionally, you should consult your doctor before using Parkrel Capsule 10's if you are pregnant, breastfeeding, or if you are managing multiple health conditions as an older adult.

Uses of Parkrel Capsule 10's

Parkrel Capsule 10's is a medicine used to manage certain psychotic symptoms associated with Parkinson's disease. Its detailed use includes:

  • Parkinson's disease psychosis: Parkrel Capsule 10's helps reduce hallucinations, such as seeing or hearing things that are not there, and delusions, which are strong beliefs that are not based on reality.

Key Benefits

Parkrel Capsule 10's helps manage hallucinations and delusions associated with Parkinson's disease psychosis while supporting daily comfort and quality of life. Its benefits include:

  • Helps reduce hallucinations and delusions without directly blocking dopamine receptors, which may help avoid worsening Parkinson's movement symptoms such as tremors and stiffness.
  • May help patients feel more comfortable, secure, and oriented in their daily surroundings by reducing distressing hallucinations and false beliefs.
  • Better control of psychotic symptoms may also reduce stress and anxiety for family members and caregivers.

Directions for Use

  • Parkrel Capsule 10's can be taken with or without food, or as advised by your doctor.
  • It is usually taken once a day or as directed by the doctor.
  • Swallow it as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Parkrel Capsule 10's Works

Parkrel Capsule 10's works by targeting the serotonin system in the brain, specifically blocking certain receptors known as 5-HT2A receptors. In Parkinson's disease, an imbalance in these receptors can lead to visual hallucinations and false beliefs. By binding to these receptors, the medication quiets down the overactive chemical signals that cause these symptoms. Because Parkrel Capsule 10's specifically targets serotonin rather than dopamine, it avoids interfering with the dopamine-based medications you take to manage your Parkinson's movement symptoms. This selective action allows you to manage mental symptoms while maintaining control over your physical movements.
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Alcohol

Unsafe

Avoid consumption of alcohol with Parkrel Capsule 10's as it may increase the risk of adverse effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Consult your doctor

It is unknown whether Parkrel Capsule 10's is safe for use in pregnant women or not. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Consult your doctor

It is unknown if this medicine is excreted into the breast milk. Please consult your doctor before taking Parkrel Capsule 10's if you are a breastfeeding mother.

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Driving

Unsafe

Parkrel Capsule 10's may cause drowsiness or dizziness. Therefore, avoid driving if you feel drowsy or dizzy after taking Parkrel Capsule 10's.

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Liver

Unsafe

Parkrel Capsule 10's is not recommended for use in patients with liver impairment. Hence, please consult your physician.

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Kidney

Caution

Parkrel Capsule 10's should be used with caution in patients with kidney problems. This medicine is not recommended for use in patients with severe kidney failure.

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Children

Unsafe

Parkrel Capsule 10's is not recommended for children as the safety and efficacy have not established.

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Heart

Consult your doctor

Please consult your doctor before using Parkrel Capsule 10's if you have pre-existing heart problems. Your doctor will prescribe Parkrel Capsule 10's if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before taking Parkrel Capsule 10's to geriatric patients. Your doctor will prescribe Parkrel Capsule 10's if the benefits outweigh the risks.

What if I have taken an overdose of Parkrel Capsule 10's

If you suspect an overdose, or if someone has accidentally taken too much of this medication, seek immediate medical attention or call your local poison control center right away. An overdose can cause serious heart rhythm complications.

Diet & Lifestyle Advise

  • Stay properly hydrated: Drink water regularly throughout the day. Good hydration supports brain health and helps prevent constipation, which can be a common side effect of Parkinson's medications.
  • Optimize your home environment: Keep hallways and rooms well-lit, and remove clutter. Good lighting reduces shadows that can sometimes trigger visual hallucinations in people with Parkinson's psychosis.
  • Avoid alcohol: Do not drink alcohol while taking Parkrel Capsule 10's, as it can worsen drowsiness, increase confusion, and impair your coordination, making movement more difficult.
  • Keep a daily symptom log: Note when hallucinations or delusions occur, how long they last, and what time you took your medication. Sharing this log with your doctor can help them optimize your care plan.
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How Soon It Starts Working

The time required for Parkrel Capsule 10's to start to work: The time needed for Parkrel Capsule 10's to show its action is not clinically established.
The time for which the effects of Parkrel Capsule 10's last: The duration of action for Parkrel Capsule 10's is not clinically established.

What if you forget to take Parkrel Capsule 10's

If you miss a dose of Parkrel Capsule 10's, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Parkrel Capsule 10's at room temperature between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inform your doctor about heart conditions: Tell your doctor about any heart problems before starting Parkrel Capsule 10's, especially if you have a history of a slow or irregular heartbeat.
  • Monitor for changes: Ask a family member or caregiver to monitor you closely when starting Parkrel Capsule 10's, particularly for changes in behavior, mood, confusion, or vision.
  • Do not stop suddenly: Do not stop taking Parkrel Capsule 10's without medical advice. Stopping treatment may cause hallucinations or delusions to return. Talk to your doctor before changing or stopping the medicine.
  • Important warning for older adults with dementia-related psychosis: Antipsychotic medicines are associated with an increased risk of stroke and death in older adults with dementia-related psychosis. Parkrel Capsule 10's is not approved for treating psychosis related to dementia unless specifically indicated by a doctor.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart rhythm medications: Combining Parkrel Capsule 10's with drugs that prolong the QT interval (such as certain antiarrhythmics, antipsychotics, or some antibiotics) can increase the risk of serious, irregular heartbeats.
  • Strong CYP3A4 inhibitors: Medications such as ketoconazole, clarithromycin, or itraconazole can raise the levels of Parkrel Capsule 10's in your body, which may increase the risk of side effects. Your doctor may need to adjust your dose.
  • Strong CYP3A4 inducers: Medicines like rifampin, carbamazepine, or phenytoin can lower the levels of Parkrel Capsule 10's in your body, making it less effective.
PimavanserinEfavirenz
Severe
PimavanserinMorphine
Severe

Drug-Drug Interactions

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PimavanserinEfavirenz
Severe
How does the drug interact with Parkrel Capsule:
Taking Efavirenz and Parkrel Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz and Parkrel Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PimavanserinMorphine
Severe
How does the drug interact with Parkrel Capsule:
Using Morphine together with Parkrel Capsule can increase the risk of central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Parkrel Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
PimavanserinGatifloxacin
Severe
How does the drug interact with Parkrel Capsule:
Taking Parkrel Capsule with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Parkrel Capsule with Gatifloxacin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PimavanserinChloroquine
Severe
How does the drug interact with Parkrel Capsule:
Using chloroquine together with Parkrel Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Parkrel Capsule and Chloroquine together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PimavanserinKetoconazole
Severe
How does the drug interact with Parkrel Capsule:
Taking Ketoconazole and Parkrel Capsule together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketoconazole and Parkrel Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Parkrel Capsule 10's when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Possible side effects of Parkrel Capsule 10's include peripheral edema and confusional state; other side effects may also occur. Some people may experience dizziness or other symptoms that can affect alertness. If you experience persistent, severe, or worsening side effects, contact your doctor. Avoid driving or operating machinery if you feel impaired.
It may take several weeks of daily, consistent use before you or your family notice a significant reduction in hallucinations and delusions. Always continue taking the medicine as prescribed, and talk to your doctor if you have concerns about your progress.
Yes. Unlike older antipsychotics, Parkrel Capsule 10's does not block dopamine receptors, so it does not interfere with carbidopa-levodopa or other medications you take to manage tremors and movement. Always let your doctor know about all medications you take.
It is recommended to swallow Parkrel Capsule 10's tablets whole with water. If you or your loved one has difficulty swallowing pills, talk to your doctor or pharmacist about alternative options or safe ways to take your medication.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take a double dose. If you are unsure, talk to your doctor or pharmacist.
Yes. For elderly patients who have dementia-related psychosis not associated with Parkinson's disease, there is an increased risk of serious side effects, including death. Parkrel Capsule 10's is only approved to treat psychosis specifically associated with Parkinson's disease. Talk to your doctor for more details.
Grapefruit and grapefruit juice can act as mild to moderate inhibitors of the enzymes that break down this medication, potentially raising its levels in your blood. It is best to avoid consuming large amounts of grapefruit while taking this medicine. Talk to your doctor for personalized dietary advice.
No, Parkrel Capsule 10's is not a cure for Parkinson's disease. It is a maintenance medication designed specifically to manage and reduce the symptoms of psychosis (hallucinations and delusions) associated with the disease. Talk to your doctor to learn more about managing your overall condition.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India.
Other Info - PAR1400

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