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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Pantosig IT 40/150 Capsule is used to treat acidity, GERD (gastro-oesophagal reflux disease), and peptic ulcers. It contains Pantoprazole and Itopride, which decrease the production of acid. Additionally, it works by accelerating gastric emptying and improving gastric sensitivity and tone. It also has anti-emetic action. Thus, it helps in preventing acid reflux, thereby providing relief from acidity. In some cases, you may experience certain common side effects such as headache, nausea, stomach pain, dizziness and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Signova Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pantosig IT 40/150 Capsule

Pantosig IT 40/150 Capsule is a combination medicine used to treat acidity, gastroesophageal reflux disease (GERD), and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.

Pantosig IT 40/150 Capsule is a combination of two drugs: Pantoprazole and Itopride. Pantoprazole works by blocking the action of an enzyme called the gastric proton pump, which is responsible for the production of acid. Itopride works by accelerating gastric emptying and improving gastric sensitivity and tension. It also has anti-emetic action. Together, Pantosig IT 40/150 Capsule helps in preventing acid reflux, thereby providing relief from acidity.

You are advised to take Pantosig IT 40/150 Capsule as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as headache, nausea, stomach pain, dizziness and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor before taking Pantosig IT 40/150 Capsule if you have a history of gastrointestinal bleeding, mechanical perforation/obstruction, or movement disorder. On long-term treatment, Pantosig IT 40/150 Capsule may cause osteoporosis and hypomagnesemia (low levels of magnesium). Consult your doctor if you are pregnant or breastfeeding. Pantosig IT 40/150 Capsule may cause drowsiness, so drive only if you are alert. Pantosig IT 40/150 Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Pantosig IT 40/150 Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Uses of Pantosig IT 40/150 Capsule

Pantosig IT 40/150 Capsule is used in the treatment of hyperacidity, gastro-oesophageal reflux disease (GERD), and peptic ulcer. The detailed uses of Pantosig IT 40/150 Capsule are as follows:

  • Hyperacidity: Pantosig IT 40/150 Capsule works by reducing excessive stomach acid production, providing relief from symptoms such as heartburn, indigestion, and stomach discomfort.
  • Gastro-oesophageal reflux disease (GERD): Pantosig IT 40/150 Capsule helps manage acid reflux by lowering acid levels, thereby reducing regurgitation, irritation of the oesophagus, and difficulty swallowing.
  • Peptic ulcer: Pantosig IT 40/150 Capsule promotes healing of stomach and intestinal ulcers by decreasing acid secretion and preventing further damage to the ulcerated tissues.

Directions for Use

  • Take Pantosig IT 40/150 Capsule 30-60 minutes before food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Pantosig IT 40/150 Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Pantosig IT 40/150 Capsule is a combination of two drugs: Pantoprazole (a proton pump inhibitor) and Itopride (a prokinetic agent). Together, they provide the following medicinal benefits:
  • Pantoprazole decreases excessive stomach acid production, preventing irritation and damage to the stomach and oesophagus.
  • Itopride enhances stomach contractions, speeds up gastric emptying, and reduces bloating, nausea, and early satiety.
  • The combined action of both medicines controls the backwards flow of stomach contents, providing relief from heartburn and indigestion.
  • Reduced acid levels and improved stomach function help in the healing of peptic ulcers and prevent their recurrence.
  • The dual mechanism offers comprehensive relief from symptoms of acid-peptic disorders, including gastro-oesophageal reflux disease (GERD).

How Pantosig IT 40/150 Capsule Works

Pantosig IT 40/150 Capsule is a combination of two drugs: Pantoprazole and Itopride. Pantoprazole works by blocking the action of an enzyme called the gastric proton pump, which is responsible for the production of acid. Itopride works by accelerating gastric emptying and improving gastric sensitivity and tension. It also has anti-emetic action. Together, Pantosig IT 40/150 Capsule helps in preventing acid reflux, thereby providing relief from acidity.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Pantosig IT 40/150 Capsule

Do not take more than the prescribed dose of Pantosig IT 40/150 Capsule as it may cause an overdose. The symptoms of overdose include fever, back pain, slow/irregular heartbeat, rash, pain while peeing or blood in urine (signs of kidney problems) or stomach pain that worsens (sign of an inflammed liver or pancreas). If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not use Pantosig IT 40/150 Capsule if you are allergic to Pantoprazole, Itopride, or any ingredient in the medicine. Seek immediate medical help if you experience symptoms of an allergic reaction such as rash, swelling, or difficulty breathing.
  • Inform your doctor about any history of gastrointestinal bleeding, stomach or intestinal perforation, bowel obstruction, movement disorders (such as Parkinson's disease), liver or kidney problems, autoimmune conditions (such as lupus), or electrolyte imbalances. Also, provide a complete list of all medications you are taking, as Pantosig IT 40/150 Capsule may interact with certain drugs or require dose adjustments.
  • Long-term use of Pantoprazole (typically beyond 3–12 months) may cause low magnesium levels, leading to tremors, muscle cramps, seizures, or abnormal heart rhythms. Periodic magnesium level monitoring is advised.
  • Prolonged use of proton pump inhibitors like Pantoprazole (≥1 year) may increase the risk of bone fractures, particularly in the hip, wrist, or spine. Use the lowest effective dose for the shortest required duration.
  • Extended use may reduce absorption of vitamin B₁₂, calcium, and iron, and may increase the risk of gastrointestinal infections (Clostridioides difficile), pneumonia, or formation of stomach polyps.
  • Report any unusual symptoms such as joint pain, persistent rash, fever, or dark-colored urine, as these may indicate rare but serious side effects such as kidney inflammation or lupus-like reactions.
  • Consult your doctor before using Pantosig IT 40/150 Capsule if you are pregnant or breastfeeding, as safety data are limited. Use in children has not been established and is generally not recommended.

Drug-Drug Interactions

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PantoprazoleRilpivirine
Critical

Drug-Drug Interactions

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PantoprazoleRilpivirine
Critical
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Co-administration of Rilpivirine is taken with Pantosig IT 40 mg/150 mg Capsule, can decrease the absorption and blood levels of Rilpivirine and make the medication less effective.

How to manage the interaction:
Taking Pantosig IT 40 mg/150 mg Capsule with Rilpivirine can lead to an interaction, please consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Co-administration of Pantosig IT 40 mg/150 mg Capsule reduces stomach acid, decreases the absorption and blood levels of Atazanavir, and reduces its effectiveness.

How to manage the interaction:
Taking Pantosig IT 40 mg/150 mg Capsule with Atazanavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Co-administration of Methotrexate with Pantosig IT 40 mg/150 mg Capsule can increase the levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Pantosig IT 40 mg/150 mg Capsule and methotrexate, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Taking Pantosig IT 40 mg/150 mg Capsule with Pazopanib may reduce the effectiveness of pazopanib.

How to manage the interaction:
If you are supposed to take Pantosig IT 40 mg/150 mg Capsule and Pazopanib together, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Taking Pantosig IT 40 mg/150 mg Capsule can make Dacomitinib less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Pantosig IT 40 mg/150 mg Capsule with Dacomitinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Taking Gefitinib with Pantosig IT 40 mg/150 mg Capsule reduces the acidity level in the stomach and may interfere with the absorption of Gefitinib and reduce its effectiveness.

How to manage the interaction:
Taking Pantosig IT 40 mg/150 mg Capsule with Gefitinib together can possibly result in an interaction, it can be taken if your doctor has advised it. You are recommended to take gefitinib 12 hours before or 12 hours after Pantosig IT 40 mg/150 mg Capsule to help minimize the impact of the interaction. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Taking Dasatinib with Pantosig IT 40 mg/150 mg Capsule may decrease the blood levels of Dasatinib and reduce its effectiveness.

How to manage the interaction:
Taking Pantosig IT 40 mg/150 mg Capsule with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. In case of any unusual side effects, contact a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Taking Erlotinib with Pantosig IT 40 mg/150 mg Capsule may interfere with the absorption of Erlotinib into the bloodstream, and reduce its effectiveness.

How to manage the interaction:
Taking Pantosig IT 40 mg/150 mg Capsule with Erlotinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
PantoprazoleNelfinavir
Severe
How does the drug interact with Pantosig IT 40 mg/150 mg Capsule:
Taking Nelfinavir with Pantosig IT 40 mg/150 mg Capsule may decrease the absorption and blood levels of Nelfinavir and reduce its effectiveness.

How to manage the interaction:
Taking Pantosig IT 40 mg/150 mg Capsule with Nelfinavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight through regular exercise.
  • Avoid lying down after eating.
  • Avoid tight-fitting clothes.
  • Maintain a healthy weight through regular exercise.
  • Practice relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes, every hour, by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pantosig IT 40/150 Capsule . Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.

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Pregnancy

Caution

Consult your doctor before taking Pantosig IT 40/150 Capsule if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Pantosig IT 40/150 Capsule ; your doctor will decide whether Pantosig IT 40/150 Capsule can be taken by breastfeeding mothers or not.

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Driving

Caution

Pantosig IT 40/150 Capsule may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking Pantosig IT 40/150 Capsule if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Pantosig IT 40/150 Capsule if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Pantosig IT 40/150 Capsule should not be given to children as safety and effectiveness were not established.

Have a query?

FAQs

Pantosig IT 40/150 Capsule is used to treat acidity, GERD (gastro-oesophagal reflux disease), and peptic ulcers.

Pantosig IT 40/150 Capsule is a combination of two drugs, namely: Pantoprazole and Itopride. Pantoprazole works by blocking the action of an enzyme called gastric proton pump, responsible for the production of acid. Itopride works by accelerating gastric emptying and improves gastric sensitivity and tension. Together, Pantosig IT 40/150 Capsule helps in preventing acid reflux, thereby provides relief from acidity.

Talk to your doctor if you do not feel better even after taking Pantosig IT 40/150 Capsule for 14 days. Do not take Pantosig IT 40/150 Capsule for longer durations unless prescribed by the doctor.

Diarrhoea might be a side-effect of Pantosig IT 40/150 Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Pantosig IT 40/150 Capsule may increase the risk of osteoporosis (weak and brittle bones). This mainly occurs in people taking higher doses of Pantosig IT 40/150 Capsule for longer durations. Consult your doctor if you have any concerns.

Take Pantosig IT 40/150 Capsule exactly as prescribed by your doctor. To avoid heartburn and acid reflux, it is recommended to take Pantosig IT 40/150 Capsule 30 to 60 minutes before food.

Usually, Pantosig IT 40/150 Capsule begins to work 2 to 4 hours after it is taken. However, it may vary from person to person.

Yes, Pantosig IT 40/150 Capsule may cause constipation as a side effect. It can be minimized by drinking plenty of water or eating foods that will help you stay hydrated and also increase your intake of high-fibre foods like raw fruits, whole grains, and vegetables.

No, a single dose of Pantosig IT 40/150 Capsule is usually not sufficient for treating conditions like GERD (gastro-oesophageal reflux disease) or peptic ulcers. Therefore, it’s important to follow your doctor's instructions and complete the full course of treatment to see full benefits.

Pantosig IT 40/150 Capsule is generally considered safe when taken as prescribed by your doctor. Do not exceed the recommended daily dose.

The long term side effects of Pantosig IT 40/150 Capsule are osteoporosis and hypomagnesemia (low levels of magnesium).

Take Pantosig IT 40/150 Capsule exactly as prescribed by your doctor. It is recommended to take Pantosig IT 40/150 Capsule 30 to 60 minutes before food, preferably in the morning.

No, do not stop taking Pantosig IT 40/150 Capsule without consulting your doctor, even if you start feeling better. Stopping Pantosig IT 40/150 Capsule too early may cause your symptoms to return or worsen, and it might not fully treat the underlying condition. Always follow your doctor's instructions and complete the full course of treatment to ensure the best results.

Weight gain is not a common side effect of Pantosig IT 40/150 Capsule . However, the long-term use of proton pump inhibitors (PPIs) like pantoprazole may indirectly cause weight gain through changes in appetite and food intake. To overcome this side effect, follow a balanced diet and consult your doctor. If you have any concerns, consult your doctor.

No, avoid drinking alcohol while taking Pantosig IT 40/150 Capsule as it causes increased production of stomach acid, thereby increasing acidity and heartburn.

Yes, you can take antacids 2 hours before or after taking Pantosig IT 40/150 Capsule , to prevent any possible interactions, this allows the antacids to work effectively without interfering with the absorption of Pantosig IT 40/150 Capsule . However, please consult a doctor before taking other medicines with Pantosig IT 40/150 Capsule .

To get relieve from acidity, include high-fibre foods like whole grains, vegetables and fruits, alkaline foods such as cauliflower, fennel, and nuts, watery foods like celery, cucumber, lettuce, and watermelon, lean proteins and ginger as they can help reduce acid reflux symptoms.

You are recommended to consult a doctor before taking pain killers along with Pantosig IT 40/150 Capsule .

The common side effects of Pantosig IT 40/150 Capsule are headache, nausea, stomach pain, dizziness and diarrhoea. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

House No-44, Ground Floor, Barthakur Mill Road, Ulubari, Guwahati, Kamrup,Assam -781007
Other Info - PAN2105

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