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compositionComposition:PALIPERIDONE-100MG
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Paliris LA 100 mg Injection 1 ml is used for the treatment of schizophrenia and schizoaffective disorder in adults. It contains Paliperidone, which works by blocking the effects of chemical messengers in the brain (i.e., dopamine and serotonin), thereby helping improve mood, behaviour and thoughts. Thus, it elevates the symptoms of the disease and prevents them from recurring. Common side effects of Paliris LA 100 mg Injection 1 ml are injection site reactions, sleepiness or drowsiness, feeling restlessness or needing to be constantly moving, dizziness, abnormal muscle movements including tremors (shaking), uncontrolled involuntary movements, shuffling and abnormal movements of your eyes.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PALIPERIDONE-100MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Paliris LA 100 mg Injection 1 ml

Paliris LA 100 mg Injection 1 ml is a prescription medicine used to treat schizophrenia and schizoaffective disorder. It belongs to a group of medicines called atypical antipsychotics, which help improve symptoms that affect how a person thinks, feels, and behaves. This medicine can reduce symptoms such as hallucinations (seeing or hearing things that are not there), delusions (strong false beliefs), and disorganised thinking, helping you manage your condition more effectively.

Paliris LA 100 mg Injection 1 ml is given as a long-acting injection by a healthcare professional. Depending on the formulation prescribed, it may be given once a month or once every few months. If you are starting the once-monthly treatment, you will usually receive two initial injections during the first week before moving to your regular monthly schedule. Keeping all your injection appointments helps maintain a steady amount of medicine in your body and reduces the risk of symptoms returning.

Most people tolerate this medicine well. Like all medicines, it can cause side effects, although not everybody gets them. Common side effects include pain at the injection site, sleepiness, dizziness, weight gain, or restlessness. Seek medical help immediately if you develop severe muscle stiffness with a high fever, unusual movements of your face or tongue, severe dizziness or fainting, or signs of a serious allergic reaction such as swelling of the face or difficulty breathing.

Before starting treatment, tell your doctor if you have kidney disease, heart problems, seizures, diabetes, or Parkinson's disease. This medicine may not be suitable for everyone. Older adults with dementia-related psychosis have a higher risk of serious complications with this medicine and should only receive it if their doctor decides the benefits outweigh the risks. In some countries, this medicine may also be prescribed for adolescents with schizophrenia, but treatment should always be supervised by a specialist.

Tell your doctor about all the medicines and supplements you take before starting treatment. Alcohol and medicines that cause drowsiness may increase some side effects. If you are pregnant, planning a pregnancy, or breastfeeding, discuss the benefits and possible risks with your doctor before receiving this medicine.

Uses of Paliris LA 100 mg Injection 1 ml

This medication is primarily prescribed for long-term mental health management. A doctor may prescribe Paliris LA 100 mg Injection 1 ml for the following conditions:

  • Schizophrenia: Paliris LA 100 mg Injection 1 ml helps reduce core symptoms such as hearing or seeing things that are not there, false beliefs, and disorganised thoughts.
  • Schizoaffective disorder: Paliris LA 100 mg Injection 1 ml helps treat mood swings and psychotic symptoms, either alone or when combined with other mood stabilisers or antidepressants.

Key Benefits

When used as directed as part of your treatment plan, Paliris LA 100 mg Injection 1 ml may provide the following benefits:

  • Helps control symptoms: Helps reduce symptoms such as hallucinations (seeing or hearing things that are not there), delusions (strong false beliefs), and disorganised thinking.
  • Helps prevent symptoms from returning: Maintaining a steady level of medicine in your body may reduce the chance of symptoms coming back.
  • Supports long-term treatment: The long-acting injection helps many people continue treatment as prescribed without needing to take a daily tablet.
  • Supports daily functioning: Better control of symptoms may make it easier to manage everyday activities, work, studies, and social relationships.
  • May reduce hospital admissions: Good symptom control may lower the risk of relapse (when symptoms return) and reduce the need for hospital treatment.
Side effects of Paliris LA 100 mg Injection 1 ml
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Managing Medication-Triggered very low levels of granulocytes (while blood cells): A Step-by-Step Guide:
  • If you take medicine and develop symptoms such as fever, chills, or serious infections, seek immediate medical attention. This could indicate neutropenia, a disorder marked by extremely low quantities of granulocytes (white blood cells).
  • To address the adverse effect, your doctor may change your treatment plan, offer supportive therapy, or prescribe other medications. They will also conduct regular blood tests to check your white blood cell level and adjust your medication as necessary.
  • Follow your doctor's advice, including dietary recommendations and lifestyle changes, and take steps to prevent infections, such as washing your hands frequently, avoiding close contact with sick people, and avoiding crowded areas.
  • Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Discuss with your doctor if you suspect a medicine is causing hyperprolactinemia. Your doctor may reduce the dose or switch to an alternative medicine with low impact on prolactin levels.
  • Assess the severity of your symptoms related to high prolactin levels, like sexual dysfunction in men and menstrual irregularities in women for treatment choices.
  • Regular blood tests are recommended to monitor prolactin levels to assess treatment effectiveness.
  • Eat smaller meals and chew food thoroughly.
  • Try foods with softer textures.
  • If you have difficulty swallowing liquids, use thickener.
  • Learn new swallowing techniques from a speech and language therapist.
  • Avoid alcohol and caffeine as these may dry your throat and mouth making it more difficult to swallow.
  • Consider alternative forms of feeding, such as feeding tubes through nose or a hole into your stomach.
  • Avoid holding and empty the bladder at regular intervals.
  • Apply cold or ice packs for few minutes.
  • Exercise regularly and maintain a healthy lifestyle.
  • Make sure to have an adequate sleep.
  • Maintain healthy diet containing fruits and vegetables.

Directions for Use

  • Paliris LA 100 mg Injection 1 ml is administered by healthcare professionals in a clinical setting, usually through an intramuscular injection.
  • The dosage and frequency are determined by your doctor, based on the severity of your condition and response to treatment.
  • Do not self-administer this injection, as improper use can cause serious side effects.
  • You may need to be monitored regularly by your doctor during treatment to check for any potential side effects and ensure the medication is effective.

How Paliris LA 100 mg Injection 1 ml Works

Paliris LA 100 mg Injection 1 ml contains paliperidone. Paliperidone works by helping to restore the balance of certain natural chemical messengers (neurotransmitters) in the brain. It mainly blocks the effects of dopamine and serotonin, which helps reduce symptoms such as hallucinations, delusions, and disorganised thinking, while improving clear thinking and emotional stability. Paliperidone also blocks other receptors in the body, including histamine and alpha-adrenergic receptors. This helps explain why some people may experience side effects such as sleepiness, weight gain, or dizziness when standing up. Not everyone experiences these side effects, and many improve as your body adjusts to treatment. Because this is a long-acting injection, the medicine is released slowly into your body over time. Depending on the formulation you receive, it may continue working for one month or several months, helping maintain steady medicine levels between injections.
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Alcohol

Caution

Avoid consumption of alcohol while taking Paliris LA 100 mg Injection 1 ml as it may cause increased drowsiness and lower your blood pressure.

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Pregnancy

Caution

Paliris LA 100 mg Injection 1 ml is not recommended for use in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Paliris LA 100 mg Injection 1 ml.

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Breast Feeding

Caution

Caution should be exercised. Paliris LA 100 mg Injection 1 ml is not recommended for use in breastfeeding unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Paliris LA 100 mg Injection 1 ml.

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Driving

Unsafe

Paliris LA 100 mg Injection 1 ml may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities.

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Liver

Caution

Inform your doctor if you have a liver impairment. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Inform your doctor if you have kidney impairment. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

The safety and efficacy of Paliris LA 100 mg Injection 1 ml are not established in children under the age of 18 years.

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Heart

Caution

Inform your doctor if you have heart problems. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Paliris LA 100 mg Injection 1 ml in elderly patients.

What if I have taken an overdose of Paliris LA 100 mg Injection 1 ml

Since this medication is administered by a healthcare professional, an overdose is highly unlikely. However, if you suspect an overdose or experience severe muscle stiffness, extreme sleepiness, or a rapid heart rate, seek immediate emergency medical care.

Diet & Lifestyle Advise

  • Stay hydrated: This medicine can make it harder for your body to cool down, so drink plenty of water, especially in hot weather or during heavy exercise.
  • Watch your weight: Eat a balanced diet rich in vegetables, lean proteins, and whole grains to help manage potential weight gain or metabolic changes.
  • Stand up slowly: To avoid dizziness or fainting from a sudden drop in blood pressure, take your time when getting up from a sitting or lying position.
  • Avoid alcohol: Limit or avoid alcoholic drinks, as they can significantly increase drowsiness and affect your coordination.
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Have a query?

How Soon It Starts Working

The time required for Paliris LA 100 mg Injection 1 ml to start to work: The exact onset time of Paliris LA 100 mg Injection 1 ml has not been clinically established. The time for which the effects of Paliris LA 100 mg Injection 1 ml last: Paliris LA 100 mg Injection 1 ml effect lasts for several days.

What if you forget to take Paliris LA 100 mg Injection 1 ml

Because this medication is a long-acting injection given by a healthcare provider, missing an appointment can cause your symptoms to return. If you miss an injection appointment, contact your doctor or clinic immediately to reschedule. Talk to your doctor or pharmacist about a plan to stay on track.

Storage

•This medicine should be stored at or below 30°C. •Do not refrigerate or freeze the pre-filled syringe.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Attend every injection appointment: Receiving your injections on schedule helps keep a steady level of medicine in your body and reduces the risk of your symptoms returning.
  • Do not stop treatment without medical advice: Continue receiving your injections even if you feel better, unless your doctor tells you to stop.
  • Be careful when standing up: This medicine may make you feel dizzy, especially after the injection. Stand up slowly from sitting or lying down.
  • Avoid alcohol: Alcohol can increase sleepiness, dizziness, and difficulty concentrating.
  • Take care when driving or operating machinery: Do not drive, cycle, or use machinery until you know how this medicine affects you.
  • Tell your healthcare team about all your medicines: Some medicines can increase side effects or affect how this medicine works.
  • Keep all follow-up appointments: Your doctor may monitor your symptoms, weight, blood sugar, cholesterol, and kidney function during treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that cause drowsiness: Sleeping tablets, anxiety medicines, opioid painkillers, muscle relaxants, and some antihistamines may increase sleepiness and dizziness.
  • Medicines that lower blood pressure: Taking these medicines together may increase the risk of dizziness or fainting when standing up.
  • Medicines that affect heart rhythm: Some medicines that affect your heartbeat may increase the risk of abnormal heart rhythms when taken with Paliris LA 100 mg Injection 1 ml.
PaliperidoneZiprasidone
Critical
PaliperidoneMoxifloxacin
Severe

Drug-Drug Interactions

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PaliperidoneZiprasidone
Critical
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
Using Paliris LA 100 mg Injection 1 ml with Ziprasidone can increase the risk of irregular heart rhythm,.

How to manage the interaction:
Taking Ziprasidone with Paliris LA 100 mg Injection 1 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PaliperidoneMoxifloxacin
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
Using Moxifloxacin together with Paliris LA 100 mg Injection 1 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Paliris LA 100 mg Injection 1 ml together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heartbeats, dizziness, trouble breathing call a doctor right away. Do not stop using any medications without a doctor's advice.
PaliperidoneDisopyramide
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
The combined use of Paliris LA 100 mg Injection 1 ml and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Paliris LA 100 mg Injection 1 ml and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PaliperidoneNilotinib
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
Combining Paliris LA 100 mg Injection 1 ml and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Paliris LA 100 mg Injection 1 ml and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PaliperidonePhenytoin
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
Coadministration of Phenytoin and Paliris LA 100 mg Injection 1 ml may reduce the blood levels of Paliris LA 100 mg Injection 1 ml.

How to manage the interaction:
Co-administration of Phenytoin with Paliris LA 100 mg Injection 1 ml can result in an interaction, but it can be taken if your doctor has advised it. When taken together, the doctor can recommend other options that won't cause any problems. Do not stop using any medications without a doctor's advice.
PaliperidoneBupropion
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
Bupropion is capable of causing seizures (fits), and combining it with Paliris LA 100 mg Injection 1 ml, may enhance the risk.

How to manage the interaction:
Co-administration of bupropion along with Paliris LA 100 mg Injection 1 ml can lead to an interaction, it can be taken if advised by a doctor. While taking these medications, you should avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
PaliperidoneChloroquine
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
Taking chloroquine and Paliris LA 100 mg Injection 1 ml together can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking chloroquine and Paliris LA 100 mg Injection 1 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PaliperidoneHydroxychloroquine
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
The combined use of Paliris LA 100 mg Injection 1 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Paliris LA 100 mg Injection 1 ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
PaliperidoneAmiodarone
Severe
How does the drug interact with Paliris LA 100 mg Injection 1 ml:
Coadministration of Amiodarone with Paliris LA 100 mg Injection 1 ml can lead to or increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Amiodarone with Paliris LA 100 mg Injection 1 ml together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Paliris LA 100 mg Injection 1 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Paliris LA 100 mg Injection 1 ml is used to treat Schizophrenia.
Paliris LA 100 mg Injection 1 ml works by balancing the chemical messengers called neurotransmitters and blocking the effect of dopamine and serotonin located in the brain, thereby helping in improving mood, behaviour and thoughts.
Paliris LA 100 mg Injection 1 ml may cause metabolic changes: So it is recommended to monitor for hyperglycemia/diabetes mellitus, dyslipidemia and weight gain. If you experience any major changes inform the doctor immediately.
Paliris LA 100 mg Injection 1 ml may cause an increase in blood glucose (sugar) levels. So, regular monitoring of blood sugar levels is advised while taking Paliris LA 100 mg Injection 1 ml. Diabetes patients should discuss with a doctor before taking Paliris LA 100 mg Injection 1 ml.
Yes, orthostatic hypotension could be a side-effect of Paliris LA 100 mg Injection 1 ml. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Paliris LA 100 mg Injection 1 ml are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.
Paliris LA 100 mg Injection 1 ml may make you sweat less, making you more likely to get heatstroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly.
Dry mouth could be a side-effect of Paliris LA 100 mg Injection 1 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Paliris LA 100 mg Injection 1 ml is known to cause increased mortality in people who are elderly with dementia. So, please inform your doctor if you have dementia; before starting Paliris LA 100 mg Injection 1 ml.
The side effects of Paliris LA 100 mg Injection 1 ml include injection site reactions, dizziness, sleepiness or drowsiness, uncontrolled involuntary movements, abnormal muscle movements including tremor, restlessness and abnormal movements of eyes. If these side effects persist or worsen, please consult your doctor.
No, Paliris LA 100 mg Injection 1 ml is not a narcotic.
Yes, Paliris LA 100 mg Injection 1 ml is an atypical antipsychotic.
Yes, Paliris LA 100 mg Injection 1 ml may cause weight gain. Therefore, follow a healthy diet to maintain proper weight during treatment with Paliris LA 100 mg Injection 1 ml. If you have any concerns regarding this, discuss with your doctor.
Paliris LA 100 mg Injection 1 ml may cause priapism (prolonged and/or painful erection), which may lead to erectile dysfunction. Therefore, you are advised to follow your doctor’s instructions regarding its use.
Paliris LA 100 mg Injection 1 ml may stay in our system/body for around 4 to 8 months.
If you are starting the once-monthly formulation, your doctor will usually give two initial injections during the first week to help the medicine reach an effective level more quickly. After that, you will usually receive injections once a month.
No. Continue receiving your injections unless your doctor tells you to stop. Stopping treatment suddenly may cause your symptoms to return.
This medicine may cause sleepiness, dizziness, or slower reactions, especially when you first start treatment. Avoid driving or operating machinery until you know how it affects you.
Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Your doctor will discuss the benefits and possible risks before deciding whether this medicine is suitable for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - PAL0256

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