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  3. PA 650mg Tablet IR

PA 650mg Tablet IR, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

PA 650mg Tablet IR is used to reduce fever and treat mild to moderate pain. Also, it is used to relieve headaches, migraines, toothaches, period pain, back pain, muscle pain, and rheumatic pains. It contains Paracetamol, which works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins. Thus, reduces pain. Also, it affects an area of the brain that regulates body temperature, known as the hypothalamic heat-regulating centre. Thereby, it reduces fever. In some cases, it may cause side effects such as nausea, stomach pain and dark-coloured urine.

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Composition :

PARACETAMOL-650MG

Manufacturer/Marketer :

Lincoln Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About PA 650mg Tablet IR

PA 650mg Tablet IR is used to reduce fever and treat mild to moderate pain. It is also used to relieve headaches, migraine, toothaches, period pain, back pain, muscle pain, and rheumatic pain. The activation of pain receptors causes pain and fever due to the release of certain natural chemicals in the body, like prostaglandin.

PA 650mg Tablet IR works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins, reducing pain. Additionally, PA 650mg Tablet IR affects an area of the brain that regulates body temperature, known as the hypothalamic heat-regulating centre, which reduces fever.

Not everyone who is taking PA 650mg Tablet IR will get these side effects. In some cases, PA 650mg Tablet IR may cause side effects such as nausea, stomach pain and dark-coloured urine. Most of these side effects of PA 650mg Tablet IR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Take PA 650mg Tablet IR as advised by your physician. Your doctor will recommend how often you should take PA 650mg Tablet IR, based on your medical condition. You can take PA 650mg Tablet IR with or without food. It is recommended not to exceed the recommended dose of PA 650mg Tablet IR. Do not chew, crush, or break the medicine.

Avoid taking PA 650mg Tablet IR if allergic to it. If you are pregnant or breastfeeding, please consult a physician before using PA 650mg Tablet IR. Avoid alcohol consumption with PA 650mg Tablet IR as it may increase the risk of liver damage. Let your doctor know if you have an impaired nutritional state caused by anorexia (eating disorder), malnutrition or alcohol abuse or if you are dehydrated before taking PA 650mg Tablet IR.

Uses of PA 650mg Tablet IR

PA 650mg Tablet IR is used for fever and pain relief. The detailed uses of PA 650mg Tablet IR are as follows:

  • Pain Relief: PA 650mg Tablet IR is commonly used to treat mild to moderate pain, including headaches, toothaches, muscle aches, and menstrual cramps. It works by suppressing the brain's production of prostaglandins, which induce pain.
  • Fever Reduction: PA 650mg Tablet IR effectively reduces fever caused by infections or other conditions. It lowers the body's temperature by working on the hypothalamic heat-regulating area.
  • Cold and Flu Symptom Relief: PA 650mg Tablet IR is also used to treat cold and flu symptoms such as body pains, fever, and headaches.
  • Post-Surgery Pain Management: PA 650mg Tablet IR is used to treat post-surgery pain, especially when it is mild to moderate, as an alternative to heavier pain drugs.
  • Arthritis-related Pain: PA 650mg Tablet IR is used to treat joint pain and discomfort caused by osteoarthritis and rheumatoid arthritis, reducing pain and inflammation.

Directions for Use

  • PA 650mg Tablet IR can be taken with or without food anytime.
  • It is usually taken every 4-6 hours or as suggested by your doctor.
  • Swallow PA 650mg Tablet IR as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • PA 650mg Tablet IR contains Paracetamol, an analgesic (pain killer) and antipyretic (reduces fever).
  • PA 650mg Tablet IR affects an area of the brain that regulates body temperature known as the hypothalamic heat-regulating centre, reducing fever.
  • It is one of the most used OTC medicine for reducing pain and fever.

How PA 650mg Tablet IR Works

PA 650mg Tablet IR works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins, reducing pain. Also, PA 650mg Tablet IR affects an area of the brain that regulates body temperature, known as the hypothalamic heat-regulating centre, reducing fever.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of PA 650mg Tablet IR
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

What if I have taken an overdose of PA 650mg Tablet IR

Do not take more than the suggested dose of PA 650mg Tablet IR as it may cause overdose resulting in the increased risk of delayed, serious liver damage. The symptoms of overdose include vomiting, nausea, diarrhoea, stomach pain and loss of appetite. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Avoid taking PA 650mg Tablet IR if allergic to it.
  • PA 650mg Tablet IR is not recommended for children below 6 years of age as the safety and efficacy are not established.
  • If you are pregnant or breastfeeding, please consult a physician before using PA 650mg Tablet IR.
  • Avoid alcohol consumption with PA 650mg Tablet IR as it may increase the risk of liver damage.
  • If you have an impaired nutritional state caused by anorexia (eating disorder), wrong nutrition or alcohol abuse or if you are dehydrated, inform your doctor before taking PA 650mg Tablet IR.
  • Avoid taking more than the recommended doses, as it may increase the risk of serious liver damage.
  • If you have a high fever or signs of infection after using PA 650mg Tablet IR for more than 3 days or if pain persists after using PA 650mg Tablet IR for more than 5 days, please consult a physician.

Drug-Drug Interactions

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ParacetamolValdecoxib
Severe
ParacetamolOxazepam
Severe

Drug-Drug Interactions

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ParacetamolValdecoxib
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of PA 650mg Tablet IR and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between PA 650mg Tablet IR and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of PA 650mg Tablet IR may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and PA 650mg Tablet IR, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of Mipomersen with PA 650mg Tablet IR may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between PA 650mg Tablet IR and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of PA 650mg Tablet IR and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between PA 650mg Tablet IR and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of Lomitapide and PA 650mg Tablet IR may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between PA 650mg Tablet IR and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of Teriflunomide with PA 650mg Tablet IR may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking PA 650mg Tablet IR with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of PA 650mg Tablet IR and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between PA 650mg Tablet IR and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolKetamine
Severe
How does the drug interact with PA 650mg Tablet IR:
Co-administration of ketamine and PA 650mg Tablet IR may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and PA 650mg Tablet IR together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and regularly apply a cold or hot compress on the joints for 15-20 minutes.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids, such as soy, berries, broccoli, grapes, and green tea, help reduce inflammation.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

PA 650mg Tablet IR Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with PA 650mg Tablet IR as it may cause severe liver damage.

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Pregnancy

Consult your doctor

Please consult a physician if you are pregnant or planning for pregnancy before using this medicine. Your physician may suggest the lowest dose of Paracetamol for the shortest duration if you are pregnant.

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Breast Feeding

Consult your doctor

PA 650mg Tablet IR may be excreted in small amounts in breast milk. Therefore, please consult a physician before using this medicine if you are breastfeeding.

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Driving

Safe if suggested

PA 650mg Tablet IR usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take PA 650mg Tablet IR with caution, especially if you have a history of liver disease. Your physician may adjust the dose as required.

bannner image

Kidney

Caution

Take PA 650mg Tablet IR with caution, especially if you have a history of kidney disease. Your physician may adjust the dose as needed.

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Children

Consult your doctor

Please consult a doctor. Your doctor will prescribe a suitable dose of PA 650mg Tablet IR based on the age, body weight and condition of your child.

Have a query?

FAQs

PA 650mg Tablet IR is used to provide relief from fever and mild-to-moderate pain.

PA 650mg Tablet IR works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins. Thus reducing pain. Also, PA 650mg Tablet IR affects an area of the brain that regulates body temperature known as the hypothalamic heat-regulating centre. Thus, it reduces fever.

You are not recommended to take PA 650mg Tablet IR with warfarin as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you are supposed to use these medicines together, you are advised to contact your physician so that the dose may be adjusted appropriately and used safely.

PA 650mg Tablet IR may affect how certain tests work, such as blood sugar tests and uric acid tests. Therefore, if you are about to undergo a blood test or any laboratory tests, inform your physician or lab technician that you are taking PA 650mg Tablet IR.

You are not recommended to take PA 650mg Tablet IR with other paracetamol-containing products as it may cause paracetamol overdose.

If you take more than the suggested dose of PA 650mg Tablet IR, it may cause an overdose and lead to serious liver damage. The symptoms of overdose include vomiting, loss of appetite, stomach pain, paleness and nausea. However, if you have overdosed or experience any of these symptoms, please consult a doctor immediately.

PA 650mg Tablet IR can be administered up to 4-6 times a day, ensuring a minimum gap of four hours between each dose. Avoid using PA 650mg Tablet IR for more than three consecutive days without medical advice, as excessive use may harm the liver.

You can take PA 650mg Tablet IR with or without a meal. However, if it causes stomach problems, it is best to take it after eating. Taking it with food may minimize the likelihood of nausea or discomfort in some people.

PA 650mg Tablet IR is generally considered safe during pregnancy and breastfeeding when taken in the recommended amounts. However, it should only be used when necessary and with your doctor’s approval to avoid any risks.

You should consult your doctor before taking PA 650mg Tablet IR with other medications. Some medications may interact with PA 650mg Tablet IR, affecting its effectiveness or increasing the risk of side effects. Always check for possible interactions, especially if you are using other suggested or over-the-counter medications.

You should not use PA 650mg Tablet IR for long-term pain management without consulting your doctor. While it is effective for short-term pain relief, using it for extended periods may raise the risk of side effects, especially liver damage.

No, PA 650mg Tablet IR is not an antibiotic. It is usually used to treat pain and fever. Antibiotics are used to treat bacterial infections, while PA 650mg Tablet IR does not have any effect on bacteria.

You can normally drive or ride a bike after taking PA 650mg Tablet IR because it rarely causes drowsiness or impairs your ability to focus. However, if you feel dizzy, drowsy, or uncomfortable, you should avoid driving or riding until you feel better.

PA 650mg Tablet IR is usually not recommended to be taken with alcohol. Alcohol can raise the chance of adverse effects, such as liver damage, particularly when combined with drugs like paracetamol. Consult your doctor for advice based on your health condition.

You can usually take PA 650mg Tablet IR with an antibiotic. PA 650mg Tablet IR helps with pain or fever, and the antibiotic treats the infection. Check with your doctor if you are taking any other medications or have any health problems.

Your doctor will prescribe the appropriate dose of PA 650mg Tablet IR for your child based on their age, weight, and condition. Please consult a doctor for guidance.

PA 650mg Tablet IR usually starts working within 30-60 minutes and can provide full relief within an hour. However, this might differ depending on your condition and how your body reacts.

You can take PA 650mg Tablet IR and ibuprofen together for short-term pain relief if advised by the doctor, as they work differently. Make sure to take them at different times to avoid side effects. It's best to use this combination for a short period and ask your doctor if you're unsure or have other health conditions.

Yes, PA 650mg Tablet IR can cause nausea and vomiting in some people, although these side effects are not very common. If you experience persistent nausea or vomiting, consult your doctor for advice.

PA 650mg Tablet IR is not usually used to treat stomach pain from indigestion. It mainly helps with pain relief or reducing fever. Always consult a healthcare provider for the proper treatment.

Taking too much of PA 650mg Tablet IR can be dangerous and may lead to serious side effects, especially liver damage. Common signs of overdose include nausea, vomiting, stomach pain, loss of appetite, yellowing of the skin or eyes, sweating, and extreme tiredness or confusion. If you take more than the recommended dose of PA 650mg Tablet IR, get medical help immediately, even if no symptoms appear.

Country of origin

India
Other Info - PA14782

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 11:18 AM IST

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Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/2b04cfdb-8571-4543-a4c9-b1380e0a92c3.pdf
  2. https://www.sahpra.org.za/wp-content/uploads/2020/06/Von-Paracetamol_PIL_Drugcompany_MCC-Format25-June-2001.pdf
  3. https://www.boots.com/wcsstore/ExtendedSitesCatalogAssetStore/Attachment/Product_PatientLeaflets/10186783%20Paracetamol%20PIL%2019%2009%202018.pdf
  4. https://www.drugs.com/paracetamol.html
  5. https://www.mims.com/india/drug/info/paracetamol?type=full&mtype=generic
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