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compositionComposition:PROPYLTHIOURACIL-50MG
prescription
Prescription Medicine
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PTU Tablet is an anti-thyroid medicine that regulates the synthesis and release of thyroid hormones by mellowing down the activity of the thyroid gland. This medicine is mainly used in the treatment of hyperthyroidism, graves disease, enlarged thyroid (toxic goitre), and thyrotoxicosis. You may experience side effects like nausea, indigestion, headache, body pain or a mild rash.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PROPYLTHIOURACIL-50MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About PTU Tablet

PTU Tablet is a prescription medication used to manage an overactive thyroid, a condition known as hyperthyroidism. It works to lower the excessive production of thyroid hormones in your body, helping to bring your metabolism back into a healthy balance.

Because this medicine stays in your body for a short time, you will usually need to take it multiple times a day at consistent intervals. It is important to take each dose exactly as scheduled, either always with food or always without food, to keep blood levels steady. Limiting iodine-rich foods, such as seaweed and iodized salt, can also help you achieve better results.

While taking this medicine, you may experience mild side effects like nausea or a minor skin rash. However, PTU Tablet carries a boxed warning for the risk of severe liver injury, including liver failure that can rarely be life-threatening. Contact your doctor immediately if you notice yellowing of your skin or eyes, dark urine, severe stomach pain, persistent nausea or vomiting, or unusual tiredness. You should also seek medical advice immediately if you develop a sudden fever, sore throat, or other signs of infection, as this medicine can rarely reduce your white blood cell count.

Talk to your doctor before starting this medicine if you have pre-existing liver disease or blood clotting problems. Do not take this if you have a history of severe allergic reactions to it or if you have experienced severe liver issues from similar treatments in the past.

This medicine can interact with blood thinners and certain heart medications, altering how they work in your body. It is also crucial for specific groups, such as pregnant women, breastfeeding mothers, or elderly individuals, to consult their doctor before taking PTU Tablet , as special monitoring is required.

Uses of PTU Tablet

PTU Tablet is used in the treatment of Hyperthyroidism, Graves' Disease, Enlarged thyroid (toxic goitre), and Thyrotoxicosis. The detailed uses of PTU Tablet are as follows:

  • Hyperthyroidism (overactive thyroid): PTU Tablet helps by reducing the amount of thyroid hormone made by the thyroid gland, relieving symptoms of an overactive metabolism.
  • Graves' disease: PTU Tablet controls symptoms of this autoimmune disorder, which is the most common cause of hyperthyroidism.
  • Pre-surgery thyroid preparation: PTU Tablet helps lower thyroid hormone levels before thyroid removal surgery or radioactive iodine treatment to make the medical procedure safer for you.

Key Benefits

  • Helps reduce the production of excess thyroid hormones, bringing your thyroid levels closer to normal.
  • Relieves symptoms of an overactive thyroid, such as a fast heartbeat, shakiness, anxiety, excessive sweating, heat intolerance, and unexplained weight loss.
  • Helps restore normal energy levels and supports better day-to-day functioning as thyroid hormone levels become balanced.
  • Protects your heart, muscles, and other organs from the long-term effects of untreated hyperthyroidism.
  • When taken regularly as prescribed and monitored with routine blood tests, it provides effective long-term control of hyperthyroidism and supports overall health.

Directions for Use

  • PTU Tablet can be taken with or without food, or as advised by a doctor.
  • Generally, it is recommended to be taken three times a day, once every 8 hours. However, follow your doctor's instructions regarding dosage and timing for optimal results.
  • Swallow PTU Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How PTU Tablet Works

PTU Tablet works directly inside your thyroid gland to block the creation of new thyroid hormones. It does this by interfering with an enzyme called thyroid peroxidase, which is responsible for attaching iodine to proteins to make thyroid hormones. By stopping this process, the medicine slows down the production of both thyroxine (T4) and triiodothyronine (T3). Additionally, PTU Tablet has a secondary beneficial effect in the rest of your body. It helps stop the conversion of the less active T4 hormone into the more active T3 hormone in your tissues. This dual action quickly reduces the amount of active thyroid hormone circulating in your system, helping your metabolism return to a stable state.
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Alcohol

Caution

Not enough studies exist to establish the effects of alcohol on PTU Tablet . However, caution is advised. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Safe if prescribed

PTU Tablet is safe if prescribed during breastfeeding. Please consult a doctor if you have any concerns.

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Driving

Caution

If you experience any side effects of PTU Tablet such as dizziness or drowsiness, do not drive.

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Liver

Caution

Exercise caution before using PTU Tablet in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Safe if prescribed

PTU Tablet is probably safe on the kidney. Please consult your doctor to address any concerns.

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Children

Caution

PTU Tablet is not recommended for use in children below 6 years of age. Please consult your doctor if you have any concerns.

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Heart

Caution

PTU Tablet should be taken with caution in patients with heart problems. Therefore, please talk to your doctor before using PTU Tablet .

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Geriatrics

Caution

PTU Tablet should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform a healthcare professional before use.

What if I have taken an overdose of PTU Tablet

If you think you or someone else has taken too much PTU Tablet , call your local emergency services or go to the nearest emergency room immediately. Do not wait for symptoms to appear. Possible signs of an overdose may include nausea, vomiting, fever, joint pain, skin itching, headache, swelling in the legs, or other unusual symptoms. Take the medicine pack with you if possible to help healthcare providers identify the medication.

Diet & Lifestyle Advise

  • Limit high-iodine foods: Avoid eating large amounts of foods rich in iodine, such as seaweed, kelp, and iodized salt, as iodine can interfere with how this medicine works.
  • Keep dietary habits consistent: Try to maintain a consistent diet, and talk to your doctor before starting any new herbal supplements, vitamins, or mineral blends.
  • Rest and monitor physical stress: An overactive thyroid puts extra strain on your heart. Get plenty of rest and avoid intense physical exercise until your doctor confirms your thyroid levels have stabilized.
  • Avoid smoking: Smoking can worsen hyperthyroidism symptoms, especially eye problems associated with Graves' disease. Seek support to quit if needed.
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How Soon It Starts Working

The time required for PTU Tablet to start to work: The effect of PTU Tablet is seen between 1 to 2 hours of administration. The time for which the effects of PTU Tablet last: PTU Tablet effect lasts for 8 to 12 hours.

What if you forget to take PTU Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you miss multiple doses.

Storage

• Store the tablets at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Schedule regular blood tests: Have regular blood tests to monitor your thyroid hormone levels, liver function, and blood cell counts as advised by your doctor.
  • Monitor for signs of infection: Contact your doctor immediately if you develop a fever, chills, sore throat, or mouth sores, as these may be signs of a low white blood cell count.
  • Watch for liver problems: Check for yellowing of your skin or eyes, dark urine, severe stomach pain, persistent nausea, or unusual tiredness, and seek medical help immediately if these occur.
  • Use caution when driving: This medicine may cause dizziness in some people. Avoid driving or operating machinery until you know how it affects you.
  • Inform all healthcare providers: Tell your dentist, surgeon, pharmacist, and other healthcare providers that you are taking PTU Tablet before any surgery or medical procedure.
  • In an emergency: If you need emergency medical care, tell the healthcare team that you are taking PTU Tablet . Carrying a medication list or medical alert card can help healthcare providers make safe treatment decisions.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin): PTU Tablet can change how your body processes blood thinners, which may increase your risk of bleeding or reduce the blood thinner's effectiveness.
  • Heart medicines (like digoxin): As your thyroid levels improve, your doctor may need to adjust your digoxin dose to prevent toxicity or under-dosing.
  • Beta-blockers: Your body's response to beta-blockers may change as your overactive thyroid is brought under control, requiring a dose adjustment.
PropylthiouracilKetoconazole
Severe
PropylthiouracilMipomersen
Severe

Drug-Drug Interactions

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PropylthiouracilKetoconazole
Severe
How does the drug interact with PTU Tablet:
Coadministration of Ketoconazole and PTU Tablet may increase the risk of liver problems.

How to manage the interaction:
Although taking Ketoconazole and PTU Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience fever, chills, joint pain, itching, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
PropylthiouracilMipomersen
Severe
How does the drug interact with PTU Tablet:
Coadministration of Mipomersen with PTU Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking PTU Tablet with Mipomersen together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms such as fever, chills, joint pain, tiredness, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without first consulting your doctor.
PropylthiouracilMethimazole
Severe
How does the drug interact with PTU Tablet:
Taking PTU Tablet with Methimazole can increase the risk of side effects.

How to manage the interaction:
Co-administration of PTU Tablet with Methimazole can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
PropylthiouracilFluphenazine
Severe
How does the drug interact with PTU Tablet:
Coadministration of Fluphenazine with PTU Tablet can increase the risk of developing infections.

How to manage the interaction:
Co-administration of PTU Tablet with Fluphenazine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, or burning urination. Do not discontinue any medications without first consulting your doctor.
PropylthiouracilDeferiprone
Severe
How does the drug interact with PTU Tablet:
Coadministration of Deferiprone with Clozapine can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between PTU Tablet and Deferiprone, you can take these medicines together if prescribed by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, or burning during urination. Do not discontinue any medications without first consulting your doctor.
PropylthiouracilLeflunomide
Severe
How does the drug interact with PTU Tablet:
Taking PTU Tablet with leflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide with PTU Tablet can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain, unusual bleeding, itching, fatigue, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PropylthiouracilCarbamazepine
Severe
How does the drug interact with PTU Tablet:
Taking PTU Tablet with carbamazepine can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between PTU Tablet and Carbamazepine, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
PropylthiouracilClozapine
Severe
How does the drug interact with PTU Tablet:
Combining PTU Tablet with Clozapine can increase the risk of infection.

How to manage the interaction:
Taking PTU Tablet with Clozapine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, and pain during urination. Do not stop using any medications without a doctor's advice.
PropylthiouracilTeriflunomide
Severe
How does the drug interact with PTU Tablet:
Coadministration of Teriflunomide with PTU Tablet can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between PTU Tablet and Teriflunomide, but it can be taken if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, joint pain, itching, tiredness, abdominal pain, dark urine, light stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without first talking to your doctor.
PropylthiouracilLomitapide
Severe
How does the drug interact with PTU Tablet:
Coadministration of lomitapide with PTU Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between PTU Tablet and Lomitapide, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, joint pain, itching, tiredness, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without first consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Iodine-rich foods: Consuming foods very high in iodine (such as kelp, seaweed, and iodized salt) can feed the thyroid gland's hormone production and make PTU Tablet less effective.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

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FAQs

PTU Tablet belongs to the group of anti-thyroid drugs used in the treatment of overactive thyroid (hyperthyroidism), Graves disease, thyrotoxicosis, and enlarged thyroid.
PTU Tablet works by inhibiting the production of new thyroid hormone and quietening an overactive thyroid gland.
No, PTU Tablet is strictly not recommended in case of hypothyroidism as PTU Tablet is an anti-thyroid drug.
In case you have missed a dose, take the missed dose as soon as possible. However, if it is almost time for the second dose, simply resume your regimen with the following dose. Do not take a double dose in any case.
Bulging eyes can occur in some people with Graves' disease due to inflammation and swelling of the tissues and muscles behind the eyes (Graves' eye disease or thyroid eye disease). It is not caused simply by high thyroid hormone levels. If you notice eye pain, redness, double vision, or worsening bulging, contact your doctor.
Not enough studies exist to explain the effects of PTU Tablet on fertility. Please consult your doctor in case of any concerns or if you are trying to conceive.
Yes, but only if clearly needed and closely monitored. PTU Tablet is often the preferred medicine during the first trimester of pregnancy to manage an overactive thyroid, but your doctor may change your treatment plan later in the pregnancy. Talk to your doctor to weigh the risks and benefits.
Regular blood tests are necessary to monitor your thyroid hormone levels, check your liver health, and ensure your white blood cell count remains at a safe level. Talk to your doctor or pharmacist about how often you need to have your blood drawn.
As your thyroid hormone levels return to normal, your metabolism will slow down, which can lead to some weight gain, especially if you lost weight due to hyperthyroidism. Talk to your doctor or a dietitian for personalized lifestyle advice.
It is highly recommended to limit or avoid alcohol while taking this medicine. Both alcohol and PTU Tablet can place stress on your liver, and combining them may increase your risk of liver damage. Talk to your doctor for specific advice.
You should contact your doctor immediately. These symptoms can be early signs of a serious condition where your body is not making enough white blood cells to fight infections. Talk to your doctor right away if this happens.
Yes, you can take it with or without food, but you must be consistent. Whichever method you choose, do it the same way every time to keep the drug absorption steady. Talk to your doctor or pharmacist if you have questions.
Mild, temporary hair thinning can sometimes occur during the first few months of starting PTU Tablet . This is usually a response to changing thyroid levels and typically improves over time. Talk to your doctor if the hair loss is severe or does not stop.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.9177 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Propylthiouracil Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Ema. propylthiouracil. [[Accessed on 6.Oct].2019]Check here
  5. Dailymed. propylthiouracil. [[Accessed on 6.Oct].2019] :Check here
  6. Amisha F, Rehman A. Propylthiouracil (PTU). NIH National Library of Medicine, National center for biotechnology information. Stat Pearls. June 2023] [Accessed on 11th January 2024].Check here
  7. Drug Bank. Propylthiouracil. [Accessed on 11th January 2024].Check here

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - PTU0002
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