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  3. P Carzine 50mg Capsule

P Carzine 50mg Capsule, Pack of 1 Capsule
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
P Carzine 50mg Capsule is an anti-cancer medicine used in the treatment of Hodgkin's lymphoma and certain brain tumors. This medicine works by inhibiting the proteins and DNA necessary for cell growth and division, thereby reducing the further growth of cancerous cells. Common side effects include nausea, vomiting, bruising, cramps, rash and loss of appetite.
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Composition :

PROCARBAZINE-50MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About P Carzine 50mg Capsule

P Carzine 50mg Capsule belongs to the group of anti-cancer drugs and chemotherapeutic agents. P Carzine 50mg Capsule is used to treat cancers and malignant conditions such as Hodgkin’s disease (cancer that originates in the white blood cells) and certain brain tumours.

P Carzine 50mg Capsule contains ‘’Procarbazine.’’ Cancer is an uncontrolled growth of cells in the body. P Carzine 50mg Capsule interferes with the growth of cells, nipping it in the bud. It functions by inhibiting the molecular production of materials such as proteins and DNA necessary for cell growth and division.

P Carzine 50mg Capsule is a prescription-only medicine. It may be taken as a tablet at the same time every day. P Carzine 50mg Capsule may be taken with or without food. It should be swallowed as a whole and not chewed or broken down. Avoid consuming P Carzine 50mg Capsule with certain foods like cheese, smoked fish, fermented wine and meat.

In some cases, P Carzine 50mg Capsule may cause common side effects such as nausea, vomiting, bruising, cramps, rash and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

It is advisable to inform your doctor if you are allergic to P Carzine 50mg Capsule or any of its components. Keep your doctor informed if you suffer from kidney or liver disease, bleeding problems, anaemia or recurrent infections. Keep your doctor informed if you are on any radiation therapy. Consult your doctor if you are pregnant, planning pregnancy or breastfeeding before taking P Carzine 50mg Capsule as P Carzine 50mg Capsule is not recommended for routine use in these states. Consult your doctor before taking alcohol with P Carzine 50mg Capsule as there may be an interaction. Avoid smoking while taking P Carzine 50mg Capsule.

Uses of P Carzine 50mg Capsule

Treatment of Hodgkin's Lymphoma.

Directions for Use

• P Carzine 50mg Capsule can be taken with or without food, but it is better to take it with food to prevent stomach upset. Avoid taking P Carzine 50mg Capsule with tyramine-rich foods such as processed cheese, smoked fish and meats, and overripe fruit.• It is usually taken 1-2 times daily or as prescribed by your doctor.• Swallow P Carzine 50mg Capsule as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

P Carzine 50mg Capsule is an antineoplastic/anti-cancer drug. It contains PROCARBAZINE. It is used primarily in the treatment of cancers, especially Hodgkin’s lymphoma. P Carzine 50mg Capsule shows antineoplastic activity, meaning it targets neoplastic (abnormally growing cells) in the body and inhibits their uncontrolled division and growth. P Carzine 50mg Capsule works by preventing DNA, RNA and protein synthesis required for the molecular development of cells. P Carzine 50mg Capsule also acts by destroying DNA, thereby arresting cell growth in the roots. Hence, P Carzine 50mg Capsule is very effective in cancer therapy.

How P Carzine 50mg Capsule Works

P Carzine 50mg Capsule contains ‘’Procarbazine.’’ Cancer is an uncontrolled growth of cells in the body. P Carzine 50mg Capsule interferes with the growth of cells, nipping it in the bud. It functions by inhibiting the molecular production of materials such as proteins and DNA necessary for cell growth and division.

Storage

• Store in a cool and dry place away from sunlight.• Store protected moisture at a temperature.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of P Carzine 50mg Capsule
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Drink plenty of water (at least 8-10 glasses a day) to thin out bronchial secretions.
  • Consume warm liquids like tea, broth, or soup to help loosen thickened secretions.
  • Include omega-3 fatty acid-rich foods like fatty fish, flaxseeds, and walnuts to reduce inflammation.
  • Eat antioxidant-rich foods like fruits, vegetables, and nuts to combat oxidative stress.
  • Stay away from pollutants, dust, and second hand smoke, which can exacerbate thickened secretions.
  • Sleep with your head elevated using extra pillows to reduce congestion.
  • Engage in gentle exercises like yoga or walking to improve lung function.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Maintain a healthy diet with fruits, whole grains, and vegetables.
  • Include easy-to-digest and antioxidant-rich food in your diet.
  • Drink plenty of water and unsweetened liquids.
  • Limit sugary foods, alcohol, refined carbs and fried foods.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

What if I have taken an overdose of P Carzine 50mg Capsule

Take P Carzine 50mg Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. Overdose symptoms may include vomiting, diarrhoea, feeling lightheaded or tremors. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

P Carzine 50mg Capsule should not be used in case of any known allergy to either of the components. Avoid foods such as processed cheese, smoked fish, meats, overripe fruit, fermented wine, and yeast while taking P Carzine 50mg Capsule. P Carzine 50mg Capsule should be used with caution in case of high-risk or previous history cancers, cardiovascular health disorders, bleeding disorders, kidney disease, liver disease or anaemia. Keep your doctor informed of your medical history and if you suffer from epilepsy, an adrenal tumour such as phaeochromocytoma, or have had a stroke. Consult your doctor before using P Carzine 50mg Capsule during pregnancy, breastfeeding, or even if you are trying to get pregnant. Keep your doctor informed if you are on painkillers or using any nasal decongestants or anti-anxiety, anti-depressant, antiepileptic, anaesthetic or analgesic medications. Keep your doctor informed in case you are undergoing any radiation therapy. Inform your doctor of your vaccination history and do not take any vaccines without consent. Avoid contact with those who have recently received live vaccines (like the nasal flu, pox, or MMR vaccine). P Carzine 50mg Capsule makes your skin more sensitive to UV radiation. Wear sunscreen and protective clothing while venturing out in the sun. P Carzine 50mg Capsule may interact with alcohol, please consult your doctor before use. P Carzine 50mg Capsule may cause dizziness and is not recommended to take while driving or operating heavy machinery.

Drug-Drug Interactions

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ProcarbazineEphedrine
Critical
ProcarbazineDextromethorphan
Critical

Drug-Drug Interactions

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ProcarbazineEphedrine
Critical
How does the drug interact with P Carzine 50mg Capsule:
Taking Ephedrine and P Carzine 50mg Capsule together can increase the risk of high blood pressure.

How to manage the interaction:
Taking Ephedrine and P Carzine 50mg Capsule together is not recommended as it can result in an interaction, it can be taken if a doctor has prescribed it. However, if you develop a sudden, severe headache, blurred vision, disorientation, seizures, chest pain, nausea, or vomiting, sudden numbness or weakness (particularly on one side of the body), difficulty speaking, fever, sweating, lightheadedness, or fainting, you should consult the doctor. Do not discontinue any medications without a doctor's advice.
ProcarbazineDextromethorphan
Critical
How does the drug interact with P Carzine 50mg Capsule:
Co-administration of Dextromethorphan and P Carzine 50mg Capsule may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of P Carzine 50mg Capsule with Dextromethorphan can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering, shaking, blurred vision, muscle spasm, stiffness, incoordination, stomach cramps, nausea, vomiting, or diarrhea - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
ProcarbazineParoxetine
Critical
How does the drug interact with P Carzine 50mg Capsule:
Using P Carzine 50mg Capsule together with paroxetine can increase the risk of a serious condition called the serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Paroxetine with P Carzine 50mg Capsule is not recommended, but should be taken if advised by a doctor. However, if you experience confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, or blurred vision contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ProcarbazineBuspirone
Critical
How does the drug interact with P Carzine 50mg Capsule:
Combining P Carzine 50mg Capsule with Buspirone can increase the risk of high blood pressure.

How to manage the interaction:
Taking Buspirone with P Carzine 50mg Capsule is not recommended, as it results in an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor’s advice
ProcarbazineMephentermine
Critical
How does the drug interact with P Carzine 50mg Capsule:
Taking P Carzine 50mg Capsule with mephentermine together may increase the hypertensive activities of Mephentermine.

How to manage the interaction:
Taking Mephentermine with P Carzine 50mg Capsule is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without consulting a doctor.
ProcarbazineLevodopa
Critical
How does the drug interact with P Carzine 50mg Capsule:
Using levodopa together with P Carzine 50mg Capsule can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking P Carzine 50mg Capsule with Levodopa together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
ProcarbazineTrazodone
Critical
How does the drug interact with P Carzine 50mg Capsule:
Coadministration of P Carzine 50mg Capsule with trazodone may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Trazodone with P Carzine 50mg Capsule is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
ProcarbazineCyproheptadine
Critical
How does the drug interact with P Carzine 50mg Capsule:
Using P Carzine 50mg Capsule together with cyproheptadine may increase side effects.

How to manage the interaction:
Taking Cyproheptadine with P Carzine 50mg Capsule is not recommended, please consult your doctor before taking it. Call a doctor if you experience dizziness, drowsiness, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, palpitation, rapid heartbeat, confusion, disorientation, and memory problems.
ProcarbazineRasagiline
Critical
How does the drug interact with P Carzine 50mg Capsule:
Taking P Carzine 50mg Capsule with Rasagiline can increase the risk of high blood pressure and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Rasagiline with P Carzine 50mg Capsule is not recommended, but can be taken together if prescribed by your doctor. However, if you experience confusion, hallucination(seeing or hearing things that does not exist), seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
ProcarbazineTetrabenazine
Critical
How does the drug interact with P Carzine 50mg Capsule:
Coadministration of P Carzine 50mg Capsule and Tetrabenazine can increase the risk of high blood pressure.

How to manage the interaction:
Taking P Carzine 50mg Capsule and Tetrabenazine together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your doctor informed if you are planning to or are pregnant.

  • Cancer can take a toll on anyone. Make sure you regularly see a therapist and take care of your mental health.

  • Meditation and yoga have also proven very effective in helping cancer patients maintain a healthy attitude and body.

  • Cut back on foods that are high in tyramine such as overripe fruit, processed cheese, smoked fish, meat etc. Eat more healthy meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy.

  • Avoid taking P Carzine 50mg Capsule with alcohol as there may be an interaction.

  • Stay hydrated by drinking plenty of water as dehydration is often seen in cancers.

  • Taking a stroll in the garden, or spending 30 mins of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired.

  • Avoid tobacco use as smoking can increase the chances of lung cancer when used with P Carzine 50mg Capsule. Inform your doctor in case of marijuana use.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

P Carzine 50mg Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Do not consume alcohol with P Carzine 50mg Capsule as there may be an interaction, causing vomiting, cramps, sweating and flushing of the face. Please consult your doctor if you have any concerns.

bannner image

Pregnancy

Unsafe

P Carzine 50mg Capsule is not recommended for use in pregnancy. It is not safe during the first trimester. If you are pregnant, inform your doctor before taking P Carzine 50mg Capsule.

bannner image

Breast Feeding

Unsafe

P Carzine 50mg Capsule is not recommended for use during breastfeeding. Please consult your doctor if you have any concerns.

bannner image

Driving

Caution

P Carzine 50mg Capsule may cause dizziness or loss of alertness, which may affect your ability to drive.

bannner image

Liver

Caution

P Carzine 50mg Capsule is not recommended for use if you have pre-existing liver disease. Hence, please consult your doctor before taking this medicine.

bannner image

Kidney

Caution

P Carzine 50mg Capsule is not recommended for use if you have pre-existing kidney disease. Hence, please consult your doctor before taking this medicine.

bannner image

Children

Caution

P Carzine 50mg Capsule should be used with caution and only in prescribed doses in children below 12 years of age. Please consult your child's doctor if you have any concerns.

Have a query?

FAQs

P Carzine 50mg Capsule belongs to the group of anti-cancer drugs and chemotherapeutic agents. P Carzine 50mg Capsule is used to treat cancers and malignant conditions such as Hodgkins disease (cancer that originates in the white blood cells) and certain brain tumours.

P Carzine 50mg Capsule works by reducing the workload on the heart and vessels and relaxing the vessels to ensure a fluid flow of blood, easing any hypertension and effects of the same.

Please consult your physician before altering your chemotherapy as any misguided change can cause serious side effects. One of the side effects of P Carzine 50mg Capsule is also hair loss. Hence it is best to discuss your treatment plan with your doctor.

If you suffer from IBD, you may be on anticholinergic therapy which may interfere with P Carzine 50mg Capsule. Please consult your doctor before use and discuss any concerns with your doctor.

P Carzine 50mg Capsule is known to play a role in the treatment of various types of cancer, however, it is not routinely indicated in the treatment of breast cancer. Only proceed once a doctor has prescribed the same because the treatment for breast cancer is nuanced.

P Carzine 50mg Capsule is known to affect fertility. Avoid P Carzine 50mg Capsule if you are trying to get pregnant. Please consult your doctor in case of any concerns.

Country of origin

India
Other Info - PC96141

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:27 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.3732.pdf
  2. https://go.drugbank.com/drugs/DB01168
  3. https://medlineplus.gov/druginfo/meds/a682094.html
  4. https://www.webmd.com/drugs/2/drug-6893/procarbazine-oral/details
  5. https://pubchem.ncbi.nlm.nih.gov/compound/Procarbazine
  6. https://www.mskcc.org/cancer-care/patient-education/procarbazine
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