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  3. Oxabenz-50 Injection 25 ml

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Oxabenz-50 Injection 25 ml, Pack of 1 Injection
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Oxabenz-50 Injection is used to treat Colon and rectal cancer. It contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer. Sometimes, Oxabenz-50 Injection may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

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Composition :

OXALIPLATIN-2MG/ML

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Oxabenz-50 Injection

Oxabenz-50 Injection belongs to the group of medicines called platinum-containing antineoplastic agents used alone or in combination with other anti-cancer medicines to treat cancer of the large bowel/intestine (advanced colon or colorectal cancer).

Oxabenz-50 Injection contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.

In some cases, Oxabenz-50 Injection may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Oxabenz-50 Injection if you are breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Oxabenz-50 Injection. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Oxabenz-50 Injection

Oxabenz-50 Injection is used in the treatment of Colon and rectal cancer. The detailed uses of Oxabenz-50 Injection are as follows:

  • Stage III colon cancer: Oxabenz-50 Injection is used to treat colon cancer after surgical removal of the tumor, to reduce the risk of recurrence.
  • Advanced or metastatic colorectal cancer: Oxabenz-50 Injection is used to treat metastatic colorectal cancer as part of first-line or second-line therapy.

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Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Oxabenz-50 Injection will be administered by a nurse or doctor.
  • Do not self-administer.

Medicinal Benefits

Oxabenz-50 Injection contains Oxaliplatin, which belongs to the group of medicines called platinum-containing antineoplastic agents used to treat stage III colon cancer after complete removal of the primary tumour and metastatic cancer of the colon and rectum. It is used in combination with other anti-cancer medicines, such as 5-fluorouracil and folinic acid. Oxabenz-50 Injection works by killing the cancer cells. Thereby, it helps treat cancer. Oxabenz-50 Injection may also be used with other medicines to prevent colon cancer from spreading in patients who have had surgery to remove the tumour.

How Oxabenz-50 Injection Works

Oxabenz-50 Injection contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.

Storage

• Store in a cool and dry place away from sunlight.• Keep Oxabenz-50 Injection out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Oxabenz-50 Injection 25 ml
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.

What if I have taken an overdose of Oxabenz-50 Injection

As Oxabenz-50 Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Oxabenz-50 Injection may cause chest pain, diarrhea, numbness or tingling in the fingers or toes, slowed breathing, slowed heartbeat, shortness of breath, tightening of the throat, vomiting, and wheezing.

Drug Warnings

Do not use Oxabenz-50 Injection if you are allergic to any of its components, if you are breastfeeding, have a low blood cell count, have severe kidney problems, tingling and numbness in the fingers/toes, and have difficulty performing fragile tasks, such as buttoning clothes. Inform the doctor if you ever suffered an allergic reaction to platinum-containing medicines, have mild/moderate kidney problems, liver problems or abnormal liver function tests during therapy, or heart disorders like prolongation of the QT interval (abnormal electrical signal), an irregular heartbeat, or a family history of heart problems. Seek immediate medical attention if you experience symptoms of an allergic reaction (rash, itching, hives, reddening of the skin, hoarseness, difficulty breathing or swallowing, feeling as if your throat is closing, dizziness, swelling of the lips and tongue, lightheadedness, or fainting), unpleasant sensation in the throat, rhabdomyolysis (muscle pain and swelling), nerve problems (sensitivity to cold temperature or cold objects, pain, tingling or burning sensation), Posterior Reversible Encephalopathy Syndrome (headache, confusion, seizures, vision problems), myelosuppression (chills or shivering, burning or pain on urination, pain on swallowing, sore throat, cough with mucus, persistent diarrhoea), lung problems (shortness of breath, wheezing, cough), or bleeding problems (vomit that looks like coffee grounds or bloody vomit, pink or brown urine, weakness, dizziness, changes in speech, confusion, unexplained bleeding or dark-coloured/tarry stools).

Drug-Drug Interactions

verifiedApollotooltip
OxaliplatinZiprasidone
Critical
OxaliplatinEfavirenz
Severe

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
How does the drug interact with Oxabenz-50 Injection 25 ml:
Combining Oxabenz-50 Injection 25 ml with Ziprasidone can increase the risk of QTc prolongation.

How to manage the interaction:
Taking Oxabenz-50 Injection 25 ml with Ziprasidone is not recommended, please consult your doctor before taking it.
OxaliplatinEfavirenz
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Taking Oxabenz-50 Injection 25 ml with Efavirenz can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Oxabenz-50 Injection 25 ml with Efavirenz together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinInfliximab
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Combining Infliximab with Oxabenz-50 Injection 25 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Oxabenz-50 Injection 25 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinTofacitinib
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Taking Tofacitinib with Oxabenz-50 Injection 25 ml may increase the risk of infection.

How to manage the interaction:
Although taking Oxabenz-50 Injection 25 ml and Tofacitinib together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to your doctor.
OxaliplatinBaricitinib
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Coadministration of baricitinib and Oxabenz-50 Injection 25 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Oxabenz-50 Injection 25 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
OxaliplatinCeritinib
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Taking Oxabenz-50 Injection 25 ml with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Oxabenz-50 Injection 25 ml and Ceritinib, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OxaliplatinClozapine
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Co-administration of Oxabenz-50 Injection 25 ml with Clozapine can increase the risk of neutropenia (low white blood count).

How to manage the interaction:
Although taking Oxabenz-50 Injection 25 ml and Clozapine together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
OxaliplatinHydroxychloroquine
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
The combined use of Oxabenz-50 Injection 25 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of oxalipatin and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
OxaliplatinSotalol
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using sotalol together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Oxabenz-50 Injection 25 ml, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
OxaliplatinThalidomide
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Taking thalidomide together with Oxabenz-50 Injection 25 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Oxabenz-50 Injection 25 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Oxabenz-50 Injection Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

It is not known if alcohol affects Oxabenz-50 Injection. Please consult your doctor.

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Pregnancy

Unsafe

Oxabenz-50 Injection may cause foetal harm. Therefore, avoid becoming pregnant during treatment with Oxabenz-50 Injection.

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Breast Feeding

Unsafe

Breastfeeding is not recommended during treatment with Oxabenz-50 Injection and for three months after the last dose.

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Driving

Caution

Oxabenz-50 Injection may cause dizziness or vision problems. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Oxabenz-50 Injection.

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Kidney

Caution

Oxabenz-50 Injection should not be used if you have severe kidney disease. If you have mild or moderate kidney disease, inform your doctor before receiving Oxabenz-50 Injection.

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Children

Unsafe

Oxabenz-50 Injection is not recommended for children as safety and effectiveness have not been established.

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Heart

Oxabenz-50 Injection may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using Oxabenz-50 Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Oxabenz-50 Injection to geriatric patients. Your doctor will prescribe Oxabenz-50 Injection if the benefits outweigh the risks.

FAQs

Oxabenz-50 Injection is used to treat Colon and rectal cancer.

Oxabenz-50 Injection works by killing the cancer cells. Thereby, it helps treat cancer.

Oxabenz-50 Injection may have an anti-fertility effect, which could be irreversible. Therefore, male patients should seek medical advice on the conservation of sperm prior to treatment with Oxabenz-50 Injection.

Avoid drinking or eating anything colder than room temperature. Do not touch any cold objects, wash your hands in cold water, go near air conditioners or freezers, or go outside in cold weather unless absolutely necessary for five days after you receive each dose of Oxabenz-50 Injection. Wear a hat, gloves, and a scarf, and cover your mouth and nose if you must go outside in cold weather.

Oxabenz-50 Injection may decrease the ability to fight infections due to reduced white blood cells. Stay away from sick people during treatment with Oxabenz-50 Injection.

Oxabenz-50 Injection is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a clinical setting.

The common side effects of Oxabenz-50 Injection are mild nausea, vomiting, diarrhoea, headache, peripheral neuropathy, fatigue, back pain, and stomach pain. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Country of origin

India

Manufacturer/Marketer address

Plot No 107, Epip Phase 1, Jharmajri, Baddi
Other Info - OXA0128

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.11052.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021759s023lbl.pdf
  3. https://medlineplus.gov/druginfo/meds/a607035.html

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