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  3. Orzine Injection 2 ml

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Orzine Injection 2 ml, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Orzine Injection 2 ml is used in the treatment of schizophrenia symptoms. Sometimes, it is also used to treat severe behavioral issues in children, intractable hiccups, acute intermittent porphyria, and tetanus. It works by inhibiting the action of dopamine (chemical messanger).
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Composition :

CHLORPROMAZINE-25MG

Manufacturer/Marketer :

Pharmafabrikon

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Orzine Injection 2 ml

Orzine Injection 2 ml belongs to a group of medications called 'antipsychotics and antiemetics indicated for the symptomatic management of psychotic disorders such as schizophrenia. It is also used to treat tetanus, acute intermittent porphyria, intractable hiccups, and severe behavioural problems in children, as well as to prevent nausea and vomiting and to relieve restlessness and apprehension prior to surgery.

Orzine Injection 2 ml contains 'Chlorpromazine', which works by blocking the action of a chemical messenger called dopamine that affects mood and thoughts.

In some cases, Orzine Injection 2 ml may cause side effects such as dry mouth, constipation, weight gain, and pain at the site of injection. Most of these side effects of Orzine Injection 2 ml do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor.

Inform your doctor if you are pregnant or breastfeeding before receiving Orzine Injection 2 ml; your doctor will prescribe only if the benefits outweigh the risks. The safety and effectiveness of Orzine Injection 2 ml in children below 12 months have not been established. Avoid driving or operating heavy machinery as Orzine Injection 2 ml may impair mental and/or physical ability. Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Orzine Injection 2 ml

Treatment of Schizophrenia, nausea and vomiting

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Directions for Use

• Orzine Injection 2 ml is administered by a healthcare professional, typically in a hospital or clinical setting.• Your healthcare provider will determine the correct dosage and frequency based on your specific needs and medical history.• Do not attempt to self-administer this injection.

Medicinal Benefits

Orzine Injection 2 ml belongs to a group of medications called 'antipsychotics and antiemetics indicated for the symptomatic management of psychotic disorders such as schizophrenia. It is also used to treat tetanus, acute intermittent porphyria, intractable hiccups, and severe behavioural problems in children, as well as to prevent nausea and vomiting and to relieve restlessness and apprehension prior to surgery. Orzine Injection 2 ml may also be used to control the manifestations of the manic phase of bipolar disorder in the short-term treatment of hyperactive children, childhood schizophrenia and autism. Orzine Injection 2 ml works by blocking the action of a chemical messenger called dopamine that affects mood and thoughts.

How Orzine Injection 2 ml Works

Orzine Injection 2 ml contains 'Chlorpromazine', which works by blocking the action of a chemical messenger called dopamine that affects mood and thoughts.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Orzine Injection 2 ml out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Orzine Injection 2 ml
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Treatments include blood transfusions, immunosuppressive therapy and bone marrow transplants.
  • Get adequate sleep and rest.
  • Avoid high-contact sports and activities.
  • Frequent stretching improves flexibility and helps to lengthen tight muscles.
  • Do strengthening exercises which involves targeted strengthening of opposing muscle groups as it helps improve movement control and balance muscle tone.
  • Consult a physical therapist for a personalized exercise program that includes aquatic therapy, manual therapy and proprioceptive training.
  • Use supportive devices like orthotics or splints to help maintain proper posture and prevent contractures.
  • In some cases, medications may be advised by the doctor.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.

What if I have taken an overdose of Orzine Injection 2 ml

Orzine Injection 2 ml is administered by a healthcare professional in a hospital setting. Hence, the chances of overdose are less. Most of the time, an overdose will only result in temporary drowsiness and a few side effects, like uncontrollably moving the lips, eyes, head, and neck. If these movements are not addressed promptly and appropriately, they might persist. Rarely, an overdose may result in more severe side effects.

Drug Warnings

Do not take Orzine Injection 2 ml if you are allergic to any of the components if you have circulatory collapse, CNS depression, or bone marrow depression. Inform your doctor if you have epilepsy, Parkinson's disease, hypoparathyroidism, myasthenia gravis, prostate hypertrophy, retinopathy, respiratory disease, Reye's syndrome, glaucoma, high/low blood pressure, asthma, heart, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding; your doctor will prescribe only if the benefits outweigh the risks. Orzine Injection 2 ml may cause tardive dyskinesia (movement disorder), neuroleptic malignant syndrome (a rare reaction associated with the use of antipsychotic drugs), postural hypotension, and motor and sensory instability; talk to your doctor if you have any concerns.

Drug-Drug Interactions

verifiedApollotooltip
ChlorpromazineCisapride
Critical
ChlorpromazineMesoridazine
Critical

Drug-Drug Interactions

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ChlorpromazineCisapride
Critical
How does the drug interact with Orzine Injection 2 ml:
Taking Orzine Injection 2 ml with Cisapride can increase the risk of a abnormal heart rhythm.

How to manage the interaction:
Taking Orzine Injection 2 ml with Cisapride is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChlorpromazineMesoridazine
Critical
How does the drug interact with Orzine Injection 2 ml:
Taking Orzine Injection 2 ml with Mesoridazine together can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Orzine Injection 2 ml with Mesoridazine is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChlorpromazineZiprasidone
Critical
How does the drug interact with Orzine Injection 2 ml:
Taking Orzine Injection 2 ml with Ziprasidone can increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Orzine Injection 2 ml with Ziprasidone is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChlorpromazineDronedarone
Critical
How does the drug interact with Orzine Injection 2 ml:
Taking Orzine Injection 2 ml with Dronedarone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Orzine Injection 2 ml with Dronedarone is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChlorpromazineThioridazine
Critical
How does the drug interact with Orzine Injection 2 ml:
Taking Thioridazine and Orzine Injection 2 ml can increase the effects of serious side effects.

How to manage the interaction:
Taking Orzine Injection 2 ml with Thioridazine is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience extreme drowsiness, confusion, irritation, vomiting, vision problem, feeling hot or cold, sweating, muscle stiffness, fainting, seizure, uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs, fever, muscle rigidity, irregular heart beat, consult the doctor. Do not discontinue any medications without consulting a doctor.
ChlorpromazineEliglustat
Critical
How does the drug interact with Orzine Injection 2 ml:
When Orzine Injection 2 ml and Eliglustat are taken together, the effect of Orzine Injection 2 ml is reduced.

How to manage the interaction:
Taking Orzine Injection 2 ml with Eliglustat is not recommended, as it can possibly result in an interaction, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChlorpromazineSparfloxacin
Critical
How does the drug interact with Orzine Injection 2 ml:
Using Orzine Injection 2 ml together with sparfloxacin can increase the risk of side effects.

How to manage the interaction:
Taking Sparfloxacin with Orzine Injection 2 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChlorpromazinePhenobarbital
Critical
How does the drug interact with Orzine Injection 2 ml:
When Orzine Injection 2 ml is taken with Phenobarbital, can change the drug levels and effects of both medications.

How to manage the interaction:
Taking Orzine Injection 2 ml with Phenobarbital is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience unusual symptoms, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChlorpromazineHaloperidol
Severe
How does the drug interact with Orzine Injection 2 ml:
Coadministration of Haloperidol with Orzine Injection 2 ml can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Orzine Injection 2 ml and Haloperidol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting your doctor.
ChlorpromazineHydroxychloroquine
Severe
How does the drug interact with Orzine Injection 2 ml:
Using hydroxychloroquine together with Orzine Injection 2 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Orzine Injection 2 ml and hydroxychloroquine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Schizophrenia:

  • Maintain a healthy diet and exercise regularly.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor's treatment plan.

Nausea & Vomiting:

  • Eat smaller meals more often.
  • Drink fluids to stay hydrated. Use oral rehydration solutions (ORS) to replace lost electrolytes.
  • Avoid solid foods until the vomiting stops.
  • Avoid foods that might cause stomach upset.
  • Take ample rest. Avoid any activity immediately after eating.
  • Consume plain, light foods such as bread and biscuits.
  • Avoid food with strong flavours and fried food.
  • Ginger tea might help in proper digestion.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Orzine Injection 2 ml Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Orzine Injection 2 ml to prevent additive effects and hypotension.

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Pregnancy

Caution

If you are pregnant or planning to conceive, inform your doctor before receiving Orzine Injection 2 ml. Your doctor will prescribe this medicine only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Orzine Injection 2 ml may pass into breast milk. Please inform your doctor if you are breastfeeding; your doctor will prescribe only if the benefits outweigh the risk.

bannner image

Driving

Unsafe

Avoid driving or operating heavy machinery as Orzine Injection 2 ml may impair mental and/or physical ability.

bannner image

Liver

Caution

Orzine Injection 2 ml should be used with caution in patients with liver diseases. If you have liver problems, please inform your doctor before taking this medicine.

bannner image

Kidney

Caution

Orzine Injection 2 ml should be used with caution in patients with kidney diseases. If you have kidney problems, please inform your doctor before taking this medicine.

bannner image

Children

Safe if prescribed

Orzine Injection 2 ml should be given to children only if prescribed by the doctor. The safety and effectiveness of Orzine Injection 2 ml in children below 12 months have not been established.

FAQs

Orzine Injection 2 ml belongs to a group of medications called antipsychotics and antiemetics indicated for the symptomatic management of psychotic disorders such as schizophrenia. It is also used to treat tetanus, acute intermittent porphyria, intractable hiccups, and severe behavioural problems in children.

Orzine Injection 2 ml works by blocking the action of a chemical messenger called dopamine that affects mood and thoughts.

Long-term use of antipsychotics such as Orzine Injection 2 ml may cause tardive dyskinesia (a movement disorder). Consult your doctor if you notice symptoms such as repetitive, involuntary movement of the face, tongue, mouth or jaw.

Orzine Injection 2 ml is not approved for the treatment of patients with dementia-related psychosis. Consult your doctor if you have any concerns.

Orzine Injection 2 ml may lower the effect of oral anti-coagulants (blood thinners). Consult your doctor before taking other medicines with Orzine Injection 2 ml.

Orzine Injection 2 ml may be used to treat behavioural problems in children marked by aggression and hyperexcitability. It is also used in the short-term treatment of hyperactive children who show excessive motor activity with conduct disorders consisting of a few or all of the following symptoms: impulsivity, aggressivity, difficulty sustaining attention, mood swings, and poor frustration tolerance.

Patients on high doses of Orzine Injection 2 ml may develop photosensitivity. Therefore, avoid exposure to strong sunlight. Wear protective clothing and sunscreen while going out.

Country of origin

India

Manufacturer/Marketer address

1/332, Othappati, Karuppayurani, Post, Madurai, Tamil Nadu 625020
Other Info - ORZ0019

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:23 AM IST

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Reference

  1. https://pdf.hres.ca/dpd_pm/00015407.PDF
  2. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c0f1fcfd-8863-4032-bf80-185df60a4ba0#LINK_adcb04e1-86d4-434f-a083-a7c7cb8775c6
  3. https://genesight.com/wp-content/uploads/2017/05/Chlorpromazine-Thorazine-FDA-Label.pdf

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