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compositionComposition:OFLOXACIN-2MG
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Prescription Medicine
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ONOFF INJECTION is an antibiotic used in treating bacterial infections. This medicine stops the growth of bacteria by inhibiting the gyrase enzyme and thereby helps reduce various bacterial infections of urinary tract, genital tract, chest, lungs, skin, and soft tissue. This medicine is not effective for treating viral infections. Common side effects include constipation, nausea, diarrhoea, headache, dizziness, light-headedness, pain, redness, and injection site reactions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

OFLOXACIN-2MG

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ONOFF INJECTION

ONOFF INJECTION is a prescription antibiotic injection used to treat severe bacterial infections in the lungs, urinary tract, skin, and pelvic organs. It works by stopping the growth of harmful bacteria responsible for these illnesses. This medicine is typically prescribed when oral treatments are not suitable or a faster medical response is required.

It is given as a slow drip into a vein (intravenous infusion), usually once or twice daily at regular intervals to maintain steady levels in your body. Drinking plenty of fluids during your treatment helps support your kidneys and prevents dehydration. Eating a balanced diet and getting enough rest will also help your body recover more quickly from the infection.

Some people may experience mild side effects like nausea, headache, or pain at the injection site. However, if you develop severe watery diarrhoea, joint pain, muscle weakness, or a skin rash, you must contact your doctor immediately.

Do not receive this medicine if you have a history of tendon problems, muscle disorders like myasthenia gravis, or a known allergy to similar antibiotics. ONOFF INJECTION is generally not recommended for children and adolescents under 18 years of age unless specifically prescribed by a doctor, as fluoroquinolone antibiotics may affect developing joints and cartilage. Talk to your doctor before starting ONOFF INJECTION if you have kidney disease, nerve issues, or a history of seizures.

This medicine can interact with blood thinners and certain pain relievers, increasing the risk of side effects. It is highly recommended to avoid alcohol and smoking during treatment to help your body heal. Pregnant or breastfeeding women, as well as elderly individuals, should consult their doctor to discuss the risks and benefits before starting treatment.

Uses of ONOFF INJECTION

ONOFF INJECTION is used to treat serious bacterial infections in different parts of the body. The detailed uses of ONOFF INJECTION are as follows:

  • Pneumonia and severe lung infections: It helps treat certain bacterial lung infections when considered appropriate by the treating physician, helping to eliminate the bacteria responsible for the infection.
  • Complicated urinary tract infections: It targets and destroys bacteria in the kidneys or bladder, relieving painful urination.
  • Skin and soft tissue infections: It stops the spread of bacteria in deep skin tissues, promoting faster wound healing.
  • Pelvic inflammatory disease: It treats severe infections of the reproductive organs to prevent long-term complications.

Key Benefits

ONOFF INJECTION helps treat bacterial infections and supports faster recovery. Key benefits of ONOFF INJECTION include:

  • Rapid Delivery: Because ONOFF INJECTION is delivered directly into your bloodstream, it reaches target tissues rapidly and may provide faster treatment initiation compared to oral formulations, making it useful for severe infections that require prompt medical management.
  • Effective Against Severe Infections: This medicine is highly effective at treating severe or complicated infections that have not responded well to standard oral antibiotics.
  • Prevents Infection Spread: By quickly stopping bacterial reproduction, it helps prevent the infection from spreading to other vital organs or entering the bloodstream.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • ONOFF INJECTION will be administered by the doctor.
  • Do not self-administer.

How ONOFF INJECTION Works

ONOFF INJECTION contains ofloxacin and belongs to a group of medicines known as quinolone antibiotics. It works by inhibiting bacterial enzymes called DNA gyrase (topoisomerase II) and topoisomerase IV, which are essential for copying, repairing, and organising bacterial DNA. When these enzymes are blocked, the bacteria cannot multiply, grow, or repair themselves. This rapidly weakens the bacteria, allowing your body's natural immune system to easily clear the remaining infection.
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Alcohol

Unsafe

Avoid alcohol consumption with ONOFF INJECTION as it may cause dizziness or sleepiness. Please consult a doctor before consuming alcohol while using ONOFF INJECTION.

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Pregnancy

Caution

Please consult a doctor if you are pregnant or planning for pregnancy. ONOFF INJECTION is given to pregnant women only if doctor thinks benefits outweigh risks.

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Breast Feeding

Unsafe

ONOFF INJECTION may be excreted in human milk. Therefore, ONOFF INJECTION is not recommended for breastfeeding mothers. Please consult a doctor if you are breastfeeding.

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Driving

Caution

ONOFF INJECTION may cause dizziness, drowsiness or changes in vision. Therefore, drive only if you are alert after taking ONOFF INJECTION.

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Liver

Caution

Take ONOFF INJECTION with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take ONOFF INJECTION with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

ONOFF INJECTION is not recommended for children below 18 years of age as the safety and effectiveness were not established.

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Heart

Caution

Take ONOFF INJECTION with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Consult your doctor

Limited information available about the use of ONOFF INJECTION in geriatric patients. Please consult your physician.

What if I have taken an overdose of ONOFF INJECTION

Since this medicine is usually given by a healthcare professional, the risk of overdose is low. However, medicine errors can occasionally occur. If you receive too much medicine or suspect an overdose, seek emergency medical care immediately. Symptoms of an overdose may include severe dizziness, confusion, or seizures.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water throughout the day to help your kidneys flush out the medicine safely and prevent crystals from forming in your urine.
  • Protect your skin from the sun: This medicine can make your skin highly sensitive to sunlight. Wear protective clothing and apply a high-SPF sunscreen when outdoors, and avoid tanning beds.
  • Avoid strenuous exercise: Because this medicine can affect your tendons, avoid heavy lifting, vigorous running, or intense physical activities during and shortly after your treatment.
  • Probiotics support: Your doctor may recommend probiotics or probiotic-rich foods, such as yoghurt, to help maintain healthy gut bacteria during or after antibiotic treatment.
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How Soon It Starts Working

The time required for ONOFF INJECTION to start to work: ONOFF INJECTION ideally shows its action within 30 minutes after administration. The time for which the effects of ONOFF INJECTION last: The effect of ONOFF INJECTION lasts for 12 hours.

What if you forget to take ONOFF INJECTION

If you miss a scheduled infusion, contact your healthcare provider immediately to get instructions. Do not double the dose to make up for a missed one.

Storage

•Store ONOFF INJECTION at room temperature, ideally between 20°C to 25°C (68°F to 77°F).•Keep the medicine in its original packaging to protect it from light.

Drug Warnings

  • Check the solution: Before each infusion, inspect the liquid carefully. It should be clear and free of particles; do not inject it if it looks cloudy or discoloured.
  • Report joint or tendon pain immediately: Stop physical activity and call your doctor right away if you experience sudden joint pain, swelling, or stiffness.
  • Complete the full course: Always finish the entire prescribed treatment, even if you start feeling better after a few days, to prevent the infection from returning.
  • Avoid driving if dizzy: This medicine can cause dizziness or lightheadedness. Avoid driving or operating machinery until you know how it affects you.
  • Practice safe needle disposal: If administering at home, safely discard all used needles and infusion lines in a puncture-proof sharps container.
  • Be aware of heart rhythm changes: ONOFF INJECTION may affect the electrical activity of the heart (QT prolongation), which can increase the risk of serious heart rhythm problems in susceptible individuals. Tell your doctor if you have a history of heart rhythm disorders, low potassium levels, or are taking medicines that affect heart rhythm.
  • Do not share your medicine: ONOFF INJECTION has been prescribed specifically for your infection. Do not share it with others, even if their symptoms appear similar, as inappropriate antibiotic use can contribute to antibiotic resistance.

verifiedApollotooltip
  • Blood thinners (like warfarin): May increase the risk of bleeding.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): Combining these can increase the risk of central nervous system side effects, including seizures.
  • Medicines that prolong the QT interval (such as amiodarone, sotalol, or certain antipsychotic medicines): Taking these together can increase the risk of heart rhythm problems.

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verifiedApollotooltip

No clinically significant food interactions are known with ONOFF INJECTION when used as directed. 

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

ONOFF INJECTION is used in the treatment of bacterial infections of the urinary tract, genital tract, chest, lungs, skin, and soft tissue.
ONOFF INJECTION works by interfering with bacterial enzyme, DNA gyrase involved in repairing and replicating the DNA (genetic material) of bacteria. Thus, ONOFF INJECTION kills bacteria and clears the infection.
ONOFF INJECTION may be used to treat lung infections caused by bacteria. ONOFF INJECTION is an antibiotic that kills bacteria and prevents the spread of infection.
You are not recommended to take ONOFF INJECTION with warfarin as co-administration of these two medicines may increase the risk of bleeding more easily. However, please consult your doctor before taking ONOFF INJECTION with other medicines.
ONOFF INJECTION may cause diarrhoea as a common side effect. However, if the condition persists, worsens or if you notice blood or mucus in stools, consult a doctor immediately.
ONOFF INJECTION is not used to treat viral infections. ONOFF INJECTION is an antibiotic which is used to treat only bacterial infections.
Yes, but only in selected cases where your doctor determines that home administration is appropriate. You or your caregiver must receive proper training from a qualified healthcare professional on how to prepare, administer, and monitor the infusion safely before attempting home treatment. Talk to your doctor to see if home administration is right for you.
Mild irritation can occur, but if you notice increasing redness, swelling, heat, or severe pain at the injection site, contact your healthcare provider immediately.
It is highly recommended to avoid alcohol during treatment, as it can worsen side effects like dizziness and put extra strain on your liver. Talk to your doctor for personalised advice.
Yes, this medicine can make your skin burn more easily. Wear protective clothing and sunblock, and avoid direct sun exposure when possible.
This medicine is generally not recommended during pregnancy or breastfeeding unless absolutely necessary. Talk to your doctor to understand the risks and benefits.
Look out for sudden pain, swelling, bruising, or stiffness in your joints, especially the back of your ankle (Achilles tendon). If this happens, rest the area and call your doctor immediately.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - ONO0019
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