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  3. Oncothal 100 mg Capsule 10's

Oncothal 100 mg Capsule 10's, Pack of 10 CAPSULES
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Oncothal 100 mg Capsule is used to treat multiple myeloma (a type of cancer) and erythema nodosum leprosum (inflammatory disorder). It contains Thalidomide, which works by preventing the development of cancer cells and stimulating the immune system to attack the cancer cells. In some cases, this medicine may cause side effects such as constipation, dizziness, sleepiness, tiredness, tremors, low blood cell count, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

THALIDOMIDE-100MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Oncothal 100 mg Capsule

Oncothal 100 mg Capsule is used to treat multiple myeloma. Oncothal 100 mg Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence. Multiple myeloma is a type of cancer that affects a type of white blood cells called plasma cells. ENL is an immune-mediated inflammatory complication of leprosy.
 
Oncothal 100 mg Capsule contains ‘Thalidomide’, which works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Oncothal 100 mg Capsule helps treat multiple myeloma.

You are advised to take Oncothal 100 mg Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as constipation, dizziness, sleepiness, tiredness, tremors, dysaesthesia (abnormal sensation), low blood cell count, nausea, vomiting, and swelling of hands and feet. Speak with your doctor if you experience any of these side effects persistently.
 
Do not take Oncothal 100 mg Capsule if you are pregnant as it might cause severe birth defects or the death of an unborn baby. Avoid taking Oncothal 100 mg Capsule if you are breastfeeding. Oncothal 100 mg Capsule may cause dizziness, sleepiness, and blurred vision, so drive only if you are alert. Oncothal 100 mg Capsule is not recommended for children below 18 years as safety and effectiveness have not been established. Avoid consuming alcohol along with Oncothal 100 mg Capsule as it could lead to increased dizziness. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Oncothal 100 mg Capsule

Treatment of Multiple myeloma, Erythema Nodosum Leprosum (ENL)

Directions for Use

• Oncothal 100 mg Capsule should be taken at least one hour after meals.• It is usually taken once daily, preferably at bedtime, or as prescribed by your doctor.• Swallow Oncothal 100 mg Capsule as a whole with a glass of water.• Do not crush, chew, or open it.

Medicinal Benefits

Oncothal 100 mg Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Oncothal 100 mg Capsule works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Oncothal 100 mg Capsule helps treat multiple myeloma. Oncothal 100 mg Capsule is also used to treat and prevent skin symptoms of erythema nodosum leprosum and as maintenance therapy for prevention and suppression of erythema nodosum leprosum recurrence.

How Oncothal 100 mg Capsule Works

Oncothal 100 mg Capsule contains ‘Thalidomide’, which works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Oncothal 100 mg Capsule helps treat multiple myeloma.

Storage

Keep Oncothal 100 mg Capsule out of reach and sight of children.
Side effects of Oncothal 100 mg Capsule
Managing Medication-Triggered Hypocalcemia (Calcium deficiency or Low Calcium Levels In Blood): A Step-by-Step Guide:
  • Consult Your Doctor: If you experience symptoms such as muscle cramps, tingling, numbness, weakness, or spasms, which may indicate low calcium levels (hypocalcemia), consult your doctor to determine if your medication is the cause.
  • Your doctor will assess your medication regimen and adjust it if necessary to minimize the risk of hypocalcemia.
  • Your doctor may order blood tests to check your calcium levels and monitor for any changes.
  • To manage hypocalcemia, your doctor recommends dietary and lifestyle modifications. This may include increasing your intake of calcium-rich foods to support bone health and calcium levels. If necessary, your doctor may also prescribe calcium and vitamin D supplements to help stabilize your calcium levels.
  • If your condition does not improve or worsens, consult your doctor immediately for further evaluation and treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Muscle weakness can be due to tiredness, which can be managed by eating often.
  • Observe your movements and understand why the muscle is weakening.
  • Regularly do strengthening exercises to improve blood flow throughout the body and reduce weakness.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet, quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.

What if I have taken an overdose of Oncothal 100 mg Capsule

Take Oncothal 100 mg Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Oncothal 100 mg Capsule if you are allergic to any of its components. Inform your doctor if you have/had blood clots, heart attack, neuropathy, slow heart rate, high blood pressure, low blood pressure, infections, viral infection, HIV, hepatitis B, epilepsy, liver or kidney problems. Do not take Oncothal 100 mg Capsule if you are pregnant, as it might cause severe birth defects or the death of the unborn baby. Avoid taking Oncothal 100 mg Capsule if you are breastfeeding, as it is not unknown if it passes into breastmilk. Oncothal 100 mg Capsule may cause dizziness, sleepiness and blurred vision, so drive only if you are alert. Oncothal 100 mg Capsule is not recommended for children. Avoid consuming alcohol with Oncothal 100 mg Capsule as it could lead to increased dizziness and sleepiness. Oncothal 100 mg Capsule , when taken with dexamethasone, increases the risk of deep vein thrombosis and pulmonary embolism. Stop taking Oncothal 100 mg Capsule and consult a doctor immediately if you have think you are pregnant, if you have irregular periods, missed a period, have any change in menstrual bleeding, or if you have had sex without using two forms of birth control.

Drug-Drug Interactions

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ThalidomideCladribine
Severe
ThalidomidePemetrexed
Severe

Drug-Drug Interactions

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ThalidomideCladribine
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with cladribine may increase the risk of blood clots.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and cladribine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomidePemetrexed
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with pemetrexed may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and pemetrexed together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideCetuximab
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with cetuximab may increase the risk of blood clots.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and cetuximab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideIrinotecan
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with irinotecan may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and irinotecan together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideOspemifene
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with ospemifene may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and ospemifene together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomidePeginesatide
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with peginesatide may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and peginesatide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideThiotepa
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with thiotepa may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and thiotepa together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideBusulfan
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with busulfan may increase the risk of blood clots.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and busulfan together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideCarboplatin
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking carboplatin with Oncothal 100 mg Capsule can increase the risk of blood clots.

How to manage the interaction:
Co-administration of carboplatin with Oncothal 100 mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience chest pain, breathing difficulty, coughing up blood, and pain, redness, or swelling in an arm or leg, sudden loss of vision, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
ThalidomideOxaliplatin
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with oxaliplatin may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and oxaliplatin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.

  • Avoid smoking and alcohol consumption.

  • Include food rich in iron, such as lean red meat, raisins, bell peppers, Brussel sprouts, and broccoli.

  • To prevent constipation, consume fibre rich foods such as whole grains, broccoli, dried fruits, nuts, beans, apples, oranges, and pears. 

Habit Forming

No

Therapeutic Class

ANTILEPROTICS

Oncothal 100 mg Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Oncothal 100 mg Capsule as it might cause increased sleepiness.

bannner image

Pregnancy

Unsafe

Oncothal 100 mg Capsule belongs to pregnancy category X. Oncothal 100 mg Capsule should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of child-bearing age. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Oncothal 100 mg Capsule as it is unknown if Oncothal 100 mg Capsule passes into breastmilk.

bannner image

Driving

Unsafe

Oncothal 100 mg Capsule may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

bannner image

Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Oncothal 100 mg Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

Have a query?

FAQs

Oncothal 100 mg Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Oncothal 100 mg Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence.

Oncothal 100 mg Capsule stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Oncothal 100 mg Capsule helps treat multiple myeloma.

Do not stop taking Oncothal 100 mg Capsule on your own. You are advised to take Oncothal 100 mg Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Oncothal 100 mg Capsule .

Orthostatic hypotension could be a side-effect of Oncothal 100 mg Capsule . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.

No, it is not safe to father a child while taking Oncothal 100 mg Capsule . Thalidomide is present in the semen of male patients taking Oncothal 100 mg Capsule ; it could cause severe birth defects or death of the unborn baby. During sexual activity with females of reproductive potential, always use effective contraception such as latex or synthetic condom while taking Oncothal 100 mg Capsule and for at least 4weeks after discontinuing Oncothal 100 mg Capsule , even if you have undergone a successful vasectomy. Male patients taking Oncothal 100 mg Capsule must not donate semen.

Patients taking Oncothal 100 mg Capsule must not donate blood during the treatment with Oncothal 100 mg Capsule and for 4weeks after discontinuation of Oncothal 100 mg Capsule as the donated blood might be given to pregnant women whose foetus should not be exposed to thalidomide since it causes severe birth defects or death of the unborn baby.

People with multiple myeloma taking Oncothal 100 mg Capsule may have an increased risk for blood clots in veins, arteries, and lungs. The risk is higher if you take dexamethasone with Oncothal 100 mg Capsule for treating multiple myeloma. Consult your doctor immediately if you notice symptoms such as shortness of breath, chest pain, and swelling in the legs or arm.

Oncothal 100 mg Capsule may cause side effects such as nausea, vomiting, indigestion, dizziness, heartburn, constipation, tiredness, tremor or swelling of hands and feet. If these side effects persist or worsen, please consult your doctor.

If you forget to take a dose of Oncothal 100 mg Capsule , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

Country of origin

India

Manufacturer/Marketer address

D' Block, 3Rd Floor, Gillander House, Netaji Subhas Road, Kolkata - 700001 (Wb)
Other Info - ONC0020

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:53 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.6317.pdf
  2. https://packageinserts.bms.com/pi/pi_thalomid.pdf
  3. https://medlineplus.gov/druginfo/meds/a699032.html
  4. https://www.drugs.com/pregnancy/thalidomide.html

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