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compositionComposition:ETOPOSIDE-100MG
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Prescription Medicine
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Oncosid 100 Injection is used to treat various cancer conditions, including testicular tumours or cancer of the testicles and lung cancer (small cell lung cancer; SCLC). It contains Etoposide, a podophyllotoxin derivative. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ETOPOSIDE-100MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Oncosid 100 Injection

Oncosid 100 Injection is an injectable chemotherapy medication prescribed to treat certain types of cancer, most notably small cell lung cancer and testicular cancer. Its primary medical purpose is to slow down or stop the growth of rapidly multiplying cancer cells in the body. By targeting these abnormal cells, it helps control the spread of the disease and can assist in bringing the condition into remission.

Because Oncosid 100 Injection is given as an injection into a vein, it is administered in cycles by healthcare professionals in a hospital or specialized clinic. Consistency is vital, and you must attend all your scheduled treatment sessions as planned by your medical team. While receiving this therapy, maintaining a balanced diet, staying well-hydrated, and resting adequately can help your body cope with the treatment and support your overall recovery.

Like many cancer treatments, Oncosid 100 Injection can cause side effects, including temporary hair loss, fatigue, nausea, and low blood cell counts. It is important to watch for serious side effects, such as a high fever, severe chills, unusual bruising, or sudden shortness of breath. If you experience any of these severe symptoms, you must contact your doctor or seek emergency medical care immediately.

Before starting this treatment, tell your doctor if you have any pre-existing health conditions, especially liver damage, kidney disease, or a history of low blood cell counts. Before each treatment, your healthcare team will review your medical history, including any previous allergic reactions to Oncosid 100 Injection or its ingredients, to help ensure the medicine is safe for you. Be sure to tell your doctor if you have ever experienced a severe allergic reaction to this medicine or any of its components. It is also unsafe for pregnant women, as it can cause serious harm to an unborn baby.

This medicine can interact with other substances, including certain prescription drugs, over-the-counter medicines, and live vaccines, which may increase your risk of severe infections or bleeding. Avoid drinking alcohol during treatment, as it can worsen liver strain and fatigue. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, talk to your doctor or pharmacist about the specific risks and precautions for your age and health group.

Uses of Oncosid 100 Injection

This medicine is used to treat certain types of cancer by slowing or stopping the growth of cancer cells. The detailed uses of this medicine are as follows:

  • Small cell lung cancer: It helps slow the rapid growth and division of cancer cells in the lungs, especially when used in combination with other chemotherapy medicines.
  • Testicular cancer: It helps destroy cancer cells in the testicles and is commonly used as part of combination chemotherapy to improve treatment outcomes.
  • Certain blood and lymph cancers: It helps slow or stop the growth of abnormal cells in the bone marrow or lymphatic system in specific types of blood and lymph cancers, as determined by your doctor.

Key Benefits

Oncosid 100 Injection helps treat certain cancers by slowing the growth and spread of cancer cells. Its benefits include:

  • Helps slow or stop the growth of rapidly dividing cancer cells, supporting effective cancer treatment.
  • Helps shrink tumors, which may relieve symptoms such as pain, persistent cough, breathing difficulties, or discomfort caused by the cancer.
  • Reduces the spread of cancer cells and supports better disease control when used as part of combination chemotherapy.
  • Improves the chances of achieving remission in certain types of cancer when used according to your treatment plan.
  • Supports overall treatment outcomes and may help improve quality of life by reducing cancer-related symptoms.
Side effects of Oncosid 100 Injection
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Focus on consuming whole, nutrient-dense foods to promote healthy, radiant skin.
  • Eat a variety of colourful fruits and vegetables, including citrus fruits, bell peppers, and broccoli.
  • Wear protective clothing, such as long-sleeved shirts and pants, during peak sun hours.
  • Drink plenty of water throughout the day to keep your skin moisturized and plump.
  • Practice mindfulness techniques, such as meditation, deep breathing, or yoga, to reduce stress and promote skin health.
  • Use gentle, fragrance-free skincare products that nourish and protect your skin.
  • Avoid prolonged sun exposure, especially during peak hours, to prevent skin damage and premature aging.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • Oncosid 100 Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Oncosid 100 Injection Works

Oncosid 100 Injection works by blocking a specific protein (an enzyme) in the body that cancer cells need to repair and copy their genetic material (DNA). When this protein is blocked, the cancer cells suffer severe DNA damage and are unable to divide or multiply. Because cancer cells grow and divide much faster than normal cells, they are highly sensitive to this action, which eventually causes the abnormal cells to die. Since this is an injection given directly into the bloodstream, the medicine travels throughout the body quickly to target cancer cells wherever they are located.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Oncosid 100 Injection.

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Pregnancy

Unsafe

Oncosid 100 Injection should not be used in pregnant women as it is known to cause fetal damage. Also, a gap of 6 months should be maintained between the last dose of Oncosid 100 Injection and your next pregnancy. Hence, inform your doctor if you are planning a pregnancy.

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Breast Feeding

Unsafe

Oncosid 100 Injection should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Oncosid 100 Injection may impact your ability to drive or operate machinery, so do not drive or do activities that require your mental alertness after taking this medicine.

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Liver

Caution

Inform your doctor before receiving the Oncosid 100 Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment or any concerns.

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Children

Caution

Safety and effectiveness in children have not been established.

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Heart

Caution

Oncosid 100 Injection can be used in patients with heart problems, but caution is essential. It may cause hypotension or worsen heart conditions, especially in those with pre-existing cardiovascular disease.

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Geriatrics

Caution

Geriatric patients can receive Oncosid 100 Injection, but it may be more sensitive to side effects like low blood counts and infections. Dose adjustments and close monitoring are essential to ensure safe and effective treatment.

What if I have taken an overdose of Oncosid 100 Injection

An overdose is highly unlikely because this medicine is measured and administered by trained healthcare professionals. However, if you suspect an error has occurred or notice any unusual symptoms after your infusion—including severe breathing difficulty, persistent dizziness, unusual bleeding, or any symptoms that concern you—inform your oncology team immediately or seek emergency medical attention. Prompt reporting helps your healthcare team assess and manage any potential treatment-related complications.

Diet & Lifestyle Advise

  • Avoid infections: Wash your hands frequently with soap and water, avoid crowds, and stay away from people who are sick, as this medicine temporarily lowers your body's ability to fight germs.
  • Stay hydrated: Drink plenty of water and clear fluids daily to help your kidneys process and clear the medication from your system safely.
  • Eat soft, bland foods: To manage nausea and prevent painful mouth sores, choose gentle, non-acidic, and non-spicy foods, and eat smaller, more frequent meals.
  • Maintain good mouth care: Brush gently with a soft toothbrush, keep your mouth clean, and rinse regularly with your doctor's recommended alcohol-free or salt-and-baking soda mouth rinse to help reduce the risk of mouth sores and infection. If painful mouth ulcers develop, inform your healthcare team promptly.
  • Use a soft toothbrush: This helps protect your gums from bleeding, which is especially important when your platelet counts are low.
  • Avoid grapefruit and grapefruit juice: Grapefruit products may affect how Oncosid 100 Injection is processed in the body and could alter its effects. Check with your doctor or pharmacist before consuming grapefruit or grapefruit juice during treatment.
health query

Have a query?

How Soon It Starts Working

The time required for Oncosid 100 Injection to start to work: Oncosid 100 Injection begins to show its action within a few hours of administration. The time for which the effects of Oncosid 100 Injection last: Oncosid 100 Injection effect lasts for several days.

What if you forget to take Oncosid 100 Injection

Since this medication is given at a clinic by a healthcare provider, missing a dose means missing a scheduled appointment. If you miss an appointment, contact your oncology clinic immediately to reschedule your infusion. Do not double the dose at your next visit to make up for a missed one.

Storage

• Oncosid 100 Injection injections are typically stored and managed by the hospital or clinic pharmacy.

Drug Warnings

  • Watch the injection site: Tell your nurse immediately if you feel any burning, stinging, coldness, or pain around the needle during your infusion, as the medicine can damage surrounding tissue if it leaks.
  • Avoid live vaccines: Do not receive any live vaccines (such as the shingles, measles, or mumps vaccine) while using Oncosid 100 Injection, as your weakened immune system could lead to a serious infection.
  • Use effective birth control: Both men and women should use highly reliable birth control during treatment and for several months after the last dose to prevent pregnancy, as this medicine can cause severe birth defects.
  • Monitor your blood pressure: Alert your healthcare provider if you feel lightheaded, dizzy, or warm during the injection, as the infusion rate may need to be slowed down.
  • Keep all blood test appointments: You will need regular blood tests before each treatment cycle to monitor your liver, kidneys, and blood cell counts.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin): Combining these can significantly increase your risk of severe bleeding.
    Other chemotherapy medicines: May increase the risk of severe bone marrow suppression, leading to dangerously low blood counts.
  • Immunosuppressant drugs: Can further weaken your immune system, making you highly susceptible to life-threatening infections.
     
EtoposideRotavirus vaccine
Critical
EtoposideThalidomide
Severe

Drug-Drug Interactions

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EtoposideRotavirus vaccine
Critical
How does the drug interact with Oncosid 100 Injection:
When the Rotavirus vaccine is used together with Oncosid 100 Injection, it may not work as well.

How to manage the interaction:
Taking Oncosid 100 Injection with the Rotavirus vaccine can cause an, please consult doctor before taking it. You may be at risk of acquiring an infection from the vaccination or having a decreased response of the vaccine depending on the dose and length of time you have been on Oncosid 100 Injection. Do not discontinue any medications without a doctor's advice.
EtoposideThalidomide
Severe
How does the drug interact with Oncosid 100 Injection:
Taking thalidomide together with Oncosid 100 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Oncosid 100 Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
EtoposideLeflunomide
Severe
How does the drug interact with Oncosid 100 Injection:
When Oncosid 100 Injection is used with Leflunomide, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Leflunomide and Oncosid 100 Injection, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideNatalizumab
Severe
How does the drug interact with Oncosid 100 Injection:
Taking Oncosid 100 Injection with natalizumab, especially taking both simultaneously with little to no time in between, may raise the risk of serious infections.

How to manage the interaction:
Although taking Oncosid 100 Injection and Natalizumab together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor immediately, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. progressive weakening on one side of your body, clumsiness of limbs, visual disturbance, disorientation, or changes in your thinking, memory, or personality. Do not stop using any medications without talking to a doctor.
EtoposideIvacaftor
Severe
How does the drug interact with Oncosid 100 Injection:
When Fenofibrate is used in combination with Ivacaftor, the blood levels of Fenofibrate might be raised.

How to manage the interaction:
Taking Oncosid 100 Injection with Ivacaftor together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
EtoposideAdalimumab
Severe
How does the drug interact with Oncosid 100 Injection:
When Oncosid 100 Injection is used with Adalimumab, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Oncosid 100 Injection and Adalimumab together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideBaricitinib
Severe
How does the drug interact with Oncosid 100 Injection:
Coadministration of baricitinib and Oncosid 100 Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Oncosid 100 Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
EtoposideFingolimod
Severe
How does the drug interact with Oncosid 100 Injection:
When Oncosid 100 Injection is used with Fingolimod, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Oncosid 100 Injection with Fingolimod together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideGolimumab
Severe
How does the drug interact with Oncosid 100 Injection:
When Oncosid 100 Injection is used with Golimumab, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Oncosid 100 Injection and Golimumab, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideCladribine
Severe
How does the drug interact with Oncosid 100 Injection:
Taking Cladribine with Oncosid 100 Injection can increase the risk of serious infections.

How to manage the interaction:
Taking Oncosid 100 Injection with Cladribine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, make sure to contact the doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Oncosid 100 Injection when used as directed. 
 

ETOPOSIDE-100MGHerbal products/medicines
Moderate

Drug-Food Interactions

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ETOPOSIDE-100MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
St. John's wort should be used with caution.This plant stimulates metabolism, which might lower Oncosid 100 Injection levels in the blood. Avoid the use of St. John's wort while taking Oncosid 100 Injection.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Oncosid 100 Injection is used to treat Testicular cancer, small cell lung cancer, monoblastic leukaemia (AML M5) and acute myelomonoblastic leukaemia (AML M4).
Oncosid 100 Injection contains Etoposide, which is used to treat various types of cancers. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.
While taking Oncosid 100 Injection, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Oncosid 100 Injection.
Do not stop taking Oncosid 100 Injection on your own. Take Oncosid 100 Injection for as long as your doctor prescribes it, depending on your medical condition. Do not hesitate to speak with your doctor if you experience difficulty while taking Oncosid 100 Injection.
Oncosid 100 Injection can make you more likely to get infections or may worsen any current infections. Avoid contact with people with infections that may spread to others (such as chickenpox, measles, or flu). Consult your doctor if you have been exposed to an infection or for more details.
The live vaccine may not work while on treatment with Oncosid 100 Injection. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
The side effects of Oncosid 100 Injection include nausea, vomiting, abdominal pain, loss of appetite, temporary hair loss, blood disorders, changes in skin colour, constipation, weakness, dizziness, diarrhoea, and injection site reactions. Consult the doctor if any of these side effects persist or worsen.
It is given as a slow intravenous infusion into a vein by a trained healthcare professional in a hospital or clinic setting. Talk to your doctor.
Yes, temporary hair loss is a very common side effect of this medicine, but your hair will typically begin to grow back after your treatment cycles are completed. Talk to your doctor.
Inform your nurse or doctor immediately, as this could mean the medicine is leaking out of the vein into the surrounding tissue. Talk to your doctor.
Some patients experience extreme tiredness, dizziness, or lightheadedness after an infusion, so it is best to arrange for someone else to drive you home. Talk to your doctor.
It temporarily lowers your body's production of white blood cells, red blood cells, and platelets, which can increase your risk of infection, anemia, and easy bleeding. Talk to your doctor.
No, this medicine is highly toxic to a developing fetus and should not be used during pregnancy. Talk to your doctor.
Blood tests are necessary before each cycle to make sure your liver, kidneys, and blood counts are healthy enough to receive the next dose safely. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. CiplaMed Clinical Compendium. Etosid Injection Product Specification Guide. Mumbai, India: Cipla; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A697011 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Etoposide Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 18 Feb. 2020]Check here
  5. Gizem Reyhanoglu; Prasanna Tadi. Etoposide. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 6th November 2023]Check here
  6. Neon Healthcare Limited. ETOPOPHOS™ 100 mg Powder for Solution for Injection Etoposide (as phosphate). Electronics Medicines Compendium. [Revised in February 2022]. [Accessed on 6th November 2023]Check here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 27 Mar. 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044.
Other Info - ONC0035
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