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  3. Olasym 150 Tablet 60's

Olasym 150 Tablet 60's, Pack of 1
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Written By Bayyarapu Mahesh Kumar , M Pharmacy

Olasym 150 Tablet 60's is used to treat various cancers, including ovarian, breast, pancreatic, and prostate. It contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Avoid taking this medication if you are pregnant or breastfeeding because this can cause harmful effects on the unborn baby. Both women and men using this should use birth control to avoid pregnancy.

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Composition :

OLAPARIB-150MG

Manufacturer/Marketer :

Symbion Lifescience

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Olasym 150 Tablet 60's

Olasym 150 Tablet 60's is an 'anti-cancer' drug used to treat various cancers, including ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.

Olasym 150 Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

To treat your condition effectually, continue taking Olasym 150 Tablet 60's for as long as your doctor has prescribed. Do not stop using the Olasym 150 Tablet 60's midway. Talk to your doctor before taking Olasym 150 Tablet 60's if you have severe allergic reactions to Olasym 150 Tablet 60's or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Olasym 150 Tablet 60's if you are pregnant or breastfeeding because this Olasym 150 Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Olasym 150 Tablet 60's should use birth control to avoid pregnancy. While on Olasym 150 Tablet 60's treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.

Uses of Olasym 150 Tablet 60's

Olasym 150 Tablet 60's is used in the treatment of Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. The detailed uses of Olasym 150 Tablet 60's are as follows:<br/>• Ovarian Cancer: Olasym 150 Tablet 60's helps in maintenance treatment for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer after response to platinum-based chemotherapy and especially effective in patients with BRCA mutations or homologous recombination deficiency (HRD).<br/>• Breast Cancer: Olasym 150 Tablet 60's is used for HER2-negative, BRCA-mutated metastatic or high-risk early breast cancer and used after chemotherapy and sometimes endocrine therapy.<br/>• Pancreatic Cancer: Olasym 150 Tablet 60's helps in maintenance treatment for germline BRCA-mutated metastatic pancreatic cancer that hasn’t progressed after platinum-based chemotherapy.<br/>• Prostate Cancer: Olasym 150 Tablet 60's is for BRCA-mutated metastatic castration-resistant prostate cancer, often after prior hormonal therapy.<br/>

Directions for Use

• Olasym 150 Tablet 60's can be taken with or without food as prescribed by your doctor.• It is usually taken twice a day in the morning and evening, or as prescribed by your doctor.• Swallow the medicine as a whole with a glass of water.• Do not break, crush or chew Olasym 150 Tablet 60's.

Medicinal Benefits

Olasym 150 Tablet 60's belongs to a group of medicines known as 'anti-cancer' drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate.  Olasym 150 Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

How Olasym 150 Tablet 60's Works

Olasym 150 Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Olasym 150 Tablet 60's out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Olasym 150 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.

What if I have taken an overdose of Olasym 150 Tablet 60's

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Olasym 150 Tablet 60's or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Olasym 150 Tablet 60's for as long as your doctor has prescribed. Do not stop Olasym 150 Tablet 60's midway. Talk to your doctor before taking Olasym 150 Tablet 60's if you have severe allergic reactions to Olasym 150 Tablet 60's or other medicines or suffer from any medical illness. Avoid taking Olasym 150 Tablet 60's if you are pregnant or breastfeeding because this Olasym 150 Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Olasym 150 Tablet 60's should use birth control to avoid pregnancy. Do not start Olasym 150 Tablet 60's unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Olasym 150 Tablet 60's and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor's approval while taking the Olasym 150 Tablet 60's.

Drug-Drug Interactions

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OlaparibNafcillin
Severe
OlaparibConivaptan
Severe

Drug-Drug Interactions

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OlaparibNafcillin
Severe
How does the drug interact with Olasym 150 Tablet:
Using Nafcillin together with Olasym 150 Tablet can reduce the blood levels of Olasym 150 Tablet.

How to manage the interaction:
Taking Olasym 150 Tablet with Nafcillin together can possibly result in an interaction, but it can be taken if your doctor has advised it. Your doctor can recommend other options that won't cause any problems when taken together. Do not discontinue any medications without first consulting your doctor.
OlaparibConivaptan
Severe
How does the drug interact with Olasym 150 Tablet:
Using Conivaptan and Olasym 150 Tablet can increase the blood levels of Olasym 150 Tablet.This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Conivaptan and Olasym 150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibMibefradil
Severe
How does the drug interact with Olasym 150 Tablet:
Using Mibefradil and Olasym 150 Tablet can increase the blood levels of Olasym 150 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Mibefradil and Olasym 150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibTeriflunomide
Severe
How does the drug interact with Olasym 150 Tablet:
Using Teriflunomide together with Olasym 150 Tablet may increase the risk of infections.

How to manage the interaction:
Combining Teriflunomide and Olasym 150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibPhenobarbital
Severe
How does the drug interact with Olasym 150 Tablet:
Phenobarbital can drastically lower Olasym 150 Tablet levels in the blood, making the medicine less effective in treating the cancer.

How to manage the interaction:
Although taking phenobarbital and Olasym 150 Tablet together can possibly result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.
OlaparibCobicistat
Severe
How does the drug interact with Olasym 150 Tablet:
Using Cobicistat and Olasym 150 Tablet can increase the blood levels of Olasym 150 Tablet.This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Cobicistat and Olasym 150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibDronedarone
Severe
How does the drug interact with Olasym 150 Tablet:
Using Dronedarone and Olasym 150 Tablet can increase the blood levels of Olasym 150 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Dronedarone and Olasym 150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibErythromycin
Severe
How does the drug interact with Olasym 150 Tablet:
Coadministration of Olasym 150 Tablet and erythromycin may significantly increase the blood levels of Olasym 150 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, less desire to eat, abdominal pain or discomfort.

How to manage the interaction:
Combining Erythromycin and Olasym 150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibPosaconazole
Severe
How does the drug interact with Olasym 150 Tablet:
Using Posaconazole and Olasym 150 Tablet can increase the blood levels of Olasym 150 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort.

How to manage the interaction:
Although there is an interaction between posaconazole and Olasym 150 Tablet, it can be taken if advised by a doctor. However, if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.
OlaparibRitonavir
Severe
How does the drug interact with Olasym 150 Tablet:
Taking Ritonavir and Olasym 150 Tablet may significantly increase the blood levels of Olasym 150 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Olasym 150 Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination contact a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Olasym 150 Tablet 60's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid alcohol consumption while on treatment with Olasym 150 Tablet 60's.

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Pregnancy

Unsafe

Olasym 150 Tablet 60's should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Olasym 150 Tablet 60's and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.

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Driving

Caution

Olasym 150 Tablet 60's may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

bannner image

Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Caution

The safety and effectiveness of Olasym 150 Tablet 60's in pediatric patients have not been established.

Have a query?

FAQs

Olasym 150 Tablet 60's is used to treat ovarian, breast, pancreatic, and prostate cancers.

Olasym 150 Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Olasym 150 Tablet 60's.

Yes, Olasym 150 Tablet 60's can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.

Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Olasym 150 Tablet 60's is not a traditional chemotherapy pill. It's a targeted therapy, also known as a PARP inhibitor, which works differently from chemotherapy.

When taking Olasym 150 Tablet 60's, avoid or limit foods high in grapefruit or grapefruit juice, as these can interact with the medication. Additionally, consult your doctor or pharmacist for personalized dietary advice.

The duration of Olasym 150 Tablet 60's treatment can vary depending on the type of cancer being treated and the patient's response to the medication. Generally, Olasym 150 Tablet 60's is taken until disease progression, unacceptable toxicity, or completion of a specified treatment period. Therefore, follow your doctor's instructions carefully.

Before taking Olasym 150 Tablet 60's, inform your doctor about all your medical conditions, sensitivities, and medications. Also, mention if you're pregnant, planning to become pregnant, or breastfeeding. This will ensure safe use and help avoid any potential interactions.

Olasym 150 Tablet 60's can interact with other medications, so do not use any other medications unless your doctor advises. Your doctor will check for potential interactions and advise you on how to take them safely with Olasym 150 Tablet 60's.

No, Olasym 150 Tablet 60's is not recommended for use during pregnancy and breastfeeding, and it causes unwanted side effects. However, please consult your doctor if you have any concerns.

The common side effects of Olasym 150 Tablet 60's are feeling very tired, pale skin, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Please consult your doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

430, Sidhharth Complex, NH 8, Vadodara
Other Info - OLA0461

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Reference

  1. https://www.myeloma.org.uk/wp-content/uploads/2023/04/Myeloma-UK-Panobinostat-Treatment-Guide.pdf
  2. https://www.lynparza.com/
  3. https://medlineplus.gov/druginfo/meds/a614060.html#:~:text=Olaparib%20is%20used%20alone%20or,tissue%20that%20lines%20the%20abdomen)
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208558s001lbl.pdf
  5. https://www.medicines.org.uk/emc/product/9204/pil#gref
  6. https://reference.medscape.com/drug/lynparza-olaparib-999934
  7. https://www.medicines.org.uk/emc/files/pil.9204.pdf
  8. https://www.lynparzahcp.com/
  9. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/olaparib-lynparza#:~:text=Olaparib%20stops%20PARP%20working.&amp;text=healthy.,damage%2C%20the%20cancer%20cells%20die.
  10. https://www.lynparza.com/what-is-lynparza.html
  11. https://www.drugs.com/drug-interactions/olaparib-index.html?filter=3
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