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Obparp-150 Tablet 8's is used to treat various cancers, including ovarian, breast, pancreatic, and prostate. It contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Avoid taking this medication if you are pregnant or breastfeeding because this can cause harmful effects on the unborn baby. Both women and men using this should use birth control to avoid pregnancy.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

OLAPARIB-150MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Obparp-150 Tablet 8's

Obparp-150 Tablet 8's is an oral prescription medication used to treat certain advanced cancers, including ovarian, breast, prostate, and pancreatic cancers. It is specifically designed for cancers that have specific abnormal genes, such as the BRCA gene. This targeted therapy helps slow down or stop the growth of cancer cells in the body.

You will typically take Obparp-150 Tablet 8's twice a day, with or without food, as directed by your doctor. It is important to take this medication consistently at the same times every day to maintain a steady level of the medicine in your body. To support your body during treatment, focus on staying hydrated, eating small, frequent meals, and getting adequate rest.

While taking Obparp-150 Tablet 8's, you may experience common side effects such as nausea, tiredness, and low red blood cell counts. However, if you develop serious symptoms like severe shortness of breath, a sudden cough, or an unexplained fever, you must contact your doctor immediately.

Before starting Obparp-150 Tablet 8's, talk to your doctor if you have a history of kidney problems or lung conditions. Do not take this if you are pregnant or breastfeeding, as it can cause serious harm to a developing baby.

This medication can interact with other drugs and certain foods like grapefruit, which can alter how the medicine works in your body. It is also important to talk to your doctor or pharmacist if you are elderly or have other chronic health conditions to ensure Obparp-150 Tablet 8's is safe for you.

Uses of Obparp-150 Tablet 8's

Obparp-150 Tablet 8's is used in the treatment of ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. The detailed uses of Obparp-150 Tablet 8's are as follows:

  • Ovarian cancer: Obparp-150 Tablet 8's helps keep the cancer from returning or spreading after it has responded to initial chemotherapy.
  • Breast cancer: It targets specific gene-mutated (BRCA-mutated) breast cancers that have spread to other areas of the body.
  • Prostate cancer: It treats advanced prostate cancer that has spread and no longer responds to standard hormone therapy.
  • Pancreatic cancer: It is used as a maintenance treatment to keep the cancer from progressing after chemotherapy.
     

Key Benefits

Obparp-150 Tablet 8's helps manage certain advanced cancers by targeting specific cancer cells and interfering with their ability to repair themselves.

The following are the benefits of this medication:

  • By blocking specific proteins that cancer cells use to repair themselves, this treatment helps extend the time that the cancer remains stable and controlled.
  • Unlike traditional chemotherapy, which affects all rapidly dividing cells, this targeted therapy focuses primarily on cancer cells with specific genetic mutations, sparing more healthy cells.
  • Because it is taken as a tablet, patients can manage their treatment at home, reducing the need for frequent, time-consuming hospital clinic visits for intravenous therapy.
     
Side effects of Obparp-150 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.

Directions for Use

  • Obparp-150 Tablet 8's can be taken with or without food as prescribed by your doctor.
  • It is usually taken twice a day in the morning and evening, or as prescribed by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not break, crush or chew Obparp-150 Tablet 8's.

How Obparp-150 Tablet 8's Works

Olaparib, the active medicine in Obparp-150 Tablet 8's, belongs to a class of drugs called PARP inhibitors. PARP is an enzyme (a type of protein) that helps cells repair damaged DNA. In normal healthy cells, there are multiple pathways to repair DNA damage. However, certain cancer cells, specifically those with BRCA gene mutations, rely heavily on PARP to repair their DNA and survive. When you take Obparp-150 Tablet 8's, it blocks the PARP enzymes from doing their job. Because the cancer cells already have a broken repair system due to their genetic mutation, blocking PARP leaves them with no way to repair their damaged DNA. This causes the cancer cells to stop growing and eventually die, helping to control the spread of the disease.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Obparp-150 Tablet 8's.

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Pregnancy

Unsafe

Obparp-150 Tablet 8's should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Obparp-150 Tablet 8's and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.

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Driving

Caution

Obparp-150 Tablet 8's may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Caution

The safety and effectiveness of Obparp-150 Tablet 8's in pediatric patients have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving Obparp-150 Tablet 8's if you have pre-existing heart problems. Your doctor will prescribe Obparp-150 Tablet 8's if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Obparp-150 Tablet 8's to geriatric patients. Your doctor will prescribe Obparp-150 Tablet 8's if the benefits outweigh the risks.

What if I have taken an overdose of Obparp-150 Tablet 8's

If you accidentally take more than your prescribed dose, seek emergency medical care immediately or contact your local poison control centre. An overdose can increase the risk of severe side effects, especially affecting your blood counts.

Diet & Lifestyle Advise

  • Avoid grapefruit products: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as they can significantly raise the level of the drug in your body and increase side effects.
  • Manage nausea with small meals: Eat small, frequent meals throughout the day rather than three large ones. Stick to bland foods like crackers, toast, or rice if you feel sick.
  • Stay well-hydrated: Drink plenty of fluids, such as water or clear broths, to prevent dehydration, especially if you experience diarrhoea or vomiting.
  • Incorporate gentle exercise: Engage in light physical activity, like short daily walks, to help combat fatigue and improve your physical well-being, but listen to your body and rest when needed.
     
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How Soon It Starts Working

The time required for Obparp-150 Tablet 8's to start to work: Obparp-150 Tablet 8's ideally shows its action within few hours after administration. The time for which the effects of Obparp-150 Tablet 8's last: The duration of action for Obparp-150 Tablet 8's is unknown.

What if you forget to take Obparp-150 Tablet 8's

If you miss a dose of Obparp-150 Tablet 8's, skip the missed dose entirely. Take your next scheduled dose at your regular time. Do not take an extra dose or a double dose to make up for the one you missed. Talk to your doctor or pharmacist if you frequently miss doses.

Storage

• Store the tablets at room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Avoid handling damaged tablets during pregnancy: If you are pregnant or planning to become pregnant, do not handle broken or crushed tablets. The medicine may be absorbed through the skin and could harm an unborn baby.
  • Check the tablets before use: Make sure each tablet is intact and looks normal. Do not take it if it is cracked, discoloured, or crumbling.
  • Use reliable contraception: Use effective birth control while taking Obparp-150 Tablet 8's and for at least 6 months after your last dose. Men with partners who could become pregnant should also use reliable contraception during treatment and for 3 months after the last dose.
  • Check your temperature: Monitor your temperature regularly during treatment. Seek immediate medical attention if you develop a fever of 38°C (100.4°F) or higher, as this may be a sign of a serious infection.
  • Attend all blood tests: Keep all scheduled appointments for blood tests. Your doctor will use these tests to check your blood cell counts, as Obparp-150 Tablet 8's can significantly lower red and white blood cells.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that block the CYP3A liver enzyme (e.g.,  ketoconazole, itraconazole, clarithromycin, ritonavir): These medications can slow down how your body breaks down Obparp-150 Tablet 8's, which may increase the risk of severe side effects.
  • Medicines that strongly increase CYP3A enzyme activity (e.g., rifampin, phenytoin, carbamazepine, St. John's wort): These medicines may speed up how your body clears Obparp-150 Tablet 8's, making Obparp-150 Tablet 8's less effective against your cancer.
     
OlaparibNafcillin
Severe

Drug-Drug Interactions

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How does the drug interact with Obparp-150 Tablet:
Taking Ritonavir and Obparp-150 Tablet may significantly increase the blood levels of Obparp-150 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Obparp-150 Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination contact a doctor. Do not stop using any medications without talking to a doctor.
OlaparibNafcillin
Severe
How does the drug interact with Obparp-150 Tablet:
Using Nafcillin together with Obparp-150 Tablet can reduce the blood levels of Obparp-150 Tablet.

How to manage the interaction:
Taking Obparp-150 Tablet with Nafcillin together can possibly result in an interaction, but it can be taken if your doctor has advised it. Your doctor can recommend other options that won't cause any problems when taken together. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Obparp-150 Tablet:
Taking Rifabutin and Obparp-150 Tablet may significantly reduce the blood levels of Obparp-150 Tablet, which may make the medication less effective.

How to manage the interaction:
Although taking Obparp-150 Tablet and Rifabutin together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OlaparibMitotane
Severe
How does the drug interact with Obparp-150 Tablet:
Using Mitotane together with Obparp-150 Tablet can reduce the blood levels of Obparp-150 Tablet.

How to manage the interaction:
Although taking Obparp-150 Tablet and Mitotane together can evidently cause an interaction, it can be taken if your doctor has suggested it. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without first talking to your doctor.
OlaparibEtravirine
Severe
How does the drug interact with Obparp-150 Tablet:
Using Etravirine together with Obparp-150 Tablet can reduce the blood levels of Obparp-150 Tablet.

How to manage the interaction:
Although taking Obparp-150 Tablet and Etravirine together can evidently cause an interaction, it can be taken if your doctor has suggested it. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Obparp-150 Tablet:
Combining Deferiprone and Obparp-150 Tablet can increase the risk of lowering white blood cell count and affect white blood cells or bone marrow function.

How to manage the interaction:
Combining Deferiprone and Obparp-150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Obparp-150 Tablet:
Using Teriflunomide together with Obparp-150 Tablet may increase the risk of infections.

How to manage the interaction:
Combining Teriflunomide and Obparp-150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibNelfinavir
Severe
How does the drug interact with Obparp-150 Tablet:
Using Nelfinavir and Obparp-150 Tablet can increase the blood levels of Obparp-150 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Nelfinavir and Obparp-150 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Obparp-150 Tablet:
Combining Cladribine with Obparp-150 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Obparp-150 Tablet with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Obparp-150 Tablet:
Using Posaconazole and Obparp-150 Tablet can increase the blood levels of Obparp-150 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort.

How to manage the interaction:
Although there is an interaction between posaconazole and Obparp-150 Tablet, it can be taken if advised by a doctor. However, if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Seville oranges: Avoid eating these fruits or drinking their juices while taking Obparp-150 Tablet 8's, as they can significantly increase the concentration of the medicine in your bloodstream.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Obparp-150 Tablet 8's is used to treat ovarian, breast, pancreatic, and prostate cancers.
Obparp-150 Tablet 8's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.
If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Obparp-150 Tablet 8's.
Yes, Obparp-150 Tablet 8's can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.
Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Obparp-150 Tablet 8's is not a traditional chemotherapy pill. It's a targeted therapy, also known as a PARP inhibitor, which works differently from chemotherapy.
When taking Obparp-150 Tablet 8's, avoid or limit foods high in grapefruit or grapefruit juice, as these can interact with the medication. Additionally, consult your doctor or pharmacist for personalized dietary advice.
The duration of Obparp-150 Tablet 8's treatment can vary depending on the type of cancer being treated and the patient's response to the medication. Generally, Obparp-150 Tablet 8's is taken until disease progression, unacceptable toxicity, or completion of a specified treatment period. Therefore, follow your doctor's instructions carefully.
Before taking Obparp-150 Tablet 8's, inform your doctor about all your medical conditions, sensitivities, and medications. Also, mention if you're pregnant, planning to become pregnant, or breastfeeding. This will ensure safe use and help avoid any potential interactions.
Obparp-150 Tablet 8's can interact with other medications, so do not use any other medications unless your doctor advises. Your doctor will check for potential interactions and advise you on how to take them safely with Obparp-150 Tablet 8's.
No, Obparp-150 Tablet 8's is not recommended for use during pregnancy and breastfeeding, and it causes unwanted side effects. However, please consult your doctor if you have any concerns.
The common side effects of Obparp-150 Tablet 8's are feeling very tired, pale skin, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Please consult your doctor if any of these side effects persist or worsen.
Yes, you can take Obparp-150 Tablet 8's with or without food. Taking it with a light meal may help manage mild stomach upset or nausea. Talk to your doctor or pharmacist if you struggle with nausea.
If you vomit after taking your dose, do not take an extra dose to replace it. Simply wait and take your next scheduled dose at your regular time. Talk to your doctor or pharmacist if vomiting persists.
While hair thinning can occasionally occur, complete hair loss is not a common side effect of Obparp-150 Tablet 8's. If you notice significant changes in your hair texture or volume, talk to your doctor or pharmacist.
It is highly recommended to limit or avoid alcohol while taking Obparp-150 Tablet 8's. Alcohol can worsen common side effects such as nausea, dizziness, and fatigue. Talk to your doctor or pharmacist before drinking alcohol.
Yes, Obparp-150 Tablet 8's can potentially affect fertility in both men and women, making it harder to conceive a child. If you plan to have children in the future, talk to your doctor or pharmacist about fertility preservation options before starting treatment.
Obparp-150 Tablet 8's can significantly lower your blood cell counts, which can lead to anaemia, a higher risk of infection, or bleeding issues. Regular blood tests allow your doctor to monitor these levels and adjust your treatment if necessary. Talk to your doctor or pharmacist for more information.

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Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - OBP0009
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