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  3. Nobel Plus Tablet 10's

Prescription drug
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Nobel Plus Tablet 10's, Pack of 10 TabletS
Nobel Plus Tablet 10's, Pack of 10 TabletS
Nobel Plus Tablet 10's, Pack of 10 TabletS
Nobel Plus Tablet 10's, Pack of 10 TabletS
Nobel Plus Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Nobel Plus Tablet is used to relieve pain. It contains Nimesulide and Acetaminophen which work by blocking the effect of prostaglandins that are responsible for inducing pain and inflammation. In some cases, this medicine may cause side effects such as stomach pain, indigestion, diarrhoea, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ACETAMINOPHEN-325MG + NIMESULIDE-100MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nobel Plus Tablet

Nobel Plus Tablet belongs to a class of medicines known as 'non-steroidal anti-inflammatory drugs (NSAIDs)', primarily indicated in the treatment of mild to moderate pain. Pain can be temporary (acute) or long-lasting (chronic) in nature. Nobel Plus Tablet relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduces fever. Acute pain is caused by damage to the tissues of the muscle, bone, or other organs for a short time. While, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, mild migraine, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.

Nobel Plus Tablet is composed of two medicines: Nimesulide and Acetaminophen. Nimesulide is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Acetaminophen acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.

Take Nobel Plus Tablet as prescribed by your doctor. You are advised to take Nobel Plus Tablet for as long as your doctor has prescribed it for you depending on your medical condition. Like all medicines, Nobel Plus Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like chest tightness, breathing difficulties, fever, skin rashes, increased heart rate, and or in case of any signs of hypersensitivity.

Do not take Nobel Plus Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Nobel Plus Tablet may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects from taking this drug. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days. Nobel Plus Tablet is usually safe to be taken in pregnancy and breastfeeding females, however, an individual should consult their doctor before taking it. Nobel Plus Tablet is well tolerated by elderly persons.

Uses of Nobel Plus Tablet

Treatment of Pain relief

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Directions for Use

• Nobel Plus Tablet should be taken after meals to minimize gastrointestinal discomfort.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Nobel Plus Tablet as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Nobel Plus Tablet is composed of nimesulide and acetaminophen, primarily used to treat mild to moderate pain. Nobel Plus Tablet is prescribed mainly to treat pain and get relief from discomfort caused by conditions like mild migraine, tooth pain, arthritis, period pain, back pain, cold/ flu pain and other types of short-term pains. Acetaminophen has got the advantage of producing less gastric irritation compared to other painkillers like aspirin.

How Nobel Plus Tablet Works

Nobel Plus Tablet is composed of two medicines: Nimesulide and Acetaminophen. Nimesulide is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Acetaminophen acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.

Storage

Keep this medicine out of the sight and reach of children.
Side effects of Nobel Plus Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.

What if I have taken an overdose of Nobel Plus Tablet

Take Nobel Plus Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Please inform your doctor before starting Nobel Plus Tablet if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in Nobel Plus Tablet is known to affect fertility, so if you are planning for pregnancy contact doctor. Nobel Plus Tablet should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take Nobel Plus Tablet as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.

Drug-Drug Interactions

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ParacetamolKetoconazole
Severe
ParacetamolOxazepam
Severe

Drug-Drug Interactions

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ParacetamolKetoconazole
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of Nobel Plus Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Nobel Plus Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of Nobel Plus Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Nobel Plus Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of Mipomersen with Nobel Plus Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Nobel Plus Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of Nobel Plus Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Nobel Plus Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of Nobel Plus Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Nobel Plus Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolKetamine
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of ketamine and Nobel Plus Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Nobel Plus Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of Teriflunomide with Nobel Plus Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Nobel Plus Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Nobel Plus Tablet:
Co-administration of Lomitapide and Nobel Plus Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Nobel Plus Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulfate, vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
  • Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
  • In chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT
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Alcohol

Caution

Taking Nobel Plus Tablet with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit the intake of alcoholic beverages with Nobel Plus Tablet .

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Pregnancy

Unsafe

Use of Nobel Plus Tablet during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby. Consult your doctor for further advice.

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Breast Feeding

Caution

Use of Nobel Plus Tablet during breastfeeding is not recommended as it may pass in very less amount through the milk and may harm the baby. Consult your doctor for further advice.

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Driving

Caution

After taking Nobel Plus Tablet , you may notice dizziness, sleepiness, drowsiness. So, you should stop taking Nobel Plus Tablet and contact your doctor.

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Liver

Caution

Nobel Plus Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Nobel Plus Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

Nobel Plus Tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

FAQs

Nobel Plus Tablet is used to relieve mild to moderate pain. It works by inhibiting the chemical messengers that cause pain.

It is advised not to take Nobel Plus Tablet as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Nobel Plus Tablet , take it in doses and duration mentioned by your doctor.

Yes, Nobel Plus Tablet should be preferably be taken with food to avoid an upset stomach. If taken on an empty stomach, it may cause stomach irritation and upset stomach.

You should not take Nobel Plus Tablet if you have a history of peptic ulceration, a history of gastrointestinal hemorrhage, Crohn's disease or ulcerative colitis.

You should avoid intake of Nobel Plus Tablet if you are allergic to Nobel Plus Tablet , nimesulide or paracetamol, a regular heavy alcohol drinker, liver disease (increased liver enzyme), any type of recent ulcer or bleeding, suffering from flu or fever (with chills), in the last trimester of pregnancy or breastfeeding mother.

No, Nobel Plus Tablet does not treat migraine, it is used to relive from symptoms of mild migraine.

Nobel Plus Tablet works by combining the pain-relieving and fever-reducing effects of Acetaminophen with the anti-inflammatory properties of Nimesulide. Acetaminophen blocks pain signals to the brain and reduces fever. At the same time, Nimesulide inhibits certain enzymes that reduce inflammation and relieve pain. Together, they provide effective relief from pain and inflammation.

It is not recommended to take Nobel Plus Tablet for six months. This medication is used only for short-term relief of mild to moderate pain. Taking it for a prolonged period may lead to serious side effects, such as liver or kidney damage, stomach ulcers, or bleeding in some people. Always follow your doctor's advice regarding the dosage and duration of Nobel Plus Tablet and avoid using it for extended periods on your own.

Don't give Nobel Plus Tablet to your child without a doctor's prescription. It's a prescribed medication that should only be taken under a doctor's guidance. Consult your child's doctor to determine the best course of treatment for their toothache.

To use Nobel Plus Tablet , follow your doctor's instructions. Typically, it should be swallowed whole with a glass of water. Do not crush or chew it.

Nobel Plus Tablet is not indicated to treat a cold. Viruses mainly cause colds, and Nobel Plus Tablet does not treat viral infections. It may help with symptoms like pain or fever, but it is best to talk to your doctor first. Your doctor will determine the underlying cause and recommend the right treatment.

Please consult your doctor before taking Nobel Plus Tablet if you are on any other medications. Nobel Plus Tablet may interact with various drugs, such as anticancer medications (e.g., methotrexate), blood thinners (e.g., warfarin), blood pressure medications, steroids (e.g., prednisone), quinolone antibiotics (e.g., ciprofloxacin), and antidepressants (e.g., duloxetine). This is not an exhaustive list, and other interactions may also occur. Be sure to inform your doctor about all your medications, including supplements and over-the-counter drugs, so they can check for potential interactions and provide personalized advice.

Nobel Plus Tablet is a combination medication that contains Nimesulide (a non-steroidal anti-inflammatory drug [NSAID]) and Acetaminophen (a pain reliever and fever reducer). Together, they help relieve mild to moderate pain associated with arthritis and dysmenorrhea and reduce fever.

You can stop taking Nobel Plus Tablet once your pain is relieved, especially if it is for acute (short-term) pain. However, if you have chronic (long-term) pain, please consult your doctor for advice regarding the proper diagnosis and duration of treatment. Stopping too early or without guidance may affect your recovery or cause the symptoms to return. Always consult your doctor before making any changes to your medication regimen.

Yes, Nobel Plus Tablet may cause nausea and vomiting in some people as a mild side effect. However, these symptoms usually go away on their own with time. If you experience nausea or vomiting persistently while using this medication, please consult your doctor.

Nobel Plus Tablet is contraindicated in patients who are allergic to any of its ingredients. It is also not recommended for people with conditions such as stomach ulcers, recent gastrointestinal bleeding, asthma, recent heart bypass surgery, or severe kidney or liver problems. This medication should be avoided during pregnancy (especially in the last trimester) and while breastfeeding, as it may affect the baby. It should not be given to children under 12 with fever, flu, or chickenpox symptoms.

You can only take Nobel Plus Tablet with Vitamin B-complex if your doctor advises. Your doctor will review your health conditions and any other medications you are taking to ensure no potential interactions could affect your treatment with Nobel Plus Tablet .

Nobel Plus Tablet is not intended to relieve stomach pain. It may sometimes cause stomach pain as a side effect. Please consult your doctor for a proper diagnosis and the right treatment for your stomach pain.

The use of Nobel Plus Tablet can damage the liver, especially with long-term use or in people who already have liver problems. However, when used as directed by your doctor, it can be used safely. To minimize risks, make sure to follow the prescribed dose and duration, monitor your liver function regularly during treatment, and contact your doctor if you notice any unusual symptoms, such as yellowing of the skin or eyes. By taking these precautions, you can use Nobel Plus Tablet safely.

It is not safe to take a higher dose of Nobel Plus Tablet than recommended, as it may cause side effects. If your pain lasts longer than ten days or your fever lasts more than three days even after using Nobel Plus Tablet , stop taking the medication and consult your doctor. Do not adjust the dose on your own.

Nobel Plus Tablet should be stored in a cool and dry place, away from direct sunlight. Keep it out of reach of children.

Nobel Plus Tablet is generally safe when used in the dose and duration as prescribed by your doctor. It is safe to use for short-term relief of mild to moderate pain. Please follow your doctor's advice, avoid using it for long periods unless advised by the doctor, and do not exceed the recommended dose to ensure its safe use.

Nobel Plus Tablet may help reduce fever, but it is not usually recommended for this purpose. It is important to consult your doctor to find out the underlying cause of your fever and get the right treatment.

You should take Nobel Plus Tablet as directed by your doctor. Generally, taking the medication with food is advised to help reduce the chances of stomach upset.

No, Nobel Plus Tablet is not an antibiotic. It is a combination of a nonsteroidal anti-inflammatory drug (Nimesulide) and antipyretic (Acetaminophen) medications that cannot treat infections like antibiotics.

The common side effects of Nobel Plus Tablet include nausea, vomiting, stomach pain, diarrhoea, constipation, indigestion, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to consult your doctor if these side effects persist.

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase III, New Delhi - 110020
Other Info - NOB0011

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:48 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.ema.europa.eu/en/documents/referral/nimesulide-article-107-procedures-annex-iii_en.pdf
  2. https://www.hpra.ie/img/uploaded/swedocuments/7fbc1048-646d-456d-90c0-18da7ec8c42f.pdf
  3. https://www.medicines.org.uk/emc/files/pil.5164.pdf
  4. https://www.nhsinform.scot/tests-and-treatments/medicines-and-medical-aids/types-of-medicine/paracetamol

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