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compositionComposition:GLYCERYL TRINITRATE-5MG
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Prescription Medicine
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Nitroplus Injection 10 ml belongs to the class of anti-anginal drugs, which is used in the treatment of angina pectoris, heart attack (myocardial infarction) and Perioperative hypertension. It helps relax and widen blood vessels, improving blood flow and reducing the workload on the heart.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

GLYCERYL TRINITRATE-5MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Nitroplus Injection 10 ml

Nitroplus Injection 10 ml is a fast-acting intravenous medicine used in hospitals to manage critical cardiovascular conditions, including severe chest pain and sudden heart failure. It works by relaxing and widening your blood vessels, which makes it much easier for blood to flow and reduces the heavy workload on your heart. This medicine is typically reserved for emergency or closely monitored medical situations where rapid heart relief is needed.

Because this medicine is given directly into a vein, healthcare professionals will manage the frequency and speed of your treatment continuously based on your blood pressure and heart rate. You do not need to worry about taking it with food, as it is only given as an infusion by medical staff in a clinical setting. To support your recovery, your doctor may suggest long-term lifestyle changes such as eating a low-sodium diet and avoiding sudden physical strain.

While receiving Nitroplus Injection 10 ml, you may experience common side effects like a throbbing headache, dizziness, or a temporary flushing of your skin. These effects are usually mild and often fade as your body adjusts, but you must tell your medical team immediately if you face serious side effects like an unusually slow heartbeat, severe dizziness, or difficulty breathing.

Before starting this medicine, tell your doctor if you have a history of head injuries, severe anemia, or increased pressure inside your skull. You must not receive this medicine if you have extremely low blood pressure, severe blood loss, or if you are currently taking certain medications for erectile dysfunction.

This medicine can interact dangerously with alcohol and other blood pressure drugs, causing your blood pressure to drop to unsafe levels. If you are pregnant, breastfeeding, or an older adult, consult your doctor as your medical team will need to monitor your response closely to ensure your safety.

Uses of Nitroplus Injection 10 ml

Your doctor may prescribe Nitroplus Injection 10 ml to help manage the following conditions:

  • High blood pressure during surgery: Nitroplus Injection 10 ml helps control sudden, dangerous rises in blood pressure before, during, or after surgical procedures.
  • Heart failure after a heart attack: Nitroplus Injection 10 ml reduces the workload on a weakened heart, helping it pump blood more effectively.
  • Severe, unstable chest pain: Nitroplus Injection 10 ml quickly widens the blood vessels supplying the heart, improving oxygen flow and relieving intense chest pain.
  • Controlled low blood pressure during surgery: Nitroplus Injection 10 ml is used to safely lower blood pressure to reduce bleeding during specific surgical operations.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Rapid Cardiovascular Support: Nitroplus Injection 10 ml provides rapid, protective support during cardiovascular emergencies.
  • Fast Chest Pain Relief: By quickly widening blood vessels, it delivers immediate relief from crushing chest pain, helping patients breathe easier and feel more comfortable almost instantly.
  • Rapid Blood Pressure Control: It also offers precise, fast-acting control over dangerously high blood pressure.
  • Protects Vital Organs: This critical action helps protect vital organs, such as the brain and kidneys, from damage during surgeries or hypertensive crises.
  • Supports Heart Recovery: Additionally, by reducing the overall strain on a struggling heart muscle, this medicine supports a safer and faster recovery process for patients experiencing acute heart failure or recovering from a heart attack.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Nitroplus Injection 10 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Nitroplus Injection 10 ml Works

Nitroplus Injection 10 ml contains glycerine nitrate, which belongs to a group of medicines known as vasodilators. It works by releasing a natural substance in the body that causes the smooth muscles within your blood vessel walls to relax. When these muscles relax, the blood vessels—especially the veins that carry blood back to your heart—widen and expand. By widening these vessels, the medicine reduces the amount of blood returning to the heart. This lowers the pressure inside the heart chambers and makes it much easier for your heart to pump blood out to the rest of your body. It also helps open up the arteries supplying the heart itself, bringing much-needed oxygen and blood flow directly to the heart muscle.
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Alcohol

Unsafe

Concomitant use of nitrates and alcohol may cause hypotension. So intake of Nitroplus Injection 10 ml should be avoided with Nitroplus Injection 10 ml.

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Pregnancy

Consult your doctor

Nitroplus Injection 10 ml should not be used during pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Nitroplus Injection 10 ml.

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Breast Feeding

Consult your doctor

The safety of Nitroplus Injection 10 ml is unknown during breastfeeding. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Nitroplus Injection 10 ml.

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Driving

Unsafe

Nitroplus Injection 10 ml can cause dizziness. So, operating machinery and driving, both of which require concentration, should be avoided.

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Liver

Consult your doctor

Tell your doctor before receiving the Nitroplus Injection 10 ml if you have a history of liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Tell your doctor before receiving the Nitroplus Injection 10 ml if you have had a kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Safety of Nitroplus Injection 10 ml is not known in children below the age of 18 years.

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Heart

Caution

Nitroplus Injection 10 ml is used to treat heart conditions like angina by improving blood flow. It must be administered with caution, especially in cases of low blood pressure or recent heart events.

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Geriatrics

Caution

Geriatric patients can receive Nitroplus Injection 10 ml, but they may be more sensitive to its effects, such as dizziness or low blood pressure. Careful monitoring and dose adjustments help ensure safe and effective use.

What if I have taken an overdose of Nitroplus Injection 10 ml

An overdose is rare because the infusion is carefully controlled by a medical pump and monitored by healthcare staff. If an overdose does occur, symptoms may include a severe headache, confusion, a rapid heart rate, or fainting. The medical team will stop the infusion immediately and provide supportive care to restore normal blood pressure.

Diet & Lifestyle Advise

  • Follow a low-sodium diet: Restricting your salt intake helps manage your blood pressure and reduces the fluid load on your heart.
  • Change positions slowly: To prevent sudden dizziness or fainting, take your time when standing up from a sitting or lying position.
  • Avoid alcohol completely: Alcohol can combine with this medicine to cause a dangerous, sudden drop in blood pressure.
  • Avoid tobacco products: Smoking damages your blood vessels and can worsen underlying heart conditions, making recovery more difficult.
  • Manage your fluid intake: Follow your doctor's specific recommendations regarding how much fluid you should drink, especially if you are managing heart failure.
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How Soon It Starts Working

  • The time required for Nitroplus Injection 10 ml to start to work: Nitroplus Injection 10 ml ideally shows its action within 1 to 2 minutes after administration.
  • The time for which the effects of Nitroplus Injection 10 ml last: The effect of Nitroplus Injection 10 ml lasts for 3 to 4 minutes.

What if you forget to take Nitroplus Injection 10 ml

Since this medicine is given continuously by healthcare professionals in a hospital, a missed dose is highly unlikely. Your medical team will monitor the delivery constantly to ensure you receive a steady and correct dose.

Storage

•This medicine is stored at controlled room temperature, typically between 15°C and 30°C (59°F to 86°F). •It must not be frozen and should be kept in its original packaging to protect it from direct light.

Drug Warnings

  • Check the solution: Always ensure the liquid is clear, colourless, and free of any floating particles before the infusion begins. Do not use if it is discoloured.
  • Use compatible tubing: This medication can interact with and be absorbed by certain types of plastic (like PVC). Ensure your medical team uses compatible, non-reactive infusion sets.
  • Monitor the injection site: Tell your nurse immediately if you feel pain, burning, redness, or swelling around the needle site.
  • Avoid sudden movements: Remain resting or sitting during and immediately after your infusion to prevent falls from temporary dizziness.
  • Share your full medication list: Ensure your healthcare provider knows about all other medicines you are taking, especially any blood pressure treatments or erectile dysfunction drugs.

Drug-Drug Interactions

verifiedApollotooltip
  • Erectile dysfunction medications (such as sildenafil or tadalafil): Must never be used with Nitroplus Injection 10 ml, as this combination can cause a sudden and life-threatening drop in blood pressure.
  • Blood pressure-lowering drugs and diuretics: May increase the risk of excessively low blood pressure when combined with Nitroplus Injection 10 ml.
  • Certain depression medications (such as tricyclic antidepressants): Can amplify the blood pressure-lowering effects of this medicine.
Glyceryl trinitrateVardenafil
Critical
Glyceryl trinitrateMethylergometrine
Critical

Drug-Drug Interactions

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Glyceryl trinitrateVardenafil
Critical
How does the drug interact with Nitroplus 10ml Inj:
Taking Vardenafil and Nitroplus 10ml Inj together can increase the risk or severity of low blood pressure.

How to manage the interaction:
Combining Vardenafil and Nitroplus 10ml Inj is generally avoided as it can lead to an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms like dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity), consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateMethylergometrine
Critical
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of Methylergometrine with Nitroplus 10ml Inj can increase the levels and side effects of Methylergometrine.

How to manage the interaction:
Taking Methylergometrine with Nitroplus 10ml Inj is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, headache, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateAvanafil
Critical
How does the drug interact with Nitroplus 10ml Inj:
Taking Avanafil and Nitroplus 10ml Inj together can increase the risk or severity of low blood pressure.

How to manage the interaction:
Combining Avanafil and Nitroplus 10ml Inj is generally avoided as it can lead to an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity), consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateBupivacaine
Severe
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of bupivacaine and Nitroplus 10ml Inj can increase the risk and severity of developing methemoglobinemia, (Red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking bupivacaine and Nitroplus 10ml Inj together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Glyceryl trinitrateProcaine
Severe
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of Procaine and Nitroplus 10ml Inj has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking procaine and Nitroplus 10ml Inj together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateTetracaine
Severe
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of Tetracaine and Nitroplus 10ml Inj has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Tetracaine and Nitroplus 10ml Inj together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateChloroprocaine
Severe
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of Chloroprocaine and Nitroplus 10ml Inj can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Chloroprocaine and Nitroplus 10ml Inj together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateMepivacaine
Severe
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of Mepivacaine and Nitroplus 10ml Inj has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Mepivacaine and Nitroplus 10ml Inj together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateLevobupivacaine
Severe
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of Levobupivacaine and Nitroplus 10ml Inj can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Levobupivacaine and Nitroplus 10ml Inj together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateEtidocaine
Severe
How does the drug interact with Nitroplus 10ml Inj:
Coadministration of Etidocaine and Nitroplus 10ml Inj can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Etidocaine and Nitroplus 10ml Inj together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Can significantly increase the blood pressure-lowering effects of Nitroplus Injection 10 ml, leading to severe dizziness, lightheadedness, or fainting.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIANGINALS]

FAQs

Nitroplus Injection 10 ml belongs to the class of anti-anginal medication, primarily used for treating angina pectoris and myocardial infarction. Nitroplus Injection 10 ml can also use to control intraoperative blood pressure.
Nitroplus Injection 10 ml contains Glyceryl Trinitrate, a natural vasodilator that relaxes the muscles surrounding blood vessels, making the heart's job easier.
Nitroplus Injection 10 ml may result in hypotension (low blood pressure). Therefore, regular blood pressure monitoring is recommended while on Nitroplus Injection 10 ml therapy.
Nitroplus Injection 10 ml is prescribed when a quick response is needed, or when individuals cannot take tablets.
No, you should not take Nitroplus Injection 10 ml with the erectile dysfunction medication, such as sildenafil, vardenafil, or tadalafil, as the simultaneous administration of Nitroplus Injection 10 ml and these drugs can dangerously drop the blood pressure.
Yes, Nitroplus Injection 10 ml can cause a headache. Please increase fluid intake as it is known to cause headaches when taking Nitroplus Injection 10 ml. If the problem persists, consult your doctor and do as advised.
Caution should be exercised while using Nitroplus Injection 10 ml, especially if you have hyperthyroidism (overactive thyroid); inform your doctor before taking Nitroplus Injection 10 ml because it may mask your symptoms or make it difficult to recognise the signs of excess thyroid hormone in the body.
No, Nitroplus Injection 10 ml is an intravenous medicine that must be given in a hospital or clinical setting where your heart rate and blood pressure can be monitored continuously. It is not suitable for self-administration at home. Talk to your doctor about transitioning to oral or patch options if you are being discharged.
The dose of Nitroplus Injection 10 ml is highly personalised and will be carefully adjusted by your doctor based on your specific medical condition, your blood pressure, and how well your heart is responding to the treatment. Talk to your doctor if you want to understand more about your specific dosage.
Nitroplus Injection 10 ml is only used during pregnancy if the potential benefit outweighs the risks to the unborn baby, as its safety has not been fully established. Your medical team will carefully evaluate your situation in an emergency. Talk to your doctor if you are pregnant or breastfeeding.
While rare, severe allergic reactions to Nitroplus Injection 10 ml can occur. Signs include a sudden skin rash, itching, hives, swelling of the face, tongue, or throat, and severe breathing difficulties. If you notice any of these symptoms during your infusion, tell your healthcare provider immediately. Talk to your doctor for more safety information.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.6296 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Glyceryl Trinitrate 5 mg/ml Sterile Concentrate — Summary of Product Characteristics (SmPC) – (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 26 Sep 2025]Check here
  3. Kim KH, Kerndt CC, Adnan G, et al. Nitroglycerin. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [Accessed on 11 Mar 2025]Check here
  4. Elkayam U, Aronow WS. Glyceryl trinitrate (nitroglycerin) ointment and isosorbide dinitrate: a review of their pharmacological properties and therapeutic use. Drugs. 1982 Mar;23(3):165-94 [Accessed on 11 Mar 2025]Check here
  5. CDSCO. [Accessed on 02 Jun. 2026]Check here
  6. Torrent Pharmaceuticals Ltd. VASOVIN XL: Summary of Product Characteristics [Internet]. Feb 2022 [Accessed on 2025 Sep 26]Check here

Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - NIT0153
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