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compositionComposition:MITOXANTRONE-20MG
prescriptionPrescription Medicine
Nitrol 20 mg Injection 10 ml

Nitrol 20 mg Injection is used to treat leukaemia and prostate cancer. It may also be used to treat multiple sclerosis (MS). Nitrol 20 mg Injection contains Mitoxantrone. In Cancer treatment, it works by slowing down the growth of cancer cells. In multiple sclerosis (MS) treatment, it works by slowing down an overactive immune system, which prevents or delays worsening symptoms. It also decreases the number of flare-ups.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MITOXANTRONE-20MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nitrol 20 mg Injection

Nitrol 20 mg Injection belongs to a group of medicines known as anthracenedioness. Nitrol 20 mg Injection treats leukaemia and prostate cancer. It may also be used to treat multiple sclerosis (MS). Leukaemia is a type of cancer that develops in blood-forming tissue. Prostate cancer is a type of cancer that only occurs in men and affects the prostate gland, a tiny gland under the bladder that produces semen. Multiple sclerosis is a condition that affects the brain and spinal cord, resulting in symptoms such as problems with sensation, balance, vision, pain, impaired coordination, and fatigue.

Nitrol 20 mg Injection contains Mitoxantrone. In Cancer treatment, Nitrol 20 mg Injection works by slowing down the growth of cancer cells. In multiple sclerosis (MS) treatment, Nitrol 20 mg Injection works by slowing down an overactive immune system, which prevents or delays worsening symptoms. It also decreases the number of flare-ups.

Nitrol 20 mg Injection should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as diarrhoea, hair loss, headache, irregular menstrual cycles or spotting, nausea, pain, redness, or swelling with sores inside the mouth or throat. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

Nitrol 20 mg Injection may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant. Talk to your care team about reliable forms of contraception. A negative pregnancy test is required before starting this medication. Do not breastfeed while taking this medication. Men using this Nitrol 20 mg Injection must use effective birth control whenever they have sex during their treatment and for a certain period after their final dose.

Uses of Nitrol 20 mg Injection

Nitrol 20 mg Injection is used in the treatment of leukemia, prostate cancer, and multiple sclerosis (MS). The detailed uses of Nitrol 20 mg Injection are as follows:

  • Leukemia treatment: Nitrol 20 mg Injection treats leukemia by intercalating DNA and inhibiting topoisomerase II, thereby slowing or stopping cancer cell growth.
  • Prostate cancer management: Nitrol 20 mg Injection is used to treat Prostate cancer, helping reduce tumour size, alleviate symptoms, and improve quality of life.
  • Multiple sclerosis management: Nitrol 20 mg Injection treats multiple sclerosis (MS) in adults, including relapsing-remitting, progressive-relapsing, and secondary progressive forms by reducing inflammation and preventing nerve damage.

Key Benefits

Nitrol 20 mg Injection contains Mitoxantrone, which belongs to a group of medicines known as anthracenedioness. Nitrol 20 mg Injection is used to treat leukaemia and prostate cancer. It may also be useful in treating multiple sclerosis (MS). Nitrol 20 mg Injection helps in cancer treatment by decreasing the proliferation of cancer cells. Nitrol 20 mg Injection acts in treating multiple sclerosis (MS) by calming down an overactive immune system, which avoids or delays the worsening of symptoms. It also reduces the frequency of flare-ups.

Side effects of Nitrol 20 mg Injection 10 ml
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Nitrol 20 mg Injection will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How Nitrol 20 mg Injection Works

Nitrol 20 mg Injection contains Mitoxantrone. In Cancer treatment, Nitrol 20 mg Injection works by slowing down the growth of cancer cells. In multiple sclerosis (MS) treatment, Nitrol 20 mg Injection works by slowing down an overactive immune system, which prevents or delays worsening symptoms. It also decreases the number of flare-ups.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Nitrol 20 mg Injection.

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Pregnancy

Unsafe

Nitrol 20 mg Injection should not be used during pregnancy as it may cause fetal harm. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Nitrol 20 mg Injection may not be safe for use in breastfeeding. Your doctor may suggest you stop breastfeeding during the treatment and until a certain period after the last dose of Nitrol 20 mg Injection.

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Driving

Caution

Nitrol 20 mg Injection may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

Nitrol 20 mg Injection should not be used to treat patients with multiple sclerosis who have liver disease. Other patients with liver disease should be treated with caution, and their dosage may need to be adjusted.

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Kidney

Caution

Limited information was available about using Nitrol 20 mg Injection in patients with kidney disease. Inform your doctor before receiving the Nitrol 20 mg Injection if you have a history of kidney diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

The safety and effectiveness of Nitrol 20 mg Injection in pediatric patients have not been established.

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Heart

Caution

Nitrol 20 mg Injection may harm heart function and is used cautiously or avoided in patients with cardiac disease. Doctors perform heart tests before and during treatment to monitor for damage and may limit total dosage.

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Geriatrics

Caution

Nitrol 20 mg Injection may be used in elderly patients when necessary, but it carries significant risks that require close monitoring. Doctors typically perform heart tests and adjust dosing to minimize toxicity.

What if I have taken an overdose of Nitrol 20 mg Injection

As Nitrol 20 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

Have a query?

How Soon It Starts Working

The time required for Nitrol 20 mg Injection to start to work: Nitrol 20 mg Injection ideally shows its action within few hours after administration. The time for which the effects of Nitrol 20 mg Injection last: The duration of action for Nitrol 20 mg Injection is unknown.

What if you forget to take Nitrol 20 mg Injection

As Nitrol 20 mg Injection is administered in a hospital by your healthcare provider, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Nitrol 20 mg Injection out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

Before taking the Nitrol 20 mg Injection, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. White blood cells protect the body from infection. This medication may cause a decrease in the amount of white blood cells in your blood. You are more prone to catching an infection if your white blood cell count is low. When the quantity of white blood cells is too low, a condition can be deadly. It is critical to treat any infection as quickly as possible. Make an immediate call to the hospital. Use a condom or effective birth control method if you are having sex with pregnant women or women who can become pregnant. Mitoxantrone injection can produce severe or life-threatening allergic reactions, especially during the first induction course. If it happens, kindly inform your doctor immediately; your doctor may stop the second induction course, which should be withheld until the toxicity resolves. Mitoxantrone injection may cause cardiac damage at any moment during treatment or months to years after treatment has discontinued. This heart damage can be severe and fatal, and it can occur even in people who are not at risk for heart disease. Before starting mitoxantrone medication, your doctor will evaluate you and do certain tests to see how well your heart is operating and if you exhibit any indicators of cardiac problems.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Nitrol 20 mg Injection interacts with medicines used to treat a wide variety of inflammatory conditions (e.g. adalimumab), immunomodulatory medication (e.g. baricitinib, fingolimod), Vaccinations (BCG Vaccine, Dengue vaccine, Smallpox vaccine), and psychiatric medication (e.g. clozapine),

Drug-Food Interactions: Do not drink Alcoholic beverages while treated with Nitrol 20 mg Injection. It can affect the way the medicine works.

Drug-Disease Interactions: Inform your doctor before taking the Nitrol 20 mg Injection if you suffer from infections (bacterial/fungal/protozoal/viral), heart disease, liver dysfunctions, fever, bone marrow depression/low blood counts, and bleeding disorders, as it requires close monitoring.

MitoxantroneNatalizumab
Severe
MitoxantroneEtanercept
Severe

Drug-Drug Interactions

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MitoxantroneNatalizumab
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Using natalizumab together with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Taking Nitrol 20 mg Injection 10 ml with Natalizumab together can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor immediately if you experience symptoms such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
MitoxantroneEtanercept
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Using etanercept together with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Although taking Nitrol 20 mg Injection 10 ml and Etanercept together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor’s advice.
MitoxantroneCladribine
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Using cladribine together with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Taking Nitrol 20 mg Injection 10 ml with Cladribine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
MitoxantroneAdalimumab
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Using adalimumab together with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Nitrol 20 mg Injection 10 ml and Adalimumab, but it can be taken if prescribed by a doctor. However, if you experience symptoms like stomach pain, ongoing fever, excessive sweating at night, unexplained weight loss, infection, fever, chills, diarrhoea, a sore throat, muscle pain, difficulty breathing, or pain or discomfort when urinating. Do not discontinue any medications without first consulting a doctor.
MitoxantroneLeflunomide
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Taking leflunomide with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Leflunomide with Nitrol 20 mg Injection 10 ml can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult a doctor immediately. Do not discontinue any medications without first consulting a doctor.
MitoxantroneTalimogene laherparepvec
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Using Talimogene laherparepvec together with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Nitrol 20 mg Injection 10 ml and Talimogene laherparepvec, but it can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor
MitoxantroneClozapine
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Co-administration of Clozapine together with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Nitrol 20 mg Injection 10 ml and Clozapine, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience symptoms such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
MitoxantroneThalidomide
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Taking thalidomide together with Nitrol 20 mg Injection 10 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Nitrol 20 mg Injection 10 ml together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
MitoxantroneDolasetron
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Using dolasetron together with Nitrol 20 mg Injection 10 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Nitrol 20 mg Injection 10 ml and Dolasetron, you can take these medicines together if prescribed by your doctor. However, consult a doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting a doctor.
MitoxantroneBaricitinib
Severe
How does the drug interact with Nitrol 20 mg Injection 10 ml:
Using baricitinib together with Nitrol 20 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Nitrol 20 mg Injection 10 ml with Baricitinib can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Nitrol 20 mg Injection is used treat Leukaemia, Prostate cancer and multiple sclerosis (MS).

Nitrol 20 mg Injection contains Mitoxantrone. In Cancer treatment, Nitrol 20 mg Injection works by slowing down the growth of cancer cells.

In multiple sclerosis (MS) treatment, Nitrol 20 mg Injection works by slowing down an overactive immune system, which prevents or delays worsening symptoms. It also decreases the number of flare-ups.

Based on the medical condition, Nitrol 20 mg Injection may be given alone or together with other medicines used to treat Prostate cancer.

No, it is unsafe to father a child while taking Nitrol 20 mg Injection. Men using this Nitrol 20 mg Injection must use effective birth control whenever they have sex during their treatment and for a certain period after their final dose.

Nitrol 20 mg Injection can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - NIT0222

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