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compositionComposition:IBRUTINIB-140MG
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Nitib 140mg Tablet is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr's macroglobulinaemia. It contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. Sometimes, Nitib 140mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IBRUTINIB-140MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nitib 140mg Tablet

Nitib 140mg Tablet is a prescription medicine used to treat certain blood cancers, including chronic lymphocytic leukaemia, small lymphocytic lymphoma, and Waldenström's macroglobulinaemia. It may also be used for certain other conditions, depending on the approved use and your treatment history.

Take this medicine regularly at the same time each day. Swallow it with water and follow the instructions for your prescribed formulation. It can generally be taken with or without food. Avoid grapefruit and Seville oranges, including their juices, because they can increase the amount of medicine in your blood and raise the risk of side effects.

Common side effects may include diarrhoea, tiredness, nausea, rash, and muscle or joint pain. This medicine can also cause serious problems, including bleeding, infections, high blood pressure, and abnormal heart rhythms. Consult your doctor right away if you develop unusual bleeding, signs of infection, chest discomfort, severe dizziness, or a fast or irregular heartbeat.

Before starting treatment, tell your doctor if you have bleeding problems, heart disease or an abnormal heart rhythm, high blood pressure, liver problems, or an infection. Do not take this medicine if you have had an allergic reaction to ibrutinib or any ingredient in your prescribed product.

Tell your doctor about all medicines, vitamins, supplements, and herbal products you take because some can affect how ibrutinib works or increase the risk of side effects. Tell your doctor if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult. Your doctor will advise you about appropriate contraception during and after treatment.

Uses of Nitib 140mg Tablet

Your doctor may prescribe Nitib 140mg Tablet to help manage certain blood cancers and related conditions:

  • Chronic lymphocytic leukaemia (CLL): Nitib 140mg Tablet helps control abnormal B cells (a type of white blood cell) and slow the progression of the disease.
  • Small lymphocytic lymphoma (SLL): This medicine helps control abnormal B cells that build up mainly in the lymph nodes and other tissues.
  • Waldenström's macroglobulinaemia: It helps control abnormal B cells that produce excessive amounts of an abnormal protein in the blood.
  • Other conditions: Ibrutinib may be used for other approved conditions depending on the country, treatment history, age, and individual clinical situation.

Key Benefits

Nitib 140mg Tablet provides targeted treatment for certain blood cancers by blocking signals that abnormal B cells need to survive and grow.

  • Helps control the disease: By reducing the growth and survival of abnormal cells, this medicine can slow disease progression.
  • May reduce disease-related symptoms: As the condition responds to treatment, symptoms such as swollen lymph nodes, tiredness, or night sweats may improve.
  • Provides an oral treatment option: Because the medicine is taken by mouth, treatment can usually be taken at home rather than requiring an intravenous infusion for each dose.
  • Supports long-term disease management: Treatment may continue for as long as it remains effective and side effects can be safely managed.
Side effects of Nitib 140mg Tablet

Directions for Use

  • Nitib 140mg Tablet can be taken with or without food.
  • It is usually recommended once daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the capsule as a whole with a glass of water.
  • Do not break, chew or crush Nitib 140mg Tablet .

How Nitib 140mg Tablet Works

Nitib 140mg Tablet contains ibrutinib, a targeted medicine that blocks Bruton’s tyrosine kinase (BTK), a protein that helps certain B cells grow and survive. In some blood cancers, abnormal B cells depend on BTK signals to keep growing. By blocking BTK, this medicine reduces these growth and survival signals, helping control the abnormal cells and slow the progression of the disease.
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Alcohol

Consult your doctor

It is not known if alcohol affects Nitib 140mg Tablet . However, avoid consumption of alcohol while on treatment with Nitib 140mg Tablet as it may worsen your condition.

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Pregnancy

Unsafe

Ibrutinib belongs to pregnancy category D. Nitib 140mg Tablet should not be used during pregnancy. Use effective contraception and avoid pregnancy during treatment with Nitib 140mg Tablet .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Nitib 140mg Tablet .

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Driving

Caution

Nitib 140mg Tablet may cause dizziness and tiredness. Do not drive or operate machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

Avoid taking Nitib 140mg Tablet if you have moderate or severe baseline liver impairment. Dose adjustment may be needed in patients with mild liver impairment. If you have a history of liver disease, inform the doctor.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before taking Nitib 140mg Tablet .

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Children

Unsafe

Nitib 140mg Tablet is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Take Nitib 140mg Tablet with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Caution

Nitib 140mg Tablet should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Nitib 140mg Tablet

If you take more medicine than prescribed, contact your doctor or seek medical care promptly. Take the medicine packaging with you if possible so healthcare professionals know what you have taken.

Diet & Lifestyle Advise

  • Stay hydrated: Drink enough fluids, particularly if you develop diarrhoea, unless your doctor has advised you to limit fluids.
  • Avoid grapefruit and Seville oranges: These fruits and their juices can increase the amount of ibrutinib in your blood and raise the risk of side effects.
  • Reduce infection risk: Wash your hands regularly and avoid close contact with people who have contagious infections when possible.
  • Protect yourself from bleeding: Use a soft toothbrush and take care when using sharp objects, particularly if you bruise or bleed easily.
  • Eat a balanced diet: Choose a varied diet that supports your nutritional needs during treatment, and discuss significant appetite or weight changes with your healthcare team.
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How Soon It Starts Working

The time required for Nitib 140mg Tablet to start to work: Nitib 140mg Tablet ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Nitib 140mg Tablet last: The effect of Nitib 140mg Tablet lasts for 4 to 6 hours.

What if you forget to take Nitib 140mg Tablet

If you miss a dose, take it as soon as you remember on the same day. If the day has already passed, skip the missed dose and take your next dose at the usual time. Do not take an extra dose to make up for the one you missed.

Storage

•Store Nitib 140mg Tablet at room temperature, preferably between 20°C and 25°C, or according to the storage instructions on the product label.

Drug Warnings

  • Watch for bleeding: Tell your doctor about unusual bruising, prolonged bleeding, black stools, blood in your urine, or other signs of bleeding.
  • Tell your doctor before procedures: Your doctor may advise stopping this medicine for a short period before and after surgery or dental procedures because of the risk of bleeding.
  • Watch for infections: Consult your doctor if you develop fever, chills, persistent cough, or other signs of infection.
  • Monitor your heart health: Tell your doctor promptly about a racing or irregular heartbeat, chest discomfort, fainting, or new shortness of breath.
  • Check your blood pressure: This medicine can cause or worsen high blood pressure, so your doctor may monitor it during treatment.
  • Discuss vaccinations: Ask your doctor before receiving any vaccine. Live vaccines are generally avoided during treatment.
  • Use contraception as advised: Ibrutinib may harm an unborn baby. Follow your doctor's instructions about effective contraception during treatment and for the recommended period after your last dose.
  • Keep your monitoring appointments: Your doctor may arrange blood tests and other checks to monitor blood cell counts, liver function, infections, bleeding risk, and other side effects.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood Thinners (like warfarin, aspirin, or ibuprofen): Taking these with Nitib 140mg Tablet can significantly increase your risk of serious bleeding.
  • Strong CYP3A Inhibitors (like ketoconazole, clarithromycin, or ritonavir): These can slow down how your body clears this medicine, raising its levels in your blood and increasing the risk of severe side effects.
  • Strong CYP3A Inducers (like rifampin, phenytoin, or carbamazepine): These can speed up how your body processes the medicine, making it less effective.
IbrutinibAmprenavir
Severe
IbrutinibDelavirdine
Severe

Drug-Drug Interactions

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IbrutinibAmprenavir
Severe
How does the drug interact with Nitib 140mg Tablet:
Taking Amprenavir with Nitib 140mg Tablet may increase the levels of Nitib 140mg Tablet. As a result, there may be an increased risk of side effects.

How to manage the interaction:
Although taking Nitib 140mg Tablet and Amprenavir together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, loss of hunger, nausea, vomiting, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, consult the doctor. Do not discontinue any medications without a doctor's advice.
IbrutinibDelavirdine
Severe
How does the drug interact with Nitib 140mg Tablet:
Taking Delavirdine with Nitib 140mg Tablet may increase the levels of Nitib 140mg Tablet.

How to manage the interaction:
Co-administration of Nitib 140mg Tablet with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Nitib 140mg Tablet:
Co-administration of Phenobarbital can significantly lower Nitib 140mg Tablet levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Nitib 140mg Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
IbrutinibFosamprenavir
Severe
How does the drug interact with Nitib 140mg Tablet:
Taking Fosamprenavir with Nitib 140mg Tablet may increase the levels of Nitib 140mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Nitib 140mg Tablet and Fosamprenavir, but it can be taken if prescribed by a doctor. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Nitib 140mg Tablet:
Co-administration of Nitib 140mg Tablet with Fingolimod can increase the risk of serious infections.

How to manage the interaction:
Taking Nitib 140mg Tablet with Fingolimod together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nitib 140mg Tablet:
Co-administration of Nitib 140mg Tablet with Dipyridamole can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Nitib 140mg Tablet with Dipyridamole together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nitib 140mg Tablet:
Co-administration of Warfarin with Nitib 140mg Tablet can increase the risk of bleeding.

How to manage the interaction:
Although taking Nitib 140mg Tablet and Warfarin together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without consulting a doctor.
IbrutinibDanaparoid
Severe
How does the drug interact with Nitib 140mg Tablet:
Co-administration of Nitib 140mg Tablet with Danaparoid can increase the risk of bleeding.

How to manage the interaction:
Taking Nitib 140mg Tablet with Danaparoid together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nitib 140mg Tablet:
Co-administration of Nitib 140mg Tablet with Reteplase can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Nitib 140mg Tablet with Reteplase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nitib 140mg Tablet:
Taking Nitib 140mg Tablet with Clarithromycin may increase the levels of Nitib 140mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Clarithromycin can be taken with Nitib 140mg Tablet if prescribed by the doctor. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Seville oranges: Avoid these fruits and their juices because they can increase the amount of ibrutinib in your blood and increase the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Nitib 140mg Tablet is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr’s macroglobulinaemia.
Nitib 140mg Tablet works by blocking the action of an abnormal protein that helps cancer cells multiply. Thereby, it stops the spread of cancer cells.
Nitib 140mg Tablet may make you bleed more easily. Therefore, consult the doctor if you are taking blood thinner medicines (heparin, warfarin), NSAIDs (aspirin, ibuprofen, naproxen), or supplements that may increase the risk of bleeding (flaxseed, vitamin E, fish oil).
Nitib 140mg Tablet may affect the heart, especially if you already have heart diseases like heart failure, heart rhythm problems, diabetes, high blood pressure, or are of advanced age. Consult the doctor instantly if you experience symptoms of heart failure like breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs.
There is no well-established direct interaction between ibrutinib and alcohol. However, alcohol may worsen some side effects or increase bleeding risk in certain situations. Ask your doctor whether alcohol is appropriate for you during treatment.
Tell your doctor, dentist, or surgeon that you take this medicine. Because it can increase bleeding risk, your doctor may advise stopping treatment for a short period before and after the procedure. Do not stop it yourself.
Hair loss is not one of the most common side effects of ibrutinib. Tell your doctor if you notice significant or unexpected hair loss during treatment.
Ask your doctor before receiving any vaccine. Live vaccines are generally avoided during treatment because your immune response may be affected. Your doctor can advise which vaccines are appropriate for you.
Ibrutinib is a targeted cancer treatment rather than traditional chemotherapy. It blocks a specific protein called BTK that certain abnormal B cells need for growth and survival.
Treatment is often continued for as long as it is controlling the condition and side effects remain manageable. Your doctor will regularly review your response and decide how long treatment should continue.
Blood tests help your doctor monitor blood cell counts, liver function, and other changes that may occur during treatment. They also help your doctor decide whether your dose or treatment needs to be adjusted.
Consult your doctor right away if you notice a racing, fluttering, or irregular heartbeat, particularly if it occurs with chest pain, shortness of breath, dizziness, or fainting.
Ibrutinib may harm an unborn baby. Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Follow your doctor's advice about contraception during and after treatment and about whether breastfeeding is appropriate.

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Country of origin

INDIA

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - NIT0304
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