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compositionComposition:NALOXONE-400MCG
prescription
Prescription Medicine
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Nex 400mcg/1ml Injection contains Naloxone, used to treat opioid dependence. It works by blocking the effect of opioid receptors and thereby blocks the effects of opioids. It is used along with counselling and social support to help patients dependent on opioid drugs. This medicine is also used after surgery to reverse the effects of opiates given during surgery.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

NALOXONE-400MCG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nex 400mcg/1ml Injection

Nex 400mcg/1ml Injection is an emergency injection used to quickly reverse the life-threatening effects of an opioid overdose. It is medically prescribed to restore normal breathing in people who have taken too much of an opioid pain reliever or an illegal opioid substance. This medication acts as a temporary rescue treatment until professional emergency medical help arrives.

Since Nex 400mcg/1ml Injection is an emergency rescue medicine, it is not used on a regular daily schedule, but rather given immediately at the first sign of a suspected opioid overdose. You should inject this medication as soon as symptoms like severe sleepiness, slow breathing, or loss of consciousness occur. While this treatment works immediately, long-term lifestyle changes such as entering a professional substance rehabilitation program and avoiding high-risk drug use are essential to prevent future overdoses.

Common side effects of this medication are primarily related to sudden opioid withdrawal, which can cause sweating, nausea, a rapid heart rate, and body aches. While these symptoms are uncomfortable, you must seek emergency medical services immediately after injecting this medicine, as more serious complications like severe chest pain or fluid in the lungs can occasionally occur.

Talk to your doctor or pharmacist about your medical history before a situation arises where you might need this medication, especially if you have pre-existing heart conditions or are pregnant. Do not inject this if you have a known severe allergy to Nex 400mcg/1ml Injection or any of its ingredients, although in a life-threatening emergency, there are no absolute reasons to withhold it.

This medicine can interact with other drugs by instantly blocking the pain-relieving effects of opioid medications, and it should be used with extreme caution alongside alcohol or other sedatives. Special user groups, such as pregnant individuals, breastfeeding mothers, and elderly patients, should consult their doctor or pharmacist to understand how this medicine affects them and how to manage their underlying health conditions safely.

Uses of Nex 400mcg/1ml Injection

Nex 400mcg/1ml Injection is used to quickly reverse the life-threatening effects of an opioid overdose. The detailed uses of Nex 400mcg/1ml Injection are as follows:

  • Opioid overdose reversal: Nex 400mcg/1ml Injection helps by rapidly blocking the effects of opioids in the nervous system, restoring normal breathing and consciousness during a life-threatening overdose.
  • Post-surgery breathing recovery: Nex 400mcg/1ml Injection helps reverse excessive drowsiness and respiratory depression when a patient is slow to wake up after receiving opioid anaesthetics during surgery.
  • Diagnosis of suspected opioid overdose: Nex 400mcg/1ml Injection helps doctors quickly determine if a patient's unconscious or unresponsive state is primarily caused by an opioid drug.
     

Key Benefits

Nex 400mcg/1ml Injection is an emergency medicine used to temporarily reverse the effects of an opioid overdose. When administered promptly, it helps restore normal breathing, improve consciousness, and provides critical time until emergency medical care is available.

  • Rapidly Reverses Opioid Overdose: By blocking the effects of opioids on the brain, this medicine quickly restores normal breathing and helps reverse life-threatening respiratory depression.
  • Restores Consciousness: As the effects of the opioid are reversed, this medicine helps the person regain alertness and responsiveness, reducing the risk of serious complications caused by prolonged oxygen deprivation.
  • Provides Critical Emergency Support: Designed for emergency use, this medicine can be administered promptly by trained caregivers or bystanders, providing life-saving support while waiting for emergency medical services.
Side effects of Nex 400mcg/1ml Injection
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Nex 400mcg/1ml Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Nex 400mcg/1ml Injection Works

Nex 400mcg/1ml Injection contains naloxone, which is an opioid antagonist. It works by travelling directly to the brain and attaching to the specific receptor sites where opioids normally bind. Because it has a much stronger attraction to these receptors than opioids do, it quickly knocks the opioid molecules off and takes their place. By blocking these receptors, it immediately stops the opioids from sending signals to slow down the nervous system, which rapidly restores normal breathing and heart function.
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Alcohol

Unsafe

Consumption of alcohol is not recommended during treatment with this medicine as it can worsen the condition of the patient.

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Pregnancy

Caution

Nex 400mcg/1ml Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. If administered during pregnancy, the doctor may need to monitor your unborn baby carefully after you receive the medication.

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Breast Feeding

Caution

Consult the doctor if you are breastfeeding. Caution should be exercised while using Nex 400mcg/1ml Injection in nursing mother.

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Driving

Caution

Nex 400mcg/1ml Injection will be administered in the hospital setting.

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Liver

Caution

Nex 400mcg/1ml Injection should be used with caution in patients with liver disease. So, inform your doctor if you have liver impairment. Regular monitoring of liver function tests is advisable while on treatment with this medicine.

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Kidney

Caution

Caution is recommended while administering Nex 400mcg/1ml Injection to patients with renal impairment. So, inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Nex 400mcg/1ml Injection.

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Children

Caution

Nex 400mcg/1ml Injection should be used in children only if advised by the doctor.

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Heart

Caution

Nex 400mcg/1ml Injection can be used in individuals with heart problems, but with caution. It may trigger side effects like arrhythmias, hypertension, or pulmonary edema, especially during rapid opioid reversal. Always consult your doctor before use to ensure it's safe for your condition.

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Geriatrics

Safe if prescribed

Nex 400mcg/1ml Injection can be given to geriatric patients in emergency opioid overdose situations. However, older adults may be more sensitive to side effects like agitation or changes in blood pressure, so close monitoring is essential.

What if I have taken an overdose of Nex 400mcg/1ml Injection

Although this medication is used to treat overdoses, receiving an excessive amount can cause severe, sudden opioid withdrawal symptoms. If you suspect someone has received too much of this medicine, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Seek professional substance use counselling or enter a drug rehabilitation program to address the underlying causes of opioid dependence.
  • Avoid using opioid medications alone; always ensure there is someone nearby who is trained to recognise an overdose and knows how to inject Nex 400mcg/1ml Injection.
  • Carry your rescue injection kit with you at all times, and ensure your family members, friends, or caregivers know exactly where it is kept and how to use it.
  • Do not mix opioid medications with alcohol, sleeping pills, or anti-anxiety drugs, as these combinations severely increase the risk of a life-threatening breathing emergency.
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Have a query?

How Soon It Starts Working

The time required for Nex 400mcg/1ml Injection to start to work: Nex 400mcg/1ml Injection ideally starts working within 2 minutes for an intravenous dose and 2-5 minutes for an intramuscular and a subcutaneous dose. The time for which the effects of Nex 400mcg/1ml Injection last: The effect of Nex 400mcg/1ml Injection lasts for 1 to 2 hours.

What if you forget to take Nex 400mcg/1ml Injection

Because this is an emergency rescue medicine used only when needed, a daily schedule does not apply. If symptoms of an overdose return after the first injection, a second injection may be given as directed by emergency personnel.

Storage

• Store this injection at room temperature, specifically between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Always inspect the liquid in the syringe or vial before use; it must be completely clear and colourless. Do not inject it if you see cloudiness or floating particles.
  • Call for emergency medical help immediately after the first injection, because the effects of this medicine may wear off before the opioids leave the patient's system.
  • Stay with the patient until professional medical help arrives, and place them on their side (the recovery position) to keep their airway clear and prevent choking.
  • Be prepared for the patient to wake up feeling highly agitated, angry, or confused, as this medicine causes sudden and intense opioid withdrawal.
  • Never reuse needles or syringes; immediately discard used injection materials in an approved sharps disposal container to prevent accidental needle sticks.

Drug-Drug Interactions

verifiedApollotooltip
  • Opioid Pain Relievers: Nex 400mcg/1ml Injection rapidly blocks the effects of opioid medicines such as morphine, oxycodone, and fentanyl. This can immediately reverse their pain-relieving effects and may cause the sudden return of severe pain in people receiving opioids for pain management.
  • Buprenorphine: Buprenorphine binds very strongly to opioid receptors, making overdose reversal more difficult. Larger or repeated doses of Nex 400mcg/1ml Injection may be required to successfully reverse the effects of buprenorphine during an overdose, and close medical monitoring is essential.
NaloxoneDroperidol
Severe
NaloxoneNaloxegol
Severe

Drug-Drug Interactions

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NaloxoneDroperidol
Severe
How does the drug interact with Nex 400mcg/1ml Injection:
Coadministration of Nex 400mcg/1ml Injection and Droperidol can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Nex 400mcg/1ml Injection and Droperidol together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience weakness, tiredness, drowsiness, chest pain or discomfort, confusion, muscle pain, cramps, dizziness, nausea, or vomiting consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
NaloxoneNaloxegol
Severe
How does the drug interact with Nex 400mcg/1ml Injection:
Coadministration of Nex 400mcg/1ml Injection and Naloxegol can enhance the risk of opioid withdrawal (a response to a sudden lack of opioids in the body).

How to manage the interaction:
Although taking Nex 400mcg/1ml Injection and Naloxegol together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like sweating, tearing, runny nose, chills, diarrhea, stomach pain, nausea, vomiting, anxiety, insomnia, irritability, or restlessness, it's important to call your doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no known significant food interactions with Nex 400mcg/1ml Injection when used as directed in emergency situations.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[OPIOID ANTAGONISTS]

FAQs

Nex 400mcg/1ml Injection is used to treat Opioid overdose.
Nex 400mcg/1ml Injection contains Naloxone, which works by inhibiting the effect of opioid receptors and thereby blocks the effects of opioids.
No, Nex 400mcg/1ml Injection should not be used with an opioid analgesic, as it may cause serious adverse effects of the drug. If you have any concerns, please discuss them with your doctor.
Inform your doctor about your medical conditions, allergic reactions, and medications you are already taking (especially opioid analgesics). Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.
Yes, if you suspect someone is suffering from an overdose, it is safer to inject this medicine. It will not cause harm if the person has not taken opioids, but it could save their life if they have. Talk to your doctor or pharmacist for guidance on identifying overdose signs.
No, this medicine only reverses the effects of opioids such as heroin, morphine, oxycodone, or fentanyl. It does not reverse overdoses caused by alcohol, stimulants, or benzodiazepines. Talk to your doctor or pharmacist about safety measures for other substances.
You must call emergency medical services (911) immediately after injecting the first dose. The effects of the medicine are temporary, and the patient could stop breathing again once it wears off. Talk to your doctor or pharmacist about how to handle emergencies safely.
Yes, in a life-threatening emergency, this medicine should be injected to save both the mother and the unborn baby, even though it can cause temporary withdrawal symptoms in the fetus. Talk to your doctor or pharmacist if you have concerns about using this medicine during pregnancy.
The effects of this medicine typically last between 30 to 90 minutes. Because many opioids stay in the body much longer than this, the patient may slide back into an overdose after the medicine wears off. Talk to your doctor or pharmacist to understand the duration of action of different medications.
Yes, if the patient does not respond or stops breathing again after 2 to 3 minutes, you should inject a second dose if it is available. Always monitor the patient closely until medical help arrives. Talk to your doctor or pharmacist about managing emergency kits.
While it is technically possible if you are still conscious, opioid overdoses usually happen too quickly for self-injection. It is critical that your family, friends, or caregivers are trained to recognise the signs and inject Nex 400mcg/1ml Injection for you. Talk to your doctor or pharmacist about training your support network.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - NEX0046

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