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  3. NEOPRATE INJECTION 5ML

NEOPRATE INJECTION 5ML, Pack of 1 Injection
NEOPRATE INJECTION 5ML, Pack of 1 Injection
NEOPRATE INJECTION 5ML, Pack of 1 Injection
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
NEOPRATE INJECTION 5ML is an anti-epileptic medication used in the treatment of severe epileptic seizures/fits, to prevent seizures during or after severe head injury and/or neurosurgery. This medicine works by decreasing the abnormal electrical activity in the brain and thus reduces seizures. Common side effects include sleepiness, dizziness, nausea, headache, and weakness.
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Composition :

SODIUM VALPROATE-500MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About NEOPRATE INJECTION 5ML

NEOPRATE INJECTION 5ML belongs to the group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, NEOPRATE INJECTION 5ML is also used to treat bipolar disorder. Epilepsy is a central nervous system disorder characterized by a sudden rush of electrical activity in the brain leading to seizures, unusual behavior, and loss of awareness. Bipolar disorder is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. 
­ 
NEOPRATE INJECTION 5ML contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. NEOPRATE INJECTION 5ML increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
NEOPRATE INJECTION 5ML will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as sleepiness, dizziness, nausea, headache, and asthenia (weakness). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

If you are of childbearing age, use effective contraception while on treatment with NEOPRATE INJECTION 5ML. Inform your doctor before taking NEOPRATE INJECTION 5ML if you are pregnant or breastfeeding. Do not drive or operate machinery as NEOPRATE INJECTION 5ML may cause sleepiness and dizziness. Avoid consuming alcohol along with NEOPRATE INJECTION 5ML as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of NEOPRATE INJECTION 5ML

Treatment of Epilepsy/seizures and Bipolar disorder

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• NEOPRATE INJECTION 5ML will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

NEOPRATE INJECTION 5ML belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). NEOPRATE INJECTION 5ML decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Additionally, NEOPRATE INJECTION 5ML is also used to treat bipolar disorder. NEOPRATE INJECTION 5ML increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 

How NEOPRATE INJECTION 5ML Works

NEOPRATE INJECTION 5ML contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. NEOPRATE INJECTION 5ML increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight.
• Keep NEOPRATE INJECTION 5ML out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Neoprate Injection 5ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of NEOPRATE INJECTION 5ML

It is unlikely that taking an overdose of NEOPRATE INJECTION 5ML will be harmful to you or your child. However, it might cause transient side effects like diarrhea, nausea, vomiting, and stomach pain. However, it is administered by a health care professional in a hospital. Hence, the chances of overdose are less. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

Do not take NEOPRATE INJECTION 5ML if you are allergic to any of its contents, if you have urea cycle problems, mitochondrial disorders, or hepatic disease/dysfunction. Inform your doctor if you have/had liver problems, porphyria (blood disorder), diabetes, immune system disorder, bleeding problems, systemic lupus erythematosus (a rare skin condition), or kidney problems. NEOPRATE INJECTION 5ML may cause hepatotoxicity (liver damage); consult your doctor if you experience symptoms such as weakness, facial swelling, vomiting, malaise (general discomfort), lethargy (lack of energy or enthusiasm), and anorexia (eating disorder). NEOPRATE INJECTION 5ML may also cause pancreatitis (inflammation of the pancreas); consult your doctor if you experience symptoms such as abdominal pain, vomiting, nausea, and/or anorexia (eating disorder).

Drug-Drug Interactions

verifiedApollotooltip
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateKetamine
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Neoprate Injection 5ml:
Combining Sodium phenylbutyrate and Neoprate Injection 5ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Neoprate Injection 5ml is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Neoprate Injection 5ml:
Co-administration of Ketamine and Neoprate Injection 5ml can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Neoprate Injection 5ml can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Neoprate Injection 5ml:
The combined use of Ertapenem and Neoprate Injection 5ml can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Neoprate Injection 5ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Neoprate Injection 5ml:
Co-administration of Leflunomide and Neoprate Injection 5ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Neoprate Injection 5ml can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Neoprate Injection 5ml:
Co-administration of Lithium with Neoprate Injection 5ml can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Neoprate Injection 5ml can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Neoprate Injection 5ml:
Co-administration of Meropenam and Neoprate Injection 5ml together can reduce the effect of Neoprate Injection 5ml.

How to manage the interaction:
Co-administration of Meropenam and Neoprate Injection 5ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Neoprate Injection 5ml:
Co-administration of Vorinostat with Neoprate Injection 5ml can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Neoprate Injection 5ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Neoprate Injection 5ml:
Using buprenorphine together with Neoprate Injection 5ml may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Neoprate Injection 5ml can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Neoprate Injection 5ml:
Co-administration of Neoprate Injection 5ml with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Neoprate Injection 5ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Neoprate Injection 5ml:
Co-administration of Teriflunomide and Neoprate Injection 5ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Neoprate Injection 5ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help in reducing the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT
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Alcohol

Unsafe

Avoid consumption of alcohol while taking NEOPRATE INJECTION 5ML as it may cause increased dizziness and sleepiness.

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Pregnancy

Caution

NEOPRATE INJECTION 5ML may cause serious congenital defects and decreased IQ. Therefore, NEOPRATE INJECTION 5ML should be given to pregnant women with epilepsy only if other medicines have failed to control their symptoms or are unacceptable.

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Breast Feeding

Caution

NEOPRATE INJECTION 5ML may pass into breastmilk. Consult your doctor before taking NEOPRATE INJECTION 5ML if you are breastfeeding.

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Driving

Unsafe

NEOPRATE INJECTION 5ML causes dizziness, sleepiness and tiredness. Avoid driving or operating machinery if you experience these symptoms.

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Liver

Unsafe

NEOPRATE INJECTION 5ML may cause hepatotoxicity (liver damage). Therefore it is not recommended in people with hepatic dysfunction. Please inform your doctor if you have a liver impairment or liver problem.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

NEOPRATE INJECTION 5ML can be given to children above 2 years if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight. NEOPRATE INJECTION 5ML should be used with extreme caution in children below 2 years as it might cause hepatotoxicity (liver damage).

Have a query?

FAQs

NEOPRATE INJECTION 5ML belongs to the group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder.

NEOPRATE INJECTION 5ML decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

NEOPRATE INJECTION 5ML is used to treat bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

NEOPRATE INJECTION 5ML may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

NEOPRATE INJECTION 5ML may cause hepatotoxicity (liver damage). Consult your doctor if you experience symptoms such as weakness, facial swelling, vomiting, malaise (general discomfort), lethargy (lack of energy or enthusiasm), and anorexia (eating disorder). Serum liver tests before starting NEOPRATE INJECTION 5ML and at regular intervals for at least six months are advised.

NEOPRATE INJECTION 5ML should not be administered to women of child-bearing age unless it is essential to manage her condition. Women of child-bearing age must use effective contraception whilst on treatment with NEOPRATE INJECTION 5ML.

Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - NEO0349

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 18, 2025 | 9:24 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020593s026lbl.pdf
  2. https://www.medsafe.govt.nz/Profs/Datasheet/e/EpilimIV.pdfhttp://editor.fresenius-kabi.us/PIs/US-PH-Valproate-Sodium-Inj-FK-45982G-10-2015-PI.pdf

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