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compositionComposition:ARFORMOTEROL-15MCG+GLYCOPYRRONIUM-25MCG
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Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) is a combination medicine used for long-term maintenance in patients with Chronic Obstructive Pulmonary Disease (COPD), including emphysema and/or chronic bronchitis. This medicine contains glycopyrronium and arformoterol, which works by relaxing the muscles around the airways and making it easier to breathe. Common side effects include headache, nausea, dry mouth, chest pain, muscle cramps, dizziness, painful and frequent urination.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ARFORMOTEROL-15MCG+GLYCOPYRRONIUM-25MCG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

Inhalation

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nebzmart-GF Combipack Smartule ( 5 x 1 ml )

Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) is an inhalation medication prescribed for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema. It helps to keep your airways open, making it much easier to breathe over time. Please remember that this medicine is not a rescue treatment and should not be used to treat sudden breathing emergencies.Living with COPD can be challenging, but using your medicine regularly along with healthy lifestyle changes can help you breathe more comfortably and stay active.

To get the most benefit, you must use Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) regularly at the same times every day, exactly as prescribed by your doctor. Because it is inhaled into the lungs, you can take it with or without food, as food does not affect how it works. Making lifestyle changes, such as avoiding tobacco smoke and staying active within your physical limits, can also significantly improve your lung health.This medicine is approved for the long-term treatment of COPD and is not approved to treat asthma.

Some people using this medicine may experience mild side effects like dry mouth, a mild cough, or a change in taste. However, if you experience serious symptoms such as chest pain, sudden severe breathing difficulty, or signs of a severe allergic reaction (such as swelling of the face, lips, tongue, or throat, or difficulty breathing), go to the nearest emergency room immediately. For other serious symptoms, such as a fast or irregular heartbeat or difficulty urinating, contact your doctor promptly.

Do not take this if you have had an allergic reaction to any of its active ingredients or similar medicines. Before starting Nebzmart-GF Combipack Smartule ( 5 x 1 ml ), tell your doctor if you have heart problems, high blood pressure, seizures, thyroid issues, diabetes, glaucoma, or prostate problems.

Certain medications, like other bronchodilators, beta-blockers, or water pills, can interact with   Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) and increase your risk of side effects or decrease its effectiveness. Smoking can further damage your lungs and reduce the benefits of this treatment, so it is highly recommended to seek help to quit. If you are pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to ensure this medicine is safe for your specific situation.

Uses of Nebzmart-GF Combipack Smartule ( 5 x 1 ml )

Your doctor may recommend Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) to help:

  • Chronic Obstructive Pulmonary Disease (COPD): Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) helps relax the muscles around the airways in your lungs, preventing symptoms like wheezing, coughing, chest tightness, and shortness of breath.
  • Chronic Bronchitis: It assists in keeping the breathing tubes open, allowing for better airflow and easier clearance of mucus in patients suffering from long-term airway inflammation.
  • Emphysema: By preventing the airways from collapsing, it helps patients with damaged air sacs breathe more comfortably and maintain better daily physical activity.

Key Benefits

The primary benefit of Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) is sustained, day-to-day improvement in your breathing. By keeping your airways consistently relaxed, this medicine reduces the frequency of sudden breathing flare-ups, allowing you to participate in daily activities with less fatigue.

  • Easier Breathing Throughout the Day: It provides continuous, long-acting airway relaxation so you can perform daily tasks like walking, climbing stairs, or bathing with less shortness of breath.
  • Reduced Risk of Flare-ups: Regular use helps prevent sudden worsening of COPD symptoms, which can reduce your need for hospital visits.
  • Better Sleep Quality: By keeping your airways open overnight, it helps prevent nighttime coughing and breathlessness, leading to more restful sleep.
Side effects of Nebzmart-GF Combipack Smartule ( 5 x 1 ml )
  • Focus on eating nutrient-rich foods such as citrus fruits, spinach, ginger, garlic, turmeric, and fermented foods to improve immunity and general health.
  • Drink plenty of water to stay hydrated, and think about taking probiotics, zinc, vitamin C, and vitamin D supplements.
  • Adopt healthful practices such as leading a balanced lifestyle and remaining at home when necessary.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

Directions for Use

  • Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) can be taken with or without food.
  • Check the instruction leaflet before use.
  • Open the smartule by twisting off the cap. Squeeze the content into the reservoir of the nebulizing chamber.
  • Discard the smartule after use.
  • Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) should be used with a nebuliser only in the dose and duration prescribed by a doctor. It is not to be injected or administered orally.
  • Any invisible damage caused during transit or storage may cause contamination. Do not use the smartule if the suspension is discolored, has any leaks upon squeezing or contains visible black particles.

How Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) Works

Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) contains two active medicines that work together in different ways to open your airways and improve your breathing. Arformoterol is a long-acting beta-agonist (LABA). It works by directly stimulating specific receptors on the smooth muscles surrounding your airways. This causes these tight muscles to relax, widening the air passages and allowing air to flow in and out of your lungs more freely. Glycopyrronium is a long-acting anticholinergic (long-acting muscarinic antagonist or LAMA). It works by blocking a specific chemical messenger in the body called acetylcholine, which normally signals the muscles in your airways to tighten. By blocking this signal, it prevents the airways from narrowing. Together, these two components provide a dual action that keeps your airways dilated and relaxed for a full 24 hours, making daily breathing much easier than using either medicine alone.
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Alcohol

Caution

You are advised not to consume alcohol while using Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) as it might cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before using Nebzmart-GF Combipack Smartule ( 5 x 1 ml ); your doctor will decide whether Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) can be used by breastfeeding mothers or not.

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Driving

Caution

Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) may cause dizziness. Drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before using Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) if you have liver impairment/liver disease or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor before using Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) if you have kidney impairment/kidney disease or any concerns regarding this.

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Children

Unsafe

Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) is not recommended for children below 18years as the safety and effectiveness have not been established.

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Heart

Caution

Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) should be used with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems.

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Geriatrics

Consult your doctor

Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) should be used in elderly patients only when prescribed by a doctor. If you have any concerns about using Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) in older adults, please consult your doctor.

What if I have taken an overdose of Nebzmart-GF Combipack Smartule ( 5 x 1 ml )

If you take too much of this medicine, seek immediate medical attention. Symptoms of an overdose can include extreme shakiness, a very fast or pounding heartbeat, severe chest pain, muscle cramps, and feeling highly anxious or dizzy.

Diet & Lifestyle Advise

  • Avoid Smoking and Secondhand Smoke: Stopping smoking is the single most effective lifestyle change to slow down lung damage and improve the effectiveness of your medication
  • Practice Controlled Breathing Exercises: Techniques like pursed-lip breathing and diaphragmatic breathing can help make your breathing more efficient and reduce shortness of breath during daily activities.
  • Stay Hydrated: Drink plenty of water throughout the day (unless your doctor advises otherwise) to help thin the mucus in your airways, making it easier to cough up.
  • Rinse Your Mouth After Use: Rinsing your mouth with water and spitting it out after each inhalation helps prevent dry mouth and reduces the risk of local irritation.
  • Maintain a Balanced, Nutrient-Dense Diet: Eating smaller, more frequent meals can prevent stomach fullness from pressing on your diaphragm, which can make breathing more difficult.
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How Soon It Starts Working

The time required for Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) to start to work: Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) ideally shows its action within few minutes after administration. The time for which the effects of Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) last: The effect of Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) lasts for 12 hours.

What if you forget to take Nebzmart-GF Combipack Smartule ( 5 x 1 ml )

If you miss a dose of Nebzmart-GF Combipack Smartule ( 5 x 1 ml ), take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and go back to your regular routine. Do not take a double dose to make up for a missed one.

Storage

• Store the unused vials in the refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze this medication.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the Liquid Before Use: Always look at the vial before opening it; the solution should be clear and colourless. Do not use it if the liquid is cloudy, discoloured, or contains visible particles.
  • Do Not Mix Medications: Never mix Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) with other medications in your nebuliser cup unless specifically instructed to do so by your doctor.
  • Avoid Eye Contact: Keep the nebuliser mist away from your eyes, as getting this medicine in your eyes can cause temporary blurred vision, pupil dilation, or worsen narrow-angle glaucoma.
  • Keep a Rescue Inhaler Close: Remember that Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) is a maintenance medicine that works slowly over time. Always keep a fast-acting rescue inhaler with you to treat sudden, acute breathing struggles.
  • Monitor Your Heart Rate: If you notice a persistent, unusually fast pulse or feel your heart racing while resting, note this down and discuss it with your healthcare provider.
  • Use Only for COPD:  Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) is intended only for the maintenance treatment of COPD. It should not be used to treat asthma unless specifically prescribed by your doctor as part of an appropriate asthma treatment plan.

Drug-Drug Interactions

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  • Other Long-Acting Bronchodilators: Combining Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) with similar medications increases the risk of severe side effects, including heart issues and tremors.
  • Beta-Blockers (such as those for high blood pressure or glaucoma): These medicines can block the effects of   Nebzmart-GF Combipack Smartule ( 5 x 1 ml ), causing your airways to tighten and worsen your breathing.
  • Diuretics (Water Pills): Taking these together may lower the potassium levels in your blood to unsafe levels, which can affect heart function.
  • Anticholinergic Medicines: Using other drugs with anticholinergic properties can increase the risk of dry mouth, constipation, and difficulty urinating.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

No. Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) is a maintenance medicine for the long-term treatment of COPD and is not a rescue medicine. Do not use it to treat a sudden COPD flare-up, wheezing, or breathing emergency. Always use your prescribed quick-relief (rescue) inhaler as directed by your doctor. If your symptoms do not improve or become worse, seek medical attention immediately.
If the mist gets into your eyes, rinse them immediately with cool, clean water. Getting this medication in your eyes can cause temporary blurred vision, dilated pupils, and eye discomfort, and could trigger narrow-angle glaucoma. Talk to your doctor if you develop persistent eye pain.
Yes, unopened vials should ideally be stored in the refrigerator between 2°C and 8°C (36°F to 46°F) to ensure their stability. You can keep them at room temperature for up to 7 days, but any unused vials must be discarded after that. Talk to your pharmacist if you have questions about proper storage.
You must use caution if you have prostate enlargement or difficulty urinating, as this medication can make urinary retention worse. Be sure to discuss your medical history with your healthcare provider before starting treatment. Talk to your doctor immediately if you find it hard to pass urine.
The safety of this medication during pregnancy is not fully established. It should only be used if the potential benefits to the mother outweigh the potential risks to the unborn baby. Talk to your doctor to discuss safer alternatives if you are pregnant or planning to become pregnant.
No, you should not mix Nebzmart-GF Combipack Smartule ( 5 x 1 ml ) with any other medications in the nebuliser cup unless your healthcare provider specifically instructs you to do so. Mixing medications can change how they work or cause physical changes in the liquid. Talk to your doctor or pharmacist for clear guidance.
An allergic reaction is rare but serious. Signs include hives, severe itching, skin rash, swelling of your face, lips, tongue, or throat, and sudden difficulty swallowing or breathing. If you experience any of these signs, seek emergency medical help and talk to your doctor immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - NEB0242
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