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  3. Nebipil SA Tablet 10's

Nebipil SA Tablet 10's, Pack of 10 TABLETS
Nebipil SA Tablet 10's, Pack of 10 TABLETS
Nebipil SA Tablet 10's, Pack of 10 TABLETS
Nebipil SA Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Nebipil SA Tablet is used to treat high blood pressure. It contains Amlodipine and Nebivolol, which relax and widen the blood vessels, making it easier for the heart to pump blood to all parts of the body. This lowers blood pressure and helps in reducing the risk of stroke, heart attack, other heart problems, or kidney problems in the future. It may cause side effects such as headaches, feeling exhausted, cold extremities, ankle swelling, slow heart rate, constipation, and tiredness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

AMLODIPINE-2.5MG + NEBIVOLOL-5MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nebipil SA Tablet

Nebipil SA Tablet is primarily used to treat high blood pressure. Hypertension or high blood pressure is a chronic condition in which the force exerted by the blood against the artery wall is high. As a result, it leads to heart diseases, irregular heartbeat, and other complications.

Nebipil SA Tablet contains amlodipine and Nebivolol. Amlodipine works by relaxing the blood vessels. Nebivolol acts by relaxing and widening the blood vessels, making it easier for the heart to pump blood to all parts of the body.

In some cases, you may experience headaches, feeling exhausted, cold extremities, ankle swelling, slow heart rate, constipation, and tiredness. Most of these side effects of Nebipil SA Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.  

Please inform your doctor if you have had an allergic reaction to Nebipil SA Tablet , are pregnant or planning to get pregnant, are breastfeeding, or have liver disease or kidney disease, heart failure, diabetes, a heart valve problem, or a heart attack. Nebipil SA Tablet is prescribed to adults and children more than six years of age.

Uses of Nebipil SA Tablet

Nebipil SA Tablet is used to treat high blood pressure. The detailed uses of Nebipil SA Tablet are as follows:

  • Hypertension: Nebipil SA Tablet lowers elevated blood pressure to protect the heart and blood vessels.
  • Prevention of cardiovascular complications: Nebipil SA Tablet reduces the risk of stroke, heart attack, and other hypertension-related issues.
  • Cardiovascular support: Nebipil SA Tablet relaxes blood vessels and decreases the heart’s workload, improving heart health.

Directions for Use

  • Take Nebipil SA Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Nebipil SA Tablet is a combination of blood pressure-lowering medicine, containing Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker), primarily used to treat high blood pressure. 
  • Amlodipine works by relaxing the blood vessels.
  • Nebivolol acts by relaxing and widening the blood vessels, making it easier for the heart to pump blood to all parts of the body.
  • This lowers your blood pressure and reduces your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future.
  • This medication must be taken regularly to be effective.

How Nebipil SA Tablet Works

Nebipil SA Tablet contains Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker), primarily used to treat high blood pressure. Amlodipine works by relaxing the blood vessels. Nebivolol acts by relaxing and widening the blood vessels, making it easier for the heart to pump blood to all parts of the body. This lowers your blood pressure and helps in reducing your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Nebipil SA Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Nebipil SA Tablet

Do not take more than the prescribed dose of Nebipil SA Tablet as it may cause serious side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Don't stop taking Nebipil SA Tablet without talking to your doctor first.
  • Stopping Nebipil SA Tablet abruptly may cause changes in your heart rhythm and blood pressure, cause chest pain, or a heart attack.
  • Your doctor will lower your dose gradually over a period of time to help prevent these symptoms.
  • You should not use Nebipil SA Tablet if you have a very slow heartbeat, asthma, a serious heart condition (sick sinus syndrome), or any heart blockage.
  • It should not be given to children less than 12 years of age.
  • Before taking Nebipil SA Tablet you should tell the doctor if you have any muscle disorder (myasthenia gravis, rhabdomyolysis), breathing problem (COPD, bronchitis, emphysema), low blood sugar level (hypoglycemia), low blood pressure (hypotension), depression, previous heart failure, liver/kidney disease, thyroid hormone disorder, adrenal gland cancer, or problems with circulation (Raynaud’s syndrome).

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
NebivololCeritinib
Severe

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Nebipil SA Tablet:
Using Nebipil SA Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Nebipil SA Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
NebivololCeritinib
Severe
How does the drug interact with Nebipil SA Tablet:
Coadministration ceritinib with Nebipil SA Tablet can slow your heart rate and increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking ceritinib with Nebipil SA Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololTheophylline
Severe
How does the drug interact with Nebipil SA Tablet:
Coadministration of Nebipil SA Tablet with Theophylline may reduce the effect of Nebipil SA Tablet.

How to manage the interaction:
Taking Nebipil SA Tablet with Theophylline together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololClonidine
Severe
How does the drug interact with Nebipil SA Tablet:
Co-administration of clonidine and Nebipil SA Tablet together may lower blood pressure and slow your heart rate.

How to manage the interaction:
Taking clonidine and Nebipil SA Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololDiltiazem
Severe
How does the drug interact with Nebipil SA Tablet:
Taking Nebipil SA Tablet with Diltiazem may increase the risk or severity of side effects.

How to manage the interaction:
Taking Nebipil SA Tablet with Diltiazem together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fatigue, headache, fainting, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.
NebivololRitodrine
Severe
How does the drug interact with Nebipil SA Tablet:
Combine use of Nebipil SA Tablet and Ritodrine may decrease the effect of Nebipil SA Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Nebipil SA Tablet and Ritodrine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience Nausea, Headache, Fatigue, Constipation, Diarrhea, Dizziness, contact a doctor. Do not discontinue any medications without a doctor's advice.
NebivololFingolimod
Severe
How does the drug interact with Nebipil SA Tablet:
Taking Fingolimod and Nebipil SA Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Fingolimod and Nebipil SA Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, shortness of breath, chest pain, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololAtenolol
Severe
How does the drug interact with Nebipil SA Tablet:
Coadministration of Atenolol and Nebipil SA Tablet may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Atenolol and Nebipil SA Tablet together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NebivololDolasetron
Severe
How does the drug interact with Nebipil SA Tablet:
Taking Dolasetron and Nebipil SA Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Dolasetron and Nebipil SA Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, shortness of breath, chest pain, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NebivololTheophylline
Severe
How does the drug interact with Nebipil SA Tablet:
Combined use of Nebipil SA Tablet with Theophylline may increase the effect of Theophylline.

How to manage the interaction:
Although there is a possible interaction between Theophylline and Nebipil SA Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience nausea, vomiting, insomnia, tremors, restlessness, irregular heartbeats, contact a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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AMLODIPINE-2.5MG+NEBIVOLOL-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AMLODIPINE-2.5MG+NEBIVOLOL-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consumption of grapefruit and grapefruit juice with Nebipil SA Tablet the levels of Nebipil SA Tablet in your bloodstream may drop. Avoid consuming a lot of grapefruit juice and grapefruit when using Nebipil SA Tablet, instead, take it with water. As a result, your body will absorb the drug more easily.

Diet & Lifestyle Advise

  • Keep your weight under control with BMI (Body Mass Index) 19.5-24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your high blood pressure by about 5 mmHg.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • If you are taking alcohol, then only one serving for women and two servings is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Monitor your blood pressure daily, and if there is too much fluctuation, then immediately contact your doctor.
  • Try to include heart-healthy omega-3 fatty acids-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to help lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Nebipil SA Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Nebipil SA Tablet to avoid unpleasant side-effects.

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Pregnancy

Consult your doctor

It is advised to consult your doctor if you plan to conceive or are already pregnant before starting Nebipil SA Tablet .

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Breast Feeding

Consult your doctor

Please consult your doctor before taking Nebipil SA Tablet if you are breastfeeding; your doctor will prescribe you Nebipil SA Tablet only if the benefits outweigh the risks.

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Driving

Caution

Nebipil SA Tablet may cause dizziness and weakness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Nebipil SA Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Nebipil SA Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

Nebipil SA Tablet should not be used by children, as the efficacy and safety have not been established.

Have a query?

FAQs

Nebipil SA Tablet is used to treat hypertension (high blood pressure).

Nebipil SA Tablet contains Amlodipine (calcium channel blocker) and Nebivolol (beta-blocker); primarily used to treat high blood pressure.‚ Amlodipine works by‚ relaxing the blood vessels. Nebivolol acts by‚ relaxing‚ and widening‚ the blood vessels making it easier for the heart to pump blood to all parts of the body. This lowers your blood pressure and helps in reducing your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future.

Your doctor may probably tell you to stop taking Nebipil SA Tablet as it lowers blood pressure (hypotension) when combined with general anaesthesia before surgery. So, please inform your doctor before surgery if you are taking Nebipil SA Tablet .

Yes, Nebipil SA Tablet is known to cause ankle swelling. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.

If you have diabetes, you should monitor your blood glucose levels often as Nebipil SA Tablet might mask hypoglycemia symptoms (low glucose levels). However, please consult your doctor before taking Nebipil SA Tablet if you have diabetes.

If you have hyperthyroidism (overactive thyroid), you should monitor your condition regularly as Nebipil SA Tablet might mask hyperthyroidism symptoms such as abnormally fast heart rate. However, please consult your doctor before taking Nebipil SA Tablet if you have hyperthyroidism.

Do not overdose on Nebipil SA Tablet or any medicine, which could lead to very unpleasant side effects. Take Nebipil SA Tablet only as prescribed by your doctor. An overdose of Nebipil SA Tablet can cause a very slow heartbeat, low blood pressure, breathlessness, and acute heart failure. Rush to your nearest doctor as early as possible if you have overdosed on Nebipil SA Tablet .

You should take Nebipil SA Tablet as advised by your doctor. But take it at the same time every day for consistency. Swallow it as whole with a glass of water. Do not break, crush or chew it.

If you miss a dose of Nebipil SA Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

Nebipil SA Tablet may cause side effects such as headache, ankle swelling, slow heart rate, tiredness, constipation or cold extremities (cold hands and feet). If these side effects persist or worsen, please consult your doctor.

You are recommended to take your doctor’s advice before taking Nebipil SA Tablet if you are pregnant or breastfeeding.

No, do not stop taking Nebipil SA Tablet even if you feel better as discontinuing Nebipil SA Tablet suddenly may raise your blood pressure. Therefore, please consult your doctor before making any changes to your dosage schedule.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - NEB0012

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 17, 2025 | 2:32 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.9966.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021742s013lbl.pdf
  3. https://www.drugs.com/mtm/nebivolol.html
  4. https://www.nhs.uk/medicines/amlodipine/
  5. https://www.drugs.com/drug-interactions/amlodipine-index.html?filter=3

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