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compositionComposition:SOFOSBUVIR-400MG
prescription
Prescription Medicine
info
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Myhep 400Mg 28 Tablets is used to treat chronic hepatitis C virus (HCV) infection. It contains Sofosbuvir, which lowers the amount of hepatitis C virus in the body and removes the virus from the blood over time. In some cases, this medication may cause common side effects such as fever, chills, headache, nausea, vomiting, diarrhoea, tiredness and irritability, dizziness, or loss of appetite.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

SOFOSBUVIR-400MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Myhep 400Mg 28 Tablets

Myhep 400Mg 28 Tablets is a prescription medicine used to treat chronic hepatitis C, a long-term viral infection that causes liver inflammation and damage. The primary medical purpose of this medicine is to clear the hepatitis C virus from your bloodstream. It is almost always used in combination with other direct-acting antiviral medications to ensure the infection is completely cured.

For this treatment to be successful, you must take Myhep 400Mg 28 Tablets consistently every single day without missing a dose. You can take this tablet with or without food, making it easy to schedule around your daily routine. Adopting a nutritious diet, maintaining good hydration, and avoiding substances that strain the liver can significantly support your body's recovery during treatment.

While Myhep 400Mg 28 Tablets is generally well-tolerated, some people may experience mild, manageable side effects like headache or fatigue. If you experience severe symptoms, such as signs of a serious allergic reaction or rapid worsening of liver function, seek emergency medical care immediately.

Talk to your doctor before starting this medicine if you have certain pre-existing health conditions, such as a history of hepatitis B infection, kidney disease, or severe liver impairment. Do not take this if you have a known allergy to any of its components or if you are taking specific medications that severely interact with it.

This medicine can interact with several other drugs, including herbal products like St. John's wort, which can make the antiviral therapy much less effective. If you are pregnant, breastfeeding, or planning a family, you must consult your doctor or pharmacist before starting Myhep 400Mg 28 Tablets, as it is used in combinations that can pose risks.

Uses of Myhep 400Mg 28 Tablets

Your doctor may prescribe Myhep 400Mg 28 Tablets to help manage the following conditions:

  • Chronic Hepatitis C Infection: Myhep 400Mg 28 Tablets works by stopping the hepatitis C virus from multiplying and copying itself inside your body. This helps clear the infection from your blood and protects your liver from long-term scarring and damage.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Clears Hepatitis C Virus: Completing your treatment with Myhep 400Mg 28 Tablets helps clear the hepatitis C virus from your body entirely. When the virus is no longer detectable in your blood for several weeks after finishing the medication, it means the infection is cured, allowing your immune system and liver to recover.
  • Supports Liver Recovery: By stopping the virus from reproducing, this medicine prevents the progression of serious liver damage, such as severe scarring (cirrhosis), liver failure, and liver cancer. This directly leads to improved long-term health, better energy levels, and peace of mind.

Directions for Use

  • Myhep 400Mg 28 Tablets can be taken with or without food because food does not impact its effectiveness.
  • It is usually taken once a day; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the tablet as a whole with a glass of water.
  • Do not break, chew or crush Myhep 400Mg 28 Tablets.

How Myhep 400Mg 28 Tablets Works

Myhep 400Mg 28 Tablets contains sofosbuvir which belongs to a class of medicines called direct-acting antivirals. It works by targeting a specific protein (NS5B RNA polymerase) that the hepatitis C virus absolutely needs to replicate its genetic material and multiply. By blocking this essential protein, the medication halts the life cycle of the virus. Without the ability to make copies of itself, the virus eventually dies off, and your immune system is able to clear the remaining virus from your body.
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Alcohol

Consult your doctor

The interaction of alcohol with Myhep 400Mg 28 Tablets is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Unsafe

Myhep 400Mg 28 Tablets is commonly used together with ribavirin. Ribavirin can harm the unborn baby. Therefore, it is important to avoid pregnancy during this therapy. However, contact your doctor immediately if you become pregnant during treatment or in the months following your treatment with Myhep 400Mg 28 Tablets.

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Breast Feeding

Consult your doctor

It is unknown whether Myhep 400Mg 28 Tablets is excreted in human milk. Therefore, if you are a breastfeeding mother, please inform your doctor before taking Myhep 400Mg 28 Tablets.

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Driving

Caution

Myhep 400Mg 28 Tablets may cause dizziness, tiredness, blurred vision and reduced attention in some patients. Therefore, avoid driving or operating heavy machinery if you feel dizzy, tired, have blurred vision or reduced attention after taking Myhep 400Mg 28 Tablets.

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Liver

Consult your doctor

If you have a liver problem, inform your doctor before taking Myhep 400Mg 28 Tablets.

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Kidney

Caution

If you have kidney problems or if you are on kidney dialysis, inform your doctor before taking Myhep 400Mg 28 Tablets.

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Children

Caution

If you have any concerns regarding the use of Myhep 400Mg 28 Tablets in children, please consult a doctor.

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Heart

Consult your doctor

Please consult your doctor before receiving Myhep 400Mg 28 Tablets if you have pre-existing heart problems. Your doctor will prescribe Myhep 400Mg 28 Tablets if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Myhep 400Mg 28 Tablets is generally considered safe for use in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Myhep 400Mg 28 Tablets

If you suspect an accidental overdose, seek emergency medical attention.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Alcohol puts immense stress on your liver and accelerates liver damage, which can hinder your recovery during hepatitis C treatment.
  • Eat a liver-friendly diet: Focus on a balanced diet rich in vegetables, fruits, whole grains, and lean proteins while limiting processed foods, saturated fats, and excess sugar.
  • Stay well-hydrated: Drink plenty of water throughout the day to support your kidneys and help your body process your medications efficiently.
  • Do not eat raw shellfish: Chronic liver conditions increase your risk of severe, life-threatening infections from bacteria found in raw or undercooked seafood.
  • Consult before taking supplements: Many herbal products and over-the-counter supplements can harm your liver. Always check with your doctor or pharmacist before starting any new product.

Health Queries

What are the recommended generic drug names (salts) and popular brand names available in India for the treatment of Hepatitis C?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Hepatitis C is highly curable today with highly effective oral medications called Direct-Acting Antivirals (DAAs). In India, the standard recommended generic drugs (salts) include: Sofosbuvir (often the backbone of therapy), Daclatasvir (usually paired with Sofosbuvir), Ledipasvir (commonly combined with Sofosbuvir)\n4. Velpatasvir (combined with Sofosbuvir to treat all viral genotypes). These generic medications are widely available, affordable, and have excellent cure rates of over 95%. Please consult a hepatologist or gastroenterologist to determine the exact combination and duration best suited for you. This is a highly manageable condition, and there is no need to panic.

What are the recommended generic drug names (salts) and popular brand names available in India for the treatment of Hepatitis C?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Hepatitis C is highly curable today with highly effective oral medications called Direct-Acting Antivirals (DAAs). In India, the standard recommended generic drugs (salts) include: Sofosbuvir (often the backbone of therapy), Daclatasvir (usually paired with Sofosbuvir), Ledipasvir (commonly combined with Sofosbuvir)\n4. Velpatasvir (combined with Sofosbuvir to treat all viral genotypes). These generic medications are widely available, affordable, and have excellent cure rates of over 95%. Please consult a hepatologist or gastroenterologist to determine the exact combination and duration best suited for you. This is a highly manageable condition, and there is no need to panic.
health query

Have a query?

How Soon It Starts Working

The time required for Myhep 400Mg 28 Tablets to start to work: Myhep 400Mg 28 Tablets ideally shows its action within few hours after administration. The time for which the effects of Myhep 400Mg 28 Tablets last: The effect of Myhep 400Mg 28 Tablets lasts for 24 hours.

What if you forget to take Myhep 400Mg 28 Tablets

If you miss a dose of Myhep 400Mg 28 Tablets, take it as soon as you remember on the same day. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed tablet. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Myhep 400Mg 28 Tablets tablets in their original container at room temperature, between 68°F and 77°F (20°C to 25°C).

Drug Warnings

  • Complete the full course: Never stop taking Myhep 400Mg 28 Tablets early, even if you feel completely cured. Stopping early can cause the virus to return and become resistant to treatments.
  • Get screened for Hepatitis B: Ensure your doctor tests you for hepatitis B before starting Myhep 400Mg 28 Tablets, as this medicine can reactivate an old hepatitis B infection, causing severe liver damage.
  • Watch your heart rate: If you take a heart medicine called amiodarone, taking Myhep 400Mg 28 Tablets can cause a dangerously slow heart rate. Seek emergency help if you experience slow pulse, severe dizziness, or fainting.
  • Set a daily alarm: Taking this medicine at the exact same time every day maximizes its ability to clear the virus.

Drug-Drug Interactions

verifiedApollotooltip
  • Amiodarone: Combining this heart medication with Myhep 400Mg 28 Tablets can lead to a dangerously slow heartbeat (bradycardia).
  • Antiseizure medications (e.g., carbamazepine, phenytoin, phenobarbital): These drugs can lower the amount of Myhep 400Mg 28 Tablets in your blood, making your antiviral treatment less effective.
  • Rifampin or Rifabutin: These antibiotics can significantly reduce the level of Myhep 400Mg 28 Tablets in your body, increasing the risk of treatment failure.
  • St. John's Wort: This herbal supplement reduces the concentration of Myhep 400Mg 28 Tablets in your system and should not be used during treatment.
SofosbuvirCarbamazepine
Severe
SofosbuvirRifabutin
Severe

Drug-Drug Interactions

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SofosbuvirCarbamazepine
Severe
How does the drug interact with Myhep 400Mg 28 Tablets:
Taking carbamazepine and Myhep 400Mg 28 Tablets together may possibly reduce the effects of Myhep 400Mg 28 Tablets, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and Myhep 400Mg 28 Tablets together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
SofosbuvirRifabutin
Severe
How does the drug interact with Myhep 400Mg 28 Tablets:
Taking Rifabutin and Myhep 400Mg 28 Tablets may significantly reduce the blood levels of Myhep 400Mg 28 Tablets, which may make the medication less effective.

How to manage the interaction:
Taking Myhep 400Mg 28 Tablets with Rifabutin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SofosbuvirOxcarbazepine
Severe
How does the drug interact with Myhep 400Mg 28 Tablets:
Oxcarbazepine can drastically lower Myhep 400Mg 28 Tablets levels in the blood, making the medicine less effective in treating.

How to manage the interaction:
Although taking oxcarbazepine with Myhep 400Mg 28 Tablets can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
SofosbuvirPhenytoin
Severe
How does the drug interact with Myhep 400Mg 28 Tablets:
Using Myhep 400Mg 28 Tablets together with phenytoin may significantly reduce the blood levels of Myhep 400Mg 28 Tablets.

How to manage the interaction:
Although there is a possible interaction between Myhep 400Mg 28 Tablets and Phenytoin, you can take these medicines together if prescribed by a doctor. Doctors can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
SofosbuvirModafinil
Severe
How does the drug interact with Myhep 400Mg 28 Tablets:
Coadministration of Myhep 400Mg 28 Tablets with Modafinil may significantly reduce the blood levels of Myhep 400Mg 28 Tablets.

How to manage the interaction:
Co-administration of Modafinil with Myhep 400Mg 28 Tablets can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having symptoms of stomach pain or swelling, Fatigue, Fever, Yellowing of skin or eyes, Dark urine, loss of appetite, or nausea contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
SofosbuvirPhenobarbital
Severe
How does the drug interact with Myhep 400Mg 28 Tablets:
Phenobarbital can drastically lower Myhep 400Mg 28 Tablets levels in the blood, making the medicine less effective.

How to manage the interaction:
Although taking phenobarbital with Myhep 400Mg 28 Tablets can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no major clinically established food interactions with Myhep 400Mg 28 Tablets. It can be taken safely with or without food.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Myhep 400Mg 28 Tablets is used to treat Chronic hepatitis C virus (HCV) infection.
Myhep 400Mg 28 Tablets contains Sofosbuvir, which lowers the amount of hepatitis C virus in the body and removes the virus from the blood over a period of time. Thus, it helps in reducing the amount of hepatitis C virus in the body.
Hepatitis C virus infection is contagious and spreads from one person to another through contact with an infected person’s blood. Therefore, it is recommended to avoid sharing personal items or needles containing an infected person's blood.
Myhep 400Mg 28 Tablets should be used with caution in diabetic patients as it may cause hypoglycaemia (low blood sugar) after starting the treatment. Therefore, if you have diabetes, inform your doctor before taking Myhep 400Mg 28 Tablets. Your doctor may monitor you closely, check your blood sugar levels or adjust your diabetes medication after starting Myhep 400Mg 28 Tablets.
No, Myhep 400Mg 28 Tablets is not a protease inhibitor. It is an antiviral medication called nucleotide polymerase inhibitor used to treat hepatitis C infection. It works by blocking the action of an enzyme called NS5B polymerase, which the hepatitis C virus needs to replicate and spread. On the other hand, protease inhibitors target a different enzyme called protease.
Myhep 400Mg 28 Tablets is an antiviral medication that can effectively treat Hepatitis C. When used in combination with other antiviral medications (such as ribavirin), it can offer a high chance of curing the infection. However, treatment success depends on several factors, including the type of Hepatitis C, the stage of liver damage, other underlying conditions, and how well the patient responds to the medication. Always follow your doctor's advice carefully and attend regular check-ups during and after treatment for the best chance of a successful cure.
Myhep 400Mg 28 Tablets may cause side effects like fever, headache, and nausea in some individuals. However, only some experience them. These side effects are usually mild and temporary. If they persist or worsen, consult your doctor.
No, you should avoid alcohol entirely during your treatment. Alcohol causes further stress and damage to your liver, which can slow down your recovery. Talk to your doctor or pharmacist if you need support avoiding alcohol.
No, you can take Myhep 400Mg 28 Tablets with or without food. The most important thing is to take it at the same time every day. If it causes mild stomach upset, taking it with food may help. Talk to your doctor if stomach discomfort persists.
If you vomit within 2 hours of taking Myhep 400Mg 28 Tablets, you should take another tablet. If you vomit more than 2 hours after your dose, you do not need to take another one. Talk to your doctor or pharmacist if you are unsure or if vomiting is a frequent problem.
Myhep 400Mg 28 Tablets is used in combination with other medications that may cause severe birth defects or harm to an unborn baby. It is critical to discuss reliable birth control options with your provider. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Hair loss is not a common side effect of Myhep 400Mg 28 Tablets alone. However, some combination regimens for hepatitis C can cause mild, temporary hair thinning. Talk to your doctor if you experience concerning changes in your hair or skin.
Some common pain relievers, like acetaminophen, can stress your liver and must be used cautiously if you have liver damage. Other pain relievers may interact with your medications. Talk to your doctor or pharmacist before taking any over-the-counter drugs.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Product Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 204671S002Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Hp003Part3V1. [Accessed on 02 Jun. 2026]Check here
  4. Gilead Sciences Ltd. Epclusa 400 mg/100 mg film-coated tablets sofosbuvir/Velpatasvir. Electronic Medicines Compendium (EMC) [Revised in May 2022] [Accessed on 4th January 2023].Check here
  5. Asegua Therapeutics LLC. SOFOSBUVIR AND VELPATASVIR- velpatasvir and sofosbuvir tablet, film coated. Dailymed.com. [Revised in May 2022]. [Accessed on 4th January 2023].Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 01 Apr. 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - MYH0009
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