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compositionComposition:PLERIXAFOR-24MG
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Prescription Medicine
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₹32649 with coupons & bank offers*

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Mozifer 1 Injection is used in the treatment of Non-Hodgkin’s Disease (a blood cancer that affects your lymph system) and multiple myeloma (a type of cancer that affects the plasma cells of the bone marrow). Mozifer 1 Injection contains Plerixafor, which belongs to the hemopoietic stem cell mobilizer class or drugs. It works by releasing stem cells from the bone marrow, making them available to collect from your bloodstream.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PLERIXAFOR-24MG

Manufacturer/Marketer :

Greenrev Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mozifer 1 Injection

Mozifer 1 Injection is an injectable medicine used to help collect blood-forming stem cells before an autologous stem cell transplant, a procedure in which your own stem cells are collected and later returned to your body. It is used in people with certain blood cancers, including non-Hodgkin lymphoma and multiple myeloma.

This medicine helps move blood-forming stem cells from the bone marrow into the bloodstream, where they can be collected by a special machine. It is generally used together with another medicine that helps increase stem cell production, such as filgrastim.

Mozifer 1 Injection is given as an injection under the skin before a planned stem cell collection. The timing is important because the medicine needs to increase the number of stem cells in the blood at the time of collection. Your healthcare team will coordinate your injections with your collection appointments.

Common side effects may include diarrhoea, nausea, headache, tiredness, and redness or swelling where the injection is given. Consult your doctor right away if you develop difficulty breathing, severe dizziness or fainting, or pain in the upper left side of your abdomen or left shoulder, as these symptoms require prompt medical assessment.

Before treatment, tell your doctor if you have kidney problems, as your dose may need to be reduced. Also tell your doctor if you have leukaemia, are pregnant or planning a pregnancy, or are breastfeeding. Plerixafor is not intended for stem cell collection in people with leukaemia because leukaemia cells may also be released into the bloodstream.

Uses of Mozifer 1 Injection

Your doctor may prescribe Mozifer 1 Injection to help with stem cell collection before an autologous stem cell transplant:

  • Stem cell collection in non-Hodgkin lymphoma: Mozifer 1 Injection helps move blood-forming stem cells from the bone marrow into the bloodstream so they can be collected for a future transplant.
  • Stem cell collection in multiple myeloma: This medicine helps increase the number of stem cells available in the blood for collection before transplantation.

Key Benefits

Mozifer 1 Injection helps increase the number of blood-forming stem cells available in the bloodstream for collection before an autologous stem cell transplant.

  • Improves stem cell collection: It helps move more stem cells into the blood, increasing the number available for collection.
  • Helps reach the collection target: It may help people who have difficulty producing enough circulating stem cells collect the number needed for transplantation.
  • Supports the transplant process: Collecting enough healthy blood-forming stem cells allows them to be stored and later returned to the body after treatment.
  • May reduce the need for additional collection sessions: Increasing the number of stem cells in the blood may help some people reach their collection target more efficiently.
     
Side effects of Mozifer 1 Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication. Typically, it is injected once a day, 11 hours prior to blood cell removal, for up to 4 days in a row.
  • Mozifer 1 Injection will be administered under the skin by a doctor or nurse in a medical facility.
  • Do not self-administer.

How Mozifer 1 Injection Works

Mozifer 1 Injection contains plerixafor. It blocks a protein called CXCR4, which normally helps keep blood-forming stem cells inside the bone marrow. By blocking CXCR4, plerixafor temporarily releases more stem cells from the bone marrow into the bloodstream. Once these cells are circulating in the blood, they can be collected using a process called apheresis, in which a machine separates the needed stem cells from the blood.
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Alcohol

Unsafe

It is unknown whether Mozifer 1 Injection interacts with alcohol or not. Please consult your doctor.

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Pregnancy

Unsafe

Mozifer 1 Injection is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Mozifer 1 Injection. Effective birth control is necessary during treatment and for one week after your last dose.

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Breast Feeding

Unsafe

Mozifer 1 Injection is not recommended if you are breastfeeding. You should not breastfeed while taking this medication and for one week after your last dose.

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Driving

Caution

Mozifer 1 Injection is generally administered to hospitalized patients. Driving is not advised after taking this medicine.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Mozifer 1 Injection. A dose adjustment may be made, or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Mozifer 1 Injection. A dose adjustment may be made, or a suitable alternative may be advised based on your condition.

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Children

Unsafe

Mozifer 1 Injection is not recommended for use in children as the safety and efficacy are not established.

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Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Mozifer 1 Injection.

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Geriatrics

Caution

Elderly patients may require caution and dose adjustments, as Mozifer 1 Injection may increase the risk of side effects.

What if I have taken an overdose of Mozifer 1 Injection

Because this medicine is generally given under medical supervision, an overdose is unlikely. If you receive or inject more than the prescribed amount, contact your healthcare team promptly. You may need monitoring and treatment for any symptoms that develop.

Diet & Lifestyle Advise

  • Stay hydrated: Drink enough fluids unless your healthcare team has advised you to limit your fluid intake.
  • Eat a balanced diet: Choose nutritious foods that provide enough energy and protein to support your body during transplant preparation.
  • Follow food-safety advice: If your immune system is weakened, carefully follow your healthcare team's instructions for preparing, cooking, and storing food.
  • Avoid strenuous activity when advised: Ask your healthcare team about exercise during stem cell mobilisation, particularly if there are concerns about enlargement of the spleen.
  • Get enough rest: Stem cell mobilisation and your underlying treatment may cause tiredness, so balance daily activity with adequate rest.
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Have a query?

How Soon It Starts Working

The time required for Mozifer 1 Injection to start to work: Mozifer 1 Injection ideally shows its action within 30 to 60 minutes after administration. The time for which the effects of Mozifer 1 Injection last: The effect of Mozifer 1 Injection lasts for 4 to 8 hours.

What if you forget to take Mozifer 1 Injection

The timing of this medicine is closely linked to your stem cell collection. If you miss an injection or collection appointment, contact your healthcare team as soon as possible. They will tell you when the medicine and collection procedure should be rescheduled. Do not take an extra dose yourself.

Storage

•Mozifer 1 Injection is usually stored and handled by healthcare professionals according to the instructions for the specific product, typically between 20°C and 25°C.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Keep to your collection schedule: The timing of your injection is coordinated with your stem cell collection, so attend all appointments as scheduled.
  • Report abdominal or shoulder pain: Consult your doctor right away if you develop pain in the upper left side of your abdomen or left shoulder, as this may indicate a problem with your spleen.
  • Tell your doctor about kidney problems: Your dose may need to be reduced if your kidneys are not working normally.
  • Mention a history of leukaemia: Plerixafor is not intended for stem cell mobilisation in people with leukaemia because cancerous cells may also be released from the bone marrow into the blood.
  • Watch for allergic reactions: Seek medical care for difficulty breathing, swelling, hives, severe dizziness, or fainting.
  • Avoid driving if you feel dizzy: Do not drive or operate machinery if the medicine makes you dizzy, light-headed, or faint.
  • Keep all blood tests and collection appointments: Your healthcare team will monitor the number of stem cells in your blood and determine whether further doses or collection sessions are needed.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Filgrastim: Plerixafor is commonly given with filgrastim to increase the number of blood-forming stem cells available for collection. This is an intended part of the treatment rather than a harmful interaction.
  • Other medicines used during transplant preparation: Your healthcare team will review all medicines used before stem cell collection and transplantation to make sure they can be used safely together.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Food: No clinically important food interaction is expected because this medicine is injected under the skin. Follow any dietary advice provided by your transplant team.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Mozifer 1 Injection is used to treat Multiple Myeloma, Non-Hodgkin’s Disease.
Mozifer 1 Injection contains Plerixafor, which works by binding to the chemokine receptor CXCR4 and inhibits the binding of its cognate ligand CXCL12.
Mozifer 1 Injection may cause tumor cell mobilization and haematological effects such as increased lymphocytes, decreased platelet count, and splenic rupture in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.
No. Plerixafor is used to help collect stem cells for transplantation. It is not used to kill cancer cells or directly treat the underlying cancer.
This medicine is injected under the skin before your scheduled stem cell collection. Your healthcare team will coordinate the timing of the injection with your collection procedure.
Filgrastim helps increase the production and release of blood-forming stem cells, while plerixafor helps release additional stem cells from the bone marrow into the bloodstream. Using them together can increase the number of cells available for collection.
You may be able to receive it, but your dose may need to be reduced depending on how well your kidneys are working. Your doctor will assess your kidney function before deciding the appropriate dose.
Rarely, stem cell mobilisation can be associated with enlargement or rupture of the spleen. Pain in the upper left abdomen or left shoulder can be a warning sign and requires prompt medical assessment.
The number of doses depends on your stem cell collection plan and how many cells are collected. Your healthcare team will decide whether additional doses and collection sessions are needed.
Plerixafor may harm an unborn baby. Tell your doctor if you are pregnant, think you may be pregnant, or are planning a pregnancy. Your doctor will advise you about appropriate contraception during treatment.
Tell your doctor if you are breastfeeding. Your healthcare team will advise whether breastfeeding should be stopped based on the potential risk to the baby and your treatment needs.
Some people may feel dizzy, light-headed, or tired. Do not drive or operate machinery if you experience symptoms that could affect your ability to do so safely.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

A- 701, FLORENTINE, HIRANANDANI GARDENS POWAI, MUMBAI, Maharashtra-400076
Other Info - MOZ0018
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