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  3. Midogest 2.5 Tablet 10's

Midogest 2.5 Tablet 10's, Pack of 10
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Midogest 2.5 Tablet 10's is used to treat orthostatic hypotension (sudden lowering in blood pressure on standing). It contains midodrine, which works by tightening the blood vessels, thereby increasing blood pressure. In some cases, this medicine may cause side effects such as headache, nausea, heartburn, and pain during urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Synonym :

MIDODRINE HYDROCHLORIDE

Composition :

MIDODRINE-2.5MG

Manufacturer/Marketer :

Bioventus Life Science

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Midogest 2.5 Tablet 10's

Midogest 2.5 Tablet 10's belongs to a category of medications called ‘Antihypotensives’ primarily used to treat hypotension (low blood pressure). Hypotension is when blood pressure drops below the normal range, reducing cardiac output and hypovolemia (low blood volume). It can cause dizziness, weakness, fainting, and risk of injury from falls.

Midogest 2.5 Tablet 10's contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.

Take Midogest 2.5 Tablet 10's as prescribed by your doctor. Depending on your medical condition, you are advised to take Midogest 2.5 Tablet 10's for as long as your doctor prescribes it. Some people may experience Supine hypertension, Reflex bradycardia, Arrhythmias, Rash, Nausea, Vomiting, Dyspepsia, Headache, and Urinary retention. Most of these side effects of Midogest 2.5 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to Midogest 2.5 Tablet 10's or other medicines. If you are a pregnant woman or nursing mother, do not consume Midogest 2.5 Tablet 10's without first consulting your doctor. It should not be used in children below 18 years. Midodrine is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.

Uses of Midogest 2.5 Tablet 10's

Treatment of Idiopathic postural hypotension or hypotension.

Directions for Use

• Midogest 2.5 Tablet 10's can be taken with meals.• It is usually taken 2-3 times daily during daytime, with each dose taken 3 hours apart, or as prescribed by your doctor.• Swallow Midogest 2.5 Tablet 10's as a whole with a glass of water.,• Do not crush, chew, or break it.

Medicinal Benefits

Midogest 2.5 Tablet 10's contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.

How Midogest 2.5 Tablet 10's Works

Midogest 2.5 Tablet 10's contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.

Storage

Keep Midogest 2.5 Tablet 10's out of the sight and reach of children.
Side effects of Midogest 2.5 Tablet
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Wear warm clothing, especially when it's cold outside.
  • Avoid drafts and heavy air conditioning.
  • Practice to stay calm during stressful or emotional situations.
  • Apply a cream that contains urea, lactic acid, salicylic acid, or alpha-hydroxy acid to help smooth rough patches and prevent more bumps.
  • Painful urination can be reduced by drinking lots of water.
  • Don't hold urine, as it can worsen the pain during urination.
  • Try taking probiotics and eating garlic, which can help reduce painful urination.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet and avoid bladder-irritating foods.
  • Quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Midogest 2.5 Tablet 10's

Take Midogest 2.5 Tablet 10's only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include palpitations, headache, pounding in ears, goose bumps, blurred vision, difficulty urinating, and cold sensation. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are known to be allergic to Midogest 2.5 Tablet 10's or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. If you get pregnant during treatment with Midodrine, you must stop the treatment immediately once the pregnancy is confirmed. It should not be used in children below 18 years. Midodrine is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.

Drug-Drug Interactions

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MidodrineDihydroergotamine
Critical
MidodrineErgotamine
Severe

Drug-Drug Interactions

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MidodrineDihydroergotamine
Critical
How does the drug interact with Midogest 2.5 Tablet:
Coadministration of Dihydroergotamine with Midogest 2.5 Tablet can increase the risk or severity of high blood pressure.

How to manage the interaction:
Taking Dihydroergotamine with Midogest 2.5 Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any of these symptoms like headaches, abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, eye redness, confusion, or slurred speech, consult a doctor right away. Do not discontinue any medications without consulting a doctor.
MidodrineErgotamine
Severe
How does the drug interact with Midogest 2.5 Tablet:
Using ergotamine together with Midogest 2.5 Tablet can increase the risk or severity of high blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Midogest 2.5 Tablet and Ergotamine, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MidodrineMethysergide
Severe
How does the drug interact with Midogest 2.5 Tablet:
Using methysergide maleate together with Midogest 2.5 Tablet may cause significant increases in blood pressure.

How to manage the interaction:
Co-administration of Midogest 2.5 Tablet with Methysergide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.
MidodrineIobenguane (131i)
Severe
How does the drug interact with Midogest 2.5 Tablet:
Coadministration of Midogest 2.5 Tablet with Iobenguane can cause a decrease in the absorption of Iobenguane resulting in a low treatment outcomes.

How to manage the interaction:
Co-administration of Midogest 2.5 Tablet with Iobenguane (131i) can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
MidodrineLinezolid
Severe
How does the drug interact with Midogest 2.5 Tablet:
Taking Midogest 2.5 Tablet along with linezolid could increase the risk or severity of high blood pressure.

How to manage the interaction:
Although taking linezolid with Midogest 2.5 Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
MidodrineDoxapram
Severe
How does the drug interact with Midogest 2.5 Tablet:
Coadministration of Midogest 2.5 Tablet with doxapram can increase effect of Doxapram.

How to manage the interaction:
Taking Doxapram with Midogest 2.5 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Add foods with high vitamin B12, including eggs, fortified cereals, and nutritional yeast, to your daily diet.

  • Salty foods can increase blood pressure. Try eating canned soup, cottage cheese, olives, and pickled items.
  • Drink coffee and caffeinated tea, which may increase blood pressure by stimulating the cardiovascular system.
  • Eat small meals more frequently; large meals may drop in blood pressure as your body works harder to digest larger meals.
  • Drink more water and limit alcohol; dehydration lowers blood pressure.
  • Change body position by standing up slowly.
  • Avoid prolonged bed rest.
  • If you exercise outdoors in extreme heat, take frequent breaks.
  • Avoid spending a long time in saunas, hot tubs, and steam rooms which cause dehydration.

Habit Forming

No

Therapeutic Class

ANTIHYPOTENSIVES

Midogest 2.5 Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Consuming alcohol along with Midogest 2.5 Tablet 10's is not advisable as it may cause unpleasant side effects.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Midogest 2.5 Tablet 10's in breastfeeding/nursing mothers.

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Driving

Caution

Patients who experience dizziness or lightheadedness while receiving Midodrine should refrain from operating machinery.

bannner image

Liver

Caution

Limited information is available on the use of Midogest 2.5 Tablet 10's in patients with liver disease. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

bannner image

Kidney

Caution

Limited information is available on the use of Midogest 2.5 Tablet 10's in patients with Kidney disease. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

bannner image

Children

Unsafe

Midogest 2.5 Tablet 10's is not recommended for children below 18 years of age.

Have a query?

FAQs

Midogest 2.5 Tablet 10's is used to treat idiopathic postural hypotension or hypotension (low blood pressure)

Midogest 2.5 Tablet 10's contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.

Do not stop taking Midogest 2.5 Tablet 10's on your own. Depending on your medical condition, you are advised to take Midogest 2.5 Tablet 10's for as long as your doctor has prescribed it for you. Do not hesitate to speak with your doctor if you experience difficulty while taking Midogest 2.5 Tablet 10's.

Midogest 2.5 Tablet 10's is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.

Midogest 2.5 Tablet 10's is metabolised to desglymidodrine, an active metabolite that activates alpha-1-adrenergic receptors on arterioles and venules, causing smooth muscle contraction and blood pressure increase. Midodrine may cause a drop in heart rate due to the vagal reflex.

The side effects of Midogest 2.5 Tablet 10's include nausea, vomiting, indigestion, supine hypertension (high blood pressure while lying down), and dysuria (painful or uncomfortable urination). If these side effects persist or worsen, please consult your doctor.

Yes, Midogest 2.5 Tablet 10's may cause high blood pressure when you are lying flat on your back (supine hypertension). Midogest 2.5 Tablet 10's should only be used by people whose low blood pressure affects their daily activities and in people who could not be treated successfully with other therapies.

You are advised not to lie down immediately after taking Midogest 2.5 Tablet 10's due to the risk of supine hypertension (high blood pressure when you are lying flat on your back). Therefore, it is recommended to take the final dose of the day at least 4 hours before bedtime. By elevating the head, you can reduce the risk of supine hypertension during the night.

Midogest 2.5 Tablet 10's may take about 1 hour to show its effects. Though the effect lasts for about 2-3 hours, the action lasts for a short time only.

Take Midogest 2.5 Tablet 10's exactly as advised by your doctor. It is taken orally with or without food. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Midogest 2.5 Tablet 10's is not recommended for patients who are allergic to any of its components, who have unusually slow heart rate, severe heart disease, high blood pressure, conditions causing tightening of the arteries, urinary retention (when the bladder cannot empty properly), overactive thyroid, enlarged prostate gland, pheochromocytoma (tumour of the adrenal medulla), acute or severe kidney disease, poor vision as a result of diabetes and narrow-angle glaucoma (elevated pressure in the eye).

Before starting Midogest 2.5 Tablet 10's, you may need to get your liver and kidney function tests done and check your blood pressure. After starting the treatment, keep a constant track of your heart rate and blood pressure, especially after lying down.

Symptoms of supine hypertension include shortness of breath, chest pain, palpitations (abnormalities of heartbeat), blurred vision, and headache. If you develop these symptoms, consult your doctor immediately. The doctor may lower the dose of Midogest 2.5 Tablet 10's or discontinue treatment if the symptoms persists.

You should be cautious while using Midogest 2.5 Tablet 10's and metoprolol together as it can decrease your heart rate significantly. If you experience dizziness, fainting and slow pulse, inform your doctor as the dose of these medicines may need to be adjusted. However, please consult your doctor before using other medicines with Midogest 2.5 Tablet 10's.

Country of origin

India

Manufacturer/Marketer address

311, 3rd Floor, Kraft 7, Opp Maruti Suzuki Showroom, Near Nehru Nagar Market, SG Highway, Gota, Ahmedabad
Other Info - MID0109

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:53 AM IST

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Reference

  1. https://www.dbth.nhs.uk/wp-content/uploads/2017/10/Midodrine-Information-Leaflet.pdf
  2. https://www.medicines.org.uk/emc/product/12496/smpc#gref
  3. https://www.medicines.org.uk/emc/files/pil.12496.pdf
  4. https://www.drugs.com/drug-interactions/midodrine.html
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