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  3. Methotex 500 mg Injection 20 ml

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Methotex 500 mg Injection 20 ml, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Methotex 500 mg Injection belongs to the class of antimetabolite medications used in the treatment of polyarticular juvenile rheumatoid arthritis, psoriasis, breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, bone cancer, and advanced stage non-Hodgkin's lymphomas. This medicine works by interfering with the immune system process that causes inflammation and prevents the growth of cancer-causing cells.
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Composition :

METHOTREXATE-500MG/20ML

Manufacturer/Marketer :

Getwell Oncology Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Methotex 500 mg Injection

Methotex 500 mg Injection belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis and severe psoriasis. Methotex 500 mg Injection is also used to treat cancer such as breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), bone cancer, and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Methotex 500 mg Injection contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Methotex 500 mg Injection prevents and stops the growth of cancer cells, thereby helps treat cancer. Methotex 500 mg Injection treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

Methotex 500 mg Injection will be administered by a qualified healthcare professional; do not self-administer. In some cases, Methotex 500 mg Injection may cause side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience any of the side effects persistently.

Do not take Methotex 500 mg Injection if you are pregnant or breastfeeding. Methotex 500 mg Injection may cause dizziness and fatigue, so avoid driving or operating machinery. Avoid consuming alcohol whilst on treatment with Methotex 500 mg Injection. If you are due to undergo any surgery, including dental surgery, inform the doctor that you are receiving Methotex 500 mg Injection. Do not have any vaccinations during treatment with Methotex 500 mg Injection without consulting your doctor. Inform your doctor about your medications and health condition to rule out any unpleasant side effects.

Uses of Methotex 500 mg Injection

Treatment of Rheumatoid arthritis, Psoriasis and Cancer

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Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Methotex 500 mg Injection will be administered by the doctor.• Do not self-administer.

Medicinal Benefits

Methotex 500 mg Injection belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis including polyarticular juvenile rheumatoid arthritis (arthritis in children) and severe psoriasis. Methotex 500 mg Injection helps treat rheumatoid arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Methotex 500 mg Injection treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Methotex 500 mg Injection is used to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Methotex 500 mg Injection prevents and stops the growth of cancer cells by interfering with DNA production.

How Methotex 500 mg Injection Works

Methotex 500 mg Injection contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Methotex 500 mg Injection prevents and stops the growth of cancer cells, thereby helps treat cancer.

Storage

• Store in a cool and dry place away from sunlight.• Keep Methotex 500 mg Injection out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Methotex 500 mg Injection 20 ml
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

What if I have taken an overdose of Methotex 500 mg Injection

Methotex 500 mg Injection is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include vomiting, diarrhoea and gastrointestinal bleeding, as well as severe bone marrow suppression and disturbance of liver function. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

Do not take Methotex 500 mg Injection if you are allergic to any of its contents; if you are pregnant or breastfeeding. Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Methotex 500 mg Injection may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue; runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately. Inform your doctor if you are undergoing radiation therapy; if you receive Methotex 500 mg Injection while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateDicloxacillin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Methotex 500 mg Injection 20 ml:
Co-administration of Etretinate with Methotex 500 mg Injection 20 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Methotex 500 mg Injection 20 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateDicloxacillin
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Co-administration of Methotex 500 mg Injection 20 ml with dicloxacillin can increase the levels and effects of Methotex 500 mg Injection 20 ml. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Methotex 500 mg Injection 20 ml and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateEtanercept
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Co-administration of Methotex 500 mg Injection 20 ml with etanercept can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between etanercept and Methotex 500 mg Injection 20 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateMeloxicam
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Co-administration of Meloxicam with Methotex 500 mg Injection 20 ml may increase the levels and side effects of Meloxicam.

How to manage the interaction:
Although there is a possible interaction between meloxicam and Methotex 500 mg Injection 20 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateProcaine benzylpenicillin
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Coadministration of Methotex 500 mg Injection 20 ml with procaine benzyl penicillin can increase the levels and side effects of Methotex 500 mg Injection 20 ml.

How to manage the interaction:
Although there is a possible interaction between procaine benzyl penicillin and Methotex 500 mg Injection 20 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms, consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateBaricitinib
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Co-administration of Baricitinib and Methotex 500 mg Injection 20 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Methotex 500 mg Injection 20 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateHuman immunoglobulin
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Taking Human immunoglobulin with Methotex 500 mg Injection 20 ml may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Methotex 500 mg Injection 20 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethotrexateEverolimus
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Coadministration of Everolimus with Methotex 500 mg Injection 20 ml can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Methotex 500 mg Injection 20 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexateTolmetin
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Coadministration of Methotex 500 mg Injection 20 ml with tolmetin can increase the levels and side effects of Methotex 500 mg Injection 20 ml.

How to manage the interaction:
Although there is a possible interaction between tolmetin and Methotex 500 mg Injection 20 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateThalidomide
Severe
How does the drug interact with Methotex 500 mg Injection 20 ml:
Using thalidomide together with Methotex 500 mg Injection 20 ml can increase the risk of developing blood clots.

How to manage the interaction:
Although there is a possible interaction between thalidoamide and Methotex 500 mg Injection 20 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, consult your doctor. Do not stop using any medications without consulting to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Methotex 500 mg Injection.

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Pregnancy

Unsafe

Methotex 500 mg Injection may cause serious birth defects. It is not recommended to take Methotex 500 mg Injection while you are pregnant.

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Breast Feeding

Unsafe

Methotex 500 mg Injection passes into breast milk. Avoid breastfeeding whilst on treatment with Methotex 500 mg Injection and for at least 1 week after the last dose.

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Driving

Caution

Methotex 500 mg Injection may cause dizziness and tiredness; do not drive or operate heavy machinery until you know how Methotex 500 mg Injection affects you.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Methotex 500 mg Injection.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Methotex 500 mg Injection.

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Children

Caution

The efficacy and safety of Methotex 500 mg Injection in children have been established in polyarticular-course juvenile rheumatoid arthritis and cancer chemotherapy. Please consult your doctor if you have any concerns regarding the usage of Methotex 500 mg Injection in children.

FAQs

Methotex 500 mg Injection acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.

Methotex 500 mg Injection works by suppressing the overactive immune system that is responsible for causing psoriasis. Methotex 500 mg Injection interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis.

Methotex 500 mg Injection may affect fertility in men and women. Consult your doctor if you have any concerns regarding this.

Methotex 500 mg Injection causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Methotex 500 mg Injection may make your skin sensitive to sunlight. Therefore, avoid prolonged or unnecessary exposure to sunlight or ultraviolet light such as tanning beds and sunlamps. Wear protective clothing, sunglasses, and sunscreen while going out.

Country of origin

India

Manufacturer/Marketer address

464, Udyog Vihar, Phase-V Sector 19, Gurugram Haryana 122016
Other Info - MET1888

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 18, 2025 | 7:01 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://medlineplus.gov/druginfo/meds/a682018.html
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011719s117lbl.pdf
  3. https://labeling.pfizer.com/ShowLabeling.aspx?id=15282

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