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  1. Home
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  3. Metaglez Forte Tablet 10's

Prescription drug
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Metaglez Forte Tablet 10's, Pack of 10 TABLETS
Metaglez Forte Tablet 10's, Pack of 10 TABLETS
Metaglez Forte Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Metaglez Forte Tablet is used in the treatment of type 2 diabetes mellitus. It contains Glipizide and Metformin, which promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. Also, it reduces serum glucose levels without increasing insulin secretion. It may cause common side effects such as hypoglycemia (low blood sugar levels), nausea, diarrhoea, indigestion, headache, dizziness, blurred vision, weakness, cold sweats, stomach pain, weight gain, and oedema (swelling). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

GLIPIZIDE-5MG + METFORMIN-500MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Metaglez Forte Tablet

Metaglez Forte Tablet belongs to the class of anti-diabetic drugs. It is used in the treatment of type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all.

Metaglez Forte Tablet is composed of two medicines, namely Glipizide and Metformin. Glipizide belongs to the class of sulfonylureas. It promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver.  It has the fastest absorption and onset of action compared to other sulfonylureas. Metformin belongs to the class of biguanides and is used to manage blood sugar levels, particularly in obese patients. It exhibits a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin.

Take Metaglez Forte Tablet with food at regular intervals as prescribed by your doctor to avoid stomach upset. Your doctor will decide the dosage form, and this may change timely depending on your blood sugar levels. The common side effects of Metaglez Forte Tablet include hypoglycemia (low blood sugar levels), nausea, diarrhoea, indigestion, headache, dizziness, blurred vision, weakness, cold sweats, stomach pain, weight gain, and oedema (swelling). Although not everyone experiences these side effects, if they occur, seek medical attention. Lactic acidosis, is a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation is reported. The risk of lactic acidosis is high in people with kidney, liver, and heart diseases.

Before starting Metaglez Forte Tablet , let your doctor know if you have any medical history of anaemia (low haemoglobin levels), seizures (fits), heart, kidney, and liver diseases. Also, speak to your doctor if you are on restricted food or fluid intake since Metaglez Forte Tablet causes dehydration, low blood sugar, and kidney damage. Do not take or stop this medicine, if the doctor did not advise you to do so.

Uses of Metaglez Forte Tablet

Metaglez Forte Tablet is used in the treatment of Type 2 Diabetes mellitus. The detailed uses of Metaglez Forte Tablet are as follows:

  • Management of Type 2 Diabetes: Metaglez Forte Tablet is primarily used to help control blood sugar levels in individuals with type 2 diabetes mellitus.
  • Weight Management: In some cases, Metaglez Forte Tablet may assist with weight management in diabetic patients by helping to regulate blood sugar levels and reduce hunger cravings.
  • Reduction of Complications: By maintaining stable blood glucose levels, Metaglez Forte Tablet may help reduce the risk of complications related to diabetes, such as neuropathy, retinopathy, and kidney damage.
  • Improvement of Insulin Sensitivity: Metaglez Forte Tablet may improve insulin sensitivity in patients, thereby aiding in the effective utilisation of glucose by the cells, which is crucial for maintaining energy levels and metabolic health.

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Directions for Use

• Take Metaglez Forte Tablet with meals or as advised by your doctor. • It is advised to take Metaglez Forte Tablet two times a day; however, follow your doctor’s recommendation regarding the dosage and duration. • Swallow Metaglez Forte Tablet as a whole with a glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

Metaglez Forte Tablet is used to treat type 2 diabetes mellitus. It is a combination of Glipizide and Metformin. Glipizide is effective in treating low blood sugar levels when used as an adjunct to diet and exercise. It promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. It also exhibits an extrapancreatic effect by improving insulin sensitivity at peripheral sites like muscle, fat, or liver cells. Metformin shows a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. It is considered to be a unique anti-diabetic drug since it does not lower blood sugar levels.

How Metaglez Forte Tablet Works

Metaglez Forte Tablet is composed of two medicines, namely Glipizide and Metformin. Glipizide belongs to the class of sulfonylureas. It promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver.  It has the fastest absorption and onset of action compared to other sulfonylureas. Metformin belongs to the class of biguanides and is used to manage blood sugar levels, particularly in obese patients. It exhibits a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Metaglez Forte Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

What if I have taken an overdose of Metaglez Forte Tablet

Do not take more than the prescribed dose of Metaglez Forte Tablet as it may cause overdose resulting in lactic acidosis or severe low blood sugar. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Metaglez Forte Tablet can cause weight gain hence possible measures like eating healthy food and exercising are advised. It may also increase the risk of cardiovascular diseases and hypoglycemic conditions in renal and liver disease patients. Metaglez Forte Tablet sometimes causes impairment of vitamin b12 absorption and results in anaemia (low haemoglobin levels). Metaglez Forte Tablet has an increased risk of lactic acidosis. The risk of lactic acidosis is high in older people with kidney, liver and heart diseases. Hence, brief your medical history and take advice from your doctor before starting Metaglez Forte Tablet . Avoid consuming excessive alcohol as it can potentiate lactic acidosis.

Drug-Drug Interactions

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MetforminIomeprol
Critical
MetforminIobitridol
Critical

Drug-Drug Interactions

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MetforminIomeprol
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Iomeprol with Metaglez Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metaglez Forte Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIobitridol
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Metaglez Forte Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metaglez Forte Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.
MetforminIoglicic acid
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Ioglicic acid with Metaglez Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metaglez Forte Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIoversol
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Ioversol with Metaglez Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metaglez Forte Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Iohexol with Metaglez Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metaglez Forte Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopromide
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Iopromide with Metaglez Forte Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Metaglez Forte Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIopanoic acid
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Iopanoic acid with Metaglez Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metaglez Forte Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminMetrizamide
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Metaglez Forte Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metaglez Forte Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIoglycamic acid
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Ioglycamic acid with Metaglez Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metaglez Forte Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopydol
Critical
How does the drug interact with Metaglez Forte Tablet:
Co-administration of Iopydol with Metaglez Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metaglez Forte Tablet with Iopydol is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a fiber-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.

  • Eat at regular intervals

  • Keep a check on your weight and exercise regularly to keep your heart healthy.

  • Your doctor also guides you on how to notice and manage the early symptoms of high/low blood sugar levels.

  • Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, and avoiding carbonated drinks and foods that cause gas.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Metaglez Forte Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

You are recommended to avoid consumption of alcohol with Metaglez Forte Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Caution

Metaglez Forte Tablet may affect the fetus during pregnancy. Please consult your doctor before starting Metaglez Forte Tablet .

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Breast Feeding

Caution

There is no sufficient data on how Metaglez Forte Tablet affects breastfeeding. It is safe to seek medical advice before you start Metaglez Forte Tablet if you are lactating.

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Driving

Caution

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if may experience dizziness or drowsiness.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment when you are prescribed Metaglez Forte Tablet .

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases when you are prescribed Metaglez Forte Tablet .

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Children

Caution

Please seek advice from a doctor before giving Metaglez Forte Tablet to a child.

FAQs

Metaglez Forte Tablet is used to treat Type 2 Diabetes mellitus.

Metaglez Forte Tablet promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. It works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines.

You are not recommended to stop taking Metaglez Forte Tablet on your own as discontinuing Metaglez Forte Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Metaglez Forte Tablet , please consult your doctor so that alternative medicine may be prescribed.

In type 1 diabetes, the body doesn’t produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completed. In type 2 diabetes, though islet cells are working, the body doesn’t respond to insulin as the body becomes resistant to insulin.

Metaglez Forte Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, and delay or missing snacks or meals. However, if you experience any signs of low blood pressure, such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

Take Metaglez Forte Tablet as advised by your doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Metaglez Forte Tablet should be taken preferably with a meal, as it lowers the blood sugar levels and causes gastrointestinal side effects. Follow your doctor’s instructions.

Metaglez Forte Tablet contains two anti-diabetic drugs, namely Glipizide and Metformin, as its active ingredients.

Metaglez Forte Tablet may cause side effects such as low blood sugar, nausea, indigestion, headache, diarrhoea, stomach pain, or blurred vision. If these side effects persist or worsen, please consult your doctor.

Yes, the use of Metaglez Forte Tablet can cause hypoglycemia (low blood sugar). Symptoms of hypoglycemia include hunger, dizziness, sweating, headache, nausea, irritability, fast heart rate and feeling anxious or shaky. It occurs more frequently if you miss or delay meals, over-exercise, drink alcohol, or take other antidiabetic medication along with it. Therefore, it is important to regularly monitor blood sugar levels. Always carry some fruit juice, honey or glucose tablets with you.

Yes, the use of Metaglez Forte Tablet can cause lactic acidosis. It is a medical emergency which occurs due to increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the metformin and thus, it is contraindicated in patients with underlying kidney disease, elderly patients or who consume large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, feeling of cold in arms and legs, dizziness, tiredness, difficulty in breathing, stomach pain, nausea, vomiting or slow heart rate. If you experience these symptoms, stop taking Metaglez Forte Tablet and consult your doctor immediately.

Yes, long term use of Metaglez Forte Tablet can cause Vitamin B12 deficiency. It interferes with absorption of Vitamin B12 in the stomach. If untreated, it may cause nerve problems and anemia and the patient may feel numbness and tingling sensation in the hands and feet, urinary problems, weakness, change in mental status and difficulty in maintaining balance (ataxia). To prevent such problems, some researchers recommend an intake of Vitamin B12 from external sources at least once a year.

Metaglez Forte Tablet is contraindicated in patients with known allergy to any of its components or excipients. Also, it should be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.

No, you are recommended to avoid alcohol consumption while taking Metaglez Forte Tablet , as it may lower blood sugar levels (hypoglycemia) and increase the risk of lactic acidosis.

Store Metaglez Forte Tablet at room temperature protected from moisture. Keep it out of reach of children.

It is recommended to take a doctor’s advice if you are pregnant or planning pregnancy before taking Metaglez Forte Tablet .

Metaglez Forte Tablet overdose can result in serious complications such as hypoglycaemia (low blood sugar) or lactic acidosis. Hence, if you suspect an overdose, seek medical attention immediately.

No, do not split or crush Metaglez Forte Tablet . Swallow it as whole with a glass of water.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - MET0082

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 11:46 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/dosage/glipizide-metformin.html
  2. https://www.ncbi.nlm.nih.gov/books/NBK459177/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214027/

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