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compositionComposition:EPALRESTAT-50MG+METHYLCOBALAMIN-500MCG
prescription
Prescription Medicine
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Mepal Tablet is used to treat diabetic neuropathy. It contains Epalrestat and Methylcobalamin which prevent the accumulation of sorbitol due to high blood sugar and promote the rejuvenation and protection of damaged nerve cells. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, dizziness, and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EPALRESTAT-50MG+METHYLCOBALAMIN-500MCG

Manufacturer/Marketer :

Kms Health Center Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mepal Tablet

Mepal Tablet is a prescription medicine designed to treat diabetic neuropathy, which is nerve damage caused by long-term high blood sugar. It helps relieve common symptoms of nerve distress, such as burning sensations, numbness, and tingling in the hands and feet. By targeting the underlying causes of nerve damage, this medicine helps maintain overall nerve function.

To get the best results, you must take Mepal Tablet consistently every single day as prescribed by your doctor. It is typically taken before meals to help your body absorb the active ingredients properly. Combining this medication with healthy lifestyle choices, such as maintaining a stable blood sugar level and eating a balanced diet, will significantly improve your overall recovery.

While taking Mepal Tablet , you may experience mild side effects like nausea, stomach discomfort, or a harmless change in your urine colour. However, if you notice severe skin rashes, persistent vomiting, or signs of liver issues, you must contact your doctor immediately. Your medical team can help monitor these symptoms and adjust your treatment if necessary.

Before starting this medication, talk to your doctor if you have a history of liver disease or kidney impairment. Do not take this if you have a known severe allergy to any of the ingredients in this formulation. Your doctor will evaluate your medical history to ensure this is the safest option for you.

This medicine can interact with certain other treatments, and drinking alcohol or smoking can reduce its effectiveness while worsening nerve pain. If you are pregnant, breastfeeding, or an elderly patient, you should consult your doctor before using this medicine to ensure it is safe for your specific situation.

Uses of Mepal Tablet

Mepal Tablet is used to treat diabetic neuropathy. The detailed uses of Mepal Tablet are as follows:

  • Diabetic Neuropathy: It is prescribed to manage and treat nerve damage in individuals with diabetes, helping to relieve symptoms like burning pain, tingling, and loss of sensation in the limbs.

Key Benefits

Mepal Tablet helps support healthy nerve function and provides relief from the symptoms of diabetic nerve damage. With regular use, it helps reduce nerve pain, improve sensation, and protect nerves from further damage.

  • Reduces Nerve Pain and Discomfort: By targeting the pathways responsible for nerve irritation, this medicine helps relieve burning, sharp-shooting pain, and tingling sensations in the hands and feet.
  • Improves Sensation and Mobility: By supporting the repair and protection of nerve pathways, this medicine helps restore normal sensation, improving balance, mobility, and overall physical comfort.
  • Supports Long-Term Nerve Health: This medicine helps protect existing nerve fibres and may slow the progression of diabetic nerve damage, supporting healthier nerve function and reducing the impact of elevated blood sugar on the nerves.

Directions for Use

  • Mepal Tablet can be taken with or without food as prescribed by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Mepal Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Mepal Tablet Works

Mepal Tablet works through a combination of two active ingredients that target nerve damage from different angles to protect and restore nerve health. The first active component, epalrestat, blocks a specific enzyme in the body called aldose reductase. When blood sugar levels are high, this enzyme converts excess glucose into a sugar alcohol called sorbitol. An accumulation of sorbitol inside nerve cells causes swelling and damages the nerves. By inhibiting this enzyme, the medicine prevents the build-up of sorbitol, protecting your nerve fibres from further damage. The second active component, methylcobalamin, is a specialised form of vitamin B12. It plays a critical role in the production of myelin, which is the protective sheath that covers and insulates your nerves. This ingredient also helps in regenerating damaged nerve cells and improves nerve signal transmission, which directly relieves pain and restores sensation in your limbs.
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Alcohol

Caution

Avoid consumption of alcohol while taking Mepal Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Mepal Tablet ; your doctor will decide whether Mepal Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Mepal Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Limited information is available regarding the use of Mepal Tablet in patients with liver disease. Please consult your doctor.

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Kidney

Caution

Limited information is available regarding the use of Mepal Tablet in patients with kidney impairment. Please consult your doctor.

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Children

Caution

Mepal Tablet should not be given to children as safety and efficacy have not been established.

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Heart

Caution

Limited information was available regarding the use of Mepal Tablet in patients with heart problems. Please consult your doctor before using Mepal Tablet .

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Geriatrics

Caution

Limited information is available regarding the use of Mepal Tablet in elderly patients. If you have any concerns about the usage of Mepal Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Mepal Tablet

Take Mepal Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Monitor Blood Sugar closely: Consistently managing your blood glucose levels is the most effective way to prevent further nerve damage and help this medicine work efficiently.
  • Check Your Feet Daily: Because diabetic neuropathy reduces sensation, inspect your feet daily for cuts, blisters, sores, or redness that you might not feel.
  • Eat a Nutrient-Rich Diet: Focus on foods rich in antioxidants and vitamins, such as leafy greens, whole grains, and lean proteins, to support your body's natural nerve repair processes.
  • Stay Physically Active: Engage in regular, low-impact exercise like walking, cycling, or swimming to improve blood flow to your hands and feet, which aids in nerve health.
  • Avoid Smoking and Alcohol: Both smoking and heavy drinking can worsen nerve damage and impair your body's ability to absorb essential vitamins.
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Have a query?

How Soon It Starts Working

The time required for Mepal Tablet to start to work: The time required for Mepal Tablet to show its action is unknown. The time for which the effects of Mepal Tablet last: The duration of action for Mepal Tablet is clinically unknown.

What if you forget to take Mepal Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store the tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Your urine may turn a reddish colour while taking this medicine. This is a normal, harmless side effect and is not a cause for concern.
  • Always complete the entire course of treatment prescribed by your doctor, even if your nerve pain begins to improve early on.
  • Have your liver function checked regularly if recommended by your doctor, as routine blood tests can monitor your liver health during long-term therapy.
  • Do not share this medication with anyone else, even if they have identical symptoms of diabetic nerve pain.

verifiedApollotooltip
  • Metformin: Long-term use of metformin can reduce the absorption of the vitamin component in Mepal Tablet , which may require monitoring.
  • Proton Pump Inhibitors and H2 Blockers: Medicines that lower stomach acid (such as omeprazole or ranitidine) can interfere with how well your body absorbs the vitamin portion of this medicine.
  • Aminosalicylic Acid: Medications used to treat certain bowel conditions or tuberculosis can decrease the absorption and effectiveness of this treatment.

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verifiedApollotooltip
  • Alcohol: Consuming alcohol can increase the risk of nerve damage and counteract the therapeutic benefits of Mepal Tablet .

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Mepal Tablet is a combination of two drugs, namely: Epalrestat and Methylcobalamin. Epalrestat prevents the accumulation of sorbitol by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Mepal Tablet helps in treating diabetic neuropathy.
Diarrhoea could be a side-effect of Mepal Tablet . Drink plenty of fluids to prevent dehydration and consume non-spicy meals if you experience diarrhoea. Consult your doctor if you have severe diarrhoea.
Before taking Mepal Tablet , inform your doctor if you have liver disease, kidney disease, allergies to any of its ingredients, or if you are pregnant or breastfeeding. Also tell your doctor if you have worsening numbness, burning or tingling sensations, non-healing foot sores, problems with urination, digestion, or sexual function, or any other unusual symptoms. This helps your doctor determine whether this medicine is suitable for you.
Do not discontinue Mepal Tablet without consulting your doctor. To treat your condition effectually, continue taking Mepal Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Mepal Tablet .
Mepal Tablet may cause peripheral oedema. Peripheral oedema is the swelling of the hands and lower legs. Avoid sitting or standing for too long. Raise your legs by putting a pillow under the legs while lying down.
No. Mepal Tablet does not lower blood sugar or treat diabetes itself. It is used to treat diabetic neuropathy (nerve damage caused by diabetes). Continue taking your prescribed diabetes medicines and maintain good blood sugar control, as this helps prevent further nerve damage. Talk to your doctor for more information.
Mepal Tablet is primarily used to treat diabetic neuropathy, which is a type of nerve damage caused by diabetes. It helps relieve symptoms like burning, numbness, tingling, and pain in the hands and feet. Talk to your doctor for more details.
Yes, this medicine can cause your urine to turn a reddish or darker colour. This is a common and harmless side effect of the medicine. Talk to your doctor if you experience pain or other urinary symptoms.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can worsen nerve damage and decrease the effectiveness of your treatment. Talk to your doctor or pharmacist if you have questions.
Mepal Tablet is usually taken before meals on an empty stomach to ensure your body absorbs the medicine effectively. However, you should always follow the specific timing instructions provided by your doctor.
The safety of this medicine during pregnancy or breastfeeding has not been fully established. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before starting this medication.
While Mepal Tablet helps manage painful symptoms, supports nerve repair, and prevents further damage, it is not a permanent cure for diabetic neuropathy. It must be paired with consistent blood sugar control. Talk to your doctor for a complete management plan.
If you develop a skin rash, itching, swelling, or any other signs of an allergic reaction, stop taking the medicine immediately and call your doctor or seek emergency medical help right away.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

No. 50-51, Balagi Nagar, 3rd Cross Street, Padi, Chennai-600050, Tamil Nadu, India
Other Info - MEP0116

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