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  3. Mejorasp 3750IU Injection 5 ml

Mejorasp 3750IU Injection 5 ml, Pack of 1 INJECTION
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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy

Mejorasp 3750IU Injection 5 ml is used to treat Acute Lymphoblastic Leukaemia, mainly as a first-line treatment. It is also beneficial for patients who are allergic to asparaginase. It works by lowering plasma asparagine, a necessary component for leukaemia cells to survive. Common side effects include nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. Let the doctor know if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Composition :

PEG L ASPARAGINASE-750IU/ML

Manufacturer/Marketer :

Sayre Therapeutics Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Mejorasp 3750IU Injection 5 ml

Mejorasp 3750IU Injection 5 ml is used in the treatment of Acute Lymphoblastic Leukaemia (ALL) and hypersensitivity to asparaginase. Acute lymphoblastic leukaemia is a type of cancer where the body makes too many abnormal white blood cells. These cells proliferate quickly and interfere with normal blood cell production, causing symptoms such as fatigue and easy bruising. It is more common in children but can also affect adults.

Mejorasp 3750IU Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood. Since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die.

A healthcare professional will administer Mejorasp 3750IU Injection 5 ml. In some cases, this medicine may cause side effects like nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. The majority of these side effects may not require medical treatment and will subside with time. However, if the side effects persist or worsen, see a doctor.

Before starting treatment, be sure to inform your doctor about any other medications or herbal products you are currently taking. Mejorasp 3750IU Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment. Pregnant and breastfeeding women should consult their doctor before receiving Mejorasp 3750IU Injection 5 ml. This medicine is given to children in doses as advised by the doctor, depending on the age. Mejorasp 3750IU Injection 5 ml should be stored in cold places at 2°C to 8°C.

Uses of Mejorasp 3750IU Injection 5 ml

First-line Treatment of Acute Lymphoblastic Leukaemia (ALL): Mejorasp 3750IU Injection 5 ml is used as the first-line treatment for Acute Lymphoblastic Leukaemia. It works by breaking down the amino acid asparagine, which is required for leukaemia cell survival, thereby reducing proliferation and promoting recovery.<br/>Treatment of Acute Lymphoblastic Leukemia (ALL): Mejorasp 3750IU Injection 5 ml is also used in the general management of Acute Lymphoblastic Leukemia.<br/>Patients with Hypersensitivity to Asparaginase: Mejorasp 3750IU Injection 5 ml is used as an alternative in patients who have developed hypersensitivity reactions to other forms of asparaginase. Its PEGylated formulation reduces the risk of immune responses and allows for prolonged therapeutic activity.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Mejorasp 3750IU Injection 5 ml will be administered by a healthcare professional in a medical setting.
  • Do not self-administer.

Medicinal Benefits

Mejorasp 3750IU Injection 5 ml is a pegylated form of L-asparaginase, an enzyme that breaks down L-asparagine. This enzyme specifically targets leukaemia cells in acute lymphoblastic leukaemia (ALL), which cannot produce enough L-asparagine on their own and depend on it from the blood for protein production. It works by breaking down the amino acid asparagine, which leukaemia cells need to proliferate. Its pegylated form reduces the risk of hypersensitivity reactions and provides a longer duration of action, allowing for less frequent dosing. This makes it more tolerable for patients, especially those who have experienced allergic reactions to other forms of asparaginase.

How Mejorasp 3750IU Injection 5 ml Works

Mejorasp 3750IU Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood. Since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die.

Storage

• Store in a cool and dry place away from sunlight.• Keep Mejorasp 3750IU Injection 5 ml out of the sight and reach of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Mejorasp 3750IU Injection 5 ml
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
  • Regularly exercise and have a balanced diet to maintain a healthy weight.
  • Eat fruits and vegetables to maintain a healthy weight.
  • Include vitamin K-rich foods in your diet for stable anticoagulation control.
  • Limit red and processed meats.
  • Avoid smoking and consumption of alcohol to improve your condition.
Managing Medication-Triggered Pancreatitis: A Step-by-Step Guide:
  • If you take medication and get severe stomach pain, feel nauseous, vomit, or have a fever, get emergency medical help right away. This could be a sign of pancreatitis, an inflammation of the pancreas.
  • Your doctor may alter your treatment plan, provide supportive therapy, or prescribe alternative medications to manage the reaction. They will also perform regular tests to monitor your progress and adjust your treatment as needed.
  • Follow your doctor's advice, including dietary recommendations and lifestyle changes, and avoid triggers like alcohol and fatty foods.
  • Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Add legumes, whole grains, fruits, vegetables, nuts and seeds in your diet.
  • Limit refined carbohydrates, sugary drinks and processed foods.
  • Eat healthy fats such as olive oil, avocado and nuts in moderate amounts.
  • Choose poultry, fish and lean meat sources.
  • To control calorie intake, pay attention to serving sizes.
  • Do regular exercise for 150 minutes per week, like cycling, walking or swimming.
  • Aim for weight loss if you are overweight as even losing small amount of weight can have a big impact on glucose intolerance.
  • Quit smoking and limit alcohol consumption.
  • Get sufficient sleep to support hormone regulation and overall health.
  • Inform your doctor about your blood clotting disorder for proper diagnosis and treatment.
  • Avoid unusual clotting by following your physician's prescription for medications.
  • Do not stand or sit for extended periods of time.
  • Regular workouts help one to enhance circulation and lower risk associated with a blood clot.
  • Give up smoking to better your health.
  • Maintain a healthy weight to reduce pressure on veins and lower blood clot risk.

What if I have taken an overdose of Mejorasp 3750IU Injection 5 ml

Mejorasp 3750IU Injection 5 ml is administered in a controlled medical setting by a healthcare professional, and the likelihood of an overdose is much less. However, if you suspect an overdose or experience any unusual effects, seek medical attention immediately.

Drug Warnings

Inform your doctor if you have had severe allergic reactions to asparaginase, bleeding problems, or blood clots. Let your doctor know if you get a fever, have liver issues, or take medicines that could harm your liver. Mejorasp 3750IU Injection 5 ml can cause liver damage, brain problems, or pancreas issues. If you experience stomach pain, let your doctor know. Mejorasp 3750IU Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment. If you are pregnant, planning for pregnancy, or are breastfeeding, please inform your doctor before receiving Mejorasp 3750IU Injection 5 ml. Avoid driving after receiving Mejorasp 3750IU Injection 5 ml if you experience drowsiness or dizziness.

Drug-Drug Interactions

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PegaspargaseInfliximab
Severe
PegaspargaseClozapine
Severe

Drug-Drug Interactions

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PegaspargaseInfliximab
Severe
How does the drug interact with Mejorasp 3750IU Injection 5 ml:
Combining Mejorasp 3750IU Injection 5 ml with Infliximab can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Mejorasp 3750IU Injection 5 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PegaspargaseClozapine
Severe
How does the drug interact with Mejorasp 3750IU Injection 5 ml:
Co-administration of clozapine with Mejorasp 3750IU Injection 5 ml may increase the risk and/or severity of infection.

How to manage the interaction:
Although there is a possible interaction between Mejorasp 3750IU Injection 5 ml and Clozapine, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet that includes fruits and vegetables rich in nutrients and low-fat proteins, such as lean meats, fish, and poultry.
  • Reduce your intake of sugary foods in order to control your blood sugar levels.
  • Include leafy greens and cruciferous vegetables in your diet to improve liver health.
  • Avoid alcohol consumption.
  • Engage in moderate exercise to maintain strength and reduce fatigue.
  • Get adequate sleep and rest.
  • Practice proper hygiene and prevent contact with sick persons.
  • Try relaxation techniques such as meditation or deep breathing.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

Avoid or limit alcohol consumption while on treatment with Mejorasp 3750IU Injection 5 ml as it may worsen your condition.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Mejorasp 3750IU Injection 5 ml. Your doctor will prescribe this medicine only if clearly needed.

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Breast Feeding

Caution

It is not known if Peg-L-Asparaginase passes into breast milk. Please consult the doctor if you are breastfeeding. Your doctor will advise you to discontinue breastfeeding or the medicine based on your condition.

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Driving

Caution

Mejorasp 3750IU Injection 5 ml may cause drowsiness or dizziness. If you experience any such side effects, avoid driving or operating machinery.

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Liver

Caution

If you have pre-existing or a history of liver disease, inform your doctor before receiving Mejorasp 3750IU Injection 5 ml. Your doctor may recommend regular tests to monitor liver function while receiving Mejorasp 3750IU Injection 5 ml.

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Kidney

Caution

If you have pre-existing or a history of kidney disease, inform your doctor before receiving Mejorasp 3750IU Injection 5 ml. Your doctor may recommend regular tests to monitor kidney function while receiving Mejorasp 3750IU Injection 5 ml.

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Children

Safe if prescribed

The dosage for children is recommended based on their age, body weight, and the child's condition.

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Heart

Please inform your doctor if you have heart problems before taking Mejorasp 3750IU Injection 5 ml, as it may cause blood clots, allergic reactions, and changes in blood pressure or glucose levels, which can be more serious in individuals with cardiovascular conditions.

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Geriatrics

Caution

Please inform your doctor if you are geriatric before taking Mejorasp 3750IU Injection 5 ml, as there is limited information available on its safety in this age group.

Have a query?

FAQs

Mejorasp 3750IU Injection 5 ml is used in the treatment of Acute Lymphoblastic Leukaemia (ALL) and hypersensitivity to asparaginase.

Mejorasp 3750IU Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood, and since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die. Thereby, Mejorasp 3750IU Injection 5 ml helps treat Acute Lymphoblastic Leukaemia.

Mejorasp 3750IU Injection 5 ml may cause glucose intolerance in some people. Consult the doctor if you have high/low blood glucose levels.

Mejorasp 3750IU Injection 5 ml is given as an injection, usually through an intravenous (IV) or intramuscular (IM) route. The dosage and frequency depend on your condition and doctor’s recommendation.

Mejorasp 3750IU Injection 5 ml may cause stomach pain in some patients. You are advised to inform your doctor immediately if you experience stomach pain, as it may be a sign of pancreatitis, an inflammation of the pancreas.

Do not drive or operate machinery while using this medication, as it may cause drowsiness, fatigue, or confusion, which can reduce your ability to concentrate and respond quickly.

Mejorasp 3750IU Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment.

If you have a history of liver complications, inform your doctor before receiving Mejorasp 3750IU Injection 5 ml, as it can affect liver function. Individuals with a history of liver issues are at higher risk for liver damage. Your doctor will monitor liver function through regular tests and may adjust the dosage if necessary.

Yes, Mejorasp 3750IU Injection 5 ml can be administered to children, particularly to treat Acute Lymphoblastic Leukaemia (ALL). However, the dosage and administration are adjusted based on the child's age and weight. Always follow your doctor's recommendations for pediatric use.

During your treatment with Mejorasp 3750IU Injection 5 ml, avoid alcohol, infection risks, blood-thinning medications, and unapproved treatments. Check with your doctor before taking any new medications or supplements, and avoid high-fat foods if you experience digestive issues. Consult a doctor if you have any concerns or if any signs of infection occur.

Mejorasp 3750IU Injection 5 ml causes side effects such as nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. Seek medical care if the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

91, 3rd Floor, G. R. Square, Amarjyothi Nagar HBCS Layout, Inner Ring Road, Domlur, Bangalore 560071, Karnataka, India
Other Info - MEJ0004

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Keep Refrigerated. Do not freeze.

Reference

  1. https://www.heterohealthcare.com/peg-l-aspatero-injection
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103411s5126lbl.pdf
  3. https://pdf.hres.ca/dpd_pm/00059708.PDF
  4. https://www.medicines.org.uk/emc/files/pil.10824.pdf
  5. https://www.sciencedirect.com/science/article/pii/S0959804921012260
  6. https://medlineplus.gov/druginfo/meds/a695031.html#precautions

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