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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Megmabend Leo 400mg/150mg Tablet is used to treat parasitic worm infections. It contains albendazole and levamisole. Albendazole inhibits tubulin polymerization, causing metabolic disruption and energy depletion in the parasite, leading to immobilization. Levamisole suppresses the worm's muscle's enzyme activity, leading to paralysis and death; this eventually leads to the death of susceptible helminths and thus prevents the growth of parasitic infections.

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Consume Type :

ORAL

Return Policy :

Not Returnable

About Megmabend Leo 400mg/150mg Tablet

Megmabend Leo 400mg/150mg Tablet belongs to the class of medications called 'anthelmintics' used to treat parasitic worm infections. Parasitic worm infections are intestinal worm infections that are caused by the ingestion of contaminated food and water.

Megmabend Leo 400mg/150mg Tablet contains albendazole and levamisole. Albendazole works by inhibiting tubulin polymerization, causing metabolic disruption and energy depletion in the parasite, leading to immobilization. Levamisole works by suppressing the worm's muscle's enzyme activity, leading to paralysis and death. This eventually leads to the death of susceptible helminths and thus prevents the growth of parasitic infections.

Take Megmabend Leo 400mg/150mg Tablet as prescribed by your doctor. The common side-effects of Megmabend Leo 400mg/150mg Tablet are nausea, vomiting, indigestion, diarrhoea, metallic taste, headache, dizziness, and stomach pain. Most of these side effects do not require medical attention and resolve gradually over time. If any of the side effects persist or worsen, please consult your doctor.

Avoid taking Megmabend Leo 400mg/150mg Tablet if you are allergic to 'albendazole', 'levamisole', or any ingredients present in it. It may cause dizziness, so refrain from activities that require you to stay alert. Megmabend Leo 400mg/150mg Tablet is not recommended in pregnancy. Before taking Megmabend Leo 400mg/150mg Tablet, inform your doctor about your complete medical history.

Uses of Megmabend Leo 400mg/150mg Tablet

Megmabend Leo 400mg/150mg Tablet is used in the treatment of Parasitic worm infections. The detailed uses of Megmabend Leo 400mg/150mg Tablet are as follows:<br/>• Intestinal Worm Infections: Megmabend Leo 400mg/150mg Tablet is used to treat parasitic worm infestations such as roundworms, hookworms, and whipworms. It works by disrupting the worms’ metabolism and paralyzing them, leading to their death and elimination from the body.<br/>• Ascariasis and Other Helminthic Conditions: Megmabend Leo 400mg/150mg Tablet is effective against a wide range of helminths by preventing glucose absorption in the parasites and suppressing their muscle activity, which leads to energy depletion and paralysis.<br/>

Directions for Use

• Take Megmabend Leo 400mg/150mg Tablet with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Megmabend Leo 400mg/150mg Tablet contains 'Albendazole' and 'Levamisole', which belong to the class of medications called 'anthelmintics'. It is a broad-spectrum antibiotic used in the treatment of parasitic infections. It can kill the disease-causing worms and stop the spread of infection effectively. Albendazole interrupts the absorption of glucose by the worm, leading to energy depletion. Levamisole works by suppressing the enzyme activity in the worm's muscle; this leads to paralysis and death.

How Megmabend Leo 400mg/150mg Tablet Works

Megmabend Leo 400mg/150mg Tablet contains albendazole and levamisole. Albendazole works by inhibiting tubulin polymerization, causing metabolic disruption and energy depletion in the parasite, leading to immobilization. Levamisole works by suppressing the worm's muscle's enzyme activity, leading to paralysis and death. This eventually leads to the death of susceptible helminths and thus prevents the growth of parasitic infections.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Megmabend Leo 400mg/150mg Tablet out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Megmabend Leo 400mg/150mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Megmabend Leo 400mg/150mg Tablet may include diarrhea, vomiting, tachycardia, and respiratory distress. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Megmabend Leo 400mg/150mg Tablet if you are allergic to any component present in it; if you are unsure, check with your healthcare professional. Due to the risk of liver or bone marrow damage during albendazole therapy, blood counts and liver function tests should be performed regularly (at least once every two weeks). Albendazole may cause fetal damage; thus, women of reproductive age should begin medication after a negative pregnancy test. Women of reproductive age should avoid becoming pregnant while taking Megmabend Leo 400mg/150mg Tablet or within one month of completing therapy. Megmabend Leo 400mg/150mg Tablet should be taken with food.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Co-administration of Megmabend Leo 400mg/150mg Tablet with Clozapine may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Megmabend Leo 400mg/150mg Tablet and Clozapine, you can take these medicines together if advised by your doctor. However, if you develop symptoms such as chills, diarrhea, fever, sore throat, shortness of breath, muscle pains, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Taking Megmabend Leo 400mg/150mg Tablet with Cladribine can increase the risk of side effects.

How to manage the interaction:
Although taking Cladribine and Megmabend Leo 400mg/150mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not stop using any medications without talking to a doctor.
LevamisoleVoclosporin
Severe
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Taking voclosporin together with Megmabend Leo 400mg/150mg Tablet may increase the risk of infections.

How to manage the interaction:
There may be a possibility of interaction between Megmabend Leo 400mg/150mg Tablet and Voclosporin, but it can be taken if prescribed by a doctor. If you have any of these symptoms - fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - immediately contact your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
When cladribine and Megmabend Leo 400mg/150mg Tablet are used together, there is a higher chance of getting serious infections.

How to manage the interaction:
There may be a possibility of interaction between Megmabend Leo 400mg/150mg Tablet and Leflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
LevamisoleRotavirus vaccine
Severe
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Taking Megmabend Leo 400mg/150mg Tablet and rotavirus vaccine together increases the risk of infection and also decreases the efficacy of the vaccine.

How to manage the interaction:
Although taking Megmabend Leo 400mg/150mg Tablet and Rotavirus vaccine together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Using natalizumab together with Megmabend Leo 400mg/150mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Although using natalizumab and Megmabend Leo 400mg/150mg Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Coadministration of baricitinib and Megmabend Leo 400mg/150mg Tablet can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Megmabend Leo 400mg/150mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
The combined use of Megmabend Leo 400mg/150mg Tablet and cladribine can increase the risk of infections.

How to manage the interaction:
Although taking Megmabend Leo 400mg/150mg Tablet and Cladribine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Taking fingolimod together with Megmabend Leo 400mg/150mg Tablet may increase the risk of infections.

How to manage the interaction:
Although using fingolimod together with Megmabend Leo 400mg/150mg Tablet can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Megmabend Leo 400mg/150mg Tablet:
Deferiprone can lower white blood cell count, and combining it with other medications like Megmabend Leo 400mg/150mg Tablet can also affect white blood cells or bone marrow function, may increase the risk. You may be more likely to develop serious infections.

How to manage the interaction:
Taking Megmabend Leo 400mg/150mg Tablet with Deferiprone together can result in an interaction, but they can be taken together if your doctor advises. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort or burning during urination. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Regularly wash your child's hands with soap and water.
  • Avoid giving raw fish and meat.
  • Thoroughly cook meat before eating.
  • Wash all fruits and vegetables properly before consuming them.
  • Wash or reheat food that has been around for a long time.
  • Avoid contact with soil that may be contaminated with faeces.
  • Avoid keeping foods open in the markets as they can be contaminated.
  • Drink boiled and purified water.

Habit Forming

No

Therapeutic Class

ANTIHELMINTICS
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Alcohol

Caution

Megmabend Leo 400mg/150mg Tablet may interact with alcohol and worsen your condition. So, consumption of alcohol should be avoided.

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Pregnancy

Caution

Megmabend Leo 400mg/150mg Tablet should not be used in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Megmabend Leo 400mg/150mg Tablet.

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Breast Feeding

Safe if prescribed

Megmabend Leo 400mg/150mg Tablet is considered safe to be used in breastfeeding. However, consult your doctor before taking Megmabend Leo 400mg/150mg Tablet.

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Driving

Caution

Megmabend Leo 400mg/150mg Tablet may cause dizziness, so do not drive or operate heavy machinery until you are alert.

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Liver

Caution

In patients with hepatic dysfunction, Albendazole has been demonstrated to induce aplastic anaemia, agranulocytosis, and bone marrow suppression. Hence, Megmabend Leo 400mg/150mg Tablet should be used with caution in patients with liver disease. Dose adjustments may be necessary. So, discuss with your doctor before receiving Megmabend Leo 400mg/150mg Tablet if you have a history of liver diseases/conditions.

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Kidney

Consult your doctor

Limited data is available. If you have kidney problems, inform your doctor before taking Megmabend Leo 400mg/150mg Tablet.

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Children

Safe if prescribed

Megmabend Leo 400mg/150mg Tablet should be used in children only if clinically needed. Please consult your child's doctor for more information.

Have a query?

FAQs

Megmabend Leo 400mg/150mg Tablet is used to treat Parasitic worm infections.

Megmabend Leo 400mg/150mg Tablet is a combination of two drugs, albendazole and Levamisole. It is used to treat certain parasite infections. It kills the parasite by preventing it from using glucose and, therefore, diminishing its energy reserves. It also paralyzes the insect, causing it to die.

Combining these two drugs may offer an effective solution for Parasitic worm infections.

Megmabend Leo 400mg/150mg Tablet is not an antibiotic. It is an anthelmintics medication used to treat parasitic worm infections in the stomach and intestine.

Common symptoms of intestinal worms are stomach or abdominal pain, diarrhoea, nausea, vomiting, gas formation, bloating, fatigue and unexplained weight.

Country of origin

India
Other Info - ME12603

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