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Macox-ZH Tablet is used to treat tuberculosis. It works by inhibiting the growth of the tuberculosis-causing bacteria. This medicine may sometimes cause side effects such as weakness, nausea, vomiting, stomach pain, and joint or muscle pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Macox-ZH Tablet

Macox-ZH Tablet belongs to the group of medicines called 'anti-tuberculosis drugs' primarily used to treat tuberculosis, also known as TB. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis that mainly affects the lungs but can also spread to other body parts such as kidneys, brain, spine, and bone marrow. Macox-ZH Tablet does not work against infections caused by the virus, including colds and flu.

Macox-ZH Tablet combines three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).

Take Macox-ZH Tablet as prescribed. Sometimes, you may experience common side effects such as weakness, nausea, vomiting, stomach pain, and joint or muscle pain. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.

Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking Macox-ZH Tablet as they might cause interaction. Maintain a gap of one hour between Macox-ZH Tablet and antacid medicines. Consult your doctor before taking Macox-ZH Tablet if you are pregnant. Avoid breastfeeding while taking Macox-ZH Tablet as it passes into breast milk.

Uses of Macox-ZH Tablet

Macox-ZH Tablet is used to treat Tuberculosis. The detailed uses of Macox-ZH Tablet are as follows:

  • Treatment of Tuberculosis (TB): Macox-ZH Tablet is a cornerstone in the initial intensive phase of TB therapy. It targets Mycobacterium tuberculosis, the bacteria responsible for the disease.
  • Pulmonary and Extrapulmonary TB: Effective against TB in the lungs as well as other parts of the body like lymph nodes, bones, and the central nervous system.

Key Benefits

Macox-ZH Tablet combines three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Macox-ZH Tablet belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat tuberculosis. Rifampicin inhibits DNA-dependent RNA polymerase activity in bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).

Directions for Use

  • Macox-ZH Tablet should be taken on an empty stomach, either 1 hour before or 2 hours after a meal.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Macox-ZH Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Macox-ZH Tablet Works

Macox-ZH Tablet combines three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).
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Alcohol

Unsafe

Avoid alcohol consumption while taking Macox-ZH Tablet as it could lead to increased liver damage.

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Pregnancy

Caution

Please consult your doctor if you are pregnant, planning for pregnancy or think you are pregnant; your doctor will prescribe Macox-ZH Tablet only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Macox-ZH Tablet passes into breast milk. Do not breastfeed while taking Macox-ZH Tablet.

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Driving

Unsafe

Macox-ZH Tablet may cause dizziness, vision problems, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Macox-ZH Tablet if you have liver impairment/liver disease before taking Macox-ZH Tablet.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Macox-ZH Tablet.

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Children

Consult your doctor

Please consult your doctor. Based on your child's age, body weight, and medical condition, your doctor may suggest a suitable dose and dosage form.

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Heart

Caution

Macox-ZH Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Consult your doctor

Macox-ZH Tablet should be given to elderly patients only if recommended by a doctor. Please consult your doctor before using Macox-ZH Tablet.

What if I have taken an overdose of Macox-ZH Tablet

Take Macox-ZH Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include stomach pain, nausea, vomiting, headache, lack of energy, and itching. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help relieve cough.
  • Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Have a query?

How Soon It Starts Working

The time required for Macox-ZH Tablet to start to work: Macox-ZH Tablet starts to show its action within 2 to 4 hours of administration. The time for which the effects of Macox-ZH Tablet last: Macox-ZH Tablet effect lasts for 24 hours.

What if you forget to take Macox-ZH Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep Macox-ZH Tablet out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take Macox-ZH Tablet if you are allergic to any of its contents, if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting Macox-ZH Tablet, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking Macox-ZH Tablet as they might cause interaction. Maintain a gap of one hour between Macox-ZH Tablet and antacid medicines. Consult your doctor before taking Macox-ZH Tablet if you are pregnant. Avoid breastfeeding while taking Macox-ZH Tablet as it passes into breast milk. Macox-ZH Tablet may cause dizziness, and vision problems, so drive cautiously. Avoid alcohol consumption while taking Macox-ZH Tablet as it could lead to increased liver damage. Keep your doctor informed about your health condition and all the medicines you take to rule out any interactions.

Drug-Drug Interactions

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Drug-Drug Interactions: Macox-ZH Tablet may interact with an antibiotic (erythromycin), painkiller (acetaminophen), anti-diabetic (insulin isophane), anti-HIV (saquinavir, ritonavir), or supplement (ergocalciferol).

Drug-Food Interactions: Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking Macox-ZH Tablet as they might cause interaction.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, diabetes, gout (high uric acid), liver toxicity, dialysis, optic neuritis (vision problems), kidney or liver dysfunction.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Macox-ZH Tablet is used to treat tuberculosis (TB).

Macox-ZH Tablet is a combination of three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).

Do not stop taking Macox-ZH Tablet despite symptomatic relief. To treat your condition effectually, continue taking Macox-ZH Tablet for as long as it has been prescribed for you.

Do not take Macox-ZH Tablet along with antacids, which might decrease its effectiveness. Maintain a minimum gap of 1 hour between both.

Consult your doctor before taking Macox-ZH Tablet with other medicines. Medicines used to treat TB, such as PAS (P-amino salicylic acid) and cycloserine, should be taken 8 hours apart from Macox-ZH Tablet if prescribed.

Macox-ZH Tablet contains isoniazid, which might interact with foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking Macox-ZH Tablet.

Macox-ZH Tablet might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking Macox-ZH Tablet. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.

Macox-ZH Tablet may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time, even after you stop taking Macox-ZH Tablet. Do not worry, as it is a common side-effect of Macox-ZH Tablet.

Yes, Macox-ZH Tablet might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lenses while taking Macox-ZH Tablet.

Macox-ZH Tablet may affect the results of some blood tests, such as those for folate, vitamin B12, and liver function. Inform the person performing the tests that you are taking Macox-ZH Tablet.

Macox-ZH Tablet may cause liver problems, especially in people aged 35 and older. Consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking Macox-ZH Tablet to check how your liver is functioning.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0035
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