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Macox-Plus Kid Tablet is used to treat and prevent tuberculosis (TB) in children weighing less than 25 kg. It kills the TB-causing bacteria by blocking essential processes needed for their growth, helping clear infections in the lungs and other parts of the body and reducing the risk of drug resistance.

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Written By Chandrakanth Jena , Pharm.D
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Macox-Plus Kid Tablet

Macox-Plus Kid Tablet is a pediatric prescription medication designed to treat and prevent tuberculosis infections in children. This medicine targets the specific bacteria responsible for the infection, helping to fully clear it from your child's body. It is formulated as an easy-to-use, dissolving tablet specifically created to meet the needs of younger patients.

For the treatment to be successful, it must be given consistently every day at the exact times prescribed by your child's doctor. Skipping doses can make the bacteria resistant, making the infection harder to treat. It is best taken on an empty stomach, either one hour before or two hours after a meal. Along with this medicine, ensuring your child gets plenty of rest and a protein-rich diet will help support their recovery.

While taking Macox-Plus Kid Tablet , your child may experience mild side effects like a temporary, harmless orange-red coloring of their urine or saliva. However, you must contact your doctor immediately if you notice serious signs such as yellowing of the skin or eyes, dark urine, or severe stomach pain, which could point to liver damage.

Before starting your child on Macox-Plus Kid Tablet , let your doctor know if they have any pre-existing health conditions, especially liver or kidney issues. Do not take this if your child has a history of active liver disease or has had a severe allergic reaction to similar lung-infection treatments in the past.

This medicine can interact with other prescription drugs, such as anti-seizure medicines, by altering how your body processes them. Additionally, older adolescents taking this medicine must completely avoid alcohol, as combining it with this treatment increases the risk of liver damage. If the patient is a young female who is pregnant or breastfeeding, talk to your doctor before using this medicine.

Uses of Macox-Plus Kid Tablet

Macox-Plus Kid Tablet is an anti-tuberculosis combination used to treat or prevent certain forms of tuberculosis (TB) by targeting the bacteria responsible for the infection. Its uses include:

  • Active Tuberculosis infection: Macox-Plus Kid Tablet helps treat active TB affecting the lungs or other parts of the body by killing susceptible TB bacteria.
  • Latent Tuberculosis infection: It may be used in selected children with latent TB infection to help prevent inactive TB bacteria from becoming active and causing symptomatic disease, as prescribed by a doctor.

Key Benefits

Macox-Plus Kid Tablet provides combined anti-tuberculosis treatment to help control TB infection while offering a convenient dosage form for children. Its benefits include:

  • This form makes it easier for children who have difficulty swallowing conventional tablets.
  • Combining two anti-tuberculosis medicines in a single tablet can simplify the treatment routine and reduce the number of separate tablets needed.
  • Helps kill or suppress susceptible tuberculosis bacteria, supporting effective infection control and gradual improvement in TB-related symptoms.
Side effects of Macox-Plus Kid Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink fluids: Water, clear broth, or electrolyte-rich beverages.
  • Follow a balanced diet, which would be rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
  • Mindfulness: Manage stress with meditation, deep breathing or yoga.
  • Stay away from smoke, dust and other irritants.
  • Get adequate rest to facilitate recovery.
  • Wash hands and avoid close contact, do not share personal items.

Directions for Use

  • Macox-Plus Kid Tablet should be administered on an empty stomach (at least 1 hour before or 2 hours after a meal), or as directed by the doctor.
  • The doctor will decide the dosage and timing of this medicine based on your child’s age and weight. It is typically given once daily at the same time each day.
  • Add the prescribed number of tablets to a clean cup of water, stir gently until fully dissolved, and give the mixture to your child immediately.
  • Do not chew or swallow the tablets whole.

How Macox-Plus Kid Tablet Works

This combination medicine works by attacking the tuberculosis bacteria from two different angles. The first active ingredient works by blocking the bacteria's ability to copy its genetic material, which stops it from multiplying and spreading through the body. The second active ingredient disrupts the formation of the bacteria's protective outer cell wall, weakening them until they die. By using these two actions together, Macox-Plus Kid Tablet effectively destroys the bacteria and prevents them from building resistance to the treatment.
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Alcohol

Not applicable

It is intended for Children.

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Pregnancy

Not applicable

It is intended for Children.

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Breast Feeding

Not applicable

It is intended for Children.

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Driving

Not applicable

It is intended for Children.

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Liver

Consult your doctor

Please consult the doctor if your child has liver problems or if you have any concerns regarding this.

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Kidney

Consult your doctor

Please consult the doctor if your child has kidney problems or if you have any concerns regarding this.

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Children

Safe if prescribed

Macox-Plus Kid Tablet is safe for children if prescribed by a doctor. The doctor will decide the dose and duration based on your child’s age and weight.

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Heart

Consult your doctor

Please consult the doctor if your child has heart problems or if you have any concerns regarding this.

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Geriatrics

Not applicable

It is intended for Children.

What if I have taken an overdose of Macox-Plus Kid Tablet

If you suspect your child has taken more than the prescribed dose, seek immediate emergency medical attention or contact a poison control center right away.

Diet & Lifestyle Advise

  • Inquire about Vitamin B6: Ask your doctor if your child needs a vitamin B6 (pyridoxine) supplement. This vitamin is often recommended alongside this treatment to help protect your child's nervous system.
  • Provide a nutrient-dense diet: Ensure your child eats a high-protein, calorie-sufficient diet to help their body repair and rebuild tissues during recovery.
  • Keep them hydrated: Encourage your child to drink plenty of fluids throughout the day, which helps their kidneys flush out the medication safely.
  • Avoid certain foods: Avoid serving aged cheeses, yeast extracts, soy sauce, and certain types of fish (like tuna) during treatment, as these can interact with the medicine and cause sudden flushing, sweating, or a rapid heartbeat.
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How Soon It Starts Working

  • The time required for Macox-Plus Kid Tablet to start to work: Macox-Plus Kid Tablet ideally starts to work within a few minutes after administration.
  • The time for which the effects of Macox-Plus Kid Tablet last: The effects of Macox-Plus Kid Tablet usually last for about 24 hours.

What if you forget to take Macox-Plus Kid Tablet

If you miss giving your child a dose, give it as soon as you remember. However, if it is almost time for their next scheduled dose, skip the missed dose and continue with the regular schedule. Do not give a double dose to make up for a missed one.

Storage

•Store Macox-Plus Kid Tablet at controlled room temperature between 15°C to 30°C (59°F to 86°F).

Drug Warnings

  • Check the packaging: Inspect the blister pack before use. Do not use the tablet if the foil is broken, torn, or damaged.
  • Handle with dry hands: Do not handle the tablets with wet hands, as moisture may cause them to dissolve prematurely.
  • Expect orange-red body fluids: Macox-Plus Kid Tablet can harmlessly turn your child's urine, saliva, and tears orange-red. Avoid soft contact lenses, as they may become permanently stained.
  • Complete the treatment: Give the full course exactly as prescribed, even if your child feels completely better, to help prevent the infection from returning.
  • Watch for yellowing: Regularly check your child's skin and eyes for yellowing. Contact your doctor immediately if you notice these changes, as they may indicate a liver problem.

Drug-Drug Interactions

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  • Anti-seizure medicines: Macox-Plus Kid Tablet may interact with medicines such as phenytoin, changing their levels in the blood and affecting their effectiveness or increasing side effects.
  • Blood thinners: It may interact with blood-thinning medicines and alter their effects, potentially increasing the risk of bleeding or reducing their effectiveness.
  • Certain pain relievers: Some pain medicines may interact with Macox-Plus Kid Tablet and change medicine levels in the body. Tell your child's doctor about all medicines being used.
Critical

Drug-Drug Interactions

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How does the drug interact with Macox-Plus Kid Tablet:
Taking darunavir with Macox-Plus Kid Tablet can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Macox-Plus Kid Tablet:
Taking saquinavir with Macox-Plus Kid Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking indinavir with Macox-Plus Kid Tablet can reduce the blood levels and effects of indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking ranolazine with Macox-Plus Kid Tablet can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking voriconazole with Macox-Plus Kid Tablet can increase the risk of infections.

How to manage the interaction:
Although there is an interaction between voriconazole and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking lemborexant with Macox-Plus Kid Tablet may reduce the blood levels and effects of lemborexant.

How to manage the interaction:
Although there is an interaction between Macox-Plus Kid Tablet and lemborexant, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Coadministration of ivabradine with Macox-Plus Kid Tablet can decrease the blood levels and effects of ivabradine.

How to manage the interaction:
Although there is an interaction between ivabradine and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Macox-Plus Kid Tablet:
Taking sonidegib with isoniazid + rifampicin can reduce the blood levels and effects of sonidegib

How to manage the interaction:
Although there is an interaction between sonidegib and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking cariprazine with Macox-Plus Kid Tablet can reduce blood levels of cariprazine and also increase the risk of side effects of Macox-Plus Kid Tablet.

How to manage the interaction:
Although there is an interaction between cariprazine and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Coadministration of sirolimus with Macox-Plus Kid Tablet can decrease the blood levels of sirolimus, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between sirolimus and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • High-fat meals: Taking Macox-Plus Kid Tablet with high-fat meals may reduce its absorption. Follow your doctor's instructions regarding when to give the medicine in relation to meals.
  • Tyramine- or histamine-rich foods: Foods such as aged cheese, soy sauce, and certain fish may cause flushing, sweating, or an increased heart rate in some people taking isoniazid. Discuss dietary restrictions with your child's doctor.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Macox-Plus Kid Tablet is used to prevent and treat tuberculosis in children who weigh less than 25 kg.
Macox-Plus Kid Tablet contains Rifampicin and Isoniazid, which work together to kill the bacteria that cause tuberculosis (TB). They stop the bacteria from growing and spreading, helping the body fight and clear the infection.
Macox-Plus Kid Tablet may cause a reddish-orange discolouration of body fluids such as tears, sputum, and urine. This is harmless and usually does not require treatment. However, speak to your doctor if you have any concerns.
Common side effects of Macox-Plus Kid Tablet may include nausea, vomiting, diarrhoea, stomach pain, loss of appetite, itching, and tingling or numbness of the skin. However, these symptoms usually resolve as your body adjusts to the medication. If these side effects persist or worsen, please consult a doctor.
Macox-Plus Kid Tablet contains isoniazid, which may interact with foods and drinks containing histamine or tyramine, such as cured meats, aged cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid giving these foods while your child is taking this medicine.
Macox-Plus Kid Tablet may affect the results of some blood tests, such as folate, vitamin B12, and liver function tests. Inform the person doing the tests that your child is taking Macox-Plus Kid Tablet .
Macox-Plus Kid Tablet is composed of two antimycobacterial drugs, Rifampicin and Isoniazid. It is used to treat and prevent tuberculosis in children.
If you forget to give a dose of Macox-Plus Kid Tablet to your child, give it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and give the next one at the usual time. Do not give two doses together, as this may increase the risk of side effects.
The best time to give Macox-Plus Kid Tablet is on an empty stomach, at least 1 hour before or 2 hours after a meal. This helps the body absorb the medicine more effectively.
Macox-Plus Kid Tablet is generally considered safe for children when used exactly as prescribed by a doctor. However, like all medicines, it may cause side effects or interact with other drugs. It is important to follow the doctor’s instructions carefully and to inform them of your child’s medical history and any other medicines they are taking to avoid potential complications.
No. Do not crush the tablets or mix them directly with food. Disperse the prescribed number of tablets in a clean cup of water as directed, stir gently until fully dispersed, and give the mixture to your child immediately. Follow your child's doctor's instructions for the correct dose and timing.
If your child vomits shortly after taking the tablet, contact your doctor or pharmacist. Do not immediately give another dose without professional guidance, as the amount of medicine already absorbed can vary.
This treatment can sometimes lower vitamin B6 levels in the body, which may lead to tingling or numbness in the hands and feet. Giving a vitamin B6 supplement helps prevent this. Talk to your doctor for the correct dose of vitamin B6.
The duration of treatment depends entirely on your child's specific condition and how they respond to the therapy. It is vital to complete the entire course prescribed by your doctor, even if your child seems fully recovered. Talk to your doctor to understand the treatment plan.
Some over-the-counter and prescription medicines can interact with this treatment. Always check with your doctor or pharmacist before starting any new medicine, including vitamins or herbal supplements, while your child is taking this medication.

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Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0006
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