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compositionComposition:MACITENTAN-10MG
prescription
Prescription Medicine
info
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Macitent Tablet is an anti-hypertensive medicine used in the treatment of pulmonary arterial hypertension (PAH). This medicine contains macitentan which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure, thus increasing blood supply and lowering blood pressure. Common side effects include headache, inflammation of the airways, and oedema.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

MACITENTAN-10MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Macitent Tablet

Macitent Tablet is a prescription medicine used to treat pulmonary arterial hypertension, which is high blood pressure in the blood vessels that supply the lungs. It helps improve your physical exercise capacity and delays the worsening of symptoms associated with this serious heart and lung condition. This medicine is prescribed for long-term management to help keep your symptoms under control.

To achieve the best results, you must take Macitent Tablet regularly and exactly as prescribed by your doctor. You can take this oral tablet with or without food, but taking it at the same time each day helps maintain a steady level of medicine in your body. Making healthy lifestyle choices, such as reducing your daily salt intake and engaging in gentle, doctor-approved physical activities, can also significantly support your treatment.

While taking Macitent Tablet , you may experience some mild, common side effects like a stuffy nose or headaches. However, you must monitor your body closely and contact your doctor immediately if you notice serious signs such as severe swelling in your legs, sudden difficulty breathing, or symptoms of liver damage.

Before starting this medicine, tell your doctor if you have a history of liver problems, anemia, or kidney issues. Do not take this if you are pregnant, planning to become pregnant, or think you might be pregnant, as this medication can cause severe, life-threatening harm to an unborn baby.

This medicine can interact with other prescription drugs, especially those that affect liver enzymes, which may either decrease the effectiveness of Macitent Tablet or increase your risk of side effects. It is important to consult your healthcare provider if you are breastfeeding, elderly, or taking other daily medications before you begin treatment.
 

Uses of Macitent Tablet

Macitent Tablet is used to treat pulmonary arterial hypertension (PAH). The detailed uses of this medicine include:

  • Pulmonary arterial hypertension (PAH): Macitent Tablet is used to treat high blood pressure in the lungs. It helps dilate the blood vessels in the lungs, making it easier for the heart to pump blood, which improves physical ability and delays the worsening of the disease.

Key Benefits

This medicine helps improve blood flow through the lungs and supports better heart function in people with pulmonary arterial hypertension. Its benefits include:

  • Helps relax and widen the blood vessels in the lungs, improving blood flow.
  • Reduces shortness of breath and tiredness during physical activity.
  • Improves your ability to perform daily activities and exercise more comfortably.
  • Helps slow the progression of pulmonary arterial hypertension.
  • Reduces the risk of worsening symptoms and related complications.
  • May help lower the need for hospitalization due to disease progression.
Side effects of Macitent Tablet
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Increase fibre intake to alleviate constipation.
  • Track your food intake to identify trigger foods.
  • Limit caffeine, fatty foods, and gas-producing foods.
  • Explore probiotics or a low fermented sugar diet for relief.
  • Regular exercise and stress management through therapy can help.
  • Stay hydrated by drinking plenty of water.
  • Your doctor may recommend medications to dissolve the small gallstones (like ursodiol) or use shock waves to break up the stones.
  • Try to eat regular meals because skipping meals can increase the risk of gallstones by making your gallbladder work less efficiently.
  • Eat breakfast soon after you wake up, as cholesterol in bile is highest in the morning.
  • If you are overweight, losing weight gradually can help lower the chance of developing gallstones.
  • Include plenty of fresh vegetables and fruits in your diet.
  • Base your meals around starchy foods like bread, pasta, rice, and potatoes, especially whole grain or high-fibre varieties.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • If you experience symptoms like difficulty breathing, stridor (high-pitched whistling sound when breathing), high fever or chest pain, consult a doctor immediately.
  • Use a nebulizer or a cool-mist humidifier to help loosen mucus and soothe inflamed airway.
  • Drink lots of water to thin mucus and help with coughing.
  • Get enough sleep to allow the body to heal.
  • Suck on lozenges to soothe sore throat.
  • Quit smoking and alcohol consumption.

Directions for Use

  • Macitent Tablet can be taken with or without food.
  • It is recommended to take Macitent Tablet once daily or as advised by your doctor.
  • Swallow Macitent Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Macitent Tablet Works

In people with pulmonary arterial hypertension, the body produces too much of a natural substance called endothelin. Endothelin causes the blood vessels in the lungs to tighten, narrow, and become thick, which forces the heart to work much harder to pump blood through them. Macitent Tablet works as an endothelin receptor antagonist (a type of medicine that blocks a natural chemical called endothelin that causes blood vessels to tighten). By blocking the action of endothelin in the blood vessels, it allows the blood vessels in the lungs to relax and widen. This significantly lowers the blood pressure in your lungs and reduces the strain on your heart.
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Alcohol

Caution

It is advised to limit alcohol intake since alcohol consumption with Macitent Tablet may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Unsafe

Macitent Tablet is not recommended in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting Macitent Tablet . You should get a negative pregnancy test for sure before using Macitent Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Macitent Tablet to avoid pregnancy.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Macitent Tablet in breastfeeding/nursing mothers.

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Driving

Unsafe

Macitent Tablet can cause side effects such as headaches and hypotension, and the symptoms of your condition can also make you less fit to drive.

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Liver

Caution

Let your doctor know before taking Macitent Tablet if you have any history of liver diseases or very high levels of liver enzymes in your blood. Your doctor will weigh the benefits and any potential risks before prescribing Macitent Tablet .

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Kidney

Caution

If you have kidney problems, talk to your doctor before using Macitent Tablet . Macitentan may lead to more blood pressure reduction and a decrease in haemoglobin in patients with kidney problems. Please consult the doctor, and your doctor will weigh the benefits and any potential risks before prescribing Macitent Tablet .

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Children

Unsafe

Safety and effectiveness of Macitent Tablet have not been established in patients below 18 years of age.

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Heart

Caution

Let your doctor know if you have any history of heart problems. Your doctor will weigh the benefits and potential risks before prescribing Macitent Tablet .

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Geriatrics

Caution

Macitent Tablet should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

What if I have taken an overdose of Macitent Tablet

If you take more than your prescribed dose, seek emergency medical assistance or contact a poison control center immediately. An overdose can lead to severe side effects that require professional monitoring.

Diet & Lifestyle Advise

  • Limit Salt Intake: Reduce your daily intake of sodium (salt) to help prevent fluid retention, which can increase the workload on your heart and lungs.
  • Stay Physically Active: Engage in regular, low-impact activities such as walking, but avoid strenuous exercise or heavy lifting unless approved by your doctor.
  • Avoid Smoking: Do not smoke, and avoid exposure to secondhand smoke, as it can further damage your lungs and lower oxygen levels.
  • Monitor Your Weight: Weigh yourself at the same time each morning and inform your doctor if you notice a sudden weight gain over a few days, as this may indicate fluid retention.
health query

Have a query?

How Soon It Starts Working

The time required for Macitent Tablet to start to work: Macitent Tablet ideally shows its action within 8 hours after administration. The time for which the effects of Macitent Tablet last: The effect of Macitent Tablet lasts for 16 hours.

What if you forget to take Macitent Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose entirely and continue with your normal schedule. Do not take a double dose to make up for a missed tablet.

Storage

• Store Macitent Tablet at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Avoid Pregnancy: Do not take this medicine if you are pregnant, as it can cause serious birth defects. Women who can become pregnant should use effective contraception during treatment and for one month after stopping the medicine.
  • Attend Regular Blood Tests: Keep all scheduled blood test appointments so your doctor can monitor your liver function, including liver enzymes (proteins in your blood that help show how well your liver is working), as well as your red blood cell counts.
  • Do Not Stop Suddenly: Never stop taking Macitent Tablet without your doctor's advice, as this may cause your pulmonary hypertension symptoms to worsen.
  • Check the Packaging: Inspect the tablet packaging before use to ensure the seal is intact and the product has not been tampered with.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that speed up Macitent Tablet breakdown: Certain medicines, such as rifampin, can cause your body to remove Macitent Tablet more quickly, making it less effective.
  • Medicines that slow Macitent Tablet breakdown: Certain medicines, such as ketoconazole, itraconazole, or ritonavir, can increase the amount of Macitent Tablet in your body and raise the risk of side effects.
MacitentanIndinavir
Severe
MacitentanNelfinavir
Severe

Drug-Drug Interactions

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MacitentanIndinavir
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Indinavir may increase the blood levels of Macitent Tablet, which increases severe side effects.

How to manage the interaction:
Taking Macitent Tablet with Indinavir together can possibly result in an interaction, but it can be taken together if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanNelfinavir
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Nelfinavir may increase the blood levels of Macitent Tablet, which increases severe side effects.

How to manage the interaction:
Although taking Macitent Tablet and Nelfinavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanMibefradil
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Mibefradil may increase the blood levels of Macitent Tablet, which increases severe side effects.

How to manage the interaction:
Taking Macitent Tablet with Mibefradil together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanDelavirdine
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Delavirdine may increase the blood levels of Macitent Tablet, which increases severe side effects.

How to manage the interaction:
Although taking Macitent Tablet and Delavirdine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanRitonavir
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Ritonavir may increase the blood levels of Macitent Tablet.

How to manage the interaction:
There may be a possibility of interaction between Macitent Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes, contact your doctor immediately. Do not stop using any medications without talking to a doctor.
MacitentanFosamprenavir
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Fosamprenavir may increase the blood levels of Macitent Tablet, which increases severe side effects.

How to manage the interaction:
Co-administration of Macitent Tablet with Fosamprenavir can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, it's important to let your doctor know. Do not stop using any medications without first talking to your doctor.
MacitentanCeritinib
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Ceritinib may increase the blood levels of Macitent Tablet.

How to manage the interaction:
Although there is a interaction between Macitent Tablet and ceritinib, but it can be taken together if prescribed by your doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakess, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanPrimidone
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Primidone may significantly reduce the blood levels of Macitent Tablet, which may make the medication less effective.

How to manage the interaction:
Co-administration of Primidone with Macitent Tablet can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MacitentanLeflunomide
Severe
How does the drug interact with Macitent Tablet:
Taking leflunomide with Macitent Tablet affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking Leflunomide and Macitent Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
MacitentanAmprenavir
Severe
How does the drug interact with Macitent Tablet:
Taking Macitent Tablet with Amprenavir may increase the blood levels of Macitent Tablet, which increases severe side effects.

How to manage the interaction:
There is a interaction between Macitent Tablet and Amprenavir, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Avoid Grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as it can increase Macitent Tablet levels in your body and increase the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

No. Do not stop taking Macitent Tablet even if you feel better or your symptoms improve. Pulmonary arterial hypertension is a chronic condition that requires ongoing treatment. Stopping the medicine without your doctor's advice may cause your symptoms to worsen. Always take it exactly as prescribed and consult your doctor before making any changes.
Yes. Your doctor will recommend blood tests before and during treatment to monitor liver function and red blood cell counts. Women who can become pregnant should also have pregnancy testing before starting treatment and regular (typically monthly) pregnancy tests during treatment. Follow your doctor's recommended monitoring schedule.
No. Do not take Macitent Tablet if you are pregnant because it may cause serious harm to an unborn baby. Women who can become pregnant should use effective contraception during treatment and for one month after the last dose. Pregnancy testing is recommended before starting treatment and regularly during treatment. Consult your doctor about suitable contraceptive methods.
No. You must swallow the tablet whole with water. Do not crush, chew, or split the tablet before taking it. Talk to your doctor if you have difficulty swallowing pills.
Swelling can be a sign of fluid buildup, which is a known side effect of this medicine. Contact your doctor immediately if you experience new or worsening swelling, especially if it is accompanied by sudden weight gain. Talk to your doctor.
You should limit or avoid alcohol while taking this medicine, as alcohol can lower your blood pressure further, causing dizziness, fainting, or headaches. Talk to your doctor.
This medicine starts working inside your body after the first few doses, but it may take several weeks to notice an improvement in your physical abilities. Always continue taking it even if you do not feel immediate changes. Talk to your doctor.
Yes, certain medications, especially strong liver enzyme inhibitors or inducers, can interact with Macitent Tablet . Ensure your doctor and pharmacist have a complete list of all medications you take. Talk to your doctor.

Disclaimer

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Country of origin

INDIA

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - MAC0348
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