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  3. Lupisulin N (NPH) 40IU/ml Injection 10 ml

Lupisulin N (NPH) 40IU/ml Injection 10 ml, Pack of 1 INJECTION
Lupisulin N (NPH) 40IU/ml Injection 10 ml, Pack of 1 INJECTION
Lupisulin N (NPH) 40IU/ml Injection 10 ml, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Lupisulin N (NPH) 40IU/ml Injection is used for the treatment of diabetes mellitus in both children (above two years of age) and adults. It mimic the insulin in humans, which helps your body utilize glucose (sugar) for energy. It works by ensuring rapid and consistent sugar control. It is a fast-acting form of insulin that helps lower blood sugar levels after food intake. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses sugar production in the liver. It may cause common side effects such as hypokalaemia (low potassium), hypoglycaemia (low blood sugar level), local injection site reactions, lipodystrophy (fat deposition under the skin), rash, and pruritus (itch skin) at the injection site.

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Composition :

INSULIN HUMAN-40IU

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Lupisulin N (NPH) 40IU/ml Injection

Lupisulin N (NPH) 40IU/ml Injection is used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children. In Type 1 diabetes, the body does not produce enough insulin to regulate blood sugar levels. In type 2 diabetes, either the body stops producing enough insulin (a hormone that helps lower blood sugar levels) or the body becomes resistant to insulin. As a result, insulin is produced in large quantities, but it is unable to function properly on the body's organs.

Lupisulin N (NPH) 40IU/ml Injection contains human insulin, a rapid-acting human insulin analogue. It works by ensuring rapid and consistent sugar control that helps lower blood sugar levels after food intake. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses sugar production in the liver.

Not everyone who is receiving Lupisulin N (NPH) 40IU/ml Injection will get these side effects. You may experience rash, injection site allergic reaction, weight gain, edema (tissue swelling or fluid overload), skin thickening at the injection site, low blood glucose levels, and itching. Most of these side effects of Lupisulin N (NPH) 40IU/ml Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Lupisulin N (NPH) 40IU/ml Injection should be administered as advised by your doctor. It should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks) only. Your doctor will explain how to inject the medicine by yourself. However, if it is difficult to inject the medicine, ask a healthcare professional to administer it. Along with Lupisulin N (NPH) 40IU/ml Injection, you should take a healthy diet, do regular exercise, and maintain your weight as advised by your doctor.

Inform your doctor if you are allergic to Lupisulin N (NPH) 40IU/ml Injection. Do not take Lupisulin N (NPH) 40IU/ml Injection if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs. Try not to stop receiving Lupisulin N (NPH) 40IU/ml Injection of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Lupisulin N (NPH) 40IU/ml Injection is a cold chain medicine, and so it must be stored in the refrigerator between 2-8 degrees Celsius, or else its efficiency might get lost. Do not store in the freezer or the fridge.

Uses of Lupisulin N (NPH) 40IU/ml Injection

Lupisulin N (NPH) 40IU/ml Injection is used in the treatment of Diabetes (Type 1 diabetes mellitus, Type 2 diabetes mellitus). The detailed uses of Lupisulin N (NPH) 40IU/ml Injection are as follows:

  • Diabetes Management: Lupisulin N (NPH) 40IU/ml Injection is primarily used to regulate blood glucose levels in individuals with diabetes mellitus, helping to keep them within a healthy range.
  • Postprandial Blood Sugar Control: Lupisulin N (NPH) 40IU/ml Injection effectively manages postprandial (after-meal) blood sugar spikes through its combination of intermediate and short-acting insulin.
  • Type 1 and Type 2 Diabetes Treatment: Lupisulin N (NPH) 40IU/ml Injection is prescribed for patients with Type 1 and Type 2 diabetes who are unable to achieve adequate glycemic control with oral hypoglycemic agents alone.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions and use it as advised by the doctor. Choose an injection site such as the thigh, upper arm, or abdomen, pinch the skin and inject the advised dose at a 45-degree angle slowly and steadily.
  • Rotate the injection site every time. Do not inject into skin that is red, bruised, or hard. Do not reuse or share needles.

Medicinal Benefits

  • Lupisulin N (NPH) 40IU/ml Injection is a hormone known as 'insulin' made in your pancreas, which helps your body utilize glucose (sugar) for energy.
  • Insulin human is the name which describes synthetic insulin, which is laboratory-grown to mimic the insulin in humans.
  • Lupisulin N (NPH) 40IU/ml Injection works by ensuring rapid and consistent sugar control.
  • Lupisulin N (NPH) 40IU/ml Injection is a fast-acting form of insulin that helps lower blood sugar levels after food intake.
  • This medicine helps prevent the risk of having severe complications of diabetes.
  • It stimulates the recovery of sugar in muscle and fat cells and thus suppresses sugar production in the liver.
  • Lupisulin N (NPH) 40IU/ml Injection helps in improving glycaemic control, which in turn decreases the risk of progression of complications of diabetes like damage to the retina (retinopathy), damage to the kidney (nephropathy), damage to nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer and others.
  • Besides this, Lupisulin N (NPH) 40IU/ml Injection can be safely prescribed to the diabetic mother during the pregnancy and the lactation stage.

How Lupisulin N (NPH) 40IU/ml Injection Works

Lupisulin N (NPH) 40IU/ml Injection works by ensuring rapid and consistent sugar control. Lupisulin N (NPH) 40IU/ml Injection is a fast-acting form of insulin that helps lower blood sugar levels after food intake. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses sugar production in the liver.

Storage

• Store in a cool and dry place away from sunlight.• Keep Lupisulin N (NPH) 40IU/ml Injection out of the sight and reach of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Lupisulin N (NPH) 40IU/ml Injection 10 ml
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.

What if I have taken an overdose of Lupisulin N (NPH) 40IU/ml Injection

Do not take more than the prescribed dose of Lupisulin N (NPH) 40IU/ml Injection as it may cause overdose and lead to low blood sugar or low blood potassium. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to Lupisulin N (NPH) 40IU/ml Injection.
  • Do not take Lupisulin N (NPH) 40IU/ml Injection if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs.
  • Do not stop taking Lupisulin N (NPH) 40IU/ml Injection without consulting your doctor, as it may cause withdrawal symptoms.
  • Lupisulin N (NPH) 40IU/ml Injection may decrease the level of potassium, leading to a state of hypokalemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death.
  • Lupisulin N (NPH) 40IU/ml Injection is for subcutaneous (under the skin) use only. If you are switching to a different insulin brand or using a different method of injection, it is recommended that you do so under strict medical supervision.
  • Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure.
  • The first symptoms of hyperglycemia (high blood sugar levels) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and an acetone odour in the breath. You should closely monitor these symptoms.
  • It is advisable not to consume alcohol, as it may either increase or decrease your blood glucose level.
  • Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule.
  • Lupisulin N (NPH) 40IU/ml Injection is a cold chain medicine, and therefore it must be stored in the refrigerator at a temperature between 2 °C and 8 °C; otherwise, its efficiency may be compromised. Do not store in the freezer or the fridge.
  • Lupisulin N (NPH) 40IU/ml Injection should not be administered intravenously (into the vein).

Drug-Drug Interactions

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Isophane InsulinGemifloxacin
Severe
Isophane InsulinCiprofloxacin
Severe

Drug-Drug Interactions

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Isophane InsulinGemifloxacin
Severe
How does the drug interact with Lupisulin N (NPH) 40IU/ml Injection 10 ml:
Taking Lupisulin N (NPH) 40IU/ml Injection 10 ml with gemifloxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Gemifloxacin and Lupisulin N (NPH) 40IU/ml Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinCiprofloxacin
Severe
How does the drug interact with Lupisulin N (NPH) 40IU/ml Injection 10 ml:
Taking Lupisulin N (NPH) 40IU/ml Injection 10 ml with ciprofloxacin effects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently..

How to manage the interaction:
Although taking ciprofloxacin and Lupisulin N (NPH) 40IU/ml Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Isophane InsulinNalidixic acid
Severe
How does the drug interact with Lupisulin N (NPH) 40IU/ml Injection 10 ml:
Taking Lupisulin N (NPH) 40IU/ml Injection 10 ml with nalidixic acid affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Nalidixic acid and Lupisulin N (NPH) 40IU/ml Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinTrovafloxacin
Severe
How does the drug interact with Lupisulin N (NPH) 40IU/ml Injection 10 ml:
Taking Lupisulin N (NPH) 40IU/ml Injection 10 ml with trovafloxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking trovafloxacin and Lupisulin N (NPH) 40IU/ml Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinCinoxacin
Severe
How does the drug interact with Lupisulin N (NPH) 40IU/ml Injection 10 ml:
Taking Lupisulin N (NPH) 40IU/ml Injection 10 ml with cinoxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Cinoxacin and Lupisulin N (NPH) 40IU/ml Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinEnoxacin
Severe
How does the drug interact with Lupisulin N (NPH) 40IU/ml Injection 10 ml:
Taking Lupisulin N (NPH) 40IU/ml Injection 10 ml with enoxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Enoxacin and Lupisulin N (NPH) 40IU/ml Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercise may lower your body’s need for insulin during and for some time after the physical activity.
  • Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of injection site (for example, the leg should not be used for injection just prior to running).
  • Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise. 
  • Avoid eating sugar food and prefer food cooked food low in calories.
  • When travelling across more than 2 time zones, you should talk to your doctor concerning adjustments in your insulin schedule.
  • Follow a healthy diet and walk for at least a few minutes to complement treatment with Lupisulin N (NPH) 40IU/ml Injection.
  • Maintain a healthy weight by exercising regularly.
  • Rest properly, and avoid stress by doing meditation or yoga.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Lupisulin N (NPH) 40IU/ml Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Lupisulin N (NPH) 40IU/ml Injection to avoid unpleasant side-effects. Alcohol may either decrease or increase the blood sugar level which can be fatal.

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Pregnancy

Safe if prescribed

Lupisulin N (NPH) 40IU/ml Injection can be used during pregnancy. Your insulin dose may need to be changed during pregnancy and after delivery.

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Breast Feeding

Safe if prescribed

Lupisulin N (NPH) 40IU/ml Injection can be given safely to nursing mothers but only under the supervision of a physician.

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Driving

Unsafe

Drive with caution, Lupisulin N (NPH) 40IU/ml Injection usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycaemia (low blood sugar).

bannner image

Liver

Caution

Lupisulin N (NPH) 40IU/ml Injection to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Lupisulin N (NPH) 40IU/ml Injection to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

bannner image

Children

Safe if prescribed

Lupisulin N (NPH) 40IU/ml Injection can be given safely to children provided; dose has to be prescribed by a child specialist.

Have a query?

FAQs

Lupisulin N (NPH) 40IU/ml Injection is used to treat Type 1 diabetes mellitus and type 2 diabetes mellitus.

Lupisulin N (NPH) 40IU/ml Injection can be given to treat both the condition of type 1 and type 2 diabetes mellitus. However, your doctor will decide whether Lupisulin N (NPH) 40IU/ml Injection can be given to you or not, depending on your present condition. Lupisulin N (NPH) 40IU/ml Injection should be avoided in patients who are allergic to Lupisulin N (NPH) 40IU/ml Injection or other forms of insulin, patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycaemia), and low potassium level (hypokalaemia).

Cold sweat; cool pale skin; headache; rapid heartbeat; feeling sick; feeling very hungry; temporary vision changes; drowsiness; unusual tiredness and weakness; nervousness or tremor; feeling anxious; feeling confused; difficulty in concentrating are some of the common signs of the low blood sugar level in an individual.

If you experience low blood sugar, eat glucose tablets or another high sugar snack (e.g. sweets, biscuits, fruit juice). Measure your blood sugar if possible and rest. Always carry glucose tablets or high sugar snacks with you. You should give a call to any of your family members if you are feeling dizziness or drowsiness.

Local allergic reactions (pain, redness, hives, inflammation, bruising, swelling and itching) at the injection site may occur. These usually disappear after a few weeks of taking your insulin. If they do not disappear, or if they spread throughout your body, talk to your doctor immediately.

Human insulin is a laboratory created by growing insulin proteins within E-coli bacteria (Escherichia coli).

You are recommended to avoid white bread, maida, poori, naan, noodles, biryani, fried rice, corn flakes, cheese, ice creams, milkshakes, beef, pork, sugarcane juice, soft drinks, sweetened health drinks and beverages. Also, avoid mango, custard apple, jack fruit, fruit salads with ice cream, and fruit-based desserts.

No, do not stop taking Lupisulin N (NPH) 40IU/ml Injection without consulting your doctor as it may lead to high blood sugar levels and may worsen your condition resulting in complications. If you experience any side effects or discomfort, contact your doctor. You may need dose adjustment.

Taking Lupisulin N (NPH) 40IU/ml Injection at the same site may cause local irritation, itching and lump formation. Therefore, it is best to avoid taking injections at the same site or maintain a gap of at least one day.

Maintain a diet that includes chapatis, puffed rice with vegetables, multigrain bread, plain cooked dal, roasted grams soups, sprouts, cooked vegetables with less oil, steamed vegetables, orange, jamun, guava, watermelon, apple, papaya, curd, cow’s milk, thin buttermilk, fish (baked, grilled, or steamed), cashew nuts, peanuts, and walnuts (handful). Avoid alcohol consumption and quit smoking. Exercise regularly and brisk walk daily for 30 minutes. Also, limit intake of sugar.

The risk factors for developing low blood sugar levels include not taking adequate meals or skipping meals, excessive insulin use, too much alcohol intake, fever and too much exercise. Some medications, like other diabetes medicine glimepiride, medicines used for fever and pain (salicylates), ramipril, etc., can result in such episodes when used with insulin. Inform your doctor about these episodes as you may need dose adjustment.

The usual sites to inject Lupisulin N (NPH) 40IU/ml Injection are thighs, abdomen and arms as these areas have fewer nerve endings and more fat. As a result, you may feel less discomfort in these areas. However, it is recommended to rotate your injection sites with each dose to reduce the risk of developing pitted or thick skin and lumps at the injection site.

The side effects of Lupisulin N (NPH) 40IU/ml Injection include local injection site reactions, low blood sugar, low potassium, itchy skin, rash, weight gain, and swelling due to fluid retention. If these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - LUP0026

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 2:03 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018780s120lbl.pdfhttp://pi.lilly.com/us/humulin-r-ppi.pdf

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