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compositionComposition:LUBIPROSTONE-24MCG
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Prescription Medicine
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Lubowel 24 Capsule is used to treat chronic constipation and constipation associated with medicines like opioids (painkillers). Besides this, it is also used to treat irritable bowel syndrome-associated constipation in women. It contains Lubiprostone, which relieves constipation and also helps in normalizing bowel movements. It may cause side effects such as diarrhoea,nausea, headache, abdominal discomfort, pain and cramps.

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Written By Dr. Aneela S , M Pharmacy, PhD
Reviewed By Dr. Syed Akram , MBBS, MD
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More about the Product

Composition :

LUBIPROSTONE-24MCG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lubowel 24 Capsule

Lubowel 24 Capsule is a prescription medication used to treat long-term chronic constipation with no known cause, as well as irritable bowel syndrome with constipation (IBS-C) in women. It is also prescribed to manage bowel issues caused by the regular use of opioid pain medicines. This medication helps restore regular bowel movements and makes stool easier to pass, relieving discomfort.

To get the best results, you should take Lubowel 24 Capsule consistently at the times prescribed by your doctor, which is typically twice a day. It is highly recommended to take this capsule with food and a full glass of water to help reduce the chance of feeling nauseous. Alongside your medicine, drinking plenty of water, eating fibre-rich foods, and staying active can significantly support your digestive health.

While taking Lubowel 24 Capsule , some people may experience mild side effects like nausea, loose stools, or mild stomach pain. However, if you develop severe diarrhoea, intense abdominal pain, or a sudden feeling of shortness of breath, you should stop taking the medicine and consult your doctor immediately.

Before starting this treatment, talk to your doctor if you have a history of liver damage, severe digestive problems, or active inflammatory bowel diseases. Do not take this if you have a known or suspected blockage in your stomach or intestines, as this can lead to serious medical emergencies.

Taking this medicine with other laxatives or certain stomach drugs may increase your risk of severe diarrhoea, so it is important to share your full medication list with your provider. If you are pregnant, breastfeeding, planning a pregnancy, or are an older adult, consult your healthcare provider to ensure this treatment is safe and appropriate for you.

Uses of Lubowel 24 Capsule

Lubowel 24 Capsule is used to manage different types of constipation by increasing fluid in the intestines and supporting easier bowel movements. Its main uses include:

  • Chronic Idiopathic Constipation (CIC): Lubowel 24 Capsule helps by increasing fluid secretion in your intestines, which softens hard, dry stools and makes them much easier to pass.
  • Irritable Bowel Syndrome with Constipation (IBS-C): In women suffering from IBS-C, Lubowel 24 Capsule relieves stomach discomfort, bloating, and infrequent bowel movements by helping food move through the digestive tract.
  • Opioid-Induced Constipation (OIC): For people taking strong pain medicines (opioids) for chronic pain, Lubowel 24 Capsule counteracts the constipating side effects of these drugs to restore a natural bowel routine.

Key Benefits

Lubowel 24 Capsule helps relieve chronic constipation by increasing fluid secretion into the intestines. This softens stools and supports easier, more regular bowel movements.

  • Relieves Constipation: Helps increase the frequency of bowel movements and reduce difficulty passing stools.
  • Reduces Straining: By softening stools and improving their movement through the bowel, it may reduce the need to strain during bowel movements.
  • Eases Abdominal Discomfort: Regular bowel movements may help reduce constipation-related bloating, abdominal discomfort, and a feeling of fullness.
  • Supports Regular Bowel Function: Helps establish more consistent bowel movements in people with chronic constipation or other approved constipation-related conditions.
  • Improves Daily Comfort: Better control of constipation symptoms may make daily activities more comfortable and reduce disruption caused by irregular or difficult bowel movements.
Side effects of Lubowel 24 Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Directions for Use

  • Take Lubowel 24 Capsule with food to lower the chances of nausea.
  • It is advised to take Lubowel 24 Capsule as directed by your doctor, at the same time each day for best results.
  • Swallow Lubowel 24 Capsule as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Lubowel 24 Capsule Works

Lubowel 24 Capsule contains lubiprostone, which works by targeting and activating specific microscopic channels in your intestinal walls called chloride channels. By opening these channels, the medicine prompts your body to secrete more natural fluids directly into your bowel. This extra fluid acts as a natural softener for dry, hard stools and increases the volume of the waste inside your intestines. This increased volume naturally signals the muscles in your intestines to contract and squeeze, moving the stool through your digestive tract more easily. This mechanism works locally in your gut without affecting other major organ systems, allowing for a safer and more targeted approach to relieving constipation.
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Alcohol

Caution

It is not known if alcohol interacts with Lubowel 24 Capsule . Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Caution

Lubowel 24 Capsule is a pregnancy category C drug. If you are pregnant, please consult your doctor before taking Lubowel 24 Capsule ; your doctor will prescribe Lubowel 24 Capsule if the benefits outweigh the risks.

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Breast Feeding

Caution

Your baby may develop diarrhea if you take Lubowel 24 Capsule while breastfeeding. Please consult your doctor before taking Lubowel 24 Capsule if you are breastfeeding, your doctor will prescribe Lubowel 24 Capsule if the benefits outweigh the risks.

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Driving

Safe if prescribed

Lubowel 24 Capsule has negligible influence on your ability to drive.

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Liver

Caution

Take Lubowel 24 Capsule with caution, especially if you have a pre-existing or a history of liver disease. The dose may be adjusted by your doctor as required. However, Lubowel 24 Capsule is not recommended in patients with severe liver disease.

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Kidney

Caution

Dose adjustment may be needed in patients with severe kidney impairment. Please consult your doctor if you have kidney problems or any concerns.

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Children

Caution

Lubowel 24 Capsule should not be given to children as safety and effectiveness have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Lubowel 24 Capsule . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Lubowel 24 Capsule is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Lubowel 24 Capsule

In case of an accidental overdose, seek immediate medical attention or call your local poison control centre. Symptoms of an overdose may include severe nausea, vomiting, watery diarrhoea, and dizziness due to fluid loss.

Diet & Lifestyle Advise

  • Stay hydrated: Drink at least 8 to 10 glasses of water daily. The medicine works by drawing water into your bowels, so maintaining high fluid intake is crucial.
  • Eat dietary fibre: Gradually increase your intake of high-fibre foods like vegetables, fruits, whole grains, and beans to help bulk up your stool naturally.
  • Keep moving: Engage in regular, gentle physical activity, such as a 30-minute daily walk, which naturally stimulates your bowel muscles to contract.
  • Listen to your body: Do not ignore the urge to have a bowel movement. Delaying it can make stools harder and more difficult to pass.

Health Queries

I have been suffering from chronic constipation for the past 7 months and have tried many medicines without any relief; what effective medication should I take to treat this?

Veda Maddala

Veda Maddala

M Pharmacy

Dealing with chronic constipation for seven months can be very frustrating. Since standard over-the-counter options haven't worked, it is time to consult a doctor, preferably a gastroenterologist, for prescription therapies. Effective generic prescription medications specifically designed for chronic constipation include linaclotide, lubiprostone, or prucalopride, which work by increasing fluid in your intestines or stimulating bowel movements. Please do not worry, as this condition is highly treatable. Your doctor will help identify the best option and ensure there are no underlying issues, while also reviewing your daily fiber and water intake to provide you with much-needed relief.

I have IBS-C with constipation and stomach discomfort. Can Ayurvedic treatment help manage these symptoms, and which remedies may be useful?

Vikas Singh

Vikas Singh

M Pharmacy

IBS-C is a form of irritable bowel syndrome where constipation, bloating, abdominal discomfort, and incomplete bowel movements occur repeatedly because the intestines become more sensitive and bowel movement slows down. Stress, irregular eating habits, low fibre intake, poor sleep, and certain foods may worsen symptoms in many people. Some people feel symptom relief with Ayurvedic approaches that focus on digestion, bowel regularity, stress reduction, and dietary balance. Mild herbal preparations, warm fluids, fibre-rich foods, regular meal timing, yoga, and relaxation practices may help improve bowel movement and reduce bloating in some individuals. However, very strong laxative herbs or repeated cleansing therapies may sometimes worsen cramps, dehydration, or dependency if overused. Management usually works best when combined with proper hydration, physical activity, adequate sleep, and identification of trigger foods such as very oily, spicy, or gas-forming meals. Persistent weight loss, blood in stool, severe pain, vomiting, or anaemia should be evaluated carefully because these symptoms may suggest conditions other than IBS.

Is IBS curable, and how can it be managed?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

Irritable bowel syndrome (IBS) is a chronic condition that is usually not completely curable, but its symptoms can be effectively managed. Treatment focuses on identifying and avoiding triggers, increasing fibre intake or following a low FODMAP diet, and managing stress. Your doctor may also prescribe medications to relieve abdominal pain, regulate bowel habits, or treat specific symptoms such as bloating, constipation, or diarrhoea.
health query

Have a query?

How Soon It Starts Working

The time required for Lubowel 24 Capsule to start to work: Lubowel 24 Capsule ideally shows its action within 2 hours after administration. The time for which the effects of Lubowel 24 Capsule last: The effect of Lubowel 24 Capsule lasts for 5 to 8 hours.

What if you forget to take Lubowel 24 Capsule

If you miss a dose, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Lubowel 24 Capsule capsules in their original container at controlled room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Protect the medicine from direct light, moisture, and extreme heat or freezing conditions.

Drug Warnings

  • Take with Food and Water: Take Lubowel 24 Capsule with food and water as prescribed, as this may help reduce nausea.
  • Swallow Capsules Whole: Do not break, chew, or open the capsules. Check that each capsule is intact before taking it.
  • Report Severe Diarrhoea: Contact your doctor promptly if you develop severe or persistent diarrhoea, as this can lead to significant fluid loss and dehydration. Do not stop treatment on your own unless advised by your doctor.
  • Watch for Breathing Difficulty: Some people may experience shortness of breath or chest tightness, sometimes shortly after a dose. Contact your doctor promptly if this occurs, and seek urgent medical help if breathing difficulty is severe or worsening.
  • Do Not Share Your Medicine: Lubowel 24 Capsule is prescribed according to individual medical needs. Do not share it with anyone else, even if they have similar symptoms.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Lubowel 24 Capsule and require caution or medical advice:

  • Anticholinergic medications: Medicines used for bladder control, allergies, or spasms may slow down your digestive tract, making Lubowel 24 Capsule less effective.
  • Other laxatives: Taking other stool softeners or laxatives without your doctor's approval can greatly increase your risk of severe, dehydrating diarrhoea.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

Food may affect how well Lubowel 24 Capsule is tolerated. Important considerations include:

  • High-fat meals: Taking this medication alongside a high-fat meal is highly recommended as it helps to significantly lower the incidence of nausea.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[LAXATIVES]

FAQs

Lubowel 24 Capsule is used to treat chronic constipation and constipation associated with medicines like opioids (painkillers). Besides this, it is also used to treat irritable bowel syndrome-associated constipation in women.
Lubowel 24 Capsule consists of 'Lubiprostone' that works by increasing the secretion of fluids in the intestine, which in turn increases the motility of the intestine, thereby making the stool soft and easier to pass.
Consult your doctor before taking Lubowel 24 Capsule with other medicines as Lubowel 24 Capsule may increase the rate of gastrointestinal transit, and this may affect the absorption of other orally administered medicines given simultaneously.
Diarrhea might be a side-effect of Lubowel 24 Capsule . Drink lots of fluids and eat fibre-rich food if you experience diarrhea. If you find blood in your stools (tarry stools) or if you experience excess diarrhea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Constipation happens when the normal actions of muscle in the large intestine get slowed down, which means the waste products (stools) do not easily eliminated from the body.
Overuse or prolonged use of Lubowel 24 Capsule may cause dehydration. Severe dehydration may cause weakness, tremors, fainting and blurry vision. Consult your doctor immediately if you experience these symptoms. Drink enough fluids to avoid dehydration.
Take Lubowel 24 Capsule with food to reduce nausea or take it as advised by your doctor. Swallow it as whole with a glass of water. Do not chew or break it. Do not exceed the recommended dose.
Lubowel 24 Capsule may cause side effects such as abdominal pain, diarrhoea, headache, nausea, vomiting, dry mouth, and trouble sleeping. If these side effects persist or worsen, consult your doctor.
Lubowel 24 Capsule should be avoided by people with severe dehydration, appendicitis, intestinal blockage, bowel obstruction, or liver disease unless prescribed by a doctor. If you are a pregnant or breastfeeding women, consult a doctor before taking Lubowel 24 Capsule . Always use Lubowel 24 Capsule under a doctor's guidance.
Pregnant women should consult their doctor before taking Lubowel 24 Capsule , as its safety in pregnancy is not fully established. If you become pregnant while taking it, inform your doctor immediately. Do not self-medicate.
Lubowel 24 Capsule may interact with certain medications, such as idelalisib (anti-cancer drug) and methadone (painkiller). Therefore, please consult your doctor before taking Lubowel 24 Capsule with other medicines.
No, you should not take Lubowel 24 Capsule on an empty stomach. Taking it with a meal and a full glass of water is highly recommended to help prevent the severe nausea that can sometimes occur with this medicine. Talk to your doctor if you continue to feel sick.
If you experience severe, watery, or persistent diarrhoea, stop taking Lubowel 24 Capsule right away and contact your healthcare provider. Severe diarrhoea can quickly lead to dehydration, so your doctor may need to adjust your treatment plan. Talk to your doctor for advice.
While there is no direct chemical interaction, alcohol can cause dehydration and worsen digestive side effects like nausea or dizziness. It is best to limit alcohol intake while taking this medicine. Talk to your doctor about your alcohol use.
Some people experience a temporary sensation of shortness of breath or chest tightness, usually within an hour of taking their first dose. This feeling typically resolves on its own within a few hours, but you should still report it to your healthcare provider immediately. Talk to your doctor if this happens.
While Lubowel 24 Capsule is prescribed to both men and women for chronic constipation, its use for Irritable Bowel Syndrome with Constipation (IBS-C) is only officially approved for women. Talk to your doctor to see if this medication is appropriate for your specific diagnosis.
You should avoid taking other laxatives or stool softeners unless your doctor specifically instructs you to do so. Combining bowel medicines can cause severe, uncontrolled diarrhoea and fluid loss. Talk to your doctor before mixing treatments.

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Reference

  1. Drugs.com Clinical Review Team. Lubiprostone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 021908S015Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Lubiprostone Lubiprostone. 2006. [Accessed on 27 Mar. 2019]Check here
  5. Brian E Lacy and L Campbell Levy. Lubiprostone: a novel treatment for chronic constipation. Journal of Clinical Interventions in Aging. June 2008 [Accessed on 16th June 2022]Check here
  6. Nicholas Wilson and Ron Schey. Lubiprostone in constipation: clinical evidence and place in therapy. Journal of Therapeutic Advances in Chronic Disease. March 2015 [Accessed on 16th June 2022]Check here
  7. Par Pharmaceutical Inc. Dailymed. Lubiprostone. [Revised in April 2021]. [Accessed on 16th June 2022].Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - LUB0038

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