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  3. Lithonik 450mg Tablet SR

Lithonik 450mg Tablet SR, Pack of 1 Tablet
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Lithonik 450mg Tablet SR belongs to the class of antipsychotic medicine used in the treatment of bipolar disorder and mania. This medicine suppresses the excess and abnormal activity of nerve cells in the brain by increasing the activity of chemical messengers in the brain. Common side effects include loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination.
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Composition :

LITHIUM CARBONATE-450MG

Manufacturer/Marketer :

Sycap Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

About Lithonik 450mg Tablet SR

Lithonik 450mg Tablet SR belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Lithonik 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Lithonik 450mg Tablet SR as prescribed. Your doctor will advise you on how often you need to take Lithonik 450mg Tablet SR based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Lithonik 450mg Tablet SR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Lithonik 450mg Tablet SR or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Lithonik 450mg Tablet SR. Regular blood tests are recommended while taking Lithonik 450mg Tablet SR to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Lithonik 450mg Tablet SR.

Uses of Lithonik 450mg Tablet SR

Treatment of Bipolar disorder and Mania

Directions for Use

• Take Lithonik 450mg Tablet SR with food for better absorption or take it as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow it as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

Lithonik 450mg Tablet SR is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Lithonik 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Lithonik 450mg Tablet SR relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

How Lithonik 450mg Tablet SR Works

Lithonik 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

• Store in a cool and dry place away from sunlight.• Keep Lithonik 450mg Tablet SR out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Lithonik 450mg Tablet SR
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

What if I have taken an overdose of Lithonik 450mg Tablet SR

Take Lithonik 450mg Tablet SR only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include vomiting, diarrhoea, muscular weakness, drowsiness, and lack of coordination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Regular blood tests are recommended while taking Lithonik 450mg Tablet SR to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Lithonik 450mg Tablet SR. If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Lithonik 450mg Tablet SR as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCidofovir
Critical
LithiumCisapride
Critical

Drug-Drug Interactions

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LithiumCidofovir
Critical
How does the drug interact with Lithonik 450mg Tablet SR:
Cidofovir can cause higher levels of Lithonik 450mg Tablet SR carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lithonik 450mg Tablet SR with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumCisapride
Critical
How does the drug interact with Lithonik 450mg Tablet SR:
Taking Cisapride with Lithonik 450mg Tablet SR can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lithonik 450mg Tablet SR with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumSotalol
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Taking Lithonik 450mg Tablet SR together with Sotalol can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Lithonik 450mg Tablet SR with Sotalol together can result in an interaction, but it can be taken if a doctor has advised it. However, consult the doctor immediately if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting a doctor.
LithiumMoxifloxacin
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Using Moxifloxacin together with Lithonik 450mg Tablet SR can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Moxifloxacin with Lithonik 450mg Tablet SR can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience dizziness, shortness of breath, or heart palpitations Do not discontinue any medications without consulting a doctor.
LithiumBupropion
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Taking Bupropion with Lithonik 450mg Tablet SR can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of bupropion along with Lithonik 450mg Tablet SR can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience any unusual symptoms like staring, stiffening of the legs and hands, stiffening of body, loss of consciousness, breathing difficulties or cessation, lack of urinary or bowel control, and Falling suddenly for no apparent reason, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
LithiumOndansetron
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Taking ondansetron with Lithonik 450mg Tablet SR can increase the risk of serotonin syndrome a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking ondansetron along with Lithonik 450mg Tablet SR can result in an interaction but can be taken together if prescribed by a doctor. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools, or fast or rapid heartbeats during therapy, consult a doctor. Do not stop using any medications without talking to a doctor.
LithiumFlurbiprofen
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Co-administration of Flurbiprofen with Lithonik 450mg Tablet SR may significantly increase the blood levels of Lithonik 450mg Tablet SR.

How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and Lithonik 450mg Tablet SR, but it can be taken if prescribed by a doctor. However, if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst and increased urination contact your doctor immediately. Do not stop using any medications without a doctor's advice.
LithiumSirolimus
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Coadministration of Sirolimus with Lithonik 450mg Tablet SR together may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Lithonik 450mg Tablet SR and Sirolimus together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
LithiumDuloxetine
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Taking Duloxetine with Lithonik 450mg Tablet SR can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between Duloxetine and Lithonik 450mg Tablet SR, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumEtodolac
Severe
How does the drug interact with Lithonik 450mg Tablet SR:
Taking Lithonik 450mg Tablet SR with etodolac may significantly increase the blood levels of Lithonik 450mg Tablet SR.

How to manage the interaction:
Co-administration of Etodolac with Lithonik 450mg Tablet SR can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking hands and legs, blurred vision, ringing in the ear, excessive thirst, and increased urination contact a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Lithonik 450mg Tablet SR.
  • Do regular exercise and maintain a stable weight as Lithonik 450mg Tablet SR may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Lithonik 450mg Tablet SR Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Lithonik 450mg Tablet SR as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Lithonik 450mg Tablet SR is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Lithonik 450mg Tablet SR as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Lithonik 450mg Tablet SR may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Lithonik 450mg Tablet SR.

bannner image

Liver

Safe if prescribed

Lithonik 450mg Tablet SR is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

bannner image

Kidney

Caution

Take Lithonik 450mg Tablet SR with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Lithonik 450mg Tablet SR is not recommended for patients with severe kidney problems.

bannner image

Children

Caution

Lithonik 450mg Tablet SR is generally not recommended for children below 12 years. However, Lithonik 450mg Tablet SR may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

Have a query?

FAQs

Lithonik 450mg Tablet SR belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.

Lithonik 450mg Tablet SR helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Lithonik 450mg Tablet SR is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Lithonik 450mg Tablet SR.

Lithonik 450mg Tablet SR may cause weight gain but it is not necessary for everyone taking Lithonik 450mg Tablet SR to experience this side effect. However, in order to avoid gaining weight while taking Lithonik 450mg Tablet SR, you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Lithonik 450mg Tablet SR may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Lithonik 450mg Tablet SR to avoid dehydration.

You are not recommended to stop taking Lithonik 450mg Tablet SR without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Lithonik 450mg Tablet SR for as long as your doctor has prescribed it and if you experience any difficulty while taking Lithonik 450mg Tablet SR, please consult your doctor so that the dose may be gradually reduced.

You are not recommended to take Lithonik 450mg Tablet SR with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Lithonik 450mg Tablet SR with any other medicines, you are advised to contact your doctor.

The effects of Lithonik 450mg Tablet SR can vary from person to person, but it generally takes 1-3 weeks for you to see the full benefits. However, it's important to continue taking the Lithonik 450mg Tablet SR regularly as prescribed by your doctor to maintain its effectiveness.

It's important to inform your doctor about your hypertension and the medications you're taking for it as Lithonik 450mg Tablet SR can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.

No, you should not increase the dose of Lithonik 450mg Tablet SR on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.

Yes, Lithonik 450mg Tablet SR can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.

Yes, Lithonik 450mg Tablet SR can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Lithonik 450mg Tablet SR.

Lithonik 450mg Tablet SR should only be started if adequate facilities for assessing Lithonik 450mg Tablet SR levels are available. Because elevated levels of Lithonik 450mg Tablet SR are linked to Lithonik 450mg Tablet SR toxicity. Lithonik 450mg Tablet SR toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lithonik 450mg Tablet SR levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.

Lithonik 450mg Tablet SR should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Lithonik 450mg Tablet SR may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Certain medications which decrease the levels of Lithonik 450mg Tablet SR in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Lithonik 450mg Tablet SR, inform your doctor about all the medicines you are taking.

The common side effects of Lithonik 450mg Tablet SR are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - LI32957

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 6:59 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10828.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/017812s033,018421s032,018558s027lbl.pdf
  3. https://www.drugs.com/lithium.html
  4. https://www.nhs.uk/medicines/lithium/
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