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Ligno-Ad Injection is used to induce local anaesthesia. It contains Lidocaine and Adrenaline which work by preventing initiation and conduction of impulses. In some cases, this medicine may cause side effects such as application site reactions (burning, itching, redness, and irritation), nausea, vomiting and allergy. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Kopran Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ligno-Ad Injection

Ligno-Ad Injection belongs to the class of local anaesthetics known as numbing medication used to produce local numbness (anaesthesia) on skin before surgical procedure and reduce pain and discomfort caused by invasive medical procedures such as surgery. It is also used to reduce the discomfort of contractions during labour. Ligno-Ad Injection is also used to treat certain types of chronic pain. Pain is a symptom triggered by the nervous system, which causes uncomfortable sensations in the body. Pain may be dull or sharp, it might be constant or may come and go. The tolerance level of pain might vary from person to person.

Ligno-Ad Injection is a combination of two drugs: Lidocaine (local anesthetic) and Adrenaline (vasoconstrictor). Lidocaine works by blocking the influx (entry) of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses. Hence, it gives an anaesthetic effect and helps decrease the sensation of pain. Adrenaline works by constricting and narrowing blood vessels to slow the dispersal. Thereby prolong the effect of Lidocaine.

Ligno-Ad Injection will be administered by a healthcare professional. Do not self-administer. In some cases, you may experience certain common side-effects such as reactions at the application site (burning, itching, redness, and irritation), nausea, vomiting and allergy. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

The usage of Ligno-Ad Injection is not allowed in patients who are hypersensitive to any of the components present in it as it may cause serious side effects.  Before starting the medication, tell your doctor about your medical history, especially if you have high blood pressure or heart problems such as a slow heart beat, hypovolaemia (decreased volume of blood), epilepsy, diabetes, liver disease, a certain blood disorder (methemoglobinemia). Please consult a doctor if you are pregnant or breastfeeding before taking Ligno-Ad Injection. Ligno-Ad Injection is not recommended for children. 

Uses of Ligno-Ad Injection

Ligno-Ad Injection is used in the treatment of Pain relief (local anaesthesia). The detailed uses of Ligno-Ad Injection are as follows:

  • Local Anesthesia for Minor Procedures: Ligno-Ad Injection is used to numb specific areas of the body during dental work, skin surgery, or other minor medical procedures. It blocks nerve signals to prevent pain.
  • Reduced Bleeding During Surgery: Ligno-Ad Injection contains adrenaline, which constricts blood vessels at the injection site, minimizing bleeding and improving visibility for the surgeon.
  • Prolonged Anesthetic Effect: Ligno-Ad Injection extends the duration of numbness by slowing the absorption of lignocaine into the bloodstream, allowing for longer pain control.

Key Benefits

Ligno-Ad Injection is a combination of two medicines, namely; Lidocaine (local anesthetic) and Adrenaline (vasoconstrictor). Ligno-Ad Injection is used to produce local numbness (anaesthesia). Lidocaine is a local anesthetic which works by blocking the transmission of the nerve signals in the body, thereby helps in decreasing the sensation of pain. Adrenaline is a vasoconstrictor which works by constricting and narrowing blood vessels to slow the dispersal. Thereby prolong the effect of Lidocaine. Ligno-Ad Injection is used to reduce pain and discomfort caused by invasive medical procedures such as surgery, needle punctures or insertion of a breathing tube or catheter. It is also used to reduce the discomfort of contractions during labour. Ligno-Ad Injection will start to work rapidly after being injected and will slowly wear off when the surgical procedure is over.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Ligno-Ad Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Ligno-Ad Injection Works

Ligno-Ad Injection is a combination of two drugs: Lidocaine (local anesthetic) and Adrenaline (vasoconstrictor). Lidocaine works by blocking the influx (entry) of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses. Hence, it gives an anaesthetic effect and helps decrease the sensation of pain. Adrenaline works by constricting and narrowing blood vessels to slow the dispersal. Thereby prolong the effect of Lidocaine.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Ligno-Ad Injection. Alcohol intake, along with Ligno-Ad Injection, may cause increased drowsiness.

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Pregnancy

Unsafe

It is not recommended to take Ligno-Ad Injection while you are pregnant. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe you Ligno-Ad Injection only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Please consult your doctor if you have any concerns regarding this, your doctor will decide whether breastfeeding mothers can take Ligno-Ad Injection or not.

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Driving

Caution

Ligno-Ad Injection may cause drowsiness and vision disturbances, do not drive or operate heavy machinery if you feel drowsy.

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Liver

Caution

Ligno-Ad Injection should be used with caution in patients with liver impairment/liver disease. Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Ligno-Ad Injection should be used with caution in patients with kidney impairment/kidney disease. Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Ligno-Ad Injection should not be used by children, as the efficacy and safety have not been established.

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Heart

Consult your doctor

Ligno-Ad Injection will be administered in the hospital setting if needed. Please inforl your doctor if you have any pre-existing heart problems.

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Geriatrics

Consult your doctor

Your doctor will administer Ligno-Ad Injection if needed in the hospital setting.

What if I have taken an overdose of Ligno-Ad Injection

Since Ligno-Ad Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Diet & Lifestyle Advise

  • ​Indulge yourself in mindfulness activities like yoga that help in reducing stress levels and pain management.

  • Never forget to get about 7-8 hours of sleep as it will help your muscles to heal fast and reduces inflammation and swelling.
  • Take out some time for meditation, read books, take a warm bubble bath, spend time with family or listen to relaxing music.
  • Make a habit of eating food rich in antioxidants such as berries, onion, milk, spinach, kidney beans, dark chocolate, etc.
  • Foods rich in flavonoids helps the body to heal faster by reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Strictly limit smoking and alcohol consumption as it may worsen the side effects of the drug.

Have a query?

How Soon It Starts Working

The time required for Ligno-Ad Injection to start to work: The time required for Ligno-Ad Injection to show its action is unknown. The time for which the effects of Ligno-Ad Injection last: The duration of action for Ligno-Ad Injection is clinically unknown.

What if you forget to take Ligno-Ad Injection

As this medicine is administered in a hospital by a healthcare professional, the chances of missing a dose are less. However, if you have any concerns, please consult a doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Ligno-Ad Injection out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not exceed the dose and duration prescribed by your doctor. Consult your doctor before taking Ligno-Ad Injection if you are pregnant or breastfeeding, your doctor will prescribe you Ligno-Ad Injection only if the benefits outweigh the risks. Ligno-Ad Injection causes drowsiness, so drive with caution. Avoid consuming alcohol along with Ligno-Ad Injection as it could lead to increased drowsiness. Ligno-Ad Injection may not be suitable for people with respiratory disease, heart disease, epilepsy, low blood pressure, kidney or liver problems. Inform your doctor about your health condition and medications before taking Ligno-Ad Injection to rule out any side-effects.

Drug-Drug Interactions

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Drug-Drug Interaction: Ligno-Ad Injection may have interaction with used to treat anxiety (lorazepam, alprazolam), medicines used to induce anaesthesia (halothane, prilocaine), a medicine used to relieve pain (tramadol), medicines used to treat an uneven heartbeat (arrhythmia) and hypertension (amiodarone,  propranolol, sodium nitrite), medicines for sickness (domperidone), medicines for mental problems (haloperidol, chlorpromazine) antidepressants (isocarboxazid, phenelzine, selegiline, tranylcypromine), antiulcer (cimetidine).

Drug-Food Interaction: Avoid consuming alcohol along with Ligno-Ad Injection as it could lead to increased drowsiness.

Drug-Disease Interaction: Ligno-Ad Injection may interact with heart dysfunction, seizures (fits), electrolyte imbalance, liver problems and kidney dysfunction.

Lidocaine + EpinephrineDihydroergotamine
Critical

Drug-Drug Interactions

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How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Linezolid with Ligno-Ad Injection 30 ml can increase the risk of high blood pressure.

How to manage the interaction:
Taking Linezolid with Ligno-Ad Injection 30 ml is not recommended as it can result in an interaction. It should be taken only if a doctor has advised it. It is advised to maintain your blood pressure. Do not discontinue any medications without consulting a doctor.
Lidocaine + EpinephrineDihydroergotamine
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
When Dihydroergotamine is taken with Ligno-Ad Injection 30 ml, the amount of Dihydroergotamine in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Dihydroergotamine with Ligno-Ad Injection 30 ml is not recommended as it can lead to an interaction. It should be taken only if your doctor has advised it. However, if you experience stomach pain, vomiting, numbness or tingling sensation, weakness or pain in the muscles, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe headache, abnormal heartbeat, breathing difficulty, blurred vision, confusion, and/or slurred speech contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml and Arbutamine together can affect the rhythm of your heart.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with arbutamine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience irregular heartbeat, chest tightness, blurred vision and nausea. Do not discontinue any medication without consulting a doctor.
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Saquinavir can increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Nitrofurantoin may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Nitrofurantoin with Ligno-Ad Injection 30 ml together can result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, breathing difficulty, a rapid heartbeat, anxiety, or confusion. Do not stop using any medications without consulting doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Combination of chloroquine and Ligno-Ad Injection 30 ml can increase the risk of methemoglobinemia (an uncommon disease that can result in low oxygen levels in tissues and important organs).

How to manage the interaction:
Taking chloroquine and Ligno-Ad Injection 30 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. If you experience any of the following symptoms: gray discoloration of the skin, abnormal blood coloring, nausea, headache, dizziness, lightheadedness, weakness, breathing difficulty, rapid heartbeat, anxiety, or confusion, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Methylergometrine can increase the risk of high blood pressure and other side effects.

How to manage the interaction:
Co-administration of Ligno-Ad Injection 30 ml with Methylergometrine may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience stomach pain, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, headache, abnormal heart rhythm, breathing difficulty, blurred vision, confusion, slurred speech, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking isosorbide dinitrate with Ligno-Ad Injection 30 ml may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking isosorbide dinitrate and lidocaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, breathing difficulty, a rapid heartbeat, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Severe
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Amprenavir may increase the risk of severe side effects such as irregular heart rhythm and other heart problems.

How to manage the interaction:
There may be a possibility of interaction between Ligno-Ad Injection 30 ml and Amprenavir, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml and Iomeprol may increase the risk of causing seizures(fits).

How to manage the interaction:
There may be a possibility of interaction between Ligno-Ad Injection 30 ml and Iomeprol, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[LOCAL ANESTHETICS]

FAQs

Ligno-Ad Injection is used to produce local numbness (anaesthesia) on skin before surgical procedure and reduce pain and discomfort caused by invasive medical procedures such as surgery.

Ligno-Ad Injection contains Lidocaine and Adrenaline. Lidocaine blocks the influx of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses (nerve signal). Hence, it gives an anesthetic effect and decreases the sensation of pain. Adrenaline works by constricting and narrowing blood vessels by acting on alpha receptors that cause muscle contractions. Thus, it decreasing the bleeding and the effects of Ligno-Ad Injection will last longer.

You are not recommended to take duloxetine (antidepressant) with Ligno-Ad Injection as co-administration of these two medicines may increase the risk of high blood pressure and heart rate. However, please consult your doctor before taking other medicines with Ligno-Ad Injection.

Ligno-Ad Injection causes drowsiness and vision disturbances. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.

A person of age 65 or older should use Ligno-Ad Injection with caution, as directed by the doctor as the chances of occurrence of side effects increase in older people.

Ligno-Ad Injection should be used with caution in patients suffering from heart rhythm disorders as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you have any heart problems before taking Ligno-Ad Injection so that the dose may be adjusted appropriately or an alternate medicine may be prescribed.

The effect of Ligno-Ad Injection may last for about 1 to 2 hours, depending on the dosage, and the site of administration. For some individuals, the effect may last longer or shorter than the average duration. However, the duration may vary from person to person.

Ligno-Ad Injection is generally well-tolerated, and patients often report mild or no pain during administration. However, individual experiences may vary, and some patients might feel slight discomfort at the injection site. To minimize potential pain, healthcare providers may use techniques such as buffering the lidocaine with sodium bicarbonate or employing smaller gauge needles.

Ligno-Ad Injection is contraindicated in individuals with a known hypersensitivity to amide-type local anaesthetics or any ingredients of the injection formulation.

No, Ligno-Ad Injection may not cause abuse as it is typically administered by the doctor or nurse. This ensures the dosage and usage are carefully monitored to avoid misuse or harmful effects.

The side effects of Ligno-Ad Injection include nausea, vomiting, reactions at the application site (burning, itching, redness, and irritation), and allergy. Most of these symptoms will resolve gradually over time. However, consult the doctor if these side effects persist or worsen.

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Author Details

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Country of origin

India

Manufacturer/Marketer address

Parijat House,1076, Dr. E. Moses Road, Worli, Mumbai - 400 018, Maharashtra (India)
Other Info - LIG0061
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