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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Ligno-Ad Injection is used to induce local anaesthesia. It contains Lidocaine and Adrenaline which work by preventing initiation and conduction of impulses. In some cases, this medicine may cause side effects such as application site reactions (burning, itching, redness, and irritation), nausea, vomiting and allergy. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Manufacturer/Marketer :

Kopran Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Ligno-Ad Injection

Ligno-Ad Injection belongs to the class of local anaesthetics known as numbing medication used to produce local numbness (anaesthesia) on skin before surgical procedure and reduce pain and discomfort caused by invasive medical procedures such as surgery. It is also used to reduce the discomfort of contractions during labour. Ligno-Ad Injection is also used to treat certain types of chronic pain. Pain is a symptom triggered by the nervous system, which causes uncomfortable sensations in the body. Pain may be dull or sharp, it might be constant or may come and go. The tolerance level of pain might vary from person to person.

Ligno-Ad Injection is a combination of two drugs: Lidocaine (local anesthetic) and Adrenaline (vasoconstrictor). Lidocaine works by blocking the influx (entry) of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses. Hence, it gives an anaesthetic effect and helps decrease the sensation of pain. Adrenaline works by constricting and narrowing blood vessels to slow the dispersal. Thereby prolong the effect of Lidocaine.

Ligno-Ad Injection will be administered by a healthcare professional. Do not self-administer. In some cases, you may experience certain common side-effects such as reactions at the application site (burning, itching, redness, and irritation), nausea, vomiting and allergy. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

The usage of Ligno-Ad Injection is not allowed in patients who are hypersensitive to any of the components present in it as it may cause serious side effects.  Before starting the medication, tell your doctor about your medical history, especially if you have high blood pressure or heart problems such as a slow heart beat, hypovolaemia (decreased volume of blood), epilepsy, diabetes, liver disease, a certain blood disorder (methemoglobinemia). Please consult a doctor if you are pregnant or breastfeeding before taking Ligno-Ad Injection. Ligno-Ad Injection is not recommended for children. 

Uses of Ligno-Ad Injection

Treatment of Pain relief (local anaesthesia).

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Ligno-Ad Injection will be administered by the doctor or nurse in a healthcare setting.• Do not self-administer.

Medicinal Benefits

Ligno-Ad Injection is a combination of two medicines, namely; Lidocaine (local anesthetic) and Adrenaline (vasoconstrictor). Ligno-Ad Injection is used to produce local numbness (anaesthesia). Lidocaine is a local anesthetic which works by blocking the transmission of the nerve signals in the body, thereby helps in decreasing the sensation of pain. Adrenaline is a vasoconstrictor which works by constricting and narrowing blood vessels to slow the dispersal. Thereby prolong the effect of Lidocaine. Ligno-Ad Injection is used to reduce pain and discomfort caused by invasive medical procedures such as surgery, needle punctures or insertion of a breathing tube or catheter. It is also used to reduce the discomfort of contractions during labour. Ligno-Ad Injection will start to work rapidly after being injected and will slowly wear off when the surgical procedure is over.

How Ligno-Ad Injection Works

Ligno-Ad Injection is a combination of two drugs: Lidocaine (local anesthetic) and Adrenaline (vasoconstrictor). Lidocaine works by blocking the influx (entry) of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses. Hence, it gives an anaesthetic effect and helps decrease the sensation of pain. Adrenaline works by constricting and narrowing blood vessels to slow the dispersal. Thereby prolong the effect of Lidocaine.

Storage

Keep Ligno-Ad Injection out of the sight and reach of children.

What if I have taken an overdose of Ligno-Ad Injection

Since Ligno-Ad Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Do not exceed the dose and duration prescribed by your doctor. Consult your doctor before taking Ligno-Ad Injection if you are pregnant or breastfeeding, your doctor will prescribe you Ligno-Ad Injection only if the benefits outweigh the risks. Ligno-Ad Injection causes drowsiness, so drive with caution. Avoid consuming alcohol along with Ligno-Ad Injection as it could lead to increased drowsiness. Ligno-Ad Injection may not be suitable for people with respiratory disease, heart disease, epilepsy, low blood pressure, kidney or liver problems. Inform your doctor about your health condition and medications before taking Ligno-Ad Injection to rule out any side-effects.

Drug-Drug Interactions

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EpinephrineDihydroergotamine
Critical

Drug-Drug Interactions

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EpinephrineDihydroergotamine
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
When Dihydroergotamine is taken with Ligno-Ad Injection 30 ml, the amount of Dihydroergotamine in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Dihydroergotamine with Ligno-Ad Injection 30 ml is not recommended as it can lead to an interaction. It should be taken only if your doctor has advised it. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, or slurred speech contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Coadministration of Ligno-Ad Injection 30 ml with Tranylcypromine can increase the risk or severity of high blood pressure or increased heart rate.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with Tranylcypromine is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Linezolid with Ligno-Ad Injection 30 ml can increase the risk of high blood pressure.

How to manage the interaction:
Taking Linezolid with Ligno-Ad Injection 30 ml is not recommended as it can result in an interaction. It should be taken only if a doctor has advised it. However, if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LidocaineArbutamine
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml and Arbutamine together can affect the rhythm of your heart.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with arbutamine is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience irregular heartbeat, chest tightness, blurred vision and nausea. Do not discontinue any medication without consulting a doctor.
LidocaineSaquinavir
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Saquinavir can increase the blood levels of Ligno-Ad Injection 30 ml and cause an irregular heart rhythm.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Coadministration of Ligno-Ad Injection 30 ml with Sotalol may reduce the effects of Ligno-Ad Injection 30 ml. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Ligno-Ad Injection 30 ml, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
EpinephrinePenbutolol
Severe
How does the drug interact with Ligno-Ad Injection 30 ml:
Coadministration of Penbutolol with Ligno-Ad Injection 30 ml can lead to high blood pressure and low heart rates.

How to manage the interaction:
Taking Penbutolol with Ligno-Ad Injection 30 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, irregular heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Coadministration of Doxepin with Ligno-Ad Injection 30 ml can enhance the effects of Ligno-Ad Injection 30 ml on blood pressure.

How to manage the interaction:
Although there is a possible interaction between Doxepin and Ligno-Ad Injection 30 ml, you can take these medicines together if prescribed by your doctor. It's important to monitor your blood pressure regularly. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, throbbing headache, tremor, or palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Nortriptyline can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with Nortriptyline together can result in an interaction, but it can be taken only if your doctor has advised it. It's important to monitor your blood pressure regularly. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Labetalol along with Ligno-Ad Injection 30 ml can reduce the effects of Ligno-Ad Injection 30 ml.

How to manage the interaction:
Taking Labetalol and Ligno-Ad Injection 30 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • ​Indulge yourself in mindfulness activities like yoga that help in reducing stress levels and pain management.

  • Never forget to get about 7-8 hours of sleep as it will help your muscles to heal fast and reduces inflammation and swelling.
  • Take out some time for meditation, read books, take a warm bubble bath, spend time with family or listen to relaxing music.
  • Make a habit of eating food rich in antioxidants such as berries, onion, milk, spinach, kidney beans, dark chocolate, etc.
  • Foods rich in flavonoids helps the body to heal faster by reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Strictly limit smoking and alcohol consumption as it may worsen the side effects of the drug.

Habit Forming

No

Therapeutic Class

LOCAL ANESTHETICS

Ligno-Ad Injection Substitute

Substitutes safety advice
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Ligno-Ad Injection. Alcohol intake, along with Ligno-Ad Injection, may cause increased drowsiness.

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Pregnancy

Unsafe

It is not recommended to take Ligno-Ad Injection while you are pregnant. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe you Ligno-Ad Injection only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Please consult your doctor if you have any concerns regarding this, your doctor will decide whether breastfeeding mothers can take Ligno-Ad Injection or not.

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Driving

Caution

Ligno-Ad Injection may cause drowsiness and vision disturbances, do not drive or operate heavy machinery if you feel drowsy.

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Liver

Caution

Ligno-Ad Injection should be used with caution in patients with liver impairment/liver disease. Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Ligno-Ad Injection should be used with caution in patients with kidney impairment/kidney disease. Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Ligno-Ad Injection should not be used by children, as the efficacy and safety have not been established.

Have a query?

FAQs

Ligno-Ad Injection is used to produce local numbness (anaesthesia) on skin before surgical procedure and reduce pain and discomfort caused by invasive medical procedures such as surgery.

Ligno-Ad Injection contains Lidocaine and Adrenaline. Lidocaine blocks the influx of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses (nerve signal). Hence, it gives an anesthetic effect and decreases the sensation of pain. Adrenaline works by constricting and narrowing blood vessels by acting on alpha receptors that cause muscle contractions. Thus, it decreasing the bleeding and the effects of Ligno-Ad Injection will last longer.

You are not recommended to take duloxetine (antidepressant) with Ligno-Ad Injection as co-administration of these two medicines may increase the risk of high blood pressure and heart rate. However, please consult your doctor before taking other medicines with Ligno-Ad Injection.

Ligno-Ad Injection causes drowsiness and vision disturbances. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.

A person of age 65 or older should use Ligno-Ad Injection with caution, as directed by the doctor as the chances of occurrence of side effects increase in older people.

Ligno-Ad Injection should be used with caution in patients suffering from heart rhythm disorders as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you have any heart problems before taking Ligno-Ad Injection so that the dose may be adjusted appropriately or an alternate medicine may be prescribed.

The effect of Ligno-Ad Injection may last for about 1 to 2 hours, depending on the dosage, and the site of administration. For some individuals, the effect may last longer or shorter than the average duration. However, the duration may vary from person to person.

Ligno-Ad Injection is generally well-tolerated, and patients often report mild or no pain during administration. However, individual experiences may vary, and some patients might feel slight discomfort at the injection site. To minimize potential pain, healthcare providers may use techniques such as buffering the lidocaine with sodium bicarbonate or employing smaller gauge needles.

Ligno-Ad Injection is contraindicated in individuals with a known hypersensitivity to amide-type local anaesthetics or any ingredients of the injection formulation.

No, Ligno-Ad Injection may not cause abuse as it is typically administered by the doctor or nurse. This ensures the dosage and usage are carefully monitored to avoid misuse or harmful effects.

The side effects of Ligno-Ad Injection include nausea, vomiting, reactions at the application site (burning, itching, redness, and irritation), and allergy. Most of these symptoms will resolve gradually over time. However, consult the doctor if these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Parijat House,1076, Dr. E. Moses Road, Worli, Mumbai - 400 018, Maharashtra (India)
Other Info - LIG0061

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