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compositionComposition:LAPATINIB-250MG
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Libset Tablet is an anti-cancer medicine used in the treatment of Breast cancer. It contains Lapatinib, which works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells; this causes inhibition of the cancer cell growth and, finally, initiation of apoptosis. It is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LAPATINIB-250MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Libset Tablet

Libset Tablet is a prescription medicine used to treat specific types of advanced or metastatic breast cancer. It is specifically designed to target cancer cells that produce too much of a protein called HER2. Doctors typically prescribe this medicine in combination with other chemotherapy or hormone therapy drugs to help slow down the spread of the disease.

For this medication to work effectively, you must take it consistently every day at the same time. It is crucial to take Libset Tablet on an empty stomach, either at least 1 hour before or 1 hour after eating a meal. To support your body during treatment, it is helpful to drink plenty of fluids and make dietary adjustments to manage potential digestive changes.

While taking Libset Tablet , you may experience common side effects such as mild diarrhoea, skin rashes, or feeling sick to your stomach. However, you must contact your doctor immediately if you experience severe diarrhoea, extreme tiredness, or signs of liver damage, such as yellowing of your skin or eyes.

Do not take this if you are allergic to any of its ingredients. Before starting treatment, tell your doctor if you have a history of heart problems, liver disease, or electrolyte imbalances. This medicine is not recommended for pregnant women, as it can harm an unborn baby.

Certain medications, alcohol, and smoking can alter how your body processes this medicine, potentially causing severe side effects or making the treatment less effective. If you are breastfeeding or are an older adult, talk to your doctor or pharmacist to discuss specific safety measures before starting Libset Tablet .

Uses of Libset Tablet

Libset Tablet is used to treat specific types of advanced or metastatic breast cancer. The detailed uses of Libset Tablet are as follows:

  • HER2-positive breast cancer: Libset Tablet is prescribed to treat advanced or metastatic breast cancer that overexpresses the HER2 protein, working alongside other therapies to help control cell growth.

Key Benefits

Libset Tablet helps treat certain types of cancer by blocking signals that promote cancer cell growth and spread. With regular use as prescribed, it helps control disease progression, provides the convenience of oral therapy, and enhances the effectiveness of combination treatment.

  • Helps Slow Cancer Progression: By targeting the pathways that drive cancer cell growth and multiplication, this medicine helps slow the progression of the disease and supports better tumour control.
  • Convenient Oral Treatment: As an oral tablet, this medicine can be taken at home as directed by your healthcare provider, reducing the need for frequent hospital visits for intravenous treatment.
  • Enhances Combination Therapy: When used with other prescribed anticancer medicines, this medicine works together to improve treatment effectiveness, strengthen disease control, and support better overall treatment outcomes.
Side effects of Libset Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Directions for Use

  • Libset Tablet can be taken 1 hour before a meal or 2 hours after a meal.
  • It is advised to take Libset Tablet once daily or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not break, chew or crush Libset Tablet .

How Libset Tablet Works

Libset Tablet contains lapatinib, which belongs to a class of medicines called kinase inhibitors. It works by entering the cancer cells and blocking specific proteins, known as HER1 and HER2 receptors, which act as switches for cell growth. When these proteins are overactive, they signal the cancer cells to grow and divide rapidly. By blocking these signals from the inside, Libset Tablet helps stop the cancer cells from multiplying and slows down the growth of the tumour.
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Alcohol

Unsafe

Alcohol intake might increase the risk of worsening your condition. Hence, avoid alcohol consumption till your condition improves.

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Pregnancy

Unsafe

Libset Tablet is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Libset Tablet . Use reliable methods of birth control while on treatment with Libset Tablet .

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Libset Tablet as it can cause serious side effects to the newborn baby.

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Driving

Consult your doctor

It is unknown whether Libset Tablet will affect your mental ability to drive or operate machines. Hence, consult your doctor for information regarding this.

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Liver

Caution

Inform your doctor if you have any pre-existing liver disease. Your doctor may adjust the dose of the medicine based on the condition. Libset Tablet is known to cause hepatotoxicity in some patients. If you notice any reactions such as itching, yellowing of the skin or eyes, dark urine, abdominal pain, unusual bleeding, or pale or dark stools, discontinue the treatment and inform your doctor immediately.

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Kidney

Caution

Limited data are available on the effect of Libset Tablet in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Libset Tablet is not recommended for use in children as the safety and efficacy are not established.

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Heart

Caution

Libset Tablet may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Libset Tablet .

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Geriatrics

Consult your doctor

Please consult a doctor before administering Libset Tablet to geriatric patients. Your doctor will prescribe Libset Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Libset Tablet

If you take too much of this medicine, seek emergency medical care immediately. An overdose can lead to serious complications and requires prompt medical attention.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear broths throughout the day, especially if you experience loose stools, to replace lost fluids and prevent dehydration.
  • Avoid grapefruit products: Do not eat grapefruit or drink grapefruit juice, as they can cause the medicine to build up to dangerous levels in your body.
  • Protect your skin: Use mild, fragrance-free soaps and moisturisers. Wear sunscreen and protective clothing when outdoors, as your skin may be highly sensitive to light and prone to dryness.
  • Eat bland, small meals: If you experience mild nausea, try eating smaller portions of bland foods like crackers, toast, or bananas rather than large, heavy, or greasy meals.
health query

Have a query?

How Soon It Starts Working

The time required for Libset Tablet to start to work: Libset Tablet ideally shows its action within 15 to 30 minutes after administration. The time for which the effects of Libset Tablet last: The effect of Libset Tablet lasts for 3 to 4 hours.

What if you forget to take Libset Tablet

If you miss a dose, skip the missed dose completely. Take your next scheduled dose at your regular time the next day. Do not take two doses at the same time to make up for a missed dose.

Storage

•Store Libset Tablet at room temperature, specifically between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Always inspect your tablets before taking them; do not take any tablets that are broken, chipped, or discoloured.
  • Do not take this medicine with food, as eating significantly increases the absorption of the drug and can cause severe side effects.
  • Ensure you attend all scheduled appointments for blood tests and heart scans, as your doctor must regularly check your liver and heart health.
  • Keep an anti-diarrheal medication handy, and start taking it at the first sign of loose stools as previously instructed by your doctor.
  • Inform all your healthcare providers, including dentists and pharmacists, that you are taking Libset Tablet before starting any new treatments or procedures.

Drug-Drug Interactions

verifiedApollotooltip
  • Antifungal medicines (like ketoconazole): May increase the level of Libset Tablet in your blood, raising the risk of severe side effects.
  • Seizure medications (like carbamazepine or phenytoin): Can lower the level of Libset Tablet , making your cancer treatment less effective.
  • Certain heart or blood pressure medicines: May increase the risk of irregular heart rhythms when combined with this medicine.
LapatinibNilotinib
Severe
LapatinibDisopyramide
Severe

Drug-Drug Interactions

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LapatinibNilotinib
Severe
How does the drug interact with Libset Tablet:
Combining Libset Tablet and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Libset Tablet and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LapatinibDisopyramide
Severe
How does the drug interact with Libset Tablet:
The combined use of Libset Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Libset Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LapatinibGatifloxacin
Severe
How does the drug interact with Libset Tablet:
Taking Gatifloxacin and Libset Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Libset Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LapatinibLoperamide
Severe
How does the drug interact with Libset Tablet:
When taken in combination Libset Tablet may significantly raise the loperamide levels in the blood. This can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking loperamide with Libset Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
LapatinibAmiodarone
Severe
How does the drug interact with Libset Tablet:
Coadministration of Amiodarone together with Libset Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Libset Tablet interact, they can be used if prescribed by a doctor. If you have cardiac problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.
LapatinibEscitalopram
Severe
How does the drug interact with Libset Tablet:
Combining Libset Tablet with Escitalopram can increase the risk of QTc prolongation.

How to manage the interaction:
Co-administration of Escitalopram with Libset Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience dizziness, fainting, abnormal heart rhythm, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LapatinibKetoconazole
Severe
How does the drug interact with Libset Tablet:
Coadministration of Libset Tablet and ketoconazole may greatly increase Libset Tablet blood levels. This can increase the risk for side effects (diarrhea, liver damage, and heart problems like decreased heartbeat and irregular heartbeat).

How to manage the interaction:
Although taking Ketoconazole and Libset Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, sudden dizziness, lightheadedness, fainting; shortness of breath, or rapid or pounding heartbeats. Do not discontinue any medication without consulting a doctor.
LapatinibPazopanib
Severe
How does the drug interact with Libset Tablet:
Taking Pazopanib with Libset Tablet may significantly increase the blood levels of pazopanib. This can make you more likely to develop serious side effects such as liver problems, irregular heart rhythm, bleeding and high blood pressure,

How to manage the interaction:
Taking Pazopanib with Libset Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, fast or pounding heartbeats, chest pain or tightness, pain in your arms, back, neck, or jaw, shortness of breath, numbness or weakness on one side of your body, and difficulty speaking. Do not stop using any medications without a doctor's advice.
LapatinibDigoxin
Severe
How does the drug interact with Libset Tablet:
Co-administration of Digoxin and Libset Tablet may increase the blood levels and effects of Digoxin.

How to manage the interaction:
If you are supposed to take Digoxin and Libset Tablet together, a doctor may adjust the dose or monitor more frequently to safely use both medications. If you experience diarrhea, nausea, loss of appetite, vomiting, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, contact a doctor as these may be signs and symptoms of excessive digoxin levels. Do not discontinue the medication without consulting a doctor.
LapatinibColchicine
Severe
How does the drug interact with Libset Tablet:
Coadministration of colchicine with Libset Tablet results in increased colchicine levels in the blood, increasing the risk of serious side effects

How to manage the interaction:
Although taking Colchicine and Libset Tablet together may possibly result in an interaction, they can be taken together if your doctor prescribes it. However, if you experience abdominal pain, numbness or tingling in your hands and legs, muscle pain, or weakness, contact your doctor immediately. Do not discontinue any medication without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food (especially high-fat meals): Drastically increases how much of the drug is absorbed, which can cause dangerous side effects.
  • Grapefruit and grapefruit juice: Block the liver enzymes that break down Libset Tablet , leading to toxic levels of the medicine in your body.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Libset Tablet is used to treat breast cancer.
Libset Tablet contains Lapatinib, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.
Inform your doctor whether you have received any other breast cancer treatment. Libset Tablet may cause left ventricular ejection fraction, hypersensitivity reactions, hepatotoxicity, severe diarrhea, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before taking Libset Tablet .
Hepatotoxicity (liver toxicity) has been reported in clinical studies and postmarketing experience with Libset Tablet . Hepatotoxicity can be fatal, and deaths have been reported. The cause of death is unknown. If you have upper stomach pain, itching, dark urine, clay-coloured faeces, or jaundice (yellowing of the skin or eyes), inform your doctor immediately.
Libset Tablet may cause side effects such as diarrhoea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
Libset Tablet is an anti-cancer medicine used in the treatment of breast cancer.
Yes, Libset Tablet can be given in combination with other anti-cancer drugs if prescribed by the doctor. Talk to the doctor if you have any concerns.
Swallow Libset Tablet whole with a glass of water. Do not crush, chew, or break the tablet. Take it on an empty stomach, either at least 1 hour before or at least 1 hour after food, because taking it with food increases absorption and may increase the risk of side effects.
Diarrhoea is a common side effect of Libset Tablet . Drink plenty of fluids to prevent dehydration and follow your doctor's advice regarding anti-diarrhoeal medicines if needed. Contact your doctor immediately if the diarrhoea is severe, lasts longer than 24 hours, is accompanied by fever, or causes signs of dehydration. Do not stop taking Libset Tablet without consulting your doctor.
Yes. Libset Tablet can cause skin problems such as dry skin, rash, redness, or hand-foot syndrome. To help protect your skin, use a gentle soap-free cleanser, apply fragrance-free moisturisers, use sunscreen, and avoid excessive sun exposure. If you develop severe, painful, blistering, or widespread skin reactions, contact your doctor immediately.
Before starting Libset Tablet , the doctor may advise heart and liver function tests.
This medicine can sometimes lower the pumping strength of your heart or cause irregular heartbeats. Your doctor will perform heart scans before and during your treatment to monitor your heart health. If you experience shortness of breath, swelling in your ankles, or a racing heartbeat, contact your doctor right away. Talk to your doctor or pharmacist for more details.
It is best to avoid alcohol while taking this medicine. Alcohol can increase the strain on your liver and worsen side effects like nausea or dizziness. If you choose to drink, consult your healthcare provider first. Talk to your doctor or pharmacist for safe lifestyle guidelines.
Grapefruit and grapefruit juice interfere with the natural enzymes in your body that break down this medication. This can cause the medicine to build up to unsafe, toxic levels in your blood, significantly increasing the risk of serious side effects. Avoid all grapefruit products during your treatment. Talk to your doctor or pharmacist if you need alternative dietary tips.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 022059S023Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A607055 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Mayo Clinic Staff. Drg 20070910 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Lapatinib Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Lapatinib ditosylate monohydrate. 2008. [Accessed on 23 Jan. 2019]Check here
  6. Lapatinib Lapatinib. 2007. [Accessed on 26 Mar. 2019]Check here
  7. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 18 Feb. 2020]Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - LIB0098
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