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Leucorin Tablet is used in cancer treatment as an antidote to reduce the toxic effects of certain cancer drugs, such as methotrexate. It contains calcium folinate, also known as Leucovorin, which is a form of vitamin B. It is folic acid in its active form. It works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells. It should be administered as soon as possible after taking methotrexate.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Leucorin Tablet

Leucorin Tablet is a prescription medicine used to protect healthy cells from the harmful, toxic side effects of certain high-dose anticancer treatments. It is also used to treat specific types of anaemia caused by a lack of folate in the body. By providing an active form of folate, this medicine supports normal cell division and helps your body generate healthy red blood cells.

This medicine is typically taken on a strict schedule determined by your doctor, especially when used alongside other treatments. It is important to take Leucorin Tablet consistently at the exact times prescribed to ensure it protects your healthy cells effectively. You can take this medicine with or without food, but taking it with a full glass of water is recommended. Supporting your body with a balanced diet rich in natural folate, such as leafy green vegetables and beans, can also help maximise your results.

Most people tolerate Leucorin Tablet very well, but some may experience mild side effects like a mild upset stomach, trouble sleeping, or skin flushing. While serious side effects are rare, you must consult your doctor immediately if you experience signs of a severe allergic reaction, such as facial swelling or difficulty breathing. Always keep your healthcare team informed of how you feel during your treatment.

Do not take this medicine if you have pernicious anaemia or other vitamin B12 deficiency anaemias, as it can mask your symptoms while allowing serious nerve damage to continue. Before starting Leucorin Tablet , talk to your doctor if you have a history of seizures, kidney disease, or severe dehydration. Your doctor will determine if this medicine is safe and appropriate for your specific health profile.

This medicine can interact with certain seizure medicines, which may reduce their effectiveness and increase your risk of seizures. Additionally, you should limit alcohol consumption while taking this medicine as it can interfere with folate absorption. If you are pregnant, breastfeeding, an older adult, or managing treatment for a child, consult your healthcare provider to discuss specific dosage schedules. Paediatric use requires strict adherence to a paediatric oncologist's instructions based on body weight or surface area.

Uses of Leucorin Tablet

Leucorin Tablet is used to protect healthy cells from the toxic effects of certain anticancer treatments and to treat folate deficiency anaemia. The detailed uses of Leucorin Tablet are as follows:

  • Toxicity from folate-blocking medicines: It is used as a rescue therapy to protect healthy tissues and organs from the toxic side effects of high-dose chemotherapy drugs (such as methotrexate).
  • Enhancement of colorectal cancer treatment: It is administered alongside fluorouracil (5-FU) chemotherapy to enhance its therapeutic effect against advanced colorectal cancer.
  • Folate deficiency anaemia: It helps treat megaloblastic anaemia (a condition with abnormally large and dysfunctional red blood cells) by restoring healthy blood cell production.

Key Benefits

Leucorin Tablet provides several important benefits by protecting healthy cells during certain cancer treatments and helping treat folate deficiency anaemia. These benefits include:

  • Protection During Cancer Therapy: One of the primary benefits of Leucorin Tablet is its ability to shield your body's healthy cells during intense cancer therapies. By acting as a protective guard, it helps minimise painful complications like mouth sores, low blood counts, and digestive tract damage, allowing you to complete your recovery safely.
  • Restores Healthy Blood Production: For those recovering from folate deficiency anaemia, Leucorin Tablet directly restores the normal production of red blood cells. As your blood counts return to healthy levels, you will experience real-world relief from constant fatigue, weakness, and shortness of breath, helping you regain your physical energy and strength.

Directions for Use

  • Leucorin Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Leucorin Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Leucorin Tablet Works

Leucorin Tablet contains calcium folinate, which is already in the fully active form of folate. To understand how it works, it helps to look at how certain anticancer medicines operate. Some chemotherapy drugs work by blocking your body's ability to activate dietary folate. While this effectively stops cancer cells from multiplying, it also starves your healthy cells, leading to severe side effects. It bypasses this block entirely. Because it is already in the fully active form of folate, it does not require the body's blocked enzymes to work. Once you take it, it enters your healthy cells directly, providing them with the necessary tools to resume normal DNA synthesis and cell division. This 'rescues' your healthy tissues while still allowing the chemotherapy to target cancer cells.
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Alcohol

Caution

Avoid the consumption of alcohol as it may cause some side effects and make the effect of Leucorin Tablet less effective.

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Pregnancy

Caution

Leucorin Tablet should not be used in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Leucorin Tablet .

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Breast Feeding

Caution

Leucorin Tablet should not be used in nursing mothers unless clearly necessary. So, inform your doctor if you are breastfeeding. Your doctor will weigh the benefits and potential risks before prescribing Leucorin Tablet .

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Driving

Safe

Leucorin Tablet does not affect your ability to drive or operate machinery.

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Liver

Caution

If you have liver problems, inform your doctor before taking Leucorin Tablet . Your doctor may adjust the dose of this medicine based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney condition, inform your doctor before taking Leucorin Tablet . Your doctor may adjust the dose of this medicine based on your condition.

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Children

Safe if prescribed

Your doctor will weigh the benefits and potential risks before prescribing Leucorin Tablet .

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Heart

Consult your doctor

If you have a heart disease or any related concerns, Please consult your doctor before using Leucorin Tablet .

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Geriatrics

Consult your doctor

Leucorin Tablet should be given to geriatrics only when prescribed by a doctor. If you have any concerns about using Leucorin Tablet for geriatrics, please consult a doctor.

What if I have taken an overdose of Leucorin Tablet

If you take too much of this medicine, seek immediate medical attention. Prompt medical evaluation is necessary to ensure your safety. mergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water throughout the day, especially if you are taking this medicine alongside high-dose chemotherapy. Proper hydration helps your kidneys clear medicines safely.
  • Eat folate-rich foods: If you are treating anaemia, support your recovery by eating foods naturally high in folate, such as spinach, broccoli, asparagus, lentils, and citrus fruits.
  • Limit alcohol: Avoid or strictly limit alcohol consumption, as alcohol can interfere with how your body absorbs and utilises folate, slowing down your recovery.
  • Eat small, frequent meals: If you experience nausea or a reduced appetite due to your overall treatment, eating smaller, nutrient-dense meals can help maintain your strength.
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How Soon It Starts Working

The time required for Leucorin Tablet to start to work: Leucorin Tablet ideally shows its action within 20 to 30 minutes after administration. The time for which the effects of Leucorin Tablet last: The duration of action for Leucorin Tablet is clinically unknown.

What if you forget to take Leucorin Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. If you are taking this as part of a chemotherapy rescue schedule, contact your doctor immediately for instructions if you miss a dose.

Storage

•Store Leucorin Tablet tablets at controlled room temperature, between 20°C to 25°C (68°F to 77°F)

Drug Warnings

  • Follow strict paediatric dosing: When prescribed for children, doses are carefully calculated by a paediatric oncologist based on body weight or body surface area; never alter a child's dose independently.
  • Set a timing alarm: Use your phone or a timer to ensure you take Leucorin Tablet at the exact scheduled times. Even a brief delay can reduce its protective benefits during rescue therapy.
  • Inspect your tablets: Before taking your dose, inspect the tablets. Do not take them if they appear discoloured, chipped, or damaged.
  • Monitor for signs of infection: Because this medicine is often used during chemotherapy, watch for symptoms like a fever, chills, or sore throat, and report them to your doctor immediately.
  • Inform all healthcare providers: Ensure all your doctors, dentists, and pharmacists know you are taking Leucorin Tablet , as it can affect how other medicines work.

Drug-Drug Interactions

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  • Seizure medicines (such as phenytoin, phenobarbital, and primidone): Leucorin Tablet may decrease the levels of these drugs in your blood, potentially increasing your risk of seizures. Your doctor may need to adjust your seizure medicine dose.
  • Fluorouracil (5-FU): When taken together, Leucorin Tablet can significantly increase both the therapeutic and toxic effects of fluorouracil, raising the risk of severe diarrhoea and mouth sores.
  • Trimethoprim-Sulfamethoxazole: Taking Leucorin Tablet alongside this antibiotic combination can interfere with its ability to treat certain infections.

Drug-Drug Interactions

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How does the drug interact with Leucorin Tablet:
Co-administration of Leucorin Tablet with Trimethoprim may increase rates of treatment failure.

How to manage the interaction:
Although there is an interaction between Leucorin Tablet and trimethoprim, but it can be taken together if prescribed by the doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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  • No clinically significant food interactions are known with Leucorin Tablet when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[DETOXIFYING AGENTS]

FAQs

Leucorin Tablet contains calcium folinate, also known as Leucovorin. Leucorin Tablet works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells.
Leucorin Tablet is an antidote to the side effects of various chemotherapy medications, such as methotrexate.
It is contraindicated to use if you are known for hypersensitivity to any components present in Leucorin Tablet or if you have Pernicious anaemia or other anaemias due to vitamin B12 deficiency.
Yes, you can take Leucorin Tablet with or without food. If you experience a mild upset stomach, taking your dose with a light meal can help make it easier to tolerate. Talk to your doctor or pharmacist for more personalised advice.
No, Leucorin Tablet is not a chemotherapy medicine. It is an active form of folate that is used to protect your healthy cells from the toxic side effects of chemotherapy or to correct a folate deficiency. Talk to your doctor for more details about your treatment plan.
No, you should not take Leucorin Tablet if you have untreated vitamin B12 deficiency or pernicious anaemia. Doing so can mask your anaemia symptoms while allowing permanent nerve damage to develop. Talk to your doctor or pharmacist before starting this medicine.
If you miss a dose while undergoing chemotherapy rescue therapy, contact your doctor or healthcare team immediately for guidance, as precise timing is critical to your safety. Talk to your doctor for specific instructions.
Leucorin Tablet should only be used during pregnancy if your doctor determines it is clearly necessary. Your healthcare provider will help you weigh the benefits and potential risks. Talk to your doctor or pharmacist to discuss your options.
No, Leucorin Tablet does not cause hair loss. However, because it is often taken alongside chemotherapy drugs that do cause hair loss, many patients experience this side effect from their primary cancer treatment. Talk to your doctor if you are concerned about side effects.
Leucorin Tablet is primarily used to prevent or reduce the toxic effects of certain anticancer medicines like methotrexate. It is also used to treat specific blood conditions, such as folate deficiency anaemia. Talk to your doctor to understand if this medicine is appropriate for your treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - LEU0001
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