apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. Letfirst Tablet 5's

Letfirst Tablet 5's, Pack of 5
Offers on medicine orders
All offers
axis icici
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Letfirst Tablet 5's is used to treat breast cancer in women who have gone through menopause (cessation of menses periods). It contains Letrozole, which prevents the growth of cancer cells. Thereby, it helps in preventing or stopping the growth of spreading the tumours (cancer cells) to other body parts. It may cause certain common side effects such as hypercholesterolemia (increased cholesterol levels), tiredness, weakness, increased sweating, feeling unwell, pain in joints, and hot flushes (feeling of warmth). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

Read more
rxMedicinePrescription drug

Whats That

tooltip

Also Explore

Momverse
Ask Apollo
insurance

Composition :

LETROZOLE-2.5MG

Manufacturer/Marketer :

UFirst Pharmaceutical Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Letfirst Tablet 5's

Letfirst Tablet 5's is used to treat breast cancer in women who have gone through menopause (cessation of menses periods). Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen.

Letfirst Tablet 5's contains 'Letrozole' that works by blocking the aromatase enzyme, which is involved in the production of the estrogen hormone. 

In some cases, Letfirst Tablet 5's may cause common side effects such as hypercholesterolemia (increased cholesterol levels), tiredness, weakness, increased sweating, feeling unwell, pain in joints, and hot flushes (feeling of warmth). Do not be reluctant to talk with your doctor if you experience any of these side-effects persistently.

You are advised to take Letfirst Tablet 5's for as long as your doctor has prescribed it for you, depending on your medical condition. It can be taken with or without food with a glass of water. Do not chew, bite or crush the medicine.

Avoid taking Letfirst Tablet 5's if you are allergic to it, or if you are pregnant or breastfeeding. Letfirst Tablet 5's may cause drowsiness and dizziness, so drive only if you are alert. Letfirst Tablet 5's should not be given to children as safety has not been established. Avoid consuming alcohol along with Letfirst Tablet 5's as it could lead to increased drowsiness and dizziness. Inform your doctor about your health condition and medications to rule out any side-effects.

Uses of Letfirst Tablet 5's

Letfirst Tablet 5's is used in the treatment of Breast cancer. The detailed uses of Letfirst Tablet 5's are as follows:<br/>

  • Breast Cancer Treatment: Letfirst Tablet 5's is primarily prescribed for postmenopausal women with hormone-receptor-positive breast cancer. It works by lowering estrogen levels, which helps slow or halt the growth of certain breast tumors.<br/>
  • Adjuvant Therapy: After surgery for early-stage breast cancer, Letfirst Tablet 5's may be used as adjuvant therapy to reduce the risk of recurrence and improve survival rates.<br/>
  • Neoadjuvant Therapy: Letfirst Tablet 5's can serve as a neoadjuvant treatment to shrink breast tumors before surgery, facilitating their removal.<br/>
  • Ovarian Function Suppression: Letfirst Tablet 5's is occasionally used off-label during fertility treatments to suppress ovarian function, particularly in cases of polycystic ovary syndrome (PCOS).<br/>

Directions for Use

• Take Letfirst Tablet 5's with or without food as advised by your doctor. • It is advised to take Letfirst Tablet 5's once daily; however, follow your doctor’s recommendation regarding the dosage and duration. • Swallow Letfirst Tablet 5's as a whole with a glass of water. • Do not crush, chew or break it.

Medicinal Benefits

  • Letfirst Tablet 5's belongs to the group of anti-cancer medicines called aromatase inhibitors.
  • Letfirst Tablet 5's is used to treat breast cancer in women who have gone through menopause (cessation of periods).
  • Letfirst Tablet 5's helps in slowing down or stopping the growth and/or spreading the tumours to other body parts.

How Letfirst Tablet 5's Works

Letfirst Tablet 5's contains 'Letrozole' that works by blocking the aromatase enzyme, which is involved in the production of the estrogen hormone. The cancer cells require estrogen for their growth. Hence, by blocking the aromatase enzyme, Letfirst Tablet 5's prevents the growth of cancer cells. Thereby Letfirst Tablet 5's helps in preventing or stopping the growth of spreading the tumours (cancer cells) to other body parts.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Letfirst Tablet
  • Consult your doctor about your risk factors for bone loss and create a personalized plan.
  • Eat foods rich in vitamin D, including fatty fish, egg yolks, and fortified dairy products.
  • Include calcium-rich foods such as dairy, leafy greens, and fortified plant-based milk in your diet.
  • Quit smoking to reduce bone loss and lower osteoporosis risk.
  • Exercise regularly with weight-bearing activities like walking, running, or weightlifting to strengthen bones.
  • Schedule regular bone density scans to track progress and adjust your treatment plan.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

What if I have taken an overdose of Letfirst Tablet 5's

Do not take more than the prescribed dose of Letfirst Tablet 5's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Letfirst Tablet 5's if you are allergic to any of its contents, if you have not yet gone through menopause (still get your periods).
  • Talk to your doctor before taking Letfirst Tablet 5's if you have osteoporosis (thinning of bones), bone fractures, severe liver or kidney disease.
  • Letfirst Tablet 5's may cause inflammation in tendons or tendon injury; contact your doctor if you observe any sign of tendon pain or swelling while taking Letfirst Tablet 5's.
  • Avoid taking Letfirst Tablet 5's if you are pregnant or breastfeeding.
  • Letfirst Tablet 5's may cause drowsiness and dizziness, so drive only if you are alert.
  • Letfirst Tablet 5's is not recommended for use in children as safety has not been established.
  • Avoid consuming alcohol along with Letfirst Tablet 5's as it could lead to increased drowsiness and dizziness. 

Drug-Drug Interactions

verifiedApollotooltip
LetrozoleEthinylestradiol
Severe
LetrozoleDesogestrel
Severe

Drug-Drug Interactions

Login/Sign Up

LetrozoleEthinylestradiol
Severe
How does the drug interact with Letfirst Tablet:
When taken together ethinyl estradiol may interfere with Letfirst Tablet's activity and make it less effective in treating the condition.

How to manage the interaction:
Although taking Letfirst Tablet and ethinylestradiol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.
LetrozoleDesogestrel
Severe
How does the drug interact with Letfirst Tablet:
Co-administration of Desogestrel together with Letfirst Tablet may decrease the effects of Letfirst Tablet.

How to manage the interaction:
Although taking Letfirst Tablet and Desogestrel together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any medications.
LetrozoleThalidomide
Severe
How does the drug interact with Letfirst Tablet:
Coadministration of thalidomide and Letfirst Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking Letfirst Tablet and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, consult a doctor. Do not discontinue any medications without a doctor's advice.
LetrozoleEstrone
Severe
How does the drug interact with Letfirst Tablet:
When taken together Letfirst Tablet's function could be blocked by estrone, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Letfirst Tablet and estrone together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleConjugated Estrogens
Severe
How does the drug interact with Letfirst Tablet:
Coadministration of Conjugated estrogens with Letfirst Tablet may reduce the effect of Letfirst Tablet.

How to manage the interaction:
Although taking Conjugated estrogen and Letfirst Tablet together can result in an interaction, it can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
LetrozoleDiethylstilbestrol
Severe
How does the drug interact with Letfirst Tablet:
Co-administration of Letfirst Tablet may have an effect when used with Diethylstilbestrol, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letfirst Tablet and diethylstilbestrol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleCitalopram
Severe
How does the drug interact with Letfirst Tablet:
Co-administration of Letfirst Tablet and Citalopram may raise the risk of a serious irregular heartbeat.

How to manage the interaction:
Although taking Letfirst Tablet and Citalopram together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
LetrozoleEstradiol
Severe
How does the drug interact with Letfirst Tablet:
Letfirst Tablet may have a negative effect when used with Estradiol, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letfirst Tablet and estradiol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleEstramustine
Severe
How does the drug interact with Letfirst Tablet:
when taken together Letfirst Tablet's function could be blocked by estramustine, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Letfirst Tablet and estramustine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.

  • Avoid smoking and alcohol consumption.

  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.

  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.

  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Letfirst Tablet 5's Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Letfirst Tablet 5's to avoid unpleasant side effects. Alcohol intake, along with Letfirst Tablet 5's, may cause increased drowsiness.

bannner image

Pregnancy

Unsafe

Letfirst Tablet 5's is pregnancy category D medicine so, should not be taken during pregnancy.

bannner image

Breast Feeding

Unsafe

Letfirst Tablet 5's should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby.

bannner image

Driving

Unsafe

Letfirst Tablet 5's may cause dizziness and drowsiness, do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Safe if prescribed

It is safe to take Letfirst Tablet 5's if prescribed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Safe if prescribed

It is safe to take Letfirst Tablet 5's if prescribed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Letfirst Tablet 5's should not be used by children, as the efficacy and safety have not been established.

Have a query?

FAQs

Letfirst Tablet 5's belongs to the group of anti-cancer medicines used to treat breast cancer in women.

Letfirst Tablet 5's works by blocking the aromatase enzyme, which is involved in the production of estrogens. The cancer cells require estrogen for their growth, so by blocking the enzyme Letfirst Tablet 5's prevents the growth of cancer cells. Thereby, Letfirst Tablet 5's helps in slowing down or stopping the growth and/or spreading the tumours to other body parts.

Letfirst Tablet 5's causes dizziness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.

High blood pressure could be a side-effect of Letfirst Tablet 5's. Regularly monitor blood pressure levels while taking Letfirst Tablet 5's. Consult your doctor if you regularly notice high blood pressure levels.

Do not stop taking Letfirst Tablet 5's on your own. You are advised to take Letfirst Tablet 5's for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Letfirst Tablet 5's.

Letfirst Tablet 5's may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Letfirst Tablet 5's.

Letfirst Tablet 5's may cause weight gain due to an increase in appetite. Eat a healthy diet and exercise regularly to maintain proper weight.

Letfirst Tablet 5's should be swallowed as a whole with water; do not crush or chew it.

Letfirst Tablet 5's can be taken with or without food.

Letfirst Tablet 5's should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.

Letfirst Tablet 5's is prescribed to treat breast cancer in women who have gone through menopause.

Letfirst Tablet 5's may cause high blood pressure. Therefore, irbesartan should be taken with Letfirst Tablet 5's only if prescribed by the doctor. Regularly monitor blood pressure levels while taking Letfirst Tablet 5's.

Letfirst Tablet 5's may cause eye problems like blurred vision and cataracts. Consult the doctor if you experience blurred vision or eye irritation.

Letfirst Tablet 5's may cause hot flushes leading to sweating. These symptoms usually improve during the first few months. However, if the symptoms persist or worsen, consult the doctor.

Serious side effects of Letfirst Tablet 5's are difficulty breathing, chest pain, fainting, rapid heart rate, formation of blood clots (bluish skin discolouration, or sudden arm, leg or foot pain) and rupture of a tendon. These side effects are rare and may not occur in everyone taking Letfirst Tablet 5's.

Letrozole may induce ovulation in anovulatory infertility patients and augment follicles for ovulatory women. However, it is an off-label use. Talk to the doctor if you have any concerns.

Letfirst Tablet 5's is not recommended for use during pregnancy or while breastfeeding.

The time required for Letfirst Tablet 5's to show its effects depends upon your condition and severity. Consult the doctor if you have any concerns.

If you miss a dose of Letfirst Tablet 5's take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

Letfirst Tablet 5's may interact with antidepressants (citalopram, escitalopram) and anticancer medicines (tamoxifen). Let the doctor know if you are taking these medicines.

Store Letfirst Tablet 5's at room temperature, in a dry place. Keep out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

903, Madurdah, Hossainpur. Beside Kabi Sukanta Metro Station. Kolkata
Other Info - LET0169

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 26, 2025 | 6:55 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://mri.cts-mrp.eu/human/downloads/NL_H_1179_001_FinalPI.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020726s014lbl.pdf
  3. https://www.novartis.com.sg/system/files/product-info/Femera%20PI%20Dec%202016.SIN_.pdf
  4. https://www.drugs.com/mtm/letrozole.html
whatsapp Floating Button
Buy Now
Add to Cart