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  3. Letfer 2.5 mg Tablet 5's

Letfer 2.5 mg Tablet 5's, Pack of 5 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Letfer 2.5 mg Tablet is used to treat breast cancer in women who have gone through menopause (cessation of menses periods). It contains Letrozole, which prevents the growth of cancer cells. Thereby, it helps in preventing or stopping the growth of spreading the tumours (cancer cells) to other body parts. It may cause certain common side effects such as hypercholesterolemia (increased cholesterol levels), tiredness, weakness, increased sweating, feeling unwell, pain in joints, and hot flushes (feeling of warmth). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

LETROZOLE-2.5MG

Manufacturer/Marketer :

Cutem Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Letfer 2.5 mg Tablet

Letfer 2.5 mg Tablet is used to treat breast cancer in women who have gone through menopause (cessation of menses periods). Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen.

Letfer 2.5 mg Tablet contains 'Letrozole' that works by blocking the aromatase enzyme, which is involved in the production of the estrogen hormone. 

In some cases, Letfer 2.5 mg Tablet may cause common side effects such as hypercholesterolemia (increased cholesterol levels), tiredness, weakness, increased sweating, feeling unwell, pain in joints, and hot flushes (feeling of warmth). Do not be reluctant to talk with your doctor if you experience any of these side-effects persistently.

You are advised to take Letfer 2.5 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. It can be taken with or without food with a glass of water. Do not chew, bite or crush the medicine.

Avoid taking Letfer 2.5 mg Tablet if you are allergic to it, or if you are pregnant or breastfeeding. Letfer 2.5 mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Letfer 2.5 mg Tablet should not be given to children as safety has not been established. Avoid consuming alcohol along with Letfer 2.5 mg Tablet as it could lead to increased drowsiness and dizziness. Inform your doctor about your health condition and medications to rule out any side-effects.

Uses of Letfer 2.5 mg Tablet

Letfer 2.5 mg Tablet is used in the treatment of Breast cancer. The detailed uses of Letfer 2.5 mg Tablet are as follows:<br/>

  • Breast Cancer Treatment: Letfer 2.5 mg Tablet is primarily prescribed for postmenopausal women with hormone-receptor-positive breast cancer. It works by lowering estrogen levels, which helps slow or halt the growth of certain breast tumors.<br/>
  • Adjuvant Therapy: After surgery for early-stage breast cancer, Letfer 2.5 mg Tablet may be used as adjuvant therapy to reduce the risk of recurrence and improve survival rates.<br/>
  • Neoadjuvant Therapy: Letfer 2.5 mg Tablet can serve as a neoadjuvant treatment to shrink breast tumors before surgery, facilitating their removal.<br/>
  • Ovarian Function Suppression: Letfer 2.5 mg Tablet is occasionally used off-label during fertility treatments to suppress ovarian function, particularly in cases of polycystic ovary syndrome (PCOS).<br/>

Directions for Use

• Take Letfer 2.5 mg Tablet with or without food as advised by your doctor. • It is advised to take Letfer 2.5 mg Tablet once daily; however, follow your doctor’s recommendation regarding the dosage and duration. • Swallow Letfer 2.5 mg Tablet as a whole with a glass of water. • Do not crush, chew or break it.

Medicinal Benefits

  • Letfer 2.5 mg Tablet belongs to the group of anti-cancer medicines called aromatase inhibitors.
  • Letfer 2.5 mg Tablet is used to treat breast cancer in women who have gone through menopause (cessation of periods).
  • Letfer 2.5 mg Tablet helps in slowing down or stopping the growth and/or spreading the tumours to other body parts.

How Letfer 2.5 mg Tablet Works

Letfer 2.5 mg Tablet contains 'Letrozole' that works by blocking the aromatase enzyme, which is involved in the production of the estrogen hormone. The cancer cells require estrogen for their growth. Hence, by blocking the aromatase enzyme, Letfer 2.5 mg Tablet prevents the growth of cancer cells. Thereby Letfer 2.5 mg Tablet helps in preventing or stopping the growth of spreading the tumours (cancer cells) to other body parts.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Letfer 2.5 mg Tablet
  • Consult your doctor about your risk factors for bone loss and create a personalized plan.
  • Eat foods rich in vitamin D, including fatty fish, egg yolks, and fortified dairy products.
  • Include calcium-rich foods such as dairy, leafy greens, and fortified plant-based milk in your diet.
  • Quit smoking to reduce bone loss and lower osteoporosis risk.
  • Exercise regularly with weight-bearing activities like walking, running, or weightlifting to strengthen bones.
  • Schedule regular bone density scans to track progress and adjust your treatment plan.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

What if I have taken an overdose of Letfer 2.5 mg Tablet

Do not take more than the prescribed dose of Letfer 2.5 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Letfer 2.5 mg Tablet if you are allergic to any of its contents, if you have not yet gone through menopause (still get your periods).
  • Talk to your doctor before taking Letfer 2.5 mg Tablet if you have osteoporosis (thinning of bones), bone fractures, severe liver or kidney disease.
  • Letfer 2.5 mg Tablet may cause inflammation in tendons or tendon injury; contact your doctor if you observe any sign of tendon pain or swelling while taking Letfer 2.5 mg Tablet.
  • Avoid taking Letfer 2.5 mg Tablet if you are pregnant or breastfeeding.
  • Letfer 2.5 mg Tablet may cause drowsiness and dizziness, so drive only if you are alert.
  • Letfer 2.5 mg Tablet is not recommended for use in children as safety has not been established.
  • Avoid consuming alcohol along with Letfer 2.5 mg Tablet as it could lead to increased drowsiness and dizziness. 

Drug-Drug Interactions

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LetrozoleEthinylestradiol
Severe
LetrozoleDesogestrel
Severe

Drug-Drug Interactions

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LetrozoleEthinylestradiol
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
When taken together ethinyl estradiol may interfere with Letfer 2.5 mg Tablet's activity and make it less effective in treating the condition.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and ethinylestradiol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.
LetrozoleDesogestrel
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
Co-administration of Desogestrel together with Letfer 2.5 mg Tablet may decrease the effects of Letfer 2.5 mg Tablet.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and Desogestrel together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any medications.
LetrozoleThalidomide
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
Coadministration of thalidomide and Letfer 2.5 mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, consult a doctor. Do not discontinue any medications without a doctor's advice.
LetrozoleEstrone
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
When taken together Letfer 2.5 mg Tablet's function could be blocked by estrone, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and estrone together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleConjugated Estrogens
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
Coadministration of Conjugated estrogens with Letfer 2.5 mg Tablet may reduce the effect of Letfer 2.5 mg Tablet.

How to manage the interaction:
Although taking Conjugated estrogen and Letfer 2.5 mg Tablet together can result in an interaction, it can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
LetrozoleDiethylstilbestrol
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
Co-administration of Letfer 2.5 mg Tablet may have an effect when used with Diethylstilbestrol, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and diethylstilbestrol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleCitalopram
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
Co-administration of Letfer 2.5 mg Tablet and Citalopram may raise the risk of a serious irregular heartbeat.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and Citalopram together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
LetrozoleEstradiol
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
Letfer 2.5 mg Tablet may have a negative effect when used with Estradiol, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and estradiol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleEstramustine
Severe
How does the drug interact with Letfer 2.5 mg Tablet:
when taken together Letfer 2.5 mg Tablet's function could be blocked by estramustine, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Letfer 2.5 mg Tablet and estramustine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.

  • Avoid smoking and alcohol consumption.

  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.

  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.

  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Letfer 2.5 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Letfer 2.5 mg Tablet to avoid unpleasant side effects. Alcohol intake, along with Letfer 2.5 mg Tablet, may cause increased drowsiness.

bannner image

Pregnancy

Unsafe

Letfer 2.5 mg Tablet is pregnancy category D medicine so, should not be taken during pregnancy.

bannner image

Breast Feeding

Unsafe

Letfer 2.5 mg Tablet should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby.

bannner image

Driving

Unsafe

Letfer 2.5 mg Tablet may cause dizziness and drowsiness, do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Safe if prescribed

It is safe to take Letfer 2.5 mg Tablet if prescribed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Safe if prescribed

It is safe to take Letfer 2.5 mg Tablet if prescribed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Letfer 2.5 mg Tablet should not be used by children, as the efficacy and safety have not been established.

Have a query?

FAQs

Letfer 2.5 mg Tablet belongs to the group of anti-cancer medicines used to treat breast cancer in women.

Letfer 2.5 mg Tablet works by blocking the aromatase enzyme, which is involved in the production of estrogens. The cancer cells require estrogen for their growth, so by blocking the enzyme Letfer 2.5 mg Tablet prevents the growth of cancer cells. Thereby, Letfer 2.5 mg Tablet helps in slowing down or stopping the growth and/or spreading the tumours to other body parts.

Letfer 2.5 mg Tablet causes dizziness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.

High blood pressure could be a side-effect of Letfer 2.5 mg Tablet. Regularly monitor blood pressure levels while taking Letfer 2.5 mg Tablet. Consult your doctor if you regularly notice high blood pressure levels.

Do not stop taking Letfer 2.5 mg Tablet on your own. You are advised to take Letfer 2.5 mg Tablet for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Letfer 2.5 mg Tablet.

Letfer 2.5 mg Tablet may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Letfer 2.5 mg Tablet.

Letfer 2.5 mg Tablet may cause weight gain due to an increase in appetite. Eat a healthy diet and exercise regularly to maintain proper weight.

Letfer 2.5 mg Tablet should be swallowed as a whole with water; do not crush or chew it.

Letfer 2.5 mg Tablet can be taken with or without food.

Letfer 2.5 mg Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.

Letfer 2.5 mg Tablet is prescribed to treat breast cancer in women who have gone through menopause.

Letfer 2.5 mg Tablet may cause high blood pressure. Therefore, irbesartan should be taken with Letfer 2.5 mg Tablet only if prescribed by the doctor. Regularly monitor blood pressure levels while taking Letfer 2.5 mg Tablet.

Letfer 2.5 mg Tablet may cause eye problems like blurred vision and cataracts. Consult the doctor if you experience blurred vision or eye irritation.

Letfer 2.5 mg Tablet may cause hot flushes leading to sweating. These symptoms usually improve during the first few months. However, if the symptoms persist or worsen, consult the doctor.

Serious side effects of Letfer 2.5 mg Tablet are difficulty breathing, chest pain, fainting, rapid heart rate, formation of blood clots (bluish skin discolouration, or sudden arm, leg or foot pain) and rupture of a tendon. These side effects are rare and may not occur in everyone taking Letfer 2.5 mg Tablet.

Letrozole may induce ovulation in anovulatory infertility patients and augment follicles for ovulatory women. However, it is an off-label use. Talk to the doctor if you have any concerns.

Letfer 2.5 mg Tablet is not recommended for use during pregnancy or while breastfeeding.

The time required for Letfer 2.5 mg Tablet to show its effects depends upon your condition and severity. Consult the doctor if you have any concerns.

If you miss a dose of Letfer 2.5 mg Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

Letfer 2.5 mg Tablet may interact with antidepressants (citalopram, escitalopram) and anticancer medicines (tamoxifen). Let the doctor know if you are taking these medicines.

Store Letfer 2.5 mg Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Country of origin

India
Other Info - LET0125

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 26, 2025 | 6:55 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://mri.cts-mrp.eu/human/downloads/NL_H_1179_001_FinalPI.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020726s014lbl.pdf
  3. https://www.novartis.com.sg/system/files/product-info/Femera%20PI%20Dec%202016.SIN_.pdf
  4. https://www.drugs.com/mtm/letrozole.html

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