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  3. Legestro 250 Injection

Legestro 250 Injection, Pack of 1 Injection
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Legestro 250 Injection is used to prevent premature labour. It contains Hydroxyprogesterone, which modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. It prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour. In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhoea.

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Composition :

HYDROXYPROGESTERONE-250MG

Manufacturer/Marketer :

Johnlee Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Legestro 250 Injection

Legestro 250 Injection belongs to the category of a synthetic progesterone female hormone called progestin used to prevent premature labour. Premature labour can start before 37 completed weeks of pregnancy and can be caused by premature rupture of membranes, high blood pressure during pregnancy (pre-eclampsia), and poor diet. Preterm labour symptoms include leaking fluid or bleeding from the vagina, the feeling of pressure in the pelvis, and cramps that feel like menstrual cramps regularly.

Legestro 250 Injection contains 'Hydroxyprogesterone', a progestin (female hormones) that modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Legestro 250 Injection prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour. Legestro 250 Injection should be administered only to those pregnant women who are pregnant with one baby or who have had a preterm (premature) delivery of one baby in the past.

Legestro 250 Injection will be administered by a healthcare professional. Do not self-administer. In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhoea. Not everybody experiences these side effects. Most of the side effects of Legestro 250 Injection do not require medical attention and gradually resolve over time. Talk to your doctor if you feel any discomfort while taking Legestro 250 Injection.

Before starting Legestro 250 Injection, please inform your doctor if you have an allergy to any medicines, have unusual vaginal bleeding related to your pregnancy, liver disease, severe hypertension (high blood pressure), or a history of breast cancer, uterus or vagina. Tell your doctor before using Legestro 250 Injection if you have had pre-eclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clot form in the blood), diabetes, depression, or epilepsy. Legestro 250 Injection may cause dizziness, so be cautious while driving and operating machinery. Avoid alcohol consumption to prevent unpleasant side effects. Inform your doctor about all medicines you are taking and about your health condition to rule out any unpleasant side effects.

Uses of Legestro 250 Injection

Treatment of Premature labor.

Directions for Use

• Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.• Legestro 250 Injection will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

Legestro 250 Injection contains “Hydroxyprogesterone” a progestin (female hormones) that is used in pregnant women who have delivered a baby too early (preterm) in the past. It works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus. Legestro 250 Injection prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had a past premature delivery.

How Legestro 250 Injection Works

Legestro 250 Injection contains 'Hydroxyprogesterone', a progestin (female hormones) that modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Legestro 250 Injection prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour.

Storage

Keep Legestro 250 Injection out of the sight and reach of children.
Side effects of Legestro 250 Injection
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

What if I have taken an overdose of Legestro 250 Injection

The overdose of Legestro 250 Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Legestro 250 Injection, please inform your doctor immediately.

Drug Warnings

You should not take Legestro 250 Injection without a doctor's advice. Before starting Legestro 250 Injection, please inform your doctor if you have an allergy to any medicines. Do not take Legestro 250 Injection if you have unusual vaginal bleeding that is not related to your pregnancy, liver disease, severe hypertension (high blood pressure), or history of cancer of the breast, uterus or vagina. Tell your doctor before using Legestro 250 Injection if you have had preeclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clot form in the blood), diabetes, depression, or epilepsy. Do not take Legestro 250 Injection on your own. Legestro 250 Injection can cause dizziness and drowsiness. Use caution while driving a motor vehicle, as dizziness or drowsiness may occur. Let your doctor know if you are a breastfeeding mother. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Legestro 250 Injection is not recommended for children younger than 16 years old. Legestro 250 Injection is not intended for use in the first trimester of pregnancy.

Drug-Drug Interactions

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HydroxyprogesteroneNicotine
Severe
HydroxyprogesteroneItraconazole
Severe

Drug-Drug Interactions

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HydroxyprogesteroneNicotine
Severe
How does the drug interact with Legestro 250 Injection:
Coadministration of Nicotine and Legestro 250 Injection may reduce the blood levels and effects of nicotine.

How to manage the interaction:
Using Nicotine and Legestro 250 Injection together can lead to an interaction, they can be taken if advised by your doctor. Consult your doctor if your symptoms do not improve or worsen. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneItraconazole
Severe
How does the drug interact with Legestro 250 Injection:
Coadministration of Itraconazole and Legestro 250 Injection can cause an increase in the levels of Legestro 250 Injection.

How to manage the interaction:
Using Itraconazole and Legestro 250 Injection together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or vaginal bleeding, consult the doctor . Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneRifabutin
Severe
How does the drug interact with Legestro 250 Injection:
Coadministration of Rifabutin and Legestro 250 Injection may reduce the blood levels and effects of Legestro 250 Injection.

How to manage the interaction:
Using Rifabutin and Legestro 250 Injection together can lead to an interaction; they can be taken if your doctor advises. However, if you experience any abnormal bleeding, or pain, swelling, itching, bruising, or a lump at the injection site, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneTirzepatide
Moderate
How does the drug interact with Legestro 250 Injection:
Legestro 250 Injection may interfere with blood glucose control and decrease the effectiveness of diabetic treatments.

How to manage the interaction:
Inform doctor about all other medications administering, including vitamins and herbs, is crucial. Consult doctor before stopping any medications.

Drug-Food Interactions

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HYDROXYPROGESTERONE-250MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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HYDROXYPROGESTERONE-250MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu, Grapefruit Juice, Grapefruit

How to manage the interaction:
Legestro 250 Injection may reduce the blood levels and effects of caffeine. Grapefruit juice may increase the blood levels of Legestro 250 Injection. Avoid or limit taking caffeine and grape juice while taking Legestro 250 Injection as it can lead to interaction.

Diet & Lifestyle Advise

  • Eat a healthy and balanced diet rich in vegetables, fruits, and whole grains to reduce the risk of preterm delivery.
  • Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil.
  • I prefer whole foods and grains to processed ones. I avoid processed foods and foods high in sugar and fat.
  • Avoid stress, as it can increase the chances of preterm delivery. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Regular physical activity and yoga keep you fit, help improve blood circulation, and regulate the oxygen supply, thereby improving your chances of carrying your baby full term.
  • Quitting smoking is the best strategy to lower the risk of premature delivery.
  • Keep your weight under control.
  • Try to avoid alcohol as it can affect your stomach and intestine and limit the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

HORMONES

Legestro 250 Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

There is not enough scientific data available for Legestro 250 Injection interaction with alcohol, hence it is best to consult a doctor.

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Pregnancy

Safe if prescribed

Safe if prescribed.

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Breast Feeding

Caution

Please consult your doctor before using Legestro 250 Injection during breastfeeding.

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Driving

Caution

It is advised to drive with caution after taking Legestro 250 Injection as it may interfere with driving capabilities. It can make you feel drowsy.

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Liver

Caution

Legestro 250 Injection should be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may have to adjust the dose.

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Kidney

Caution

Legestro 250 Injection should be taken with caution, especially if you have a history of kidney liver diseases/conditions. Your doctor may have to adjust the dose.

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Children

Unsafe

Legestro 250 Injection not indicated for use in children. Safety and effectiveness in pediatric patients less than 16 years of age have not been established.

Have a query?

FAQs

Legestro 250 Injection is used to prevent premature labour. It prevents miscarriage and helps lower the risk of premature birth in pregnant women.

Legestro 250 Injection may cause weight gain. It can be due to water retention. If you feel that you are gaining a lot of weight while taking Legestro 250 Injection, please consult your doctor.

Legestro 250 Injection works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus.

Legestro 250 Injection should be taken in the dose and duration as prescribed by the doctor.

Progesterone is an endogenous steroid and progestogen sex hormone secreted by the female reproductive part in the second half of the menstrual cycle to prepare for the release of the egg in the uterus. It is also necessary for the implantation of the fertilized egg in the uterus, for maintaining pregnancy and in hormonal replacement therapy in women deficient in progesterone.

Some of the common side effects of Legestro 250 Injection include nausea, vomiting, itching, hives (skin rashes), swelling of the face, lips, tongue, or throat, and diarrhoea.

You should stop using Legestro 250 Injection and tell a doctor before using Legestro 250 Injection if you have uncontrolled high blood pressure (hypertension), unusual vaginal bleeding, liver disease, liver cancer, jaundice during pregnancy, circulation problems or bleeding problems, stroke, blood clot problems, breast cancer, uterus/cervix/vaginal cancer.

Since Legestro 250 Injection is administered by a doctor, it's unlikely you will stop taking Legestro 250 Injection on your own. Complete the duration of treatment as prescribed by the doctor.

Legestro 250 Injection prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour.

You should stop using Legestro 250 Injection if you have uncontrolled high blood pressure (hypertension), unusual vaginal bleeding, liver disease, liver cancer, jaundice during pregnancy, circulation problems or bleeding problems, stroke, blood clot problems, breast cancer, uterus/cervix/vaginal cancer.

Legestro 250 Injection is a synthetic progesterone female hormone called progestin used to prevent premature labour.

Legestro 250 Injection will be administered by a doctor. The doctor will determine the dose based on your condition.

Since Legestro 250 Injection is administered by a doctor, it's unlikely for you to miss a dose. Consult the doctor if you think you have missed a dose.

You should not receive Legestro 250 Injection if you are allergic to any of its components, if you have blood clotting problems, uncontrolled high blood pressure, or breast cancer.

Other Info - LE43349

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:39 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf
  2. https://www.drugs.com/mtm/hydroxyprogesterone-injection.html
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