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compositionComposition:LEFLUNOMIDE-100MG
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Prescription Medicine
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Leflodol 100mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. This medicine may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LEFLUNOMIDE-100MG

Manufacturer/Marketer :

TNT Lifesciences

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Leflodol 100mg Tablet

Leflodol 100mg Tablet is a prescription medication primarily used to treat active rheumatoid arthritis in adults. It belongs to a class of medicines known as disease-modifying antirheumatic drugs (DMARDs), which help control swelling, pain, and stiffness in your joints. By managing these chronic symptoms, this medicine helps prevent long-term joint damage and assists you in maintaining your daily physical function.

To get the most benefit, you must take Leflodol 100mg Tablet consistently every day, exactly as prescribed by your healthcare provider. You can take this tablet with or without food, but taking it at the same time each day will help you build a reliable routine. Making healthy adjustments, such as eating a balanced diet and doing gentle, joint-friendly exercises, can support your treatment outcomes.

While taking Leflodol 100mg Tablet, some people may experience mild side effects like diarrhoea, nausea, or temporary hair thinning. However, you must contact your doctor immediately if you notice serious symptoms such as yellowing of your eyes or skin, dark urine, or unusual tiredness, as these could indicate liver damage.

Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine can cause severe harm to an unborn baby. Before starting Leflodol 100mg Tablet, talk to your doctor if you have a history of liver disease, severe infections, kidney problems, or a weakened immune system.

This medicine can interact with certain other drugs, alcohol, and live vaccinations, which may increase your risk of liver issues or serious infections. Because of these risks, elderly individuals and people with pre-existing medical conditions should talk to their doctor or pharmacist before starting treatment to ensure it is safe for them.

Uses of Leflodol 100mg Tablet

Leflodol 100mg Tablet may be prescribed for the following inflammatory joint conditions: 

  • Rheumatoid Arthritis: Leflodol 100mg Tablet helps reduce inflammation, swelling, and stiffness in the joints, preventing progressive joint damage and preserving daily physical function.
  • Psoriatic Arthritis: In certain cases, doctors may prescribe this medication to help control joint symptoms and inflammatory skin plaques associated with this condition.
     

Key Benefits

Leflodol 100mg Tablet helps control inflammation and slow disease progression in certain autoimmune joint disorders. Its benefits may include: 

  • Slowing Joint Damage: Unlike simple pain relievers that only mask symptoms, Leflodol 100mg Tablet works deep within the immune system to slow down the progression of joint destruction, helping you preserve your joint health over the long term.
  • Improved Daily Mobility: By targeting chronic swelling and stiffness, this medicine makes daily physical activities, such as walking, bending, and reaching, much easier and more comfortable.
  • Long-lasting Inflammatory Relief: Regular use helps stabilise your body's overactive immune response, leading to fewer painful flare-ups and a more consistent level of physical comfort throughout your day.
     

Directions for Use

To use Leflodol 100mg Tablet safely and effectively, follow these instructions: 

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed.
  • You can take Leflodol 100mg Tablet with or without food. If you experience mild stomach upset, taking it with a meal may help.
  • Try to take your dose at the same time every day to maintain a steady level of the medication in your system.

Always follow your doctor's exact instructions. Do not stop taking this medication suddenly without consulting your doctor first, even if you begin to feel better.
 

How Leflodol 100mg Tablet Works

Leflodol 100mg Tablet contains the active drug leflunomide, which works by targeting the body's overactive immune system. In conditions like rheumatoid arthritis, certain white blood cells (called lymphocytes) multiply too quickly and attack healthy joint tissue, causing painful inflammation and wear. Leflunomide blocks a specific enzyme that these rapidly multiplying immune cells need to produce their DNA. By limiting the growth of these overactive cells, the medicine effectively tones down the autoimmune attack on your joints. This reduces swelling, eases pain, and helps protect your joint structures from permanent damage.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Leflodol 100mg Tablet. Alcohol intake, along with Leflodol 100mg Tablet, may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Leflodol 100mg Tablet while you are pregnant. Leflodol 100mg Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Leflodol 100mg Tablet while you are breastfeeding. Leflodol 100mg Tablet passes into breast milk.

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Driving

Caution

Leflodol 100mg Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment before taking Leflodol 100mg Tablet.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Leflodol 100mg Tablet.

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Children

Unsafe

Leflodol 100mg Tablet is not approved for children under the age of 18 years.

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Heart

Unsafe

Avoid taking Leflodol 100mg Tablet if you have any cardiac problems. If prescried, caution should be exercised while taking Leflodol 100mg Tablet.

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Geriatrics

Consult your doctor

Please consult a doctor before giving Leflodol 100mg Tablet to geriatric patients.

What if I have taken an overdose of Leflodol 100mg Tablet

Do not take more than the prescribed dose of Leflodol 100mg Tablet as it may cause an overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Since leflunomide can cause strain on your liver, drinking alcohol while taking this medicine significantly increases your risk of severe liver damage.
  • Protect yourself from infections: Because this medicine suppresses part of your immune system, wash your hands frequently, avoid close contact with people who are sick, and talk to your doctor before getting any vaccinations.
  • Eat an anti-inflammatory diet: Incorporate foods rich in omega-3 fatty acids, such as walnuts, flaxseeds, and fatty fish, which can naturally help support joint health and manage inflammation.
  • Engage in low-impact physical activity: Practice gentle exercises like swimming, walking, or stationary cycling to keep your joints flexible and strengthen the surrounding muscles without putting too much stress on them.
     
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How Soon It Starts Working

The time required for Leflodol 100mg Tablet to start to work: Leflodol 100mg Tablet starts working within 4 weeks of treatment. However, it might take four to six months to feel the full effect of the drug.

The time for which the effects of Leflodol 100mg Tablet last: The duration of action for Leflodol 100mg Tablet is unknown.

What if you forget to take Leflodol 100mg Tablet

If you miss a dose of Leflodol 100mg Tablet, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Leflodol 100mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Schedule regular blood tests: You will need regular blood tests to monitor your liver function and complete blood counts while taking this medicine. Do not skip these appointments.
  • Use effective birth control: Both men and women taking this medicine must use reliable birth control. The active drug can remain in your body for a long time, so talk to your doctor before trying to conceive, even after you stop taking the drug.
  • Be cautious with vaccines: Avoid live vaccines (such as the nasal spray flu vaccine or yellow fever vaccine) during your treatment, as your weakened immune system may not handle them safely.
  • Monitor your blood pressure: This medicine can sometimes increase your blood pressure, so it is important to check your blood pressure regularly at home or during your clinic visits.
  • Tell all healthcare providers: Always inform any dentist, surgeon, or specialist that you are taking Leflodol 100mg Tablet before undergoing any medical procedures or starting new medications.
     

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Leflodol 100mg Tablet:

  • Other Liver-Affecting Medicines: Taking Leflodol 100mg Tablet with medicines that can affect the liver, such as methotrexate or certain cholesterol-lowering medicines, may significantly increase the risk of liver damage.
  • Blood Thinners: Medicines such as warfarin may interact with Leflodol 100mg Tablet and alter blood clotting, requiring closer monitoring.
  • Other Immunosuppressants: Using Leflodol 100mg Tablet with other immunosuppressing medicines may increase the risk of serious infections.

Drug-Food Interactions

The following food and drink interactions may affect the safety of Leflodol 100mg Tablet: 

  • Alcohol: Do not consume alcohol while taking Leflodol 100mg Tablet, as this combination may greatly increase the risk of severe liver damage.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Leflodol 100mg Tablet, as it may worsen your condition or cause complications:

  • Liver Disease: Do not take this medicine if you have pre-existing liver disease, as it may worsen liver damage.
  • Severe Infections: Avoid using Leflodol 100mg Tablet if you have an active or uncontrolled infection, as it may reduce your body's ability to fight infections.
  • Weakened Immune System: Use this medicine with caution if you have an immunodeficiency disorder, as it may further suppress immune function and increase the risk of infections.
     

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Habit Forming

No

Therapeutic Class

[ANTIRHEUMATICS]

FAQs

Leflodol 100mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.
Leflodol 100mg Tablet is a disease-modifying antirheumatic drug (DMARD) which stops the DNA (genetic material) of the provoked immune system cells required for their survival. It thereby helps in treating inflammation, redness, and swelling at the damaged site (especially joints).
Leflodol 100mg Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Inform your doctor if you have liver disease, kidney disease, a weak immune system and serious infections like pneumonia, or tuberculosis (TB).
The best time to take leflunomide is usually in the morning, with food, to help minimize stomach upset. However, following your doctor's specific instructions for taking leflunomide is essential, as the optimal timing may vary depending on your needs and health status.
Leflodol 100mg Tablet is not a steroid. It contains leflunomide, which is an immunomodulatory medication used to treat rheumatoid arthritis and psoriatic arthritis. Leflunomide works by reducing inflammation and slowing the progression of the disease.
Leflodol 100mg Tablet may cause weight loss as a side effect. This weight loss is usually insignificant and may be due to a loss of appetite. If you experience significant weight loss, it is essential to consult your doctor.
Patients taking leflunomide should notify their doctor if they experience any unusual symptoms, side effects, or concerns. They should also keep their doctor informed about any changes in their health or medications.
Leflodol 100mg Tablet takes a long time to be eliminated from your body. It is generally recommended to wait at least 2 years after stopping Leflodol 100mg Tablet before planning a pregnancy. It is essential to consult your healthcare provider for personalized advice and to discuss the best plan for pregnancy after stopping Leflodol 100mg Tablet.
While taking leflunomide, it's reassuring to know that the risk of cancer is extremely low. Although there's a slight increase in the risk of certain types of cancer, such as lymphoma, this is very rare. Your healthcare provider will closely monitor you and address any concerns. Regular check-ups make you feel confident and safe while managing your condition with leflunomide.
It can take anywhere from 4 to 12 weeks to notice a significant improvement in your joint pain and swelling. Since this medicine works gradually to regulate your immune system, it is important to keep taking it consistently, even if you do not feel immediate relief. Talk to your doctor if you do not notice any changes after several weeks.
No, you should completely avoid alcohol while taking this medicine. Both alcohol and the active drug in Leflodol 100mg Tablet are processed by the liver, and combining them can cause severe, potentially permanent liver damage. Talk to your doctor if you have concerns about avoiding alcohol.
Some people may experience mild, temporary hair thinning or loss while taking this medication. This is usually a temporary side effect that improves over time or after stopping the treatment. Talk to your doctor if the hair loss becomes severe or bothersome.
Your doctor will order regular blood tests to check your liver enzymes and monitor your complete blood counts. Because this medicine can affect your liver and your blood cells, these regular checks ensure the medication remains safe for you to continue. Talk to your doctor to understand your monitoring schedule.
No, you must not take this medicine if you are pregnant or planning to become pregnant, as it can cause serious birth defects. Because the drug stays in the body for a very long time, you must use effective birth control during treatment and undergo a specific drug washout procedure under medical supervision before trying to conceive. Talk to your doctor immediately if you plan to start a family.
Yes, this medicine works by calming an overactive immune system, which can make it slightly harder for your body to fight off infections. You should practice good hygiene, avoid close contact with sick individuals, and seek medical advice at the first sign of an infection, such as a fever or sore throat. Talk to your doctor if you get sick.
You should avoid receiving live vaccines while taking this medicine, as your immune system may not be able to process them safely. Non-live vaccines, such as the standard flu shot, are generally safe, but you should always confirm with your healthcare provider first. Talk to your doctor before scheduling any vaccinations.
Diarrhoea is a common side effect of this medicine, but if it becomes severe, persistent, or is accompanied by stomach pain, you should notify your healthcare provider right away. Do not try to treat severe diarrhoea with over-the-counter medicines without consulting a professional first. Talk to your doctor for guidance on managing this side effect safely.

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