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  3. LEDIHEP TABLET 28'S

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LEDIHEP TABLET 28'S, Pack of 1 TABLET
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

LEDIHEP TABLET is used to treat chronic (long-term) hepatitis C virus infection in adults and children three years of age and older. Hepatitis C virus infection is a severe liver infection caused by the hepatitis C virus (HCV). It contains the active ingredients ledipasvir and sofosbuvir. Ledipasvir and Sofosbuvir work together to prevent the virus from growing and reproducing. Thus, the infection can be eliminated entirely from the body.

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Composition :

LEDIPASVIR-90MG + SOFOSBUVIR-400MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About LEDIHEP TABLET

LEDIHEP TABLET belongs to a class of drugs called antivirals. It is used to treat chronic (long-term) hepatitis C virus infection in adults and children three years of age and older. Hepatitis C virus infection is a severe liver infection caused by the hepatitis C virus (HCV). It is contagious (spreads from one person to another) and spreads through contact with the infected person’s blood.

LEDIHEP TABLET contains the active ingredients ledipasvir and sofosbuvir. Ledipasvir and Sofosbuvir work together to prevent the virus from growing and reproducing. Thus, the infection can be completely eliminated from the body.

LEDIHEP TABLET should be taken as prescribed by the doctor. In some cases, LEDIHEP TABLET may cause common side effects such as headache, tiredness, rash, dizziness, muscle pain, irritability, diarrhea, and angioedema (swelling). Most of these side effects of LEDIHEP TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to ledipasvir, sofosbuvir, or any of the other ingredients in this medication, do not take it. Inform your healthcare professional about your medical conditions before taking LEDIHEP TABLET , especially if you have liver problems other than hepatitis C, are awaiting a liver transplant, have a current or previous infection with the hepatitis B virus or kidney problems or are on kidney dialysis, or are receiving ongoing HIV treatment; your doctor may want to monitor you more closely.

Uses of LEDIHEP TABLET

LEDIHEP TABLET is used in the treatment of chronic hepatitis C virus (HCV) infection. The detailed uses of LEDIHEP TABLET are as follows:<br/>• Treats HCV genotypes 1, 4, 5, and 6: LEDIHEP TABLET is indicated for patients with or without compensated cirrhosis, helping eliminate the hepatitis C virus from the body.<br/>• Prevents viral replication: LEDIHEP TABLET works by inhibiting key proteins essential for HCV replication, stopping the virus from multiplying and allowing the body to clear the infection.<br/>

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Directions for Use

• Take LEDIHEP TABLET with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

LEDIHEP TABLET used to treat chronic (long-term) hepatitis C virus infection in adults and children 3 years of age and older. LEDIHEP TABLET contains the active ingredients ledipasvir and sofosbuvir. Ledipasvir and Sofosbuvir work together to prevent the virus from growing and reproducing. Thus, the infection can be completely eliminated from the body.

How LEDIHEP TABLET Works

LEDIHEP TABLET contains the active ingredients ledipasvir and sofosbuvir. Ledipasvir and Sofosbuvir work together to prevent the virus from growing and reproducing. Thus, the infection can be completely eliminated from the body.

Storage

• Store in a cool and dry place away from sunlight.• Keep LEDIHEP TABLET out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of LEDIHEP TABLET

If you accidentally take more than the recommended dose you should contact your doctor or nearest emergency department immediately for advice.

Drug Warnings

Please tell your doctor if you are allergic to Sofosbuvir or other medicines. Additional monitoring is required if you are currently taking antibiotics (rifampicin and rifabutin); herbal medicine used to treat depression (St. John’s wort); drugs used to treat epilepsy and prevent seizures (carbamazepine and phenobarbital); a medication used to treat high cholesterol (rosuvastatin), medicine to treat irregular heartbeats (amiodarone), so inform your doctor before taking LEDIHEP TABLET . Avoid pregnancy during treatment with LEDIHEP TABLET as it may harm the unborn baby when used in combination with ribavirin. You or your partner must use an effective birth control method during and after this treatment. However, contact your doctor immediately if you become pregnant during therapy or in the months following your treatment with LEDIHEP TABLET . You are advised to take proper precautions if you are infected with the hepatitis C virus infection to prevent the spread of infection to others.

Drug-Drug Interactions

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SofosbuvirModafinil
Severe
SofosbuvirOxcarbazepine
Severe

Drug-Drug Interactions

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SofosbuvirModafinil
Severe
How does the drug interact with Ledihep Tablet:
Coadministration of Ledihep Tablet with Modafinil may significantly reduce the blood levels of Ledihep Tablet.

How to manage the interaction:
Co-administration of Modafinil with Ledihep Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having symptoms of stomach pain or swelling, Fatigue, Fever, Yellowing of skin or eyes, Dark urine, loss of appetite, or nausea contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
SofosbuvirOxcarbazepine
Severe
How does the drug interact with Ledihep Tablet:
Oxcarbazepine can drastically lower Ledihep Tablet levels in the blood, making the medicine less effective in treating.

How to manage the interaction:
Although taking oxcarbazepine with Ledihep Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
SofosbuvirRifabutin
Severe
How does the drug interact with Ledihep Tablet:
Taking Rifabutin and Ledihep Tablet may significantly reduce the blood levels of Ledihep Tablet, which may make the medication less effective.

How to manage the interaction:
Taking Ledihep Tablet with Rifabutin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SofosbuvirCarbamazepine
Severe
How does the drug interact with Ledihep Tablet:
Taking carbamazepine and Ledihep Tablet together may possibly reduce the effects of Ledihep Tablet, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and Ledihep Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
SofosbuvirPhenobarbital
Severe
How does the drug interact with Ledihep Tablet:
Phenobarbital can drastically lower Ledihep Tablet levels in the blood, making the medicine less effective.

How to manage the interaction:
Although taking phenobarbital with Ledihep Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without consulting a doctor.
SofosbuvirPhenytoin
Severe
How does the drug interact with Ledihep Tablet:
Using Ledihep Tablet together with phenytoin may significantly reduce the blood levels of Ledihep Tablet.

How to manage the interaction:
Although there is a possible interaction between Ledihep Tablet and Phenytoin, you can take these medicines together if prescribed by a doctor. Doctors can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include plenty of vegetables and fruits, as well as whole grains such as brown rice, oats, quinoa, and barley.
  • Eat lean protein such as skinless chicken, fish, beans and egg whites.
  • Include healthy fats like avocados, olive oil and nuts.
  • Eat low-fat or non-fat dairy products to minimise damage to the liver.
  • Drink plenty of water for better processing of food by the body.
  • Avoid sugary foods such as cake, cookies, packaged baked food or soda. Also, avoid heavy salt foods.
  • Avoid foods containing saturated fats such as fried foods, fatty cuts of meat, sour cream, butter and other high-fat dairy products, as they may lead to weight gain and result in fatty liver.
  • Avoid smoking and alcohol consumption as they may increase the risk of liver damage.

Habit Forming

No

Therapeutic Class

ANTIVIRALS

LEDIHEP TABLET Substitute

Substitutes safety advice
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Alcohol

Caution

The interaction of alcohol with LEDIHEP TABLET is unknown. However, as a precautionary measure, consumption of alcohol should be avoided.

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Pregnancy

Caution

It is unknown how LEDIHEP TABLET will affect a pregnant woman. See your doctor before using this medication if you are pregnant, suspect you might be pregnant, or intend to become pregnant. Pregnancy must be avoided if LEDIHEP TABLET is taken together with ribavirin. It is crucial that you carefully read the ribavirin package leaflet's 'Pregnancy' section. An unborn child may suffer significant harm from ribavirin. Therefore, if there is a chance that sexual activity will result in pregnancy, extra precautions must be taken.

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Breast Feeding

Caution

Do not breastfeed during treatment with LEDIHEP TABLET . The two active ingredients in Harvoni, ledipasvir and sofosbuvir, are unknown to enter human breast milk.

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Driving

Caution

If you feel tired after taking LEDIHEP TABLET , you should not participate in activities requiring concentration; for example, do not drive, ride a bike or operate machines.

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Liver

Caution

Inform your doctor if you have liver problems before taking LEDIHEP TABLET ; your doctor will weigh the benefits and potential risks before prescribing LEDIHEP TABLET based on your liver conditions.

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Kidney

Caution

LEDIHEP TABLET has not been fully tested in patients with severe kidney problems. So, inform your doctor if you have kidney problems before taking LEDIHEP TABLET . your doctor will weigh the benefits and potential risks before prescribing LEDIHEP TABLET .

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Children

Safe if prescribed

LEDIHEP TABLET is given to treat chronic (long-term) hepatitis C virus infection in children three years of age and older. If you have any concerns regarding the use of LEDIHEP TABLET in children, discuss them with your doctor.

FAQs

LEDIHEP TABLET is used to treat Chronic hepatitis C virus (HCV) infection.

LEDIHEP TABLET contains the active ingredients ledipasvir and sofosbuvir. Ledipasvir and Sofosbuvir work together to prevent the virus from growing and reproducing. Thus, the infection can be completely eliminated from the body.

Hepatitis C virus infection is contagious and spreads from one person to another through contact with an infected person’s blood. Therefore, it is recommended to avoid sharing personal items or needles containing an infected person&#039;s blood.

In patients receiving continuing HIV therapy, LEDIHEP TABLET should be used with caution because your doctor may wish to monitor your condition regularly. Tell your doctor if you are taking tenofovir disoproxil fumarate or any medicine containing tenofovir disoproxil fumarate used to treat HIV infection.

Caution should be exercised while using LEDIHEP TABLET if you currently take or have taken amiodarone in the last few months. So, inform your doctor. If treatment with LEDIHEP TABLET is needed, you may require additional heart monitoring.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India
Other Info - LED0027

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:07 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/3461/pil
  2. https://www.harvoni.com/
  3. https://medlineplus.gov/druginfo/meds/a614051.html#:~:text=The%20combination%20of%20ledipasvir%20and%20sofosbuvir%20is%20used%20alone%20or,years%20of%20age%20and%20older.

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