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  3. Lari-500 Tablet 10's

Lari-500 Tablet 10's, Pack of 10 TABLETS
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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy

Lari-500 Tablet is a combination medication used in the treatment of malaria. It works by blocking the nucleic acid and protein synthesis of Plasmodium parasites, effectively halting the progression and spread of the infection. Common side effects may include nausea, vomiting, diarrhoea, headache, dizziness, anaemia and rash. If you are pregnant or breastfeeding, make sure to consult your doctor before using Lari-500 Tablet .

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Composition :

PYRIMETHAMINE-25MG + SULFAMETHOXYPYRAZINE-500MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lari-500 Tablet

Lari-500 Tablet belongs to a group of anti-malarial medications used in the treatment of malaria. Malaria is a serious infectious disease caused by parasites of the Plasmodium genus, which are transmitted to humans through the bites of infected female mosquitoes. It leads to symptoms such as fever, chills, and fatigue.

Lari-500 Tablet is a combination of Pyrimethamine and Sulfamethoxypyrazine. Pyrimethamine stops the parasite division, especially during the formation of new parasites in red blood cells and the liver. Sulfamethoxypyrazine works by blocking the production of folic acid, which is essential for the growth of the parasites.

Take Lari-500 Tablet for the duration prescribed by your doctor based on your medical condition. Some common side effects of Lari-500 Tablet may include nausea, vomiting, diarrhoea, headache, dizziness, anaemia and rash. These effects are usually temporary and do not require medical attention. However, if they continue or worsen, see your doctor for advice.

It is advisable not to take Lari-500 Tablet if you are allergic to any of its ingredients. If you are pregnant or breastfeeding, make sure to consult your doctor before using Lari-500 Tablet . Also, inform your doctor if you have a history of heart problems, seizures, anaemia, liver/kidney disease, or are taking any other medicines.

Uses of Lari-500 Tablet

Lari-500 Tablet is used in the treatment of malaria. The detailed uses of Lari-500 Tablet are as follows:

  • Lari-500 Tablet is used in the treatment of malaria.
  • Lari-500 Tablet may also be used to manage toxoplasmosis, an infection caused by Toxoplasma gondii.

Directions for Use

  • Lari-500 Tablet can be taken with meals to avoid stomach upset.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Lari-500 Tablet as a whole with a glass of water.
  • Do not break, crush or chew it.

Medicinal Benefits

Lari-500 Tablet combines Pyrimethamine and Sulfamethoxypyrazine, making it effective in treating malaria. It works by inhibiting the growth and reproduction of Plasmodium parasites, helping to reduce symptoms and support recovery. It may also be used in the treatment of toxoplasmosis. Additionally, its antimicrobial properties make it useful for managing infections, particularly in individuals with weakened immune systems.

How Lari-500 Tablet Works

Lari-500 Tablet contains Pyrimethamine and Sulfamethoxypyrazine. Pyrimethamine acts as a folic acid antagonist by blocking an enzyme in Plasmodium parasites, which prevents the production of purines and pyrimidines needed for DNA and cell growth. This stops the parasite division, especially during the formation of new parasites in red blood cells and the liver. Sulfamethoxypyrazine inhibits the bacterial enzyme dihydropteroate synthetase, preventing para-aminobenzoic acid (PABA) from binding, thereby blocking the production of folic acid, which is essential for the growth of the parasites. Together, Lari-500 Tablet helps treat malaria.

Storage

• Store in a cool and dry place away from sunlight.• Keep Lari-500 Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Lari-500 Tablet

Take Lari-500 Tablet only as advised by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Avoid taking Lari-500 Tablet if you are allergic to any of its ingredients or have a history of severe allergic reactions. Inform your doctor if you have liver or kidney problems, blood disorders, or a history of folate deficiency. If you are pregnant or breastfeeding, consult your doctor for advice. Regular blood tests may be required during treatment to monitor for potential side effects, such as blood cell changes or anaemia. Lari-500 Tablet is recommended for use in children only if prescribed by your doctor. Let the doctor know if you have pre-existing medical conditions or are taking any other medicines, including supplements or herbal products.

Diet & Lifestyle Advise

  • Eat nutritious food that helps to improve malaria-induced weakness.
  • Consume fruits rich in vitamins A and C, such as lemon, grapes, beetroot, and carrot.
  • Avoid eating fried and processed foods, junk food, oily foods, and spicy foods, as they can aggravate nausea and disturb the body's digestion process.
  • Spray insecticides at home and outside to prevent mosquito breeding.
  • Cover your skin in areas that are abundant with mosquitoes.
  • Use insect-repellent creams/spray.
  • Avoid pickles, alcohol, coffee, tea, carbonated beverages, and spicy food.

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Lari-500 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of Lari-500 Tablet with alcohol is unknown. If you have any concerns, discuss them with your doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Lari-500 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Pyrimethamine is excreted in human milk. Therefore, if breastfeeding, inform your doctor before receiving Lari-500 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Lari-500 Tablet may cause dizziness. Therefore, avoid driving if you feel dizzy after taking Lari-500 Tablet .

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Liver

Caution

Inform your doctor if you have liver disease before using Lari-500 Tablet . Your doctor will determine potential risks before prescribing the medicine.

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Kidney

Caution

Inform your doctor if you have kidney disease before using Lari-500 Tablet . Your doctor will determine potential risks before prescribing the medicine.

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Children

Caution

Lari-500 Tablet should be given to children only when prescribed by a doctor. If you have any concerns regarding the use of Lari-500 Tablet for children, please consult a doctor.

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Heart

Please consult your doctor if you have any pre-existing heart disease before using Lari-500 Tablet . Your doctor will prescribe Lari-500 Tablet if the benefits outweigh the risk.

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Lari-500 Tablet in elderly patients.

Have a query?

FAQs

Lari-500 Tablet is used to treat malaria. The combination of Pyrimethamine and Sulfamethoxypyrazine works together to inhibit the parasites' ability to reproduce, effectively treating and reducing the severity of malaria symptoms.

Lari-500 Tablet is a combination of Pyrimethamine and Sulfamethoxypyrazine. Pyrimethamine acts as a folic acid antagonist by blocking an enzyme in Plasmodium parasites, which prevents the production of purines and pyrimidines needed for DNA and cell growth. This stops the parasite division, especially during the formation of new parasites in red blood cells and the liver. Sulfamethoxypyrazine inhibits the bacterial enzyme dihydropteroate synthetase, preventing para-aminobenzoic acid (PABA) from binding, thereby blocking the production of folic acid, which is essential for the growth of the parasites. Together, Lari-500 Tablet helps treat malaria.

If you are pregnant or planning pregnancy, inform your doctor before receiving Lari-500 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

Pyrimethamine is excreted in human milk. Therefore, if you are breastfeeding, inform your doctor before receiving Lari-500 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

Lari-500 Tablet may reduce the number of platelets in the blood, increasing the risk of bleeding. Be cautious when using sharp objects. Contact your doctor if you notice blood in your stools, black or tarry stools, or any unusual bleeding or bruising.

If you don't get better after using Lari-500 Tablet for the prescribed treatment period, please contact your doctor. They may need to adjust your treatment plan or check for other possible causes of your symptoms. Always follow your doctor's instructions and seek help if your symptoms get worse while using this medicine.

Lari-500 Tablet might cause increased sensitivity to the sun. Avoid exposure to sunlight and tanning beds. Wear protective coverings and SPF when going outside.

Taking higher doses than prescribed is ineffective and may cause side effects. Therefore, it's essential to follow the dosage instructions provided by your doctor to ensure safe and effective use.

Do not stop taking Lari-500 Tablet without consulting your doctor; it may reduce the medication’s effectiveness. To treat your condition effectively, continue taking Lari-500 Tablet for as long as your doctor prescribes.

Common side effects of Lari-500 Tablet include nausea, vomiting, diarrhoea, headache, dizziness, anaemia and rash. Seek medical care if the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra.
Other Info - LAR0173

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Reference

  1. https://www.drugs.com/mtm/pyrimethamine.html
  2. https://www.mims.com/philippines/drug/info/sulfalene?mtype=generic
  3. https://go.drugbank.com/drugs/DB00664

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