How does Kyvance 60 Injection work?

Kyvance 60 Injection contains Carfilzomib, which inhibits proteasomes and thereby prevents protein breakdown in MM (multiple myeloma) cells. When the proteasome action within the MM cell is disturbed, a protein accumulation occurs, destroying the cancerous cells.

Is it safe to father a child while taking Kyvance 60 Injection?

No, it is unsafe to father a child while taking Kyvance 60 Injection. It is recommended for sexually active men to use condoms while on treatment and for at least several months after their last dose of Kyvance 60 Injection.

Is Kyvance 60 Injection combined with other medications to treat multiple myeloma?

Based on the medical condition, Kyvance 60 Injection may be given alone or together with other medicines used to treat multiple myeloma.

What should I do if I experience Infusion-related reactions?

Tell your healthcare professional immediately if you get any signs of an infusion-related reaction during or after the infusion. Your doctor may give other medicines, or the infusion may need to be slowed down or stopped.

Kyvance 60 Injection causes a drop in blood cell count?

Kyvance 60 Injection can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.

Is Kyvance 60 Injection right for me?

Kyvance 60 Injection treats multiple myeloma that has returned or no longer responds to treatment. It's often used with other medications. If you have questions or concerns, talk to your doctor. They will help you understand if Kyvance 60 Injection is right for you.

How is Kyvance 60 Injection administered?

Kyvance 60 Injection is to be administered by intravenous infusion in a hospital setting under the supervision of a physician qualified to administer cancer chemotherapeutic agents.

How often will I be given Kyvance 60 Injection?

Kyvance 60 Injection is given on two consecutive days each week for three weeks followed by a 12-day rest period or it may be given once a week for 3 weeks followed by a 13-day rest period. However, the pattern and duration of treatment may vary. Please consult the doctor if you have any concerns.

I am experiencing nausea and extreme tiredness. Is this due to the Kyvance 60 Injection?

You may experience nausea and extreme tiredness from Kyvance 60 Injection. To cope with nausea, try eating small meals, avoiding strong smells, and staying hydrated. For tiredness, prioritize rest, break tasks into smaller chunks, and take regular breaks. Practice relaxation techniques like deep breathing, meditation, or yoga, and stay hydrated and energized with nutritious food. However, if these are bothering you consult your doctor immediately.

Does Kyvance 60 Injection reduce immunity?

Kyvance 60 Injection can lower your blood cell and platelet counts, increasing the risk of infections, anemia, and bleeding. To keep an eye on this, your doctor will likely order regular blood tests before and during treatment. Consult your doctor if you suspect any symptoms of low immunity like delayed healing or frequent infections.

When should I seek a doctor’s advice?

If you experience any of the following, seek a doctor's advice right away: fever, infection signs, unusual bleeding, shortness of breath, chest pain, severe nausea, weakness, confusion, or severe headache. Also, consult your doctor if you have concerns or questions about your treatment, notice any health changes or side effects, miss a dose, or need to change your treatment schedule.

Can Kyvance 60 Injection be used during breastfeeding?

Do not breastfeed while you are receiving Kyvance 60 Injection and for two weeks after your final dose as it may pass into the breastmilk. Consult your doctor if you have any concerns regarding it.

Kyvance 60 Injection

₹15724

(Inclusive of all Taxes)

₹2358.6 Cashback (15%)

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Kyvance 60 Injection is used to treat Multiple Myeloma. It contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells. Sometimes, Kyvance 60 Injection may cause side effects such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever).

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About Kyvance 60 Injection

Kyvance 60 Injection belongs to the group of proteasome inhibitors (anti-cancer medicines). It is used alone and in combination with other medications to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with other medicines. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Kyvance 60 Injection contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Kyvance 60 Injection is administered in a hospital setting by a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Kyvance 60 Injection, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Kyvance 60 Injection can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Do not skip any laboratory checks because Thrombocytopenia, Hepatic Toxicity and Hepatic Failure may occur. If it happens, reduce or interrupt dosing as clinically indicated.

Uses of Kyvance 60 Injection

Kyvance 60 Injection is used in the treatment of Multiple Myeloma. The detailed uses of Kyvance 60 Injection are as follows:<br/>• Relapsed or refractory multiple myeloma: Kyvance 60 Injection is used for the treatment of multiple myeloma in adult patients whose cancer has relapsed or is refractory to one or more lines of therapy. It is specifically indicated when the disease becomes resistant to previous treatments, helping to slow disease progression and extend survival. By targeting cancer cells that have adapted to earlier therapies, Kyvance 60 Injection provides a critical second-line or later treatment option.<br/>• Combination therapy support: Kyvance 60 Injection is used in combination with other agents such as dexamethasone or lenalidomide to enhance overall treatment efficacy in patients with relapsed or refractory multiple myeloma. These combinations have shown improved response rates and longer progression-free survival compared to monotherapy. The synergy between Kyvance 60 Injection and these medications helps increase cancer cell death while maintaining manageable toxicity profiles.<br/>• Proteasome inhibition in cancer therapy: Kyvance 60 Injection is used as a selective proteasome inhibitor that blocks the activity of proteasomes, which are cellular structures responsible for breaking down unneeded or damaged proteins. In cancer cells, this inhibition disrupts protein homeostasis and causes toxic proteins to accumulate, leading to cellular stress and programmed cell death (apoptosis). By targeting the increased protein turnover demands of myeloma cells, Kyvance 60 Injection effectively eliminates cancer cells while leaving most normal cells relatively unaffected.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Kyvance 60 Injection will be administered by a doctor or nurse in a healthcare facility.• Do not self-administer.

Medicinal Benefits

Carfilzomib, a proteasome inhibitor, is present in Kyvance 60 Injection. It suppresses proteasomes, preventing protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

How Kyvance 60 Injection Works

Kyvance 60 Injection contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Kyvance 60 Injection out of reach and sight of children.• Cold chain - To be stored in cold places at 2ÂºC to 8ÂºC.

Side effects of Kyvance 60 Inj

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Shortness Of Breath

Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):

Tell your doctor immediately if you experience shortness of breath after taking medication.
Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Anemia

Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
Consume vitamin C-rich foods as they aid iron absorption.
Limit tea, cocoa, and coffee as these can slow iron absorption.
Exercise regularly; however, do not overdo it.

What if I have taken an overdose of Kyvance 60 Injection

As Kyvance 60 Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Kyvance 60 Injection may cause chills, dizziness, and decreased urination.

Drug Warnings

Before taking Kyvance 60 Injection, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Kyvance 60 Injection if you are pregnant or breastfeeding or allergic to any component present in Kyvance 60 Injection. Both women and men using this Kyvance 60 Injection should use birth control to avoid pregnancy. Inform your doctor right away if you or your partner become pregnant during treatment with Kyvance 60 Injection. Inform your doctor if you have a history of heart failure and ischemia, Pulmonary Hypertension, Thrombocytopenia, low blood pressure or hepatic toxicity; your doctor will closely monitor and manage it. Carfilzomib injection may induce serious or life-threatening responses for up to 24 hours following administration. Before each dose of carfilzomib, you will be given specific drugs to assist in preventing a reaction. If you develop any of the following symptoms after your treatment, contact your doctor right away: fever, chills, joint or muscle pain, flushing or swelling of the face, swelling or tightening of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.

Drug-Drug Interactions

CarfilzomibAdalimumab

Severe

CarfilzomibTofacitinib

Severe

Drug-Drug Interactions

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CarfilzomibAdalimumab

Severe

How does the drug interact with Kyvance 60 Inj:
Combining Adalimumab with Kyvance 60 Inj can increase the risk of infections.

How to manage the interaction:
Co-administration of Kyvance 60 Inj with Adalimumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without first talking to your doctor.

CarfilzomibTofacitinib

Severe

How does the drug interact with Kyvance 60 Inj:
Taking Kyvance 60 Inj with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Tofacitinib with Kyvance 60 Inj can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

CarfilzomibErythropoietin

Severe

How does the drug interact with Kyvance 60 Inj:
Kyvance 60 Inj can cause serious blood clots and taking it alongside Erythropoietin may enhance the risk.

How to manage the interaction:
Co-administration of Erythropoietin with Kyvance 60 Inj can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

CarfilzomibAminocaproic acid

Severe

How does the drug interact with Kyvance 60 Inj:
Coadministration of Aminocaproic acid and Kyvance 60 Inj can increase the risk of developing blood clots.

How to manage the interaction:
Co-administration of Kyvance 60 Inj with Aminocaproic acid can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms, such as chest pain, shortness of breath, redness or swelling in an arm or leg, or weakness, contact a doctor right away. Do not discontinue any medications without consulting a doctor.

CarfilzomibDarbepoetin alfa

Severe

How does the drug interact with Kyvance 60 Inj:
Combining Darbepoetin alfa with Kyvance 60 Inj can increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Kyvance 60 Inj and Darbepoetin alfa, you can take these medicines together if prescribed by your doctor. However, if you experience chest pain; shortness of breath; difficulty breathing; coughing up blood; sudden loss of vision; pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.

CarfilzomibPrasterone

Severe

How does the drug interact with Kyvance 60 Inj:
Taking Prasterone with Kyvance 60 Inj can increase the risk of clotting.

How to manage the interaction:
Co-administration of Prasterone with Kyvance 60 Inj can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience sudden loss of eyesight, chest pain, breathing difficulties, coughing up blood, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor, immediately. Do not stop using any medications without a doctor's advice.

CarfilzomibTamoxifen

Severe

How does the drug interact with Kyvance 60 Inj:
Taking Kyvance 60 Inj with tamoxifen may increase the risk of blood clots. The risk is also increased with age, cigarette smoking, high blood pressure, or high cholesterol.

How to manage the interaction:
Although taking tamoxifen and Kyvance 60 Inj together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not stop using any medications without consulting doctor.

CarfilzomibLeflunomide

Severe

How does the drug interact with Kyvance 60 Inj:
Combining Kyvance 60 Inj with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Taking Kyvance 60 Inj with Leflunomide together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include liver damage, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or bleeding. Do not discontinue any medications without consulting your doctor.

CarfilzomibTranexamic acid

Severe

How does the drug interact with Kyvance 60 Inj:
Co-administration of Kyvance 60 Inj with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Kyvance 60 Inj with tranexamic acid is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

CarfilzomibStanozolol

Severe

How does the drug interact with Kyvance 60 Inj:
Coadministration of Kyvance 60 Inj and sulfasalazine can increase the risk or severity of developing blood clots.

How to manage the interaction:
Although taking Kyvance 60 Inj and sulfasalazine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
Performing yoga may also help in improving both physical and mental health.
Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
Eat a healthy diet and exercise regularly to maintain proper weight.
Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
Get optimal sleep; rest well.
Avoid smoking and alcohol consumption.
Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Alcohol

Caution

Avoid alcohol consumption while on treatment with Kyvance 60 Injection.

Pregnancy

Unsafe

Kyvance 60 Injection should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.

Breast Feeding

Unsafe

Do not breastfeed while you are receiving Kyvance 60 Injection and for two weeks after your final dose.

Driving

Caution

Kyvance 60 Injection may cause fatigue, dizziness, fainting, and/or a drop in blood pressure. So, if you have any of these symptoms while in therapy, you should not operate machinery or drive a car.

Liver

Caution

Extreme caution is exercised while using Kyvance 60 Injection in patients with liver impairment. Inform your doctor if you have liver impairment. Your doctor monitors liver enzymes and withholds dosing if suspected.

Kidney

Caution

Limited information is available. Please inform your doctor before prescribing Kyvance 60 Injection if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Kyvance 60 Injection.

Children

Caution

The safety and effectiveness of Kyvance 60 Injection in pediatric patients have not been established.

Have a query?

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Country of origin

India

Other Info - KYV0003

Author Details

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:05 AM IST

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Kyvance 60 Injection

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FAQs

What is the use of Kyvance 60 Injection?

How does Kyvance 60 Injection work?

Is it safe to father a child while taking Kyvance 60 Injection?

Is Kyvance 60 Injection combined with other medications to treat multiple myeloma?

What should I do if I experience Infusion-related reactions?

Kyvance 60 Injection causes a drop in blood cell count?

Is Kyvance 60 Injection right for me?

How is Kyvance 60 Injection administered?

How often will I be given Kyvance 60 Injection?

I am experiencing nausea and extreme tiredness. Is this due to the Kyvance 60 Injection?

Does Kyvance 60 Injection reduce immunity?

When should I seek a doctor’s advice?

Can Kyvance 60 Injection be used during pregnancy?

Can Kyvance 60 Injection be used during breastfeeding?

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Author Details

Reference