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  3. Kynteles 300 mg Injection 1's

Kynteles 300 mg Injection 1's, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Kynteles 300 mg Injection is used to treat moderately to severely Crohn's disease and ulcerative colitis. It contains Vedolizumab, which works by selectively reducing gut inflammation in these conditions. Common side effects of this medication may include nausea, headache, fever, joint pain, tiredness, cough, back pain, itching, dizziness, and injection site reactions.

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Composition :

VEDOLIZUMAB-300MG

Manufacturer/Marketer :

Takeda Pharmaceuticals India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Kynteles 300 mg Injection

Kynteles 300 mg Injection belongs to the class of monoclonal antibodies which is used in the treatment of moderately to severe Crohn’s disease (a chronic inflammatory bowel disease that affects any part of the gastrointestinal tract, mainly small and large intestine) and ulcerative colitis (an inflammatory bowel disease that causes swelling in the digestive tract). 

Kynteles 300 mg Injection consists of Vedolizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. 

Kynteles 300 mg Injection may cause side effects such as nausea, headache, fever, joint pain, tiredness, cough, back pain, itching, dizziness, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor on priority. Kynteles 300 mg Injection is a parenteral medicine. It will be administered by a trained healthcare doctor. Hence, do not self-administer. 

Kynteles 300 mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, tuberculosis, gastrointestinal disorders, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Kynteles 300 mg Injection may cause dizziness, so drive only if you are alert and focused. Kynteles 300 mg Injection should not be given to children below 18 years of age as safety has not been established. Consult the doctor if you are pregnant or breastfeeding.

Uses of Kynteles 300 mg Injection

Kynteles 300 mg Injection is used in the treatment of Crohn's disease and ulcerative colitis. The detailed uses of Kynteles 300 mg Injection are as follows:<br/>• Ulcerative Colitis (UC): Kynteles 300 mg Injection is used to treat moderately to severely active UC, it helps induce and maintain clinical remission, improve mucosal healing, reduce or eliminate the need for corticosteroids.<br/>• Crohn’s Disease (CD): Kynteles 300 mg Injection is used with moderately to severely active CD, it can induce and maintain remission and improve quality of life by reducing flare-ups and symptoms.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Kynteles 300 mg Injection will be administered by a nurse or doctor.• Do not self-administer.

Medicinal Benefits

Kynteles 300 mg Injection consists of Vedolizumab as an active ingredient, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. This alters the gene expression of blood monocytes and thus helps reduce inflammation and is used in the treatment of moderately to severe Crohn’s disease and Ulcerative colitis.

How Kynteles 300 mg Injection Works

Kynteles 300 mg Injection consists of Vedolizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation.

Storage

• Store in a cool and dry place away from sunlight.• Keep Kynteles 300 mg Injection out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Kynteles 300 mg Injection
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

What if I have taken an overdose of Kynteles 300 mg Injection

Since Kynteles 300 mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Kynteles 300 mg Injection should be avoided if allergic to it or any other components present. Inform your doctor if you have any history of serious infections, tuberculosis, gastrointestinal disorders, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Do not take live vaccines while being treated with Kynteles 300 mg Injection to prevent any serious consequences.  Kynteles 300 mg Injection may cause serious reactions, including infusion-related or allergic reactions. It may also increase the risk of hepatotoxicity, serious infections and hypersensitivity reactions in some patients. Hence, patients should be carefully monitored for changes during and after the treatment. Hence, patients should be carefully monitored for changes during and after the treatment.  Kynteles 300 mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established. Kynteles 300 mg Injection may cause dizziness, so drive only if you are alert and focused. This medicine can cause Progressive Multifocal Leukoencephalopathy (PML) in most patients with compromised immune systems. Hence, Kynteles 300 mg Injection is contraindicated in patients who have or had PML. Consult your doctor immediately if the patient develops confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.

Drug-Drug Interactions

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VedolizumabTofacitinib
Severe
VedolizumabInfliximab
Severe

Drug-Drug Interactions

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VedolizumabTofacitinib
Severe
How does the drug interact with Kynteles 300 mg Injection:
Taking Kynteles 300 mg Injection with Tofacitinib may increase the risk of infection.

How to manage the interaction:
Taking Tofacitinib with Kynteles 300 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.Do not stop using any medications without a doctor's advice.
VedolizumabInfliximab
Severe
How does the drug interact with Kynteles 300 mg Injection:
Combining Infliximab with Vedolizumabcan lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Kynteles 300 mg Injection with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
VedolizumabBaricitinib
Severe
How does the drug interact with Kynteles 300 mg Injection:
Coadministration of Kynteles 300 mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Baricitinib and Kynteles 300 mg Injection, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
VedolizumabLenalidomide
Severe
How does the drug interact with Kynteles 300 mg Injection:
Combining Lenalidomide with Kynteles 300 mg Injection can increase the chances of experiencing harmful side effects.

How to manage the interaction:
Taking Lenalidomide with Kynteles 300 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor if you experience any symptoms of infection, such as chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort, or burning during urination. Do not stop using any medications without first talking to your doctor.
VedolizumabCladribine
Severe
How does the drug interact with Kynteles 300 mg Injection:
Taking Cladribine with Kynteles 300 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Kynteles 300 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
VedolizumabEtanercept
Severe
How does the drug interact with Kynteles 300 mg Injection:
When Etanercept is used with Kynteles 300 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Kynteles 300 mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.
  • Eat more fibre-rich foods such as fruits and vegetables.
  • Eat smaller meals all day and drink small amounts of water throughout the day.
  • If you are intolerant to lactose, lower your intake of milk.
  • Avoid foods high in sugar, fat, and processed foods, as these may cause inflammation.
  • Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES
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Alcohol

Unsafe

Avoid alcohol consumption, as it may worsen your existing stomach problems.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Kynteles 300 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Kynteles 300 mg Injection is known to pass in the breastmilk. Hence, if you are breastfeeding, inform your doctor before receiving Kynteles 300 mg Injection. Your doctor may prescribe Kynteles 300 mg Injection only if the benefits outweigh the risks.

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Driving

Caution

Kynteles 300 mg Injection may cause confusion, blurred vision or loss of vision. If you experience such symptoms after taking Kynteles 300 mg Injection, do not drive or do activities that require your clear vision and mental alertness.

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Liver

Caution

Kynteles 300 mg Injection may cause liver problems in some patients. Hence, caution should be exercised. Inform your doctor if you observe any symptoms of tiredness, loss of appetite, dark urine, yellowing of the skin and eyes, or pain in the abdomen. Dose adjustment may be needed in patients with liver impairment.

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Kidney

Caution

Kynteles 300 mg Injection should be used with caution if you have kidney disease. Dose adjustment may be needed in patients with kidney impairment.

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Children

Unsafe

Kynteles 300 mg Injection is not recommended in children below 18 years of age as the safety and efficacy are not established.

Have a query?

FAQs

Kynteles 300 mg Injection is used to treat Crohn’s disease and ulcerative colitis.

Kynteles 300 mg Injection works by binding to the chemical substance called α4β7 integrin, which is responsible for inflammation. This alters the gene expression of blood monocytes and thus helps reduce inflammation.

Inform your doctor about your complete medical and medication history, especially if you have any history of serious infections, tuberculosis, gastrointestinal disorders, liver or kidney diseases, or a weak immune system, as it can worsen your health condition.

Country of origin

India

Manufacturer/Marketer address

6th Floor, Building 8, Tower C, DLF Cyber City, DLF Phase 2, Gurgaon 122002, Haryana, India
Other Info - KYN0001

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:20 PM IST

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Reference

  1. https://go.drugbank.com/drugs/DB09033
  2. https://medlineplus.gov/druginfo/meds/a614034.html
  3. https://reference.medscape.com/drug/entyvio-vedolizumab-999901
  4. https://www.entyvio.com/
  5. https://www.drugs.com/vedolizumab.html
  6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125476Orig1s046lbl.pdf

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