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  3. Kupen 500 mg Injection 1's

Kupen 500 mg Injection 1's, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Kupen 500 mg Injection is an anti-infective medicine used in treating bacterial infections. This medicine stops the growth of bacteria and thereby helps reduce various bacterial infections. It helps by inhibiting the bacterial cell synthesis and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections. Common side effects include swelling, pain, itching, nausea, vomiting, diarrhoea, headache, and rash.
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Composition :

MEROPENEM-1000MG + SULBACTAM-500MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Kupen 500 mg Injection

Kupen 500 mg Injection belongs to the group of medications called anti-infectives used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Kupen 500 mg Injection contains Meropenem and Sulbactam. Meropenem is a type of antibiotic. It works by preventing the formation of the bacterial protective covering, which is required for bacterial survival. Sulbactam is a beta-lactamase inhibitor that reduces resistance and improves Meropenem antibacterial activity.

Kupen 500 mg Injection should only be administered under the supervision of a healthcare professional. The dose depends on the type of infection you have, where the infection is in the body, and how severe the infection is. Your doctor will decide on the dose that you need. The common side-effects of Kupen 500 mg Injection may include injection site reactions that may occur, including swelling, pain, itching, nausea, vomiting, diarrhoea, headache, and rash. These side effects are usually mild and temporary. However, if any of these side effects persist or get worse, inform your doctor immediately.

To treat your condition effectually, continue using Kupen 500 mg Injection for as long as your doctor has prescribed it. Do not use Kupen 500 mg Injection without a doctor's advice if you had a skin reaction or irritation to any medicine. Consult your doctor before using Kupen 500 mg Injection if you are pregnant or breastfeeding. Do not use Kupen 500 mg Injection in more than prescribed doses or longer duration as it may cause adverse effects. Do not discontinue or abruptly stop the medication as it may lead to antibiotic resistance, a condition in which bacteria become resistant to antibiotics. Keep your doctor informed about your health condition and all the medicines you take before taking Kupen 500 mg Injection to rule out any side effects. It is not known whether Kupen 500 mg Injection can interact with alcohol or may affect your ability to drive. So, please discuss with your doctor the possible risks and benefits before taking this medicine.

Uses of Kupen 500 mg Injection

Treatment of Bacterial infections

Directions for Use

• Follow your doctor's instructions on the dosage and timing of Kupen 500 mg Injection. Typically, it is administered every 6 to 8 hours.• Kupen 500 mg Injection will be administered by a doctor or nurse in a hospital setting.• Do not self-administer this medication.

Medicinal Benefits

Kupen 500 mg Injection contains Meropenem and Sulbactam. Meropenem is an antibiotic that treats the infection by killing the bacteria. Sulbactam is a beta-lactamase (an enzyme produced by bacteria that can destroy antibiotics) inhibitor and prevents the destruction of Meropenem from the bacteria. Kupen 500 mg Injection has broad-spectrum activity and is effective against both gram-positive and gram-negative bacteria. It is used to treat bacterial infections such as skin infections, gynecological infections, and intra-abdominal infections.

How Kupen 500 mg Injection Works

Kupen 500 mg Injection contains Meropenem and Sulbactam. Meropenem is a type of antibiotic. It works by preventing the formation of the bacterial protective covering, which is required for bacterial survival. Sulbactam is a beta-lactamase inhibitor that reduces resistance and improves Meropenem antibacterial activity.

Storage

Keep Kupen 500 mg Injection out of reach and sight of children.
Side effects of Kupen 500 mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
  • Stay hydrated by drinking plenty of water to help reduce swelling.
  • Include anti-inflammatory foods like turmeric, ginger, and omega-3 rich foods in your diet.
  • Avoid processed and high-sodium foods that can exacerbate swelling.
  • Utilize an ice pack wrapped in a cloth to cool the affected area, helping to alleviate swelling and discomfort.
  • Gently massage the site, if recommended by your healthcare provider, to promote lymphatic drainage.
  • Rotate injection sites to minimize irritation and swelling.
  • Allow your body time to rest and recuperate, limiting physically demanding tasks to facilitate a smoother recovery.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.

What if I have taken an overdose of Kupen 500 mg Injection

Since Kupen 500 mg Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

It is not recommended to take Kupen 500 mg Injection if you are allergic to other antibiotics or this medicine's contents. Kupen 500 mg Injection is not recommended for people with infectious mononucleosis (viral infection with sore throat and fever) and colitis (intestine inflammation). Kupen 500 mg Injection should be used with caution in patients with kidney impairment. Do not discontinue or abruptly stop the medication as it may lead to antibiotic resistance, a condition in which bacteria become resistant to antibiotics. Should use Kupen 500 mg Injection with caution in children, pregnant women, breastfeeding mothers and older people. It is not known whether Kupen 500 mg Injection can interact with alcohol or may affect your ability to drive. So, please discuss with your doctor the possible risks and benefits before taking this medicine.

Drug-Drug Interactions

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MeropenemTramadol
Severe
MeropenemBCG vaccine
Severe

Drug-Drug Interactions

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MeropenemTramadol
Severe
How does the drug interact with Kupen 500 mg Injection:
Taking Tramadol with Kupen 500 mg Injection together may cause higher levels of Kupen 500 mg Injection in the blood.

How to manage the interaction:
Taking Kupen 500 mg Injection with Tramadol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MeropenemBCG vaccine
Severe
How does the drug interact with Kupen 500 mg Injection:
When BCG vaccine is used with Kupen 500 mg Injection, its effectiveness may be reduced.

How to manage the interaction:
Taking Kupen 500 mg Injection with the BCG vaccine together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MeropenemIomeprol
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Iomeprol and Kupen 500 mg Injection together can increase the risk of causing seizures.

How to manage the interaction:
Taking Kupen 500 mg Injection with Iomeprol together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs - close monitoring, seizures, or head injury - contact a doctor right away." Do not stop using any medications without talking to a doctor.
MeropenemSodium Valproate
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Meropenam and Sodium valproate together can reduce the effect of Sodium valproate.

How to manage the interaction:
Co-administration of Meropenam and Sodium valproate can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MeropenemDivalproex
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Divalproex and Kupen 500 mg Injection can reduce the blood levels of Divalproex sodium.

How to manage the interaction:
Co-administration of Divalproex with Kupen 500 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
MeropenemMetrizamide
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Metrizamide and Kupen 500 mg Injection together can increase the risk of seizures.

How to manage the interaction:
Taking Kupen 500 mg Injection with Metrizamide together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs - being closely monitored by your doctor, having seizures, or having a condition or head injury - contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Probiotics should be taken after taking an entire course of Kupen 500 mg Injection to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria.
  • Include more fibre enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet.
  • Avoid alcoholic beverages with Kupen 500 mg Injection as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Kupen 500 mg Injection in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- INFECTIVES

Kupen 500 mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Alcohol may increase the side effects of Kupen 500 mg Injection. Hence, it is advised to limit the intake of alcohol while using Kupen 500 mg Injection.

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Pregnancy

Caution

Kupen 500 mg Injection should be used in pregnant women only if clinically needed when the benefits outweigh the risks. Your doctor will weigh the benefits and any potential risks before prescribing Kupen 500 mg Injection.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Kupen 500 mg Injection in breastfeeding/nursing mothers.

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Driving

Caution

It is not known whether Kupen 500 mg Injection alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Kupen 500 mg Injection should be used with caution in patients with liver diseases as it may affect liver function. The dose may have to be adjusted by your doctor. Please consult the doctor.

bannner image

Kidney

Caution

Kupen 500 mg Injection should be used with caution in patients with kidney diseases. Your doctor will weigh the benefits and any potential risks before prescribing Kupen 500 mg Injection.

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Children

Caution

Kupen 500 mg Injection should be used in children only if clinically needed. The doctor may have to adjust the dose based on age, body weight and medical history.

Have a query?

FAQs

Kupen 500 mg Injection belongs to the group of medications called anti-infectives used to treat bacterial infections.

Kupen 500 mg Injection is used to treat bacterial infections. It contains Meropenem and Sulbactam. Meropenem reduces the infection by inhibiting bacterial growth. It disrupts the cell wall formation (outer layer), which is essential for bacteria's survival. Sulbactam inhibits the action of beta-lactamase, an enzyme produced by the bacteria to destroy antibiotics (Meropenem).

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.

Do not stop using Kupen 500 mg Injection even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and to worsening of the disease.

Kupen 500 mg Injection should not be given to the people with infectious mononucleosis (viral infection with sore throat and fever) and colitis (inflammation of the intestine) as Kupen 500 mg Injection worsen these conditions.

Country of origin

INDIA

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - KUP0006

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 18, 2025 | 6:55 AM IST

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Reference

  1. https://pubmed.ncbi.nlm.nih.gov/18707240/
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/050706s032s034lbl.pdf
  3. https://www.medicines.org.uk/emc/files/pil.9074.pdf

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